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Find hotels in Defiance, MO from SAR 229

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Compare 823 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Our top choices for Defiance hotels

Drury Inn & Suites St. Louis St. Peters

3.0 star property
9.2 out of 10, Wonderful, (1000)
"Very friendly staff and very handy location!"
The price is SAR 413
SAR 474 total
includes taxes & fees
14 Sep - 15 Sep
Drury Inn & Suites St. Louis St. Peters

Drury Plaza Hotel St. Louis St. Charles

3.0 star property
9.6 out of 10, Exceptional, (1002)
"We liked the indoor/outdoor pool, the free drinks, and the breakfast was great"
The price is SAR 413
SAR 478 total
includes taxes & fees
21 Sep - 22 Sep
Drury Plaza Hotel St. Louis St. Charles

The Wildwood Hotel

3.5 star property
9.2 out of 10, Wonderful, (1563)
"Great place to stay."
The Wildwood Hotel

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3.0 star property
8.2 out of 10, Very Good, (1001)
"Very good hotel for the price"
The price is SAR 335
SAR 387 total
includes taxes & fees
9 Sep - 10 Sep
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Drury Plaza Hotel St. Louis Chesterfield

3.0 star property
9.6 out of 10, Exceptional, (1005)
"Great place to stay! "
The price is SAR 488
SAR 566 total
includes taxes & fees
14 Sep - 15 Sep
Drury Plaza Hotel St. Louis Chesterfield

Best Western Plus Fenton

2.5 star property
9.2 out of 10, Wonderful, (109)
"It was a perfect hotel"
The price is SAR 372
SAR 430 total
includes taxes & fees
10 Sep - 11 Sep
Best Western Plus Fenton

Super 8 by Wyndham Washington

2.0 star property
8.4 out of 10, Very Good, (667)
"It was clean and quaint for the price and was also close to where I was going the next morning. "
The price is SAR 328
SAR 373 total
includes taxes & fees
14 Sep - 15 Sep
Super 8 by Wyndham Washington

Comfort Inn & Suites St. Louis - O'Fallon

2.5 star property
7.6 out of 10, Good, (1000)
"And nice hotel at a nice price "
The price is SAR 278
SAR 328 total
includes taxes & fees
29 Sep - 30 Sep
Comfort Inn & Suites St. Louis - O'Fallon

Comfort Suites St Charles - St Louis

2.5 star property
8.4 out of 10, Very Good, (1002)
"Everything was great, clean, close to the places we were going too. "
The price is SAR 393
SAR 452 total
includes taxes & fees
14 Sep - 15 Sep
Comfort Suites St Charles - St Louis

Sleep Inn & Suites O'Fallon MO - Technology Drive

2.5 star property
8.8 out of 10, Excellent, (1005)
"Great location very clean and friendly staff!!!"
The price is SAR 334
SAR 394 total
includes taxes & fees
14 Sep - 15 Sep
Sleep Inn & Suites O'Fallon MO - Technology Drive

Hampton Inn St. Charles St. Peters

2.5 star property
8.0 out of 10, Very Good, (1002)
"Easily accessible from I-70."
The price is SAR 307
SAR 353 total
includes taxes & fees
28 Sep - 29 Sep
Hampton Inn St. Charles St. Peters

Holiday Inn Express St. Louis West - O'Fallon by IHG

2.5 star property
8.6 out of 10, Excellent, (777)
"The staff were very nice & the breakfast was enjoyable. The hotel was clean."
The price is SAR 379
SAR 447 total
includes taxes & fees
21 Sep - 22 Sep
Holiday Inn Express St. Louis West - O'Fallon by IHG

Best Western Plus Washington Hotel

2.5 star property
9.0 out of 10, Wonderful, (590)
"Great breakfast, comfortable room, and wonderful staff, all for a reasonable price. We stay here every time we are in Washington."
The price is SAR 484
SAR 551 total
includes taxes & fees
7 Sep - 8 Sep
Best Western Plus Washington Hotel

Super 8 by Wyndham Union

2.0 star property
8.2 out of 10, Very Good, (613)
"Good room for a reasonable price "
Super 8 by Wyndham Union

Holiday Inn St. Louis West Six Flags by IHG

3.0 star property
8.8 out of 10, Excellent, (1001)
"Beautiful property with a lot of history. Very fun place with a lot of things to do."
The price is SAR 364
SAR 424 total
includes taxes & fees
9 Sep - 10 Sep
Holiday Inn St. Louis West Six Flags by IHG

Best Western Plus The Charles Hotel

3.0 star property
8.0 out of 10, Very Good, (1005)
"I enjoyed my stay the food was good!"
The price is SAR 348
SAR 403 total
includes taxes & fees
17 Sep - 18 Sep
Best Western Plus The Charles Hotel

Country Inn & Suites by Radisson, St. Charles Historic District

2.5 star property
9.4 out of 10, Exceptional, (1007)
"The hotel is so warm and comforting and fits right into the quaint downtown area. "
The price is SAR 427
SAR 491 total
includes taxes & fees
11 Sep - 12 Sep
Country Inn & Suites by Radisson, St. Charles Historic District

Hampton Inn St. Louis Southwest

2.5 star property
9.0 out of 10, Wonderful, (945)
"Room was very nice and comfortable bed….still ongoing hotel makeover happening but comfortable room…."
The price is SAR 415
SAR 485 total
includes taxes & fees
5 Oct - 6 Oct
Hampton Inn St. Louis Southwest

Extended Stay America Suites St Louis St Peters

2.5 star property
7.0 out of 10, Good, (564)
"Now hotel , bathroom new and very big "
The price is SAR 321
SAR 369 total
includes taxes & fees
12 Sep - 13 Sep
Extended Stay America Suites St Louis St Peters

Holiday Inn Express & Suites St Peters by IHG

2.5 star property
9.2 out of 10, Wonderful, (345)
"Very nice place. Clean... quiet and very friendly staff!! We will definitely stay here again!!"
The price is SAR 432
SAR 519 total
includes taxes & fees
7 Oct - 8 Oct
Holiday Inn Express & Suites St Peters by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

Top Defiance Hotel Reviews

More cheap stays in Defiance

More cheap stays in Defiance

Hotels in Defiance with star-rating

Hotels in Defiance with star-rating

Explore a world of travel with Expedia

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Frequently asked questions

What's the best place to stay in Defiance?

Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay based on our traveler data. Other good choices for your stay in the area are Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham and Sonesta ES Suites St. Louis - Chesterfield. See all available top hotels, or vacation rentals in Defiance.

What's the top vacation rental in Defiance?

Stunning 1890's Home - Sleeps 8! : Visitors like this Defiance vacation home rental. It is equipped with a barbecue grill, air-conditioning, and laundry facilities to help you feel comfortable during your stay. It has 4 bedrooms as well as a kitchen with a dishwasher, a stovetop, and a microwave, so you can cook with friends or family. See all vacation rentals in Defiance.

If I need to cancel my hotel reservation in Defiance, will I receive a refund?

Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.

Where can I learn more about changing or cancelling my trip to Defiance?

For more information about changing or cancelling your trip to Defiance, head over to our customer service page.

Where is the best hotel to stay with easy access to August A. Busch Memorial Conservation Area?

Sleep Inn & Suites O'Fallon MO - Technology Drive is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located 2.6 mi (4.3 km) from August A. Busch Memorial Conservation Area. Other good options within a few miles include Hilton Garden Inn St. Louis/O'Fallon MO and Holiday Inn Express St. Louis West - O'Fallon, an IHG Hotel.

What about the best place to stay near Chandler Hill Vineyards?

One of the top choices for your stay is The Wildwood Hotel, located 10 mi (16.1 km) from Chandler Hill Vineyards, and this 3.5-star hotel offers free breakfast and an indoor pool.

What are some accommodations with pools in Defiance?
What's the best place to stay near Lambert-St. Louis International Airport (STL)?

Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.

What's it like to stay in Defiance?

Visitors can enjoy all that Defiance has to offer including the wineries and parks. Top sights in the area include St. Louis Union Station, Busch Stadium, and Gateway Arch. In Defiance, there are 20 hotels and other accommodations to choose from. Find out more about Defiance.

What is there to see in Defiance?

Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River, and Matson Hill Park Trailhead. A couple of additional sights to add to your agenda are Yellow Farmhouse Winery and Chandler Hill Vineyards. Check out what more to see and do in Expedia's Defiance guide.

What's the seasonal weather like in Defiance?

The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.