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In two weeks
19 Sep - 21 Sep
In two months
31 Oct - 2 Nov
In three months
28 Nov - 30 Nov
In four months
26 Dec - 28 Dec

Apartments in Defiance

Our top choices for Defiance apartments

Overlook Main St. in this 2 Bedroom Owners Suite!
Fridge, microwave, oven, stovetop

Overlook Main St. in this 2 Bedroom Owners Suite!

4.0 star property
9.4 out of 10, Exceptional, (32)
"Perfect place for a visit to St Charles! Hope to return and stay here again!"
Overlook Main St. in this 2 Bedroom Owners Suite!
The Lofts of North Main Street
Dining

The Lofts of North Main Street

9.6 out of 10, Exceptional, (146)
"Perfect location!"
The price is SAR 436
SAR 935 total
includes taxes & fees
8 Sep - 9 Sep
The Lofts of North Main Street
Studio on Historic Main by StayLage
1 bedroom, iron/ironing board, WiFi, bed sheets

Studio on Historic Main by StayLage

9.4 out of 10, Exceptional, (29)
"My wife and I stayed for her birthday weekend and had a great time. The property is located at the end of the strip so it was perfect to start the bar hoping. The apartment was very cozy and clean. Definitely recommend for the quick get a way!!"
The price is SAR 344
SAR 786 total
includes taxes & fees
7 Sep - 8 Sep
Studio on Historic Main by StayLage
The Hidden Gem - 2BR Basement Apartment on 7 Acres
Fridge, microwave, oven, stovetop

The Hidden Gem - 2BR Basement Apartment on 7 Acres

10.0 out of 10, Exceptional, (12)
"Great place, nice neighborhood. "
The price is SAR 516
SAR 1,034 total
includes taxes & fees
25 Sep - 26 Sep
The Hidden Gem - 2BR Basement Apartment on 7 Acres
Prime Loft of Main Street
Smart TV

Prime Loft of Main Street

9.8 out of 10, Exceptional, (99)
"The apartment had everything we needed for a quick getaway with family. Cute place and perfectly located. "
The price is SAR 436
SAR 935 total
includes taxes & fees
8 Sep - 9 Sep
Prime Loft of Main Street
The Historic Bricks on Main
TV

The Historic Bricks on Main

9.0 out of 10, Wonderful, (12)
"Love how close it is to everything. Very clean. Would stay there again. "
The price is SAR 426
SAR 880 total
includes taxes & fees
4 Sep - 5 Sep
The Historic Bricks on Main
Back Door Guest Suite, Zia My Retreat
TV

Back Door Guest Suite, Zia My Retreat

10.0 out of 10, Exceptional, (4)
"Beautiful relaxing place in adorable neighborhood! Quite the find!"
The price is SAR 525
SAR 863 total
includes taxes & fees
4 Sep - 5 Sep
Back Door Guest Suite, Zia My Retreat
Cozy Studio Oasis Blocks from Main Street
Fridge, microwave, oven, stovetop

Cozy Studio Oasis Blocks from Main Street

9.6 out of 10, Exceptional, (39)
"We appreciated the easy checkin and nice accommodations exactly as advertised."
Cozy Studio Oasis Blocks from Main Street
Cozy Clark Suite in Frenchtown Saint Charles
Smart TV

Cozy Clark Suite in Frenchtown Saint Charles

9.2 out of 10, Wonderful, (7)
"Lovely apartment in delightful Frenchtown, quiet and charming, just moments away from historic diwntown St. Charles. Owner was responsive and accommodating. "
Cozy Clark Suite in Frenchtown Saint Charles
Private Basement Retreat w/ HOT TUB by StayLage
TV

Private Basement Retreat w/ HOT TUB by StayLage

9.0 out of 10, Wonderful, (7)
"My husband could not say enough about his stay. We not only recommend this place but will stay there again. Great communication and a beautiful space!"
The price is SAR 344
SAR 891 total
includes taxes & fees
8 Sep - 9 Sep
Private Basement Retreat w/ HOT TUB by StayLage
Amazing Renovated Historic Loft on Main Street
Fridge, microwave, oven, stovetop

Amazing Renovated Historic Loft on Main Street

10.0 out of 10, Exceptional, (53)
"The place was great, just as advertised. Location was close to everything and made for a nice weekend away from kids"
The price is SAR 436
SAR 935 total
includes taxes & fees
8 Sep - 9 Sep
Amazing Renovated Historic Loft on Main Street
Lovely Couples Escape on Mississippi River!
Desk, internet, bed sheets

Lovely Couples Escape on Mississippi River!

10.0 out of 10, Exceptional, (17)
"We had a great time staying in the home along the Mississippi. It was beautifully decorated and perfect for a relaxing long weekend. "
Lovely Couples Escape on Mississippi River!
Shaman Suite, Zia My Retreat
Property grounds

Shaman Suite, Zia My Retreat

10.0 out of 10, Exceptional, (21)
"Big fan of this place and the property owner was very nice."
Shaman Suite, Zia My Retreat
Landing at The Parq at Chesterfield - 1 Bedroom...
Pool

Landing at The Parq at Chesterfield - 1 Bedroom...

8.0 out of 10, Very Good, (1)
Landing at The Parq at Chesterfield - 1 Bedroom...
1st Capitol Mansion - Suite 401
Private kitchen

1st Capitol Mansion - Suite 401

8.4 out of 10, Very Good, (7)
"Nice property and a great location to all the shops and restaurants that St. Charles has to offer. The place was clean and nicely updated. Will definitely stay here again!"
The price is SAR 334
SAR 884 total
includes taxes & fees
4 Sep - 5 Sep
1st Capitol Mansion - Suite 401
Swim, Fish, Hike, Horseback
Outdoor dining

Swim, Fish, Hike, Horseback

9.6 out of 10, Exceptional, (62)
"We were in town for a wedding and this property was wonderful for us all to stary together. The owners were very friendlt and had so much knowledge to share with us of the area and their property. 10/10 reccomend staying here!"
Swim, Fish, Hike, Horseback
The Wild West Getaway- 204-1
2 bedrooms, iron/ironing board, travel crib, WiFi

The Wild West Getaway- 204-1

7.8 out of 10, Good, (7)
"Just make sure you are fit and able to navigate steps. Great party place for the younger generation. The bar below has a nice back outside sitting area we were able to use. "
The Wild West Getaway- 204-1
Charming Duplex on Main
Fridge, microwave, stovetop, toaster

Charming Duplex on Main

10.0 out of 10, Exceptional, (15)
"We had an AMAZING time here and you can't beat the close walking distance to main st!! Absolutely loved our stay. "
The price is SAR 466
SAR 1,004 total
includes taxes & fees
11 Sep - 12 Sep
Charming Duplex on Main
Cozy country setting 4 miles from route 66
Terrace/patio

Cozy country setting 4 miles from route 66

9.8 out of 10, Exceptional, (7)
"Great, quiet country getaway. Very pleasant!"
The price is SAR 901
SAR 1,281 total
includes taxes & fees
28 Sep - 29 Sep
Cozy country setting 4 miles from route 66
Great for Business Travelers! Pool + Gym
Pool

Great for Business Travelers! Pool + Gym

The price is SAR 537
SAR 709 total
includes taxes & fees
4 Sep - 5 Sep
Great for Business Travelers! Pool + Gym
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

10/10 Excellent
"The front desk was amazing in helping us with all of our needs, and the steak house was great "
Edward 2-night trip
Posted 3 days ago
Ameristar Casino Resort and Spa
The Wildwood Hotel

The Wildwood Hotel

10/10 Excellent
"Very quiet, nice area. Walkable to restaurants and shops. The staff was extremely welcoming. This is a beautiful facility and is even pet friendly. I would highly recommend this hotel if you need to stay in this area. "
Karen 1-night trip
Posted 4 days ago
The Wildwood Hotel

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

What's it like to stay at an apartment in Defiance?
You'll find 9 apartments to choose from in Defiance for your stay.
Why choose an apartment versus a traditional hotel?
Often more spacious than a traditional hotel room, an apartment includes a kitchen for convenient home-cooked meals. Apartments are ideal for families who want the conveniences of home, and also for couples who want something in a quieter part of town.
What's a favorite apartment for a stay in Defiance?
Listed below are some of the more popular apartments in the area: 'the Ruebling House' Historic Defiance Apartment!: Situated in Defiance, 0.1 mi/0.2 km from the heart of Defiance. 'The Chardonnay Chalet' Defiance Studio Trail!: Located 0.3 mi/0.4 km away in Defiance. Amenities include private patios. The Ruebling House Cozy Defiance Apartment!: It's located in Defiance, 0.1 mi/0.2 km away. Overlook Main St. in this 2 Bedroom Owners Suite!: Located 18.5 mi/29.7 km away in St. Charles. Private patios, sofa beds, and Smart TVs are included. Access to onsite laundry facilities is available on site. The Lofts of North Main Street: Located in St. Charles, 19.2 mi/30.8 km from Defiance. Includes free WiFi, sofa beds, and Smart TVs. Access to onsite laundry facilities is available on site.
How many apartments will I be able to find in Defiance?
Expedia has 9 apartments to book in Defiance.
What can I expect from the weather during my trip to Defiance?
Weather is only one factor, but it can really affect your travel plans, especially if you're planning an extended stay in Defiance. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.
What are the must-see places to visit in Defiance?
August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. While here, Yellow Farmhouse Winery and Chandler Hill Vineyards are other places worth a visit.
What's the best way to get to and around Defiance?
Knowing a bit about the transportation options can save you time when you get to your destination. Fly into St. Louis, MO (SUS-Spirit of St. Louis), which is located 7.5 mi (12 km) from the heart of the city. You can also search for flights into St. Louis Lambert Intl. Airport (STL), which is 23.5 mi (37.8 km) away. If you'd like to explore around the area, you may want a rental car for your journey.