Find hotels in San Francisco, Panama City from SAR 112
Change your mind
Be picky
Go beyond your typical stay in San Francisco
Check prices for these dates
Discover 1,490 San Francisco hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Casa Orquídea
Casa Orquídea

Ramada Plaza By Wyndham Panama Punta Pacífica
Ramada Plaza By Wyndham Panama Punta Pacífica

Boutique Apartments Panamá Coco del Mar
Boutique Apartments Panamá Coco del Mar

Sheraton Grand Panama
Sheraton Grand Panama

JW Marriott Panama
JW Marriott Panama

Residence Inn by Marriott Panama City
Residence Inn by Marriott Panama City
Where to stay in San Francisco
Casco Viejo
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Metropolitan Cathedral of Panama or Interoceanic Canal Museum while you're exploring the area.

Bella Vista
Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina.
El Cangrejo
The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.
Punta Paitilla
Travelers come to Punta Paitilla for its abundant dining options, and you can see top attractions like Avenida Balboa and Multicentro Panama while you're in town.

Calidonia
You might enjoy the shopping while in Calidonia. Cinta Costera is a notable sight, and you can get around town at Estación Lotería or Santo Tomas Station to see more of the city.
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in top Panama City neighborhoods
- Hotels in Casco Viejo
- Hotels in Bella Vista
- Hotels in El Cangrejo
- Hotels in San Francisco
- Hotels in Punta Paitilla
- Hotels in Calidonia
- Hotels in San Felipe
- Hotels in Costa del Este
- Hotels in Marbella
- Hotels in Obarrio
- Hotels in Punta Pacifica
- Hotels in Amador
- Hotels in Santa Ana
- Hotels in Balboa
- Hotels in Bethania
- Hotels in El Chorrillo
- Hotels in Juan Diaz
- Hotels in Parque Lefevre
- Hotels in Curundu
- Hotels in Pueblo Nuevo
Hotels near popular Panama City Attractions
- Hotels near Multiplaza Pacific Mall
- Hotels near Avenida Balboa
- Hotels near ATLAPA Conventions Center
- Hotels near Multicentro Panama
- Hotels near Pacific Center
- Hotels near Panama Canal Murals
- Hotels near Hospital Punta Pacífica
- Hotels near Omar Torrijos Recreational Park
- Hotels near Colonial Religious Art Museum
- Hotels near Albrook Shopping Mall
More Hotel Options in San Francisco
- Adults Only Resorts & Hotels in San Francisco
- Adventure Hotels in San Francisco
- Beach Hotels in San Francisco
- Business Hotels in San Francisco
- Casinos in San Francisco
- Family Hotels in San Francisco
- Historic Hotels in San Francisco
- Hotel with a Concierge in San Francisco
- Hotels with Bars in San Francisco
- Hotels with Free Parking in San Francisco
- Hotels with WiFi in San Francisco
- Hotels with a Pool in San Francisco
- Hotels with smoking rooms in San Francisco
- Pet-friendly Hotels in San Francisco
- Resorts & Hotels with Spas in San Francisco
- Shopping Hotels in San Francisco
Hotels Close to Nearby Airports
San Francisco Hotels by Star Rating
San Francisco Hotels by Brand
Explore more hotels
- San Francisco by Wynwood House
- Boutique Apartments Panamá Coco del Mar
- Hotel Riu Plaza Panama
- Dreams Playa Bonita Panama - All Inclusive
- Crowne Plaza Panama Airport by IHG
- Waymore Hotel Spa & Casino
- Hotel El Panama by Faranda Grand, a member of Radisson Individuals
- The Westin Playa Bonita Panama
- Principe Hotel and Suites
- Studio Coliving
- Novotel Panama City
- Hospedium Princess Hotel Panama