Photo by Isa

Find hotels in Santa Ana, Panama City from SAR 177

    calendar shield illustration
    Change your mind
    Book hotels with free cancellation
    deals illustration
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration
    Be picky
    Search almost a million properties worldwide

Check prices for these dates

Tonight
24 Jun - 25 Jun
Tomorrow
25 Jun - 26 Jun
This weekend
27 Jun - 29 Jun
Next weekend
4 Jul - 6 Jul

Filter by

Guest rating
Guest rating
Star rating

Discover 1,444 Santa Ana hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Casco View Apartments
Apartment (4) | Terrace/patio

Casco View Apartments

3.0 star property
9.4 out of 10, Exceptional, (38)
"Great view, good price"
Casco View Apartments
Hostal La Cigarra
Bar (on property)

Hostal La Cigarra

2.5 star property
7.4 out of 10, Good, (46)
"Great budget place to stay. Friendly, clean, good location. Would be happy to stay again in future."
Hostal La Cigarra
Hotel República
Balcony

Hotel República

2.0 star property
6.6 out of 10, (169)
"The wifi is strong enough to use for work. "
Hotel República
ART CASCO The Hotel
Front of property

ART CASCO The Hotel

2.0 star property
4.0 out of 10, (2)
"Prácticamente el lugar es un motel no un hotel "
ART CASCO The Hotel
Hotel Riazor
Single Room | 1 bedroom, free WiFi, bed sheets

Hotel Riazor

3.0 star property
3.4 out of 10, (9)
"Rough neighborhood "
Hotel Riazor
La Manzana by Wynwood House
Apartment (20) | 1 bedroom, iron/ironing board, free WiFi, bed sheets

La Manzana by Wynwood House

3.5 star property
6.8 out of 10, (11)
"Great hotel. Very close to Casco viejo"
The price is SAR 177
SAR 270 total
includes taxes & fees
6 Jul - 7 Jul
La Manzana by Wynwood House
Room-sofa Bed Stay Rooftop Pool & Gym, A
Room, Multiple Bedrooms, Accessible, Smoking | Pool | Outdoor pool

Room-sofa Bed Stay Rooftop Pool & Gym, A

2.0 star property
The price is SAR 532
SAR 585 total
includes taxes & fees
25 Jun - 26 Jun
Room-sofa Bed Stay Rooftop Pool & Gym, A
Crowne Plaza Panama Airport by IHG
Outdoor pool, pool umbrellas, sun loungers

Crowne Plaza Panama Airport by IHG

4.0 star property
8.4 out of 10, Very Good, (2113)
"Great place to stay"
The price is SAR 413
SAR 454 total
includes taxes & fees
14 Jul - 15 Jul
Crowne Plaza Panama Airport by IHG
Central Hotel Panama Casco Viejo
47-inch flat-screen TV with cable channels, TV

Central Hotel Panama Casco Viejo

4.0 star property
9.0 out of 10, Wonderful, (925)
"Everything was excellent, friendly and helpful staff. Beautiful hotel. "
Central Hotel Panama Casco Viejo
Dreams Playa Bonita Panama - All Inclusive
4 outdoor pools, open 8:00 AM to 8:00 PM, free cabanas, sun loungers

Dreams Playa Bonita Panama - All Inclusive

4.0 star property
7.4 out of 10, Good, (1001)
"My stay at dreams Playa Bonita was a good, the staff where welcoming and ensure that"
Dreams Playa Bonita Panama - All Inclusive
Riande Aeropuerto Hotel & Casino
Outdoor pool, open 7:00 AM to 10:30 PM, free cabanas, pool umbrellas

Riande Aeropuerto Hotel & Casino

4.0 star property
8.4 out of 10, Very Good, (1869)
"Excellent property convenient to the airport"
The price is SAR 474
SAR 521 total
includes taxes & fees
26 Jun - 27 Jun
Riande Aeropuerto Hotel & Casino
TRYP by Wyndham Panamá Centro
Breakfast, lunch, dinner served; Mediterranean cuisine

TRYP by Wyndham Panamá Centro

3.5 star property
9.0 out of 10, Wonderful, (1008)
"Hotel very clean and the staff was excellent "
The price is SAR 306
SAR 337 total
includes taxes & fees
30 Jun - 1 Jul
TRYP by Wyndham Panamá Centro
The Westin Playa Bonita Panama
3 outdoor pools, pool umbrellas, sun loungers

The Westin Playa Bonita Panama

5.0 star property
8.0 out of 10, Very Good, (1002)
"Pool was great"
The price is SAR 558
SAR 614 total
includes taxes & fees
4 Jul - 5 Jul
The Westin Playa Bonita Panama
Hospedium Princess Hotel Panama
Outdoor pool, open 9:00 AM to 9:00 PM, sun loungers

Hospedium Princess Hotel Panama

3.5 star property
7.6 out of 10, Good, (535)
"Very nice and friendly staff"
Hospedium Princess Hotel Panama
La Concordia Boutique Hotel
Exclusive House | Terrace/patio

La Concordia Boutique Hotel

4.0 star property
9.4 out of 10, Exceptional, (170)
"Fantastic location and excellent staff at the front desk "
The price is SAR 613
SAR 674 total
includes taxes & fees
28 Jun - 29 Jun
La Concordia Boutique Hotel
Hotel Riu Plaza Panama
Outdoor pool, sun loungers

Hotel Riu Plaza Panama

5.0 star property
9.0 out of 10, Wonderful, (4037)
"Excellent location amazing service great food friendly staff "
The price is SAR 411
SAR 452 total
includes taxes & fees
23 Jul - 24 Jul
Hotel Riu Plaza Panama
Megapolis Hotel Panamá
Front of property

Megapolis Hotel Panamá

4.5 star property
8.4 out of 10, Very Good, (928)
"I loved the service, cleanliness, food, everything!"
The price is SAR 477
SAR 524 total
includes taxes & fees
28 Jun - 29 Jun
Megapolis Hotel Panamá
Hotel Coral Suites
Reception

Hotel Coral Suites

3.5 star property
9.0 out of 10, Wonderful, (1000)
"Nice Hotel "
Hotel Coral Suites
Novotel Panama City
Front of property

Novotel Panama City

4.0 star property
9.0 out of 10, Wonderful, (1003)
"Great Place to stay!"
The price is SAR 338
SAR 371 total
includes taxes & fees
28 Jun - 29 Jun
Novotel Panama City
Waldorf Astoria Panama
View from property

Waldorf Astoria Panama

5.0 star property
9.0 out of 10, Wonderful, (1002)
"Great hotel "
The price is SAR 773
SAR 851 total
includes taxes & fees
11 Jul - 12 Jul
Waldorf Astoria Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.
Casco Viejo map

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Metropolitan Cathedral of Panama or Interoceanic Canal Museum while you're exploring the area.

Bella Vista map

Bella Vista

1 out of top 10 points of interest in this area

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina.

El Cangrejo map

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Francisco map

San Francisco

1 out of top 10 points of interest in this area

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Calidonia map

Calidonia

3 out of top 10 points of interest in this area

You might enjoy the shopping while in Calidonia. Cinta Costera is a notable sight, and you can get around town at Estación Lotería or Santo Tomas Station to see more of the city.

Frequently asked questions

What's it like in Santa Ana?

Santa Ana is a neighborhood that travelers like for its seafood restaurants, shopping, and parks. Are you looking for Santa Ana travel tips? Be sure to check out Cinta Costera and Avenida Balboa while you're in the neighborhood.

Where is the best hotel for a stay in Santa Ana?

Based on Expedia customer reviews, Hotel República is the highest ranked property in Santa Ana. This hotel is a short 4-minute walk from Avenida Balboa, and it offers a rooftop terrace and free WiFi. Another top choice in the area is Hostal La Cigarra.

How many hotels can I expect to find in Santa Ana?

Expedia has 100 hotels and other accommodations in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.

If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?

Yes! Most hotel room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Add dates, click "Search", then use the "fully refundable" filter to get top deals in Santa Ana.

Where can I learn more about changing or cancelling my trip to Santa Ana?

To find more details about picking new dates or cancelling your trip to Santa Ana, head over to our customer service page.

What is there to do in this Panama City neighborhood?

If you're looking forward to a day of shopping in Santa Ana, consider Avenida Central or Avenida Balboa, and pick out the perfect souvenir. A visit to Cinta Costera is also worth the trip while you're discovering the neighborhood. Albrook Shopping Mall, Amador Theater, and Museum of Contemporary Art Panama are just a few of the places to visit in and around Santa Ana. When you're sightseeing in Panama City, Mi Pueblito and Iglesia de la Merced are also worth a stop.