A tree-lined landscape with a river and fields.

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Check prices for these dates

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28 Sep - 29 Sep
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29 Sep - 30 Sep
This weekend
2 Oct - 4 Oct
Next weekend
9 Oct - 11 Oct

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Our top choices for East Prairie hotels

1. Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
Sikeston
United States
Scott
SAR 353
SAR 406 total
includes taxes & fees
4 Oct - 5 Oct
Drury Inn & Suites Sikeston, MO

2. Hampton Inn Sikeston

Hampton Inn Sikeston
Sikeston
United States
John
SAR 382
SAR 432 total
includes taxes & fees
4 Oct - 5 Oct
Hampton Inn Sikeston

3. Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
Sikeston
United States
Melissa
SAR 379
SAR 429 total
includes taxes & fees
18 Oct - 19 Oct
Holiday Inn Express & Suites Sikeston Southwest by IHG

4. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
Sikeston
United States
Allen
SAR 379
SAR 429 total
includes taxes & fees
4 Oct - 5 Oct
Fairfield Inn & Suites by Marriott Sikeston

5. Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
Sikeston
United States
Shelley
SAR 324
SAR 370 total
includes taxes & fees
29 Oct - 30 Oct
Best Western Plus Sikeston I-55

6. TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
Sikeston
United States
Stacy
SAR 375
SAR 425 total
includes taxes & fees
4 Oct - 5 Oct
TownePlace Suites by Marriott Sikeston

7. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Sikeston
United States
Sharika West
SAR 240
SAR 274 total
includes taxes & fees
30 Sep - 1 Oct
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
Charleston
United States
William
SAR 223
SAR 248 total
includes taxes & fees
29 Sep - 30 Sep
Super 8 by Wyndham Charleston/Sikeston East MO

9. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
Charleston
United States
France
SAR 250
SAR 277 total
includes taxes & fees
4 Oct - 5 Oct
The Riverstone Hotel Charleston-Sikeston

10. Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
Sikeston
United States
Starlette
SAR 323
SAR 368 total
includes taxes & fees
29 Oct - 30 Oct
Comfort Inn & Suites Sikeston I-55

11. Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
Sikeston
United States
David
SAR 249
SAR 284 total
includes taxes & fees
30 Sep - 1 Oct
Days Inn and Suites by Wyndham Sikeston

12. Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
Marston
United States
Brenda
SAR 216
SAR 247 total
includes taxes & fees
1 Oct - 2 Oct
Super 8 By Wyndham Marston

13. Eagle Inn Charleston

Eagle Inn Charleston
Charleston
United States
Jackson
SAR 248
SAR 275 total
includes taxes & fees
29 Sep - 30 Sep
Eagle Inn Charleston

14. Country Yard Inn and Suite

Country Yard Inn and Suite
Sikeston
United States
William
SAR 212
SAR 252 total
includes taxes & fees
7 Oct - 8 Oct
Country Yard Inn and Suite

15. Quality Inn Cairo I-57

Quality Inn Cairo I-57
Cairo
United States
Santiago
SAR 256
SAR 284 total
includes taxes & fees
16 Oct - 17 Oct
Quality Inn Cairo I-57

16. Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
Union City
United States
Ben
SAR 309
SAR 367 total
includes taxes & fees
11 Oct - 12 Oct
Sleep Inn at Discovery Park of America

17. Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
Union City
United States
Terri
SAR 443
SAR 526 total
includes taxes & fees
4 Oct - 5 Oct
Holiday Inn Express & Suites Union City by IHG

18. Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
Sikeston
United States
William
SAR 214
SAR 244 total
includes taxes & fees
4 Oct - 5 Oct
Super 8 by Wyndham Sikeston/Miner Area

19. Hampton Inn Union City

Hampton Inn Union City
Union City
United States
Clarence
SAR 444
SAR 527 total
includes taxes & fees
11 Oct - 12 Oct
Hampton Inn Union City

20. Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
Union City
United States
Jade
SAR 226
SAR 268 total
includes taxes & fees
4 Oct - 5 Oct
Country Hearth Inn & Suites Union City
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Stay near popular East Prairie attractions

Big Oak Tree State Park

8.0/10 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artifacts tell the story of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
A tree-lined landscape with a river and fields.

Top East Prairie Hotel Reviews

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

10/10 Excellent
"Everything was great clean helpful Everything friendly."
Kathleen 1-night trip
Posted 8 hours ago
The Riverstone Hotel Charleston-Sikeston
Quality Inn Union City US 51

Quality Inn Union City US 51

10/10 Excellent
"Perfect stop over location on my way to pick up my new pup. From Canada, I'd never had biscuits and gravy, and that alone is reason enough to stay here! Welcoming staff and interested desk clerk. Thank you!"
Terrence Peter 1-night trip
Posted 14 hours ago
Quality Inn Union City US 51
Hampton Inn Union City

Hampton Inn Union City

10/10 Excellent
"Don’t need to change a thing. Great job!"
Travis 1-night trip
Posted 1 day ago
Hampton Inn Union City
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

10/10 Excellent
"It has been updated somewhat but is still an older building. I don't think carpets are ever clean enough. The staff is always friendly and helpful. I love staying here."
jerri 1-night trip
Posted 2 days ago
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Clean room and perfect stay. We have come to consistently appreciate Drury brand for a quality stay. We would definitely recommend this location for clean comfortable accommodations."
Hiram 1-night trip
Posted 5 days ago
Drury Inn & Suites Sikeston, MO
Hampton Inn Sikeston

Hampton Inn Sikeston

10/10 Excellent
"Staff was great"
Alex 2-night trip
Posted 6 days ago
Hampton Inn Sikeston
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent
"This was a very good value. It has been the best hotel I've stayed at in awhile."
David 1-night trip
Posted 7 days ago
Days Inn and Suites by Wyndham Sikeston
Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG

8/10 Good
"Love the staff and the parking and the quiet"
Stefani 2-night trip
Posted 10 days ago
Holiday Inn Express & Suites Union City by IHG
Reelfoot Lake Inn

Reelfoot Lake Inn

10/10 Excellent
"clean room, nice lake view, very quiet area. Just a good decent place to stay. Not a fancy 5 star hotel, but well worth it to me. Great place....Thanks!"
Larry 4-night trip
Posted 1 month ago
Reelfoot Lake Inn

More cheap stays in East Prairie

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2609 E Malone Ave Sikeston MO
SAR 214
SAR 244 total
4 Oct - 5 Oct
includes taxes & fees
Super 8 by Wyndham Sikeston/Miner Area
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St Charleston MO
SAR 223
SAR 248 total
29 Sep - 30 Sep
includes taxes & fees
Super 8 by Wyndham Charleston/Sikeston East MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO
SAR 249
SAR 284 total
30 Sep - 1 Oct
includes taxes & fees
Days Inn and Suites by Wyndham Sikeston
Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

1111 BLue Heron Lane Union City TN
SAR 309
SAR 367 total
11 Oct - 12 Oct
includes taxes & fees
9.2/10 Wonderful! (436 reviews)
Sleep Inn at Discovery Park of America
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO
SAR 324
SAR 370 total
29 Oct - 30 Oct
includes taxes & fees
Best Western Plus Sikeston I-55
Hampton Inn Sikeston

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO
SAR 382
SAR 432 total
4 Oct - 5 Oct
includes taxes & fees
9/10 Wonderful! (624 reviews)
Hampton Inn Sikeston

Find out more about East Prairie

Top reasons to visit East Prairie

  • Outdoor Adventures: East Prairie offers extensive hiking and biking trails, perfect for nature lovers and adventure seekers.
  • Scenic Beauty: The area features stunning landscapes that enhance the overall vacation experience.
  • Community Charm: Enjoy the warm hospitality and small-town vibe that East Prairie embodies.
  • Cultural Exploration: Discover local history through museums and events that showcase the region's rich heritage.
  • Diverse Accommodations: A variety of lodging options are available, ensuring a comfortable stay for every traveler.

Find great hotels near East Prairie

East Prairie, Missouri, offers a variety of accommodation options perfect for every type of traveler, from pet-friendly hotels to family-friendly motels. Whether you're visiting for business or leisure, you'll find a selection of hotels that cater to your needs. Explore the best hotels in East Prairie and read reviews to find the ideal stay for your vacation. Enjoy the comfort and convenience of this charming town during your visit.

  • Days Inn and Suites by Wyndham Sikeston: Experience comfort and convenience at Days Inn and Suites by Wyndham Sikeston, a pet-friendly hotel that caters to both leisure and business travelers. Located 17.7km from East Prairie, this property is perfect for those traveling with furry companions, as it accommodates dogs and cats with specific restrictions. The hotel features essential amenities for business travelers, ensuring a productive stay, while its welcoming atmosphere makes it a great choice for families. Guests appreciate the waived fees for service animals, making this hotel a thoughtful option for their diverse needs.
  • Drury Inn & Suites Sikeston, MO: Ideal for families and business travelers alike, Drury Inn & Suites Sikeston, MO offers a welcoming environment just 17.7km from East Prairie. This 3-star hotel is pet-friendly and features amenities tailored for children, including complimentary cribs for younger guests. The hotel focuses on providing a comfortable stay with a range of services designed to cater to families and business professionals. With a pet policy that allows pets with restrictions, guests can enjoy a worry-free experience while making lasting memories with their loved ones.
  • Pear Tree Inn Sikeston: Pear Tree Inn Sikeston is a charming hotel that prioritizes family-friendly accommodations while also being pet-friendly, located 17.7km from East Prairie. This property is designed for travelers seeking a comfortable stay, offering amenities for children such as free cribs. With a welcoming atmosphere, the hotel ensures guests feel at home, and the pet policy allows for dogs and cats with specific restrictions. Whether you’re traveling for business or leisure, Pear Tree Inn provides a relaxing escape near the heart of Sikeston.

Where to stay near East Prairie

East Prairie, Missouri, offers a delightful blend of outdoor adventure and small-town charm. Explore the nearby scenic landscapes perfect for family-friendly excursions and relaxing getaways. Just a short drive from downtown Sikeston, you'll find friendly communities and ample open spaces for recreation. Shopping enthusiasts will appreciate local boutiques and nearby facilities that cater to all your needs. Whether you're seeking relaxation or adventure, East Prairie is an ideal destination for your vacation.

  • Sikeston: Located 20.9km from East Prairie, Sikeston offers a diverse travel experience perfect for families, couples, and outdoor enthusiasts. Visitors enjoy a range of activities from exploring recreational areas to shopping at local centers. The city is known for its charming landmarks, including a picturesque lake and a well-equipped event conference venue. Sikeston's vibrant community and welcoming atmosphere make it a great spot to unwind and experience the local culture.
  • Charleston: Just 16.1km from East Prairie, Charleston is a hidden gem for those seeking scenic beauty and adventure. This city is a haven for outdoor lovers, with easy access to national parks and historic sites that showcase the area’s rich heritage. Visitors can partake in various activities, including exploring recreational areas and enjoying entertainment at local arenas. Charleston’s unique combination of natural beauty and historical significance makes it a must-visit destination.
  • Bertrand: Situated 16.1km from East Prairie, Bertrand is perfect for travelers who appreciate nature and adventure. The city is surrounded by stunning landscapes, including national parks, forests, and serene lakes ideal for outdoor exploration. Bertrand attracts visitors seeking an immersive experience in nature, with opportunities for hiking, fishing, and more. Its tranquil environment and breathtaking scenery offer a peaceful escape for those looking to recharge and connect with the outdoors.

Things to do near East Prairie

East Prairie, Missouri, is perfect for outdoor enthusiasts seeking adventure and scenic beauty. Visitors can enjoy recreational areas, a golf course, and various trail access for hiking and biking. Major attractions include local parks and the charm of prairie tourism, providing a unique experience that highlights the natural landscape and community spirit. Whether you're exploring the trails or relaxing on the green, East Prairie offers memorable activities for every traveler.

Shopping

If you're up for a drive, the County Market Place offers a variety of shopping options 49.9km away from East Prairie, combining family-friendly vibes with a city feel. You can find unique gifts and souvenirs to bring back home during your visit.

Recreation

Experience tranquility at The Wellness Retreat, where you can enjoy rejuvenating yoga sessions and soothing massage therapies. Explore the nearby Lake County Park for leisurely walks and picnics, or participate in community fitness classes to stay active while enjoying the welcoming local atmosphere.

Adventure

Explore the nearby Mississippi River for kayaking and fishing adventures, allowing you to connect with nature. For hiking, visit the nearby Bear Creek Trail, where stunning landscapes and wildlife await. Don't miss the local parks for picnicking and enjoying outdoor games with family or friends.

Nightlife

For a vibrant night out, catch a show at the Union City Masquerade Theatre, located 49.9km from East Prairie. With its romantic ambiance and cultural entertainment, it's the perfect spot to enjoy an evening filled with art and creativity.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for East Prairie

To save money on your trip to East Prairie, Missouri, consider visiting between December and February when accommodation prices are lower. Sundays are the best day for cheaper stays, while Saturdays tend to be the priciest. Use Expedia to find budget-friendly hotel options and compare room rates; consider package deals for additional savings by bundling flights and activities. Take advantage of free local attractions and look into public transport options to reduce travel costs throughout your visit.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in East Prairie are December to February, where the prices are slightly lower. This is in comparison to April, June and August, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in East Prairie is Sunday. The most expensive day to stay in East Prairie is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia's search tool to narrow down your options based on your budget, desired location, and preferred hotel type. To find the best prices and deals, simply arrange the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your East Prairie hotel reservations with your flights and activities through an Expedia package deal.

Find the best attractions in and around East Prairie

East Prairie, Missouri, is an ideal destination for outdoor enthusiasts and adventure seekers. Visitors can explore attractions like national parks, history museums, and event venues that showcase the area's rich culture and scenic beauty. Whether you're hiking through nature or delving into local history, East Prairie offers a variety of experiences that cater to all interests. Don't miss the nearby attractions that enhance your visit and provide even more opportunities for exploration.

  • Big Oak Tree State Park: Immerse yourself in the serene beauty of Big Oak Tree State Park, a haven for nature lovers. Here, you'll find sprawling landscapes, towering trees, and opportunities for outdoor adventures like hiking and picnicking, all within the comfort of East Prairie.
  • Central Park: Located 20.9km away, Central Park offers a vibrant urban escape. Enjoy family-friendly activities, beautifully landscaped gardens, and plenty of space for relaxation amidst the lively city atmosphere, making it a perfect spot for a day out.
  • Sikeston Depot Museum: About 20.9km from East Prairie, the Sikeston Depot Museum showcases the rich culture of the region. Explore fascinating exhibits that highlight local history, art, and heritage, providing a unique glimpse into the area's past.

Best time to go to East Prairie

The best time to visit East Prairie is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are moderately high and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are moderately high and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January36.3°F (2.4°C)Light RainMostly SunnyModerately HighSlightly Low
February39.4°F (4.1°C)Light RainMostly SunnyAverageSlightly Low
March49.5°F (9.7°C)Light RainMostly SunnyAverageAverage
April58.5°F (14.7°C)Light RainMostly SunnyAverageSlightly High
May68.2°F (20.1°C)Light RainMostly SunnyAverageAverage
June77.0°F (25.0°C)Light RainMostly SunnyModerately HighSlightly High
July79.5°F (26.4°C)Light RainMostly SunnyModerately HighAverage
August77.5°F (25.3°C)Light RainMostly SunnyAverageSlightly High
September72.1°F (22.3°C)Light RainMostly SunnyAverageAverage
October60.8°F (16.0°C)Light RainMostly SunnyModerately LowAverage
November48.6°F (9.2°C)Light RainMostly SunnyModerately LowAverage
December41.2°F (5.1°C)Light RainMostly SunnyModerately LowSlightly Low

The nearest major airports for your trip to East Prairie

When planning your visit to East Prairie, Missouri, you have several airport options. Paducah, KY (PAH-Barkley Regional) is located 62.8km away, with nearby hotels such as The Respite Bed and Breakfast, a charming 4.5-star B&B, and Harrah's Metropolis Hotel & Casino, which offers entertainment and comfort just 9.7km from the airport. Cape Girardeau, MO (CGI-Cape Girardeau Municipal) is 51.5km away, featuring hotels like Drury Plaza Hotel Cape Girardeau, conveniently 9.7km from the airport. Lastly, Cairo, IL (CIR-Cairo Regional) is 33.8km from East Prairie, with options like Quality Inn, just 3.2km away, ensuring easy access for your stay.

Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay based on our traveler data. Other good options for your visit to the area are Days Inn and Suites by Wyndham Sikeston and Best Western Plus Sikeston I-55. See all available top hotels, or vacation rentals in East Prairie.
What are some of the best vacation rentals that East Prairie has to offer?
Duck Hunting, Fishing or Relaxing Family Vacation: Visitors like this East Prairie vacation home rental. It is located on a lake and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. See all vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
Where can I learn more about changing or cancelling my trip to East Prairie?
To access more information about rescheduling or cancelling your trip to East Prairie, click here.
What's the best hotel for staying near Cape Girardeau Municipal Airport (CGI)?
Candlewood Suites Cape Girardeau is one of the top choices for your stay and is a popular hotel, featuring an indoor pool and free WiFi. It's located 4.4 mi (7 km) from Cape Girardeau Municipal Airport.
What's it like to stay in East Prairie?
Visitors are sure to enjoy all that East Prairie has to offer. There are 36 hotels and other accommodations in the surrounding area. Find out more about East Prairie.
What should I do while I'm visiting East Prairie?
The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Columbus-Belmont State Park and Fort Defiance State Park in the area. Check out what more to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for East Prairie is 60 inches.