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Compare hotels near Cairo Regional airport with room rates, reviews, and updated availability. Most hotels are fully refundable.

Quality Inn Cairo I-57
Quality Inn Cairo I-57
6.6 out of 10, (264)
The price is SAR 259
SAR 287 total
includes taxes & fees
14 Sep - 15 Sep

Eagle Inn Charleston
Eagle Inn Charleston
6.8 out of 10, (100)
The price is SAR 239
SAR 266 total
includes taxes & fees
3 Sep - 4 Sep

Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MO
6.6 out of 10, (585)
The price is SAR 217
SAR 241 total
includes taxes & fees
8 Sep - 9 Sep
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Hotels Close to Nearby Airports
Hotels near popular Cairo Attractions
- Shawnee National Forest
- Mississippi River
- Ohio River
- Southeast Missouri State University
- Isle Casino Cape Girardeau
- Riverfront Bridge Park
- Columbus-Belmont State Park
- Riverfront Park
- Henry N Barkhausen Cache River Wetlands Center
- Cape Rock Park
- eDen Spa & Salon
- Sikeston Depot Museum
- Central Park
- Mound City National Cemetery
- Fort Defiance State Park
- Ullin City Hall
- Fort D Historic Site
Hotel options around Cairo Regional
- Pear Tree Inn Sikeston
- Best Western Plus Sikeston
- Beautiful Cabin Retreat
- Drury Inn & Suites Sikeston, MO
- Days Inn and Suites by Wyndham Sikeston
- The Riverview
- Country Yard Inn and Suite
- Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
- Super 8 by Wyndham Sikeston/Miner Area
- Comfort Inn & Suites Sikeston I-55
- Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
- Charming cottage overlooking Lake Acre
- Courtyard by Marriott Cape Girardeau Downtown
- Charming Home just minutes from Interstate and Mall
- Beautiful newly renovated farm house overlooking 5 acre lake. ****New Rates ***
- Building at Cape Girardeau Regional Airport
- Hampton Inn Sikeston
- Next door to Wildlife Mgmt Area. Full kitchen, washer/dryer.
- Holiday Inn Express & Suites Sikeston Southwest by IHG
- Serenity South -- Gardens, River-Views, and Refreshing Space