East Prairie, MO

Travel Guide

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
The price is SAR 337 per night from Jan 14 to Jan 15
SAR 337
SAR 388 total
14 Jan - 15 Jan
includes taxes & fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,000 reviews)
The room was very nice and the bathroom was very clean. Everything was very nice and the breakfast was good. We were very pleased with everything. I recommend it highly.

Reviewed on 2 January 2026

Drury Inn & Suites Sikeston, MO
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
The price is SAR 374 per night from Feb 8 to Feb 9
SAR 374
SAR 423 total
8 Feb - 9 Feb
includes taxes & fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
8.8/10 Excellent! (457 reviews)
Room was very spacious, clean and well equipped Breakfast was good, staff was great and they had a great little mini store

Reviewed on 5 January 2026

Hampton Inn Sikeston
Best Western Plus Sikeston

Best Western Plus Sikeston

2.5 out of 5
120 S Interstate Drive Sikeston MO
The price is SAR 252 per night from Jan 18 to Jan 19
SAR 252
SAR 287 total
18 Jan - 19 Jan
includes taxes & fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.2/10 Very Good! (1,005 reviews)
Everything was very good from entering to exiting.

Reviewed on 3 January 2026

Best Western Plus Sikeston
See all 86 properties in East Prairie
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Duck Hunting, Fishing or Relaxing Family Vacation

Duck Hunting, Fishing or Relaxing Family Vacation

Hornbeak TN
Stay at this vacation home in Hornbeak. Enjoy a garden, laundry facilities, and patios. Popular attractions Willow Towhead and Rat Island are located ...
9.8/10 Exceptional! (219 reviews)
Excellent spot and amenities

Reviewed on 5 January 2026

Duck Hunting, Fishing or Relaxing Family Vacation
Log Cabin.

Log Cabin.

Hornbeak TN
Stay at this cabin in Hornbeak. Enjoy free WiFi, laundry facilities, and patios. Popular attractions Lake Isom National Wildlife Refuge and Willow Towhead are ...
9/10 Wonderful! (33 reviews)
House was in good condition for a place to stay on a hunting trip. Plenty of beds, and open storage places as well. Will look to rebook in the future if group size stays the same or grows.

Reviewed on 13 December 2025

Log Cabin.
Come and relax at the Refuge at beautiful Reelfoot Lake!

Come and relax at the Refuge at beautiful Reelfoot Lake!

Hornbeak TN
Enjoy free WiFi, laundry facilities, and patios. Popular attractions Willow Towhead and Rat Island are located nearby.
9.2/10 Wonderful! (23 reviews)
Great place

Reviewed on 11 December 2025

Come and relax at the Refuge at beautiful Reelfoot Lake!
See all properties in East Prairie
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Big Oak Tree State Park

You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.

Big Oak Tree State Park