The Best Hotels Closest to Sikeston Depot Museum in Sikeston for 2026

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Sikeston Depot Museum hotels

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

1. Fairfield Inn & Suites by Marriott Sikeston

2.4 km from Sikeston Depot Museum

Allen

SAR 379

SAR 431 total

includes taxes & fees

18 Oct - 19 Oct

A modern hotel room with a large window, a gray sofa, a small round table, a white chair, and a bed.

An outdoor bar area with a modern design, featuring a counter, bar stools, and a seating area with chairs.

2. TownePlace Suites by Marriott Sikeston

2.3 km from Sikeston Depot Museum

Stacy

SAR 380

SAR 432 total

includes taxes & fees

18 Oct - 19 Oct

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

A Hampton Inn hotel with a modern facade, a stone entrance, and a well-lit entrance area.

An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.

A hotel lobby with a bar area, seating arrangements, and a large window providing natural light.

3. Hampton Inn Sikeston

2.3 km from Sikeston Depot Museum

Carolyn

SAR 396

SAR 450 total

includes taxes & fees

18 Oct - 19 Oct

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A kitchenette with a coffee machine, a kettle, and storage shelves.

A buffet with various food items, including omelets and baked goods, served in metal containers.

A reception area with a reception desk, a large wall-mounted sign, and a potted plant.

4. Holiday Inn Express & Suites Sikeston Southwest by IHG

2.1 km from Sikeston Depot Museum

Melissa

SAR 342

SAR 389 total

includes taxes & fees

8 Nov - 9 Nov

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

A spacious lobby with a polished floor, seating areas, and modern lighting fixtures.

5. Drury Inn & Suites Sikeston, MO

5.1 km from Sikeston Depot Museum

Scott

SAR 353

SAR 406 total

includes taxes & fees

18 Oct - 19 Oct

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and large windows providing natural light.

A reception area with a wooden reception desk, a large painting on the wall, and a potted plant.

6. Best Western Plus Sikeston I-55

5.4 km from Sikeston Depot Museum

Shelley

SAR 315

SAR 359 total

includes taxes & fees

11 Oct - 12 Oct

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

A reception area with a sign for 'Travel Inn and Suites' and a counter with a computer and a phone.

A living room with a sofa, two chairs, a coffee table, a television, and a window with blinds.

A Travel Inn and Suites with a brick facade, a flat roof, and a welcoming entrance.

7. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

5 km from Sikeston Depot Museum

Craig

SAR 230

SAR 262 total

includes taxes & fees

18 Oct - 19 Oct

A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.

A hot tub area with a tiled floor, a wooden deck surrounding the tub, and a view of the sky through large windows.

A living room with two sofas, a coffee table, a TV, and a cabinet.

A hotel lobby with a reception desk, seating area, and large windows offering a view of the outdoors.

8. Comfort Inn & Suites Sikeston I-55

4.9 km from Sikeston Depot Museum

Kathryn

SAR 312

SAR 356 total

includes taxes & fees

1 Nov - 2 Nov

A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

A spacious lobby with a central atrium, a piano, and a reception desk.

A spacious room with a large dining table and chairs, a kitchenette area, and a television mounted on the wall.

A Days Inn hotel with a brick facade, large windows, and a sign above the entrance.

9. Days Inn and Suites by Wyndham Sikeston

5.4 km from Sikeston Depot Museum

David

SAR 249

SAR 284 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

A hotel kitchen with a long counter, various appliances, and a tiled backsplash.

A hotel room with a flat-screen TV, a microwave, a coffee maker, a dining table, and two sofas.

A motel with a covered entrance, multiple rooms, and a parking lot.

10. Super 8 by Wyndham Sikeston/Miner Area

4.7 km from Sikeston Depot Museum

Marcia

SAR 214

SAR 244 total

includes taxes & fees

18 Oct - 19 Oct

A hotel room with two beds, a desk, a chair, a TV, and a mirror.

A reception area with a counter, a coffee machine, and seating.

A reception area with a sofa, a small table, a trash bin, a microwave, and a book display.

A bathroom with a bathtub, toilet, and shower curtain.

11. Country Yard Inn and Suite

5.5 km from Sikeston Depot Museum

William

SAR 202

SAR 240 total

includes taxes & fees

11 Oct - 12 Oct

View all properties

Compare popular hotels close to Sikeston Depot Museum

Property	Property class	Guest rating
Fairfield Inn & Suites by Marriott Sikeston	9.4 Exceptional 117 reviews	View
TownePlace Suites by Marriott Sikeston	9.4 Exceptional 26 reviews	View
Hampton Inn Sikeston	9.0 Wonderful 632 reviews	View
Holiday Inn Express & Suites Sikeston Southwest by IHG	8.8 Excellent 517 reviews	View
Drury Inn & Suites Sikeston, MO	9.6 Exceptional 1,007 reviews	View

Top Sikeston Depot Museum Hotel Reviews

Holiday Inn Express & Suites Sikeston Southwest by IHG

10/10 Excellent

"Clean, comfortable room. Nice staff and good breakfast choices."

Days Inn and Suites by Wyndham Sikeston

8/10 Good

"We were traveling through and wanted a quiet clean place to sleep. This was quiet clean although it is a bit dated. Only issue with maintenance was the outlet in the bathroom did not work which did not bother us but it should be attended to. We actually had a suite so it was very spacious. It was about $30 less than other rooms that were available in the area so it was quite a value in my opinion."

Hampton Inn Sikeston

10/10 Excellent

"Loved the modern, CLEAN, room and staff was extremely friendly and helpful. We were greeted and served by "Brittany" at check-in who was so nice and friendly and even gave us dinner suggestions. We would definitely stay here again!"

Comfort Inn & Suites Sikeston I-55

8/10 Good

"Our room was very clean and comfy. The bathroom was clean but could use an update. The bathroom tissue and face tissues are on the thin side. Breafast bar was excellent. The staff was very nice and helpful."

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8/10 Good

"NA NA NA NA NA NA NA NA NA NA NA NA NA"

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

8/10 Good

"Host is great. I've stayed here many times."

TownePlace Suites by Marriott Sikeston

10/10 Excellent

"My overall experience was amazing from the time I checked in until I left. The staff were super pleasant and incredible. My room was clean and spacious. I never been in an extended stay room before. I definitely will be booking a suite like this one again."

Eagle Inn Charleston

10/10 Excellent

"Great"

Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!

10/10 Excellent

"The host was very quick to respond and so great to work with for on our stay. "

Other attractions near Sikeston Depot Museum

Central Park

7.2/10 (56 reviews)

Explore the great outdoors at Central Park, a lovely green space in Sikeston. While in this family-friendly area, you can savor the top-notch restaurants.

See properties

City of Miner Convention Center

Learn about the events happening at City of Miner Convention Center during your trip to Miner. While in this relaxing area, you can savor the top-notch restaurants.

See properties

Front Street Studio & Art Gallery

8.6/10 (15 reviews)

You can spend time browsing the exhibits at Front Street Studio & Art Gallery during your travels in Blodgett. While in this relaxing area, you can savor the top-notch restaurants.

See properties

Hunter-Dawson State Historic Site

7.6/10 (13 reviews)

You can browse the exhibits at Hunter-Dawson State Historic Site, a museum with a story of its own, during your travels to New Madrid. Amble around the area's parks or experience its museums.

See properties

River Ridge Winery

8.4/10 (15 reviews)

You can enjoy a tasting or tour at River Ridge Winery during your travels to New Madrid. Amble around the area's parks or experience its museums.

See properties

New Madrid Historical Museum

8.2/10 (36 reviews)

You can study the exhibits at New Madrid Historical Museum, a museum with a storied past, during your travels to New Madrid. Amble around the area's parks or experience its museums.

See properties

Dexter Welcome Center Depot and Museum

7.6/10 (12 reviews)

You can study the exhibits at Dexter Welcome Center Depot and Museum, a museum with a story of its own, during your trip to Dexter. While in this family-friendly area, you can enjoy the restaurants.

See properties

The Heritage House

8.4/10 (7 reviews)

Learn about the local history of Dexter when you take a trip to The Heritage House. While in this family-friendly area, you can enjoy the restaurants.

See properties

Frequently asked questions

What's the area like around Sikeston Depot Museum?

Sikeston Depot Museum is located in a welcoming area of Sikeston known for its array of dining options. If you're looking for a convenient place to stay, check out the 5 hotels and other accommodations you'll find within a mile.

What's the best hotel to stay near Sikeston Depot Museum?

Drury Inn & Suites Sikeston, MO is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an outdoor pool. It's located 3.2 mi (5.1 km) from Sikeston Depot Museum. Other good choices within 5 miles include Hampton Inn Sikeston and Days Inn and Suites by Wyndham Sikeston.

How many hotels should I expect to find close to Sikeston Depot Museum?

Expedia has 5 hotels and other accommodations within a mile from Sikeston Depot Museum.

If I need to cancel the hotel reservation for my stay near Sikeston Depot Museum, will I receive a refund?

Yes! The majority of hotel room reservations are fully refundable if cancelled prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of booking. Put your dates in and click on "Search", then use the filter option "fully refundable" to get the best deals near Sikeston Depot Museum.

Where can I learn more about changing or cancelling my trip in the area near Sikeston Depot Museum?

To find more details about picking new dates or cancelling your stay near Sikeston Depot Museum, head over to our customer service page.

Find hotels near Sikeston Depot Museum, Sikeston from SAR 240

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Sikeston Depot Museum hotels

1. Fairfield Inn & Suites by Marriott Sikeston

2. TownePlace Suites by Marriott Sikeston

3. Hampton Inn Sikeston

4. Holiday Inn Express & Suites Sikeston Southwest by IHG

5. Drury Inn & Suites Sikeston, MO

6. Best Western Plus Sikeston I-55

7. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8. Comfort Inn & Suites Sikeston I-55

9. Days Inn and Suites by Wyndham Sikeston

10. Super 8 by Wyndham Sikeston/Miner Area

11. Country Yard Inn and Suite

Compare popular hotels close to Sikeston Depot Museum

Top Sikeston Depot Museum Hotel Reviews

Holiday Inn Express & Suites Sikeston Southwest by IHG

Days Inn and Suites by Wyndham Sikeston

Hampton Inn Sikeston

Comfort Inn & Suites Sikeston I-55

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

TownePlace Suites by Marriott Sikeston

Eagle Inn Charleston

Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!

Other attractions near Sikeston Depot Museum

Central Park

City of Miner Convention Center

Front Street Studio & Art Gallery

Hunter-Dawson State Historic Site

River Ridge Winery

New Madrid Historical Museum

Dexter Welcome Center Depot and Museum

The Heritage House

Frequently asked questions