Find Luxury Hotels in Otay Mesa, CA

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Check availability on Otay Mesa Luxury Hotels

Tonight
26 Jul - 27 Jul
Tomorrow
27 Jul - 28 Jul
Next weekend
1 Aug - 3 Aug
In two weeks
8 Aug - 10 Aug

Top Otay Mesa Luxury Hotels

Quality Suites San Diego Otay Mesa
Desk, laptop workspace, blackout drapes, iron/ironing board

Quality Suites San Diego Otay Mesa

2.5 star property
7.2 out of 10, Good, (1004)
"Great location and spacious room "
The price is SAR 446
SAR 508 total
includes taxes & fees
31 Jul - 1 Aug
Quality Suites San Diego Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Otay Mesa Hotel Reviews

Sheraton San Diego Resort

Sheraton San Diego Resort

10/10 Excellent
"The check in was a bit ‘long’ as their credit card system was not working for incidental charges. However, the staff compensated for the wait and was very apologetic. "
Thelma 1-night trip
Posted 1 day ago
Sheraton San Diego Resort

Frequently asked questions

Are you searching for the perfect hotel for your luxury getaway to Otay Mesa?
Use Expedia to arrange your flight to Tijuana Intl. Airport (TIJ) airport or San Diego Intl. Airport (SAN) airport, and then select from a variety of places to stay that will deliver the luxury you want. Amenities are an important consideration when you plan a vacation, so we make it easy to get what you want to make your stay special. If you want a posh hotel that has fine dining, a spa, or several swimming pools, Expedia can help you find the best luxury hotel experience that Otay Mesa has to offer. During your visit, you might want to enjoy the restaurants which Otay Mesa is known for.
What's the best time to vacation in Otay Mesa?
The hottest months are usually August and September with an average temperature of 71°F,
  • Coldest months: February, January, December, and March
  • Driest months: June, July, September, and August
  • Rainiest months: December, February, January, and March
What's there to see and do in Otay Mesa?
Enjoy Otay Mesa and visit San Diego Zoo, San Ysidro Border Crossing, and Hotel del Coronado. If you have a bit of extra time while you're in the area, you might want to check out Petco Park and Coronado Beach.