The Best Hotels Closest to Duke Regional Hospital in Raleigh for 2026

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Our top choices for Duke Regional Hospital hotels

A breakfast area with a chalkboard menu, a sign indicating breakfast starts here, and a variety of food items like waffles, oatmeal, and fruits.

A large indoor swimming pool with clear blue water, surrounded by beige tiled flooring and walls, with large windows allowing natural light.

A narrow hallway with shelves stocked with snacks and beverages, leading to a room with a desk and chair.

A Hampton Inn hotel with a modern facade, multiple floors, and a parking lot.

1. Hampton Inn & Suites Durham/North I-85

2.2 km from Duke Regional Hospital

Shwetha

SAR 459

SAR 521 total

includes taxes & fees

8 Nov - 9 Nov

A hotel room with two beds, a flat-screen TV, a wooden headboard, and a carpeted floor.

A Holiday Inn Express hotel with a modern design, featuring a prominent sign, multiple windows, and a well-lit entrance.

A hotel lobby with a seating area, a reception desk, and artwork on the walls.

A coffee station with two coffee machines, a coffee press, and various coffee-related items on a counter.

2. Holiday Inn Express Durham by IHG

2.4 km from Duke Regional Hospital

Kimberly R

SAR 387

SAR 439 total

includes taxes & fees

15 Nov - 16 Nov

A hotel room with a television on a wooden cabinet, a desk with a chair, and a lamp.

A spacious hallway with wooden flooring, white walls, and multiple windows with blinds. There are two white chairs and a small table with a basket.

A hotel room with a bed, bedside tables, a nightstand, a mirror, and a bathroom with a sink and mirror.

A Red Roof Cafe with a stone wall, a coffee machine, and two white chairs.

3. Red Roof Inn Durham - Duke Univ Medical Center

2.3 km from Duke Regional Hospital

Luis

SAR 235

SAR 273 total

includes taxes & fees

1 Nov - 2 Nov

A stone fire pit surrounded by striped chairs and tables in an outdoor lounge area with a view of a building in the background.

A modern hotel lobby with a reception desk, seating area, and a cityscape mural on the wall.

A modern dining area with a long table, multiple chairs, and a sofa with red ottomans.

An indoor swimming pool with clear blue water, surrounded by lounge chairs and a tiled floor.

4. Hampton Inn & Suites Durham University Medical Center

5 km from Duke Regional Hospital

Nicole

SAR 475

SAR 539 total

includes taxes & fees

25 Oct - 26 Oct

A modern living room with a fireplace, comfortable seating, and a large window with curtains.

A hotel reception area with a counter, coffee station, and a large window with curtains.

A swimming pool with lounge chairs and a view of a building with large windows.

A courtyard with a pathway leading to a building with large windows and a yellow facade.

5. La Quinta Inn & Suites by Wyndham Univ Area Chapel Hill

North Garrett Road, 10.4 km from Duke Regional Hospital

Yolanda

SAR 308

SAR 350 total

includes taxes & fees

1 Nov - 2 Nov

A bar area with wooden bar stools, pendant lighting, and a counter with a glass display. There are tables and chairs in the background, and the room has a wooden floor.

A colonial-style building with a covered porch, multiple windows, and outdoor seating.

A hotel room with two beds, a sofa, a TV, and a bathroom visible through a door.

A covered porch with steps leading to a door, a brick wall, and a street lamp.

6. The Colonial Inn, an Ascend Collection Hotel

18.6 km from Duke Regional Hospital

Matt W

SAR 407

SAR 462 total

includes taxes & fees

25 Oct - 26 Oct

A hotel room with two beds, a desk, a chair, and a window with a view.

A modern lobby with a central seating area, a TV screen, and a patterned wall.

A reception area with a counter, a welcome sign, a digital screen, and a hallway leading to a dining area.

A modern kitchen with a built-in refrigerator, a gray sofa, and a gray armchair.

7. Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek

18.2 km from Duke Regional Hospital

Maurice

SAR 443

SAR 502 total

includes taxes & fees

25 Oct - 26 Oct

A hotel room with a bed, a desk, a chair, a small table, a coffee machine, and a trash bin.

A Comfort Inn & Suites hotel with a modern design, featuring a prominent entrance and a landscaped front yard.

A restaurant with a large ice dispenser, wooden paneling, and red cushioned booths.

A reception area with a wooden reception desk, blue seating, a flat-screen TV, and a stone accent wall.

8. Comfort Inn & Suites Durham near Duke University

Croasdaile Farm Master, 3.3 km from Duke Regional Hospital

Chrissy

SAR 327

SAR 371 total

includes taxes & fees

25 Oct - 26 Oct

A lobby with a green sofa, yellow chairs, a coffee table with drinks, and a window with plants.

A Hilton Garden Inn hotel with a modern design, featuring a large entrance and a parking area with a delivery van.

A business center with wooden paneling, multiple workstations, and framed artwork on the walls.

A bar area with a granite countertop, wooden chairs, and a large television screen.

9. Hilton Garden Inn Durham/University Medical Center

9th Street District, 4 km from Duke Regional Hospital

Michael

SAR 491

SAR 558 total

includes taxes & fees

9 Nov - 10 Nov

An outdoor patio area with round tables and chairs, large umbrellas, and a glass door entrance.

A modern living room with a fireplace, two sofas, a coffee table, and a TV mounted on the wall.

A hotel room with two beds, a desk, a chair, a sofa, and a TV.

A modern restaurant with round tables and yellow chairs, a bar area, and a 'Hello Fall' sign.

10. Fairfield by Marriott Inn & Suites Durham

18.2 km from Duke Regional Hospital

Chip

SAR 445

SAR 506 total

includes taxes & fees

30 Oct - 31 Oct

An indoor swimming pool with clear water, a no diving sign, and a seating area with chairs and tables.

A modern hotel lobby with a long dining table, multiple chairs, a sofa, and a bar area.

A modern hotel lobby with a sectional sofa, armchairs, and a coffee table.

A modern hotel lobby with a reception desk, several chairs, a large monitor, and pendant lighting.

11. Hyatt House Raleigh / RDU / Brier Creek

17.8 km from Duke Regional Hospital

Shelby

SAR 413

SAR 468 total

includes taxes & fees

1 Nov - 2 Nov

A modern hotel reception area with two wooden reception desks, a large digital display wall, and a seating area with chairs.

A hotel room with two beds, a desk, and a chair.

A modern lobby with a fireplace, seating area, and wooden wall accents.

12. Hilton Durham near Duke University

5.4 km from Duke Regional Hospital

tigist

SAR 428

SAR 485 total

includes taxes & fees

25 Oct - 26 Oct

A hotel entrance with a stone facade, large wooden doors, and a view into the interior.

An indoor swimming pool with clear blue water, surrounded by lounge chairs and potted plants.

A hotel with a stone lion statue, a covered entrance, and a landscaped garden.

A dining area with a chandelier, tables, chairs, and a Christmas tree.

13. Washington Duke Inn & Golf Club

6.6 km from Duke Regional Hospital

Lowell

SAR 892

SAR 1,012 total

includes taxes & fees

25 Oct - 26 Oct

A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

An indoor swimming pool with clear water, a lifeguard chair, and a sign indicating no diving.

A reception area with two wooden reception desks, a potted plant, and a computer on the wall.

14. Courtyard Raleigh-Durham Airport/Brier Creek

16.6 km from Duke Regional Hospital

Sharon

SAR 485

SAR 550 total

includes taxes & fees

25 Oct - 26 Oct

An outdoor seating area with sofas, chairs, and a fire pit, adjacent to a modern building with large windows.

A modern bar area with a long counter, multiple bar stools, and a large screen displaying a sports event.

A modern living room with a fireplace, seating area, and a pool table.

A modern reception area with a marble counter, a wooden bench, and a unique chandelier.

15. JB Duke Hotel

6.2 km from Duke Regional Hospital

samantha

SAR 650

SAR 737 total

includes taxes & fees

21 Oct - 22 Oct

A long, narrow hallway with dark walls and wooden flooring.

A compact kitchenette with a refrigerator, microwave, and a flat-screen TV on a dark cabinet.

A hotel room with a large bed, two bedside lamps, a chair, a desk, a heater, and a window with curtains.

A modern reception area with a reception desk, a seating area with chairs and a table, and a bookshelf with books.

16. University Inn Durham next to Duke University Medical Center

4.5 km from Duke Regional Hospital

Nicole

SAR 436

SAR 494 total

includes taxes & fees

25 Oct - 26 Oct

An outdoor patio with a table set for a meal, surrounded by chairs and a red umbrella.

A hotel room with a large bed, two bedside tables, and two wall-mounted lamps.

A bathroom with a granite countertop, a mirror, and a potted plant.

A tented outdoor dining area with round tables set for a meal, each with white chairs and yellow tablecloths.

17. DoubleTree Suites by Hilton Raleigh - Durham

14.2 km from Duke Regional Hospital

Sierra

SAR 386

SAR 438 total

includes taxes & fees

5 Nov - 6 Nov

A spacious lobby with high ceilings, a central fountain, and seating areas.

An outdoor patio area with wicker furniture, stone pillars, and string lights.

A spacious lobby with a curved seating area, large windows, and a modern chandelier.

A modern bedroom with a large bed, a fireplace, a walk-in closet, and a bathroom with a round mirror and vanity.

18. Embassy Suites by Hilton Raleigh Durham Airport Brier Creek

18.2 km from Duke Regional Hospital

Darren C.

SAR 597

SAR 676 total

includes taxes & fees

25 Oct - 26 Oct

A modern hotel building with a prominent 'HOME 2' sign, multiple windows, and a flagpole with an American flag.

A swimming pool with a tiled deck, surrounded by lounge chairs and tables.

A multi-story hotel with a prominent 'HOME 2' sign, a large parking lot, and a well-lit entrance.

A modern interior with multiple seating areas, a flat-screen TV, and a variety of decorative items on shelves.

19. Home2 Suites by Hilton Durham University Medical Center

5 km from Duke Regional Hospital

katey

SAR 539

SAR 612 total

includes taxes & fees

25 Oct - 26 Oct

An outdoor seating area with wicker furniture and a stone fire pit.

A conference room with a long table, chairs, and a modern chandelier.

A hotel lobby with a sofa, chairs, a table, and a large window offering a view of the building.

A modern hotel lobby with seating areas, large windows, and a dining section.

20. Residence Inn Raleigh-Durham Airport/Brier Creek

16.6 km from Duke Regional Hospital

Janet

SAR 523

SAR 592 total

includes taxes & fees

31 Oct - 1 Nov

View all properties

Compare popular hotels close to Duke Regional Hospital

Property	Property class	Guest rating
Hampton Inn & Suites Durham/North I-85	9.0 Wonderful 1,000 reviews	View
Holiday Inn Express Durham by IHG	8.8 Excellent 1,000 reviews	View
Red Roof Inn Durham - Duke Univ Medical Center	6.8 1,001 reviews	View
Hampton Inn & Suites Durham University Medical Center	9.6 Exceptional 576 reviews	View
The Colonial Inn, an Ascend Collection Hotel	9.6 Exceptional 324 reviews	View

Top Duke Regional Hospital Hotel Reviews

Comfort Inn & Suites Durham near Duke University

10/10 Excellent

"My room was very nice and clean. Breakfast is good. The location is great and the staff are wonderful. I had a problem with my sink and they came to my assistance promptly, fixed it and asked what else they could do for me. Whenever I come to town I stay here so I am getting to know the weekend staff. This is a good place to stay."

Millennium Hotel Durham

10/10 Excellent

"Clean room, accomodating staff, restsurants not open"

The Lodge at Duke Medical Center

10/10 Excellent

"Dry helpful and pleasant staff, great shuttle service, clean and comfortable room."

Hampton Inn & Suites Durham/North I-85

10/10 Excellent

"Very clean room, and friendly staff"

Everything within 1 mile

10/10 Excellent

"This home is thoughtfully laid out and much more spacious than it looks in photos. Our kids enjoyed the snacks each night, and their grandma loved that the home is all one level with smooth floors and bright lighting. Location was perfect for attending events in Durham, Wake Forest and Raleigh. There's also a running path across the street."

Unscripted Durham, Part of JDV by Hyatt

8/10 Good

"The place was awesome! I'm not going into details....I came home with some bed bug bites......🤔"

Curated & Caffeinated! Gem near Duke & Downtown • Espresso bar, Eco+, Fire Pit

10/10 Excellent

"The house was absolutely immaculate and Kristin could not have nicer or more helpful. The location was just 25 minutes from RDU, 12 minutes from downtown Durham and about a half an hour from Chapel Hill. Comfortable living room for my small group, large screen TV with all the streaming channels and a very cool coffee grinder/maker for regular or espresso coffee. Highly recommend. John L"

Cottage with Yard, Mins to Duke

10/10 Excellent

"This was a cheerful home with comfortable beds and many thoughtful extras. We enjoyed our time here."

Durham Retreat: 10 mins from Duke & Downtown, 20 mins from RTP & RDU I Sleeps 8

10/10 Excellent

"!"

Frequently asked questions

What's the area like around Duke Regional Hospital?

Duke Regional Hospital is located in an area of Durham known for its stunning cathedral. If you're looking for a convenient place to stay, check out the 10 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Duke Regional Hospital?

Courtyard Durham Near Duke University/Downtown is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and free parking. It's located 2.2 mi (3.5 km) from Duke Regional Hospital. Other good choices within a few miles include Holiday Inn Express Durham by IHG and Red Roof Inn Durham - Duke Univ Medical Center.

How many hotels can I expect to find near Duke Regional Hospital?

Expedia has 10 hotels and other accommodations within a mile from Duke Regional Hospital.

If I need to cancel the hotel reservation for my stay near Duke Regional Hospital, will I receive a refund?

Yes! Most hotel room reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of booking. Add dates, click "Search", then you can filter by "fully refundable" to get the best deals near Duke Regional Hospital.

Where can I learn more about changing or cancelling my trip in the area near Duke Regional Hospital?

To find more details about changing or cancelling your stay near Duke Regional Hospital, click here.

What can I see and do near Duke Regional Hospital?

You might want to spend some time browsing the exhibits at Museum of Life and Science, Nasher Museum of Art at Duke University, or Bennett Place. While you're exploring, swing by American Tobacco Campus, Cameron Indoor Stadium, and Wallace Wade Stadium to learn a bit about the area. You can enjoy live performances at Carolina Theatre and Common Ground Theatre.

Find hotels near Duke Regional Hospital, Raleigh from SAR 273

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Treat yourself

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Check prices for these dates

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Our top choices for Duke Regional Hospital hotels

1. Hampton Inn & Suites Durham/North I-85

2. Holiday Inn Express Durham by IHG

3. Red Roof Inn Durham - Duke Univ Medical Center

4. Hampton Inn & Suites Durham University Medical Center

5. La Quinta Inn & Suites by Wyndham Univ Area Chapel Hill

6. The Colonial Inn, an Ascend Collection Hotel

7. Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek

8. Comfort Inn & Suites Durham near Duke University

9. Hilton Garden Inn Durham/University Medical Center

10. Fairfield by Marriott Inn & Suites Durham

11. Hyatt House Raleigh / RDU / Brier Creek

12. Hilton Durham near Duke University

13. Washington Duke Inn & Golf Club

14. Courtyard Raleigh-Durham Airport/Brier Creek

15. JB Duke Hotel

16. University Inn Durham next to Duke University Medical Center

17. DoubleTree Suites by Hilton Raleigh - Durham

18. Embassy Suites by Hilton Raleigh Durham Airport Brier Creek

19. Home2 Suites by Hilton Durham University Medical Center

20. Residence Inn Raleigh-Durham Airport/Brier Creek

Compare popular hotels close to Duke Regional Hospital

Top Duke Regional Hospital Hotel Reviews

Comfort Inn & Suites Durham near Duke University

Millennium Hotel Durham

The Lodge at Duke Medical Center

Hampton Inn & Suites Durham/North I-85

Everything within 1 mile

Unscripted Durham, Part of JDV by Hyatt

Curated & Caffeinated! Gem near Duke & Downtown • Espresso bar, Eco+, Fire Pit

Cottage with Yard, Mins to Duke

Durham Retreat: 10 mins from Duke & Downtown, 20 mins from RTP & RDU I Sleeps 8

Frequently asked questions