The Best Hotels Closest to Duke Regional Hospital in Raleigh for 2026

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Our top choices for Duke Regional Hospital hotels

A breakfast area with a chalkboard menu, a sign indicating breakfast starts here, and a variety of food items like waffles, oatmeal, and fruits.

A Hampton Inn hotel with a modern facade, multiple floors, and a parking lot.

A hotel room with a bed, a desk with a chair, a flat-screen TV, a microwave, and a mirror.

A large indoor swimming pool with clear blue water, surrounded by beige tiled flooring and walls, with large windows allowing natural light.

1. Hampton Inn & Suites Durham/North I-85

2.2 km from Duke Regional Hospital

Shwetha

SAR 459

SAR 521 total

includes taxes & fees

8 Nov - 9 Nov

A hotel room with two beds, a flat-screen TV, a wooden headboard, and a carpeted floor.

A swimming pool with a metal railing, surrounded by a building with multiple windows and a sign indicating no lifeguard on duty.

A hotel lobby with a seating area, a reception desk, and artwork on the walls.

A Holiday Inn Express hotel with a modern design, featuring a prominent sign, multiple windows, and a well-lit entrance.

2. Holiday Inn Express Durham by IHG

2.4 km from Duke Regional Hospital

Kimberly R

SAR 387

SAR 439 total

includes taxes & fees

15 Nov - 16 Nov

A hotel room with a television on a wooden cabinet, a desk with a chair, and a lamp.

A Red Roof Inn with a modern architectural design, featuring a prominent red sign and a well-maintained lawn.

A hotel room with a bed, bedside tables, a nightstand, a mirror, and a bathroom with a sink and mirror.

A spacious hallway with wooden flooring, white walls, and multiple windows with blinds. There are two white chairs and a small table with a basket.

3. Red Roof Inn Durham - Duke Univ Medical Center

2.3 km from Duke Regional Hospital

Luis

SAR 235

SAR 273 total

includes taxes & fees

1 Nov - 2 Nov

A stone fire pit surrounded by striped chairs and tables in an outdoor lounge area with a view of a building in the background.

An indoor swimming pool with clear blue water, surrounded by lounge chairs and a tiled floor.

A Hampton Inn & Suites hotel with a modern facade, multiple windows, and a parking lot.

A modern hotel lobby with a reception desk, seating area, and a cityscape mural on the wall.

4. Hampton Inn & Suites Durham University Medical Center

5 km from Duke Regional Hospital

Nicole

SAR 475

SAR 539 total

includes taxes & fees

25 Oct - 26 Oct

A bar area with wooden bar stools, pendant lighting, and a counter with a glass display. There are tables and chairs in the background, and the room has a wooden floor.

A hotel room with two beds, a sofa, a TV, and a bathroom visible through a door.

A colonial-style building with a covered porch, multiple windows, and outdoor seating.

A bar area with wooden shelves, a chalkboard menu, and various bottles.

5. The Colonial Inn, an Ascend Collection Hotel

18.6 km from Duke Regional Hospital

Matt W

SAR 450

SAR 511 total

includes taxes & fees

8 Nov - 9 Nov

An outdoor patio area with round tables and chairs, large umbrellas, and a glass door entrance.

A modern restaurant with round tables and yellow chairs, a bar area, and a 'Hello Fall' sign.

A hotel room with two beds, a desk, a chair, a sofa, and a TV.

A modern living room with a fireplace, two sofas, a coffee table, and a TV mounted on the wall.

6. Fairfield by Marriott Inn & Suites Durham

18.2 km from Duke Regional Hospital

Chip

SAR 445

SAR 506 total

includes taxes & fees

30 Oct - 31 Oct

A modern lobby with a central seating area, a TV screen, and a patterned wall.

A modern kitchen with a built-in refrigerator, a gray sofa, and a gray armchair.

An indoor swimming pool with clear water, surrounded by lounge chairs and potted plants.

A reception area with a counter, a welcome sign, a digital screen, and a hallway leading to a dining area.

7. Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek

18.2 km from Duke Regional Hospital

Maurice

SAR 443

SAR 502 total

includes taxes & fees

25 Oct - 26 Oct

An indoor swimming pool with clear water, a no diving sign, and a seating area with chairs and tables.

A modern kitchen with built-in shelves, a glass backsplash, and a variety of kitchenware.

A modern hotel lobby with a reception desk, several chairs, a large monitor, and pendant lighting.

A modern hotel lobby with a sectional sofa, armchairs, and a coffee table.

8. Hyatt House Raleigh / RDU / Brier Creek

17.8 km from Duke Regional Hospital

Shelby

SAR 413

SAR 468 total

includes taxes & fees

1 Nov - 2 Nov

A reception area with two wooden reception desks, a potted plant, and a computer on the wall.

An indoor swimming pool with clear water, a lifeguard chair, and a sign indicating no diving.

A hotel room with a sofa, a small table, a desk, a chair, a TV, and a window with curtains.

9. Courtyard Raleigh-Durham Airport/Brier Creek

16.6 km from Duke Regional Hospital

Sharon

SAR 485

SAR 550 total

includes taxes & fees

25 Oct - 26 Oct

An outdoor seating area with sofas, chairs, and a fire pit, adjacent to a modern building with large windows.

A modern living room with a fireplace, seating area, and a pool table.

A modern bar area with a long counter, multiple bar stools, and a large screen displaying a sports event.

A modern kitchen with a central island, bar stools, wooden cabinets, and pendant lighting.

10. JB Duke Hotel

6.2 km from Duke Regional Hospital

samantha

SAR 650

SAR 737 total

includes taxes & fees

21 Oct - 22 Oct

A spacious lobby with high ceilings, a central fountain, and seating areas.

An outdoor patio area with wicker furniture, stone pillars, and string lights.

A bar area with multiple liquor cabinets and hanging pendant lights.

A spacious lobby with a curved seating area, large windows, and a modern chandelier.

11. Embassy Suites by Hilton Raleigh Durham Airport Brier Creek

18.2 km from Duke Regional Hospital

Darren C.

SAR 597

SAR 676 total

includes taxes & fees

25 Oct - 26 Oct

An outdoor patio with a table set for a meal, surrounded by chairs and a red umbrella.

A bathroom with a granite countertop, a mirror, and a potted plant.

A tented outdoor dining area with round tables set for a meal, each with white chairs and yellow tablecloths.

A modern hotel room with a kitchenette, a dining area, a living room with a sofa and a coffee table, and a large window with curtains.

12. DoubleTree Suites by Hilton Raleigh - Durham

14.2 km from Duke Regional Hospital

Sierra

SAR 386

SAR 438 total

includes taxes & fees

5 Nov - 6 Nov

A hotel entrance with a stone facade, large wooden doors, and a view into the interior.

A person performing a yoga pose outdoors with trees and a golf course in the background.

A hotel with a stone lion statue, a covered entrance, and a landscaped garden.

An indoor swimming pool with clear blue water, surrounded by lounge chairs and potted plants.

13. Washington Duke Inn & Golf Club

6.6 km from Duke Regional Hospital

Lowell

SAR 892

SAR 1,012 total

includes taxes & fees

25 Oct - 26 Oct

A gym with exercise equipment, including kettlebells, medicine balls, and a stationary bike.

A compact kitchen with a stainless steel refrigerator, a microwave, a coffee maker, and a dishwasher.

An outdoor patio area with a barbecue grill, tables, and chairs.

14. Home2 Suites by Hilton Durham University Medical Center

5 km from Duke Regional Hospital

katey

SAR 539

SAR 612 total

includes taxes & fees

25 Oct - 26 Oct

A lobby with a green sofa, yellow chairs, a coffee table with drinks, and a window with plants.

A business center with wooden paneling, multiple workstations, and framed artwork on the walls.

A Hilton Garden Inn hotel with a modern design, featuring a large entrance and a parking area with a delivery van.

A bar area with a granite countertop, wooden chairs, and a large television screen.

15. Hilton Garden Inn Durham/University Medical Center

9th Street District, 4 km from Duke Regional Hospital

Michael

SAR 491

SAR 558 total

includes taxes & fees

9 Nov - 10 Nov

An outdoor dining area with tables and chairs, large windows, and a view of greenery.

A modern restaurant with long communal tables, hanging pendant lights, and geometric patterned walls.

A modern living room with a pool table, a sofa, and a dining area.

16. The Westin Raleigh-Durham Airport

18.2 km from Duke Regional Hospital

Dina

SAR 807

SAR 914 total

includes taxes & fees

1 Nov - 2 Nov

An outdoor seating area with wicker furniture and a stone fire pit.

A conference room with a long table, chairs, and a modern chandelier.

A modern hotel lobby with seating areas, large windows, and a dining section.

A hotel lobby with a sofa, chairs, a table, and a large window offering a view of the building.

17. Residence Inn Raleigh-Durham Airport/Brier Creek

16.6 km from Duke Regional Hospital

Janet

SAR 523

SAR 592 total

includes taxes & fees

31 Oct - 1 Nov

A modern hotel with a prominent entrance, multiple floors, and a balcony on the second floor.

A modern hotel lobby with a reception desk, a beverage refrigerator, and a well-stocked snack bar.

A modern hotel room with a bed, a desk, a chair, a small seating area, and a kitchenette.

An outdoor patio with a fire feature, seating, and a building with large windows.

18. SpringHill Suites by Marriott Durham City View

5.4 km from Duke Regional Hospital

Taurean

SAR 482

SAR 547 total

includes taxes & fees

1 Nov - 2 Nov

A swimming pool with lounge chairs and a wooden fence.

A modern bar area with a refrigerated display, wooden bar counter, and seating.

A spacious lobby with a reception desk, seating area, and artwork on the walls.

A hotel room with a bed, a sofa, a desk with a chair, a television, and a painting on the wall.

19. Hyatt Place Durham Southpoint

16.1 km from Duke Regional Hospital

Jessica

SAR 507

SAR 575 total

includes taxes & fees

25 Oct - 26 Oct

A brick pathway flanked by neatly trimmed hedges leading to a building with a red facade and a grey roof.

A spacious lobby with a long corridor, comfortable seating areas, and large windows providing natural light.

A modern living room with two sofas facing a glass coffee table, a large window with curtains, and a brick wall.

An outdoor dining area with tables set for four, surrounded by a brick pathway and lush greenery.

20. Rizzo Center, a Destination by Hyatt Hotel

17 km from Duke Regional Hospital

Andrea

SAR 668

SAR 758 total

includes taxes & fees

1 Nov - 2 Nov

View all properties

Compare popular hotels close to Duke Regional Hospital

Property	Property class	Guest rating
Hampton Inn & Suites Durham/North I-85	9.0 Wonderful 1,000 reviews	View
Holiday Inn Express Durham by IHG	8.8 Excellent 1,000 reviews	View
Red Roof Inn Durham - Duke Univ Medical Center	6.8 1,002 reviews	View
Hampton Inn & Suites Durham University Medical Center	9.6 Exceptional 576 reviews	View
The Colonial Inn, an Ascend Collection Hotel	9.6 Exceptional 325 reviews	View

Top Duke Regional Hospital Hotel Reviews

Curated & Caffeinated! Gem near Duke & Downtown • Espresso bar, Eco+, Fire Pit

10/10 Excellent

"Super cute and clean!"

Comfort Inn & Suites Durham near Duke University

10/10 Excellent

"My room was very nice and clean. Breakfast is good. The location is great and the staff are wonderful. I had a problem with my sink and they came to my assistance promptly, fixed it and asked what else they could do for me. Whenever I come to town I stay here so I am getting to know the weekend staff. This is a good place to stay."

The Lodge at Duke Medical Center

10/10 Excellent

"Dry helpful and pleasant staff, great shuttle service, clean and comfortable room."

Hampton Inn & Suites Durham/North I-85

10/10 Excellent

"Very clean room, and friendly staff"

Everything within 1 mile

10/10 Excellent

"This home is thoughtfully laid out and much more spacious than it looks in photos. Our kids enjoyed the snacks each night, and their grandma loved that the home is all one level with smooth floors and bright lighting. Location was perfect for attending events in Durham, Wake Forest and Raleigh. There's also a running path across the street."

Unscripted Durham, Part of JDV by Hyatt

8/10 Good

"The place was awesome! I'm not going into details....I came home with some bed bug bites......🤔"

Cottage with Yard, Mins to Duke

10/10 Excellent

"This was a cheerful home with comfortable beds and many thoughtful extras. We enjoyed our time here."

Durham Retreat: 10 mins from Duke & Downtown, 20 mins from RTP & RDU I Sleeps 8

10/10 Excellent

"!"

Not Your Average Stay” +Glow Room by 9th St, Duke, Alexa,Games & WiFi + NEW! 2bd

10/10 Excellent

"We loved it! Rooms were large and well decorated, everything was so cute! We played football in the yard and lots of other games. The neighborhood is really nice and safe too. Lots of kids and families. I would definitely stay again!"

Frequently asked questions

What's the area like around Duke Regional Hospital?

Duke Regional Hospital is located in an area of Durham known for its stunning cathedral. If you're looking for a convenient place to stay, check out the 10 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Duke Regional Hospital?

Courtyard Durham Near Duke University/Downtown is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and free parking. It's located 2.2 mi (3.5 km) from Duke Regional Hospital. Other good choices within a few miles include Holiday Inn Express Durham by IHG and Red Roof Inn Durham - Duke Univ Medical Center.

How many hotels can I expect to find near Duke Regional Hospital?

Expedia has 10 hotels and other accommodations within a mile from Duke Regional Hospital.

If I need to cancel the hotel reservation for my stay near Duke Regional Hospital, will I receive a refund?

Yes! Most hotel room reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of booking. Add dates, click "Search", then you can filter by "fully refundable" to get the best deals near Duke Regional Hospital.

Where can I learn more about changing or cancelling my trip in the area near Duke Regional Hospital?

To find more details about changing or cancelling your stay near Duke Regional Hospital, click here.

What can I see and do near Duke Regional Hospital?

You might want to spend some time browsing the exhibits at Museum of Life and Science, Nasher Museum of Art at Duke University, or Bennett Place. While you're exploring, swing by American Tobacco Campus, Cameron Indoor Stadium, and Wallace Wade Stadium to learn a bit about the area. You can enjoy live performances at Carolina Theatre and Common Ground Theatre.

Find hotels near Duke Regional Hospital, Raleigh from SAR 273

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Treat yourself

Be picky

Check prices for these dates

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Our top choices for Duke Regional Hospital hotels

1. Hampton Inn & Suites Durham/North I-85

2. Holiday Inn Express Durham by IHG

3. Red Roof Inn Durham - Duke Univ Medical Center

4. Hampton Inn & Suites Durham University Medical Center

5. The Colonial Inn, an Ascend Collection Hotel

6. Fairfield by Marriott Inn & Suites Durham

7. Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek

8. Hyatt House Raleigh / RDU / Brier Creek

9. Courtyard Raleigh-Durham Airport/Brier Creek

10. JB Duke Hotel

11. Embassy Suites by Hilton Raleigh Durham Airport Brier Creek

12. DoubleTree Suites by Hilton Raleigh - Durham

13. Washington Duke Inn & Golf Club

14. Home2 Suites by Hilton Durham University Medical Center

15. Hilton Garden Inn Durham/University Medical Center

16. The Westin Raleigh-Durham Airport

17. Residence Inn Raleigh-Durham Airport/Brier Creek

18. SpringHill Suites by Marriott Durham City View

19. Hyatt Place Durham Southpoint

20. Rizzo Center, a Destination by Hyatt Hotel

Compare popular hotels close to Duke Regional Hospital

Top Duke Regional Hospital Hotel Reviews

Curated & Caffeinated! Gem near Duke & Downtown • Espresso bar, Eco+, Fire Pit

Comfort Inn & Suites Durham near Duke University

The Lodge at Duke Medical Center

Hampton Inn & Suites Durham/North I-85

Everything within 1 mile

Unscripted Durham, Part of JDV by Hyatt

Cottage with Yard, Mins to Duke

Durham Retreat: 10 mins from Duke & Downtown, 20 mins from RTP & RDU I Sleeps 8

Not Your Average Stay” +Glow Room by 9th St, Duke, Alexa,Games & WiFi + NEW! 2bd

Frequently asked questions