The Best Hotels Closest to Duke Regional Hospital in Raleigh for 2026

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Our top choices for Duke Regional Hospital hotels

A breakfast area with a chalkboard menu, a sign indicating breakfast starts here, and a variety of food items like waffles, oatmeal, and fruits.

A hotel room with a bed, a desk with a chair, a flat-screen TV, a microwave, and a mirror.

A Hampton Inn hotel with a modern facade, multiple floors, and a parking lot.

A narrow hallway with shelves stocked with snacks and beverages, leading to a room with a desk and chair.

1. Hampton Inn & Suites Durham/North I-85

2.2 km from Duke Regional Hospital

Shwetha

SAR 460

SAR 522 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with two beds, a flat-screen TV, a wooden headboard, and a carpeted floor.

A coffee station with two coffee machines, a coffee press, and various coffee-related items on a counter.

A Holiday Inn Express hotel with a modern design, featuring a prominent sign, multiple windows, and a well-lit entrance.

A breakfast buffet with a bakery section, a coffee station, and a sign indicating the availability of breakfast.

2. Holiday Inn Express Durham by IHG

2.4 km from Duke Regional Hospital

Kimberly R

SAR 428

SAR 486 total

includes taxes & fees

8 Nov - 9 Nov

A hotel room with a television on a wooden cabinet, a desk with a chair, and a lamp.

A hotel room with a bed, bedside tables, a nightstand, a mirror, and a bathroom with a sink and mirror.

A spacious hallway with wooden flooring, white walls, and multiple windows with blinds. There are two white chairs and a small table with a basket.

A Red Roof Inn with a modern architectural design, featuring a prominent red sign and a well-maintained lawn.

3. Red Roof Inn Durham - Duke Univ Medical Center

2.3 km from Duke Regional Hospital

Luis

SAR 235

SAR 274 total

includes taxes & fees

1 Nov - 2 Nov

A stone fire pit surrounded by striped chairs and tables in an outdoor lounge area with a view of a building in the background.

A Hampton Inn & Suites hotel with a modern facade, multiple windows, and a parking lot.

A modern dining area with a long table, multiple chairs, and a sofa with red ottomans.

A modern hotel lobby with a reception desk, seating area, and a cityscape mural on the wall.

4. Hampton Inn & Suites Durham University Medical Center

5 km from Duke Regional Hospital

Nicole

SAR 476

SAR 540 total

includes taxes & fees

25 Oct - 26 Oct

A bar area with wooden bar stools, pendant lighting, and a counter with a glass display. There are tables and chairs in the background, and the room has a wooden floor.

A bar area with wooden shelves, a chalkboard menu, and various bottles.

A hotel room with two beds, a sofa, a TV, and a bathroom visible through a door.

A covered porch with steps leading to a door, a brick wall, and a street lamp.

5. The Colonial Inn, an Ascend Collection Hotel

18.6 km from Duke Regional Hospital

Elizabeth

SAR 408

SAR 463 total

includes taxes & fees

25 Oct - 26 Oct

A multi-story hotel with a prominent "HOME 2" sign, a brick facade, and a well-lit entrance.

An indoor swimming pool with clear blue water, surrounded by lounge chairs and a tiled floor.

A modern indoor space with multiple seating areas, including tables and chairs, a television, and decorative shelves.

6. Home2 Suites by Hilton Durham University Medical Center

5 km from Duke Regional Hospital

katey

SAR 539

SAR 612 total

includes taxes & fees

25 Oct - 26 Oct

A modern lobby with a central seating area, a TV screen, and a patterned wall.

A modern hotel room with a bed, bedside table, TV, and a small desk area.

An indoor swimming pool with clear water, surrounded by lounge chairs and potted plants.

A modern kitchen with a built-in refrigerator, a gray sofa, and a gray armchair.

7. Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek

18.2 km from Duke Regional Hospital

Maurice

SAR 444

SAR 502 total

includes taxes & fees

25 Oct - 26 Oct

A modern restaurant with long communal tables, hanging pendant lights, and geometric patterned walls.

A bar area with multiple shelves of bottles, glasses, and a bar counter.

A modern living room with a pool table, a sofa, and a dining area.

8. The Westin Raleigh-Durham Airport

18.2 km from Duke Regional Hospital

Dina

SAR 807

SAR 914 total

includes taxes & fees

25 Oct - 26 Oct

A brick pathway flanked by neatly trimmed hedges leading to a building with a red facade and a grey roof.

A modern living room with two sofas facing a glass coffee table, a large window with curtains, and a brick wall.

A restaurant with brick walls, wooden tables, and blue chairs.

A spacious lobby with a long corridor, comfortable seating areas, and large windows providing natural light.

9. Rizzo Center, a Destination by Hyatt Hotel

17 km from Duke Regional Hospital

Dale

SAR 669

SAR 759 total

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with high ceilings, a central fountain, and seating areas.

A spacious lobby with a curved seating area, large windows, and a modern chandelier.

A modern bedroom with a large bed, a fireplace, a walk-in closet, and a bathroom with a round mirror and vanity.

A bar area with multiple liquor cabinets and hanging pendant lights.

10. Embassy Suites by Hilton Raleigh Durham Airport Brier Creek

18.2 km from Duke Regional Hospital

Darren C.

SAR 597

SAR 677 total

includes taxes & fees

1 Nov - 2 Nov

A hotel entrance with a stone facade, large wooden doors, and a view into the interior.

A dining area with a chandelier, tables, chairs, and a Christmas tree.

An indoor swimming pool with clear blue water, surrounded by lounge chairs and potted plants.

A hotel with a stone lion statue, a covered entrance, and a landscaped garden.

11. Washington Duke Inn & Golf Club

6.6 km from Duke Regional Hospital

Lowell

SAR 901

SAR 1,023 total

includes taxes & fees

25 Oct - 26 Oct

A swimming pool with lounge chairs and a wooden fence.

A spacious lobby with a reception desk, seating area, and artwork on the walls.

A hotel room with a bed, a sofa, a desk with a chair, a television, and a painting on the wall.

A modern bar area with a refrigerated display, wooden bar counter, and seating.

12. Hyatt Place Durham Southpoint

16.1 km from Duke Regional Hospital

Jessica

SAR 507

SAR 575 total

includes taxes & fees

21 Oct - 22 Oct

An indoor swimming pool with clear water, a no diving sign, and a seating area with chairs and tables.

A modern hotel lobby with a long dining table, multiple chairs, a sofa, and a bar area.

A modern hotel lobby with a reception desk, several chairs, a large monitor, and pendant lighting.

A modern kitchen with built-in shelves, a glass backsplash, and a variety of kitchenware.

13. Hyatt House Raleigh / RDU / Brier Creek

17.8 km from Duke Regional Hospital

Alton

SAR 413

SAR 468 total

includes taxes & fees

1 Nov - 2 Nov

An outdoor seating area with wicker furniture and a stone fire pit.

A hotel lobby with a sofa, chairs, a table, and a large window offering a view of the building.

An indoor swimming pool with clear water, a lifeguard chair, and a sign indicating no diving.

A modern hotel lobby with seating areas, large windows, and a dining section.

14. Residence Inn Raleigh-Durham Airport/Brier Creek

16.6 km from Duke Regional Hospital

Janet

SAR 524

SAR 593 total

includes taxes & fees

18 Oct - 19 Oct

An outdoor seating area with sofas, chairs, and a fire pit, adjacent to a modern building with large windows.

A modern reception area with a marble counter, a wooden bench, and a unique chandelier.

A modern bar area with a long counter, multiple bar stools, and a large screen displaying a sports event.

A modern kitchen with a central island, bar stools, wooden cabinets, and pendant lighting.

15. JB Duke Hotel

6.2 km from Duke Regional Hospital

samantha

SAR 747

SAR 848 total

includes taxes & fees

14 Oct - 15 Oct

An outdoor patio with a table set for a meal, surrounded by chairs and a red umbrella.

A bathroom with a granite countertop, a mirror, and a potted plant.

A hotel room with two beds, a desk, a mirror, a television, and a kitchenette.

A tranquil lakeside setting with a dock, boats, and a seating area.

16. DoubleTree Suites by Hilton Raleigh - Durham

14.2 km from Duke Regional Hospital

Stephen

SAR 409

SAR 464 total

includes taxes & fees

2 Nov - 3 Nov

A modern hotel with a prominent entrance, multiple floors, and a balcony on the second floor.

A modern hotel room with a bed, a desk, a chair, a small seating area, and a kitchenette.

An outdoor patio with a fire feature, seating, and a building with large windows.

A modern hotel lobby with a reception desk, a beverage refrigerator, and a well-stocked snack bar.

17. SpringHill Suites by Marriott Durham City View

5.4 km from Duke Regional Hospital

Taurean

SAR 482

SAR 547 total

includes taxes & fees

1 Nov - 2 Nov

A lobby with a green sofa, yellow chairs, a coffee table with drinks, and a window with plants.

A bar area with a granite countertop, wooden chairs, and a large television screen.

A business center with wooden paneling, multiple workstations, and framed artwork on the walls.

A Hilton Garden Inn hotel with a modern design, featuring a large entrance and a parking area with a delivery van.

18. Hilton Garden Inn Durham/University Medical Center

9th Street District, 4 km from Duke Regional Hospital

Michael

SAR 492

SAR 558 total

includes taxes & fees

9 Nov - 10 Nov

A spacious, elegantly decorated interior with a central round table, high ceilings, and classic architectural columns.

A well-lit living room with a sofa, armchairs, a coffee table, and a fireplace.

A large, historic building with a central courtyard, columns, and a brick facade.

A banquet hall with round tables, chandeliers, and floral centerpieces.

19. The Carolina Inn, a Destination by Hyatt Hotel

19.9 km from Duke Regional Hospital

Stephanie Pauline

SAR 1,378

SAR 1,564 total

includes taxes & fees

1 Nov - 2 Nov

A multi-story brick building with a modern glass section, surrounded by trees and a clear sky.

A gym with treadmills, elliptical machines, a bench press, and a blue balance board.

A hotel room with two beds, a desk, a TV, and a sofa.

A spacious lobby with a reception desk, seating area, and a beverage kiosk.

20. Residence Inn Durham McPherson/Duke University Medical Cntr

Trinity Park, 4.1 km from Duke Regional Hospital

Patricia

SAR 559

SAR 634 total

includes taxes & fees

18 Oct - 19 Oct

View all properties

Compare popular hotels close to Duke Regional Hospital

Property	Property class	Guest rating
Hampton Inn & Suites Durham/North I-85	9.0 Wonderful 1,006 reviews	View
Holiday Inn Express Durham by IHG	8.8 Excellent 1,005 reviews	View
Red Roof Inn Durham - Duke Univ Medical Center	6.8 1,000 reviews	View
Hampton Inn & Suites Durham University Medical Center	9.6 Exceptional 572 reviews	View
The Colonial Inn, an Ascend Collection Hotel	9.6 Exceptional 322 reviews	View

Top Duke Regional Hospital Hotel Reviews

Hilton Durham near Duke University

10/10 Excellent

"Good location and has all ameneties for a comfortable stay"

Courtyard Durham Near Duke University/Downtown

10/10 Excellent

"I want to personally thank "HEIDI", the front desk staff person. She was fantatstic in every way. She went the extra mile to help us check in early and made sure we were accommodated. Please commend her."

Hampton Inn & Suites Durham/North I-85

10/10 Excellent

"Very clean room, and friendly staff"

Everything within 1 mile

10/10 Excellent

"This home is thoughtfully laid out and much more spacious than it looks in photos. Our kids enjoyed the snacks each night, and their grandma loved that the home is all one level with smooth floors and bright lighting. Location was perfect for attending events in Durham, Wake Forest and Raleigh. There's also a running path across the street."

Comfort Inn & Suites Durham near Duke University

10/10 Excellent

"Arrived a little early and was accommodated by getting my room 30 minutes early. The room was very clean and comfy. The bed was firm but comfortable and the water pressure in the shower wasn’t great but was good enough. We never made it down for breakfast so I can’t comment on it. Also lots of good eating choices within a few minutes drive. I would recommend this property if you are wanting a good hotel for an affordable price."

The Lodge at Duke Medical Center

8/10 Good

"Very convenient to the medical center and university. The staff was very helpful. Good value. Very safe."

Unscripted Durham, Part of JDV by Hyatt

8/10 Good

"The place was awesome! I'm not going into details....I came home with some bed bug bites......🤔"

Curated & Caffeinated! Gem near Duke & Downtown • Espresso bar, Eco+, Fire Pit

10/10 Excellent

"The house was absolutely immaculate and Kristin could not have nicer or more helpful. The location was just 25 minutes from RDU, 12 minutes from downtown Durham and about a half an hour from Chapel Hill. Comfortable living room for my small group, large screen TV with all the streaming channels and a very cool coffee grinder/maker for regular or espresso coffee. Highly recommend. John L"

Cottage with Yard, Mins to Duke

10/10 Excellent

"This was a cheerful home with comfortable beds and many thoughtful extras. We enjoyed our time here."

Frequently asked questions

What's the area like around Duke Regional Hospital?

Duke Regional Hospital is located in an area of Durham known for its stunning cathedral. If you're looking for a convenient place to stay, check out the 10 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Duke Regional Hospital?

Courtyard Durham Near Duke University/Downtown is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and free parking. It's located 2.2 mi (3.5 km) from Duke Regional Hospital. Other good choices within a few miles include Holiday Inn Express Durham by IHG and Red Roof Inn Durham - Duke Univ Medical Center.

How many hotels can I expect to find near Duke Regional Hospital?

Expedia has 10 hotels and other accommodations within a mile from Duke Regional Hospital.

If I need to cancel the hotel reservation for my stay near Duke Regional Hospital, will I receive a refund?

Yes! Most hotel room reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of booking. Add dates, click "Search", then you can filter by "fully refundable" to get the best deals near Duke Regional Hospital.

Where can I learn more about changing or cancelling my trip in the area near Duke Regional Hospital?

To find more details about changing or cancelling your stay near Duke Regional Hospital, click here.

What can I see and do near Duke Regional Hospital?

You might want to spend some time browsing the exhibits at Museum of Life and Science, Nasher Museum of Art at Duke University, or Bennett Place. While you're exploring, swing by American Tobacco Campus, Cameron Indoor Stadium, and Wallace Wade Stadium to learn a bit about the area. You can enjoy live performances at Carolina Theatre and Common Ground Theatre.

Find hotels near Duke Regional Hospital, Raleigh

Change your mind

Treat yourself

Be picky

Check prices for these dates

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Our top choices for Duke Regional Hospital hotels

1. Hampton Inn & Suites Durham/North I-85

2. Holiday Inn Express Durham by IHG

3. Red Roof Inn Durham - Duke Univ Medical Center

4. Hampton Inn & Suites Durham University Medical Center

5. The Colonial Inn, an Ascend Collection Hotel

6. Home2 Suites by Hilton Durham University Medical Center

7. Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek

8. The Westin Raleigh-Durham Airport

9. Rizzo Center, a Destination by Hyatt Hotel

10. Embassy Suites by Hilton Raleigh Durham Airport Brier Creek

11. Washington Duke Inn & Golf Club

12. Hyatt Place Durham Southpoint

13. Hyatt House Raleigh / RDU / Brier Creek

14. Residence Inn Raleigh-Durham Airport/Brier Creek

15. JB Duke Hotel

16. DoubleTree Suites by Hilton Raleigh - Durham

17. SpringHill Suites by Marriott Durham City View

18. Hilton Garden Inn Durham/University Medical Center

19. The Carolina Inn, a Destination by Hyatt Hotel

20. Residence Inn Durham McPherson/Duke University Medical Cntr

Compare popular hotels close to Duke Regional Hospital

Top Duke Regional Hospital Hotel Reviews

Hilton Durham near Duke University

Courtyard Durham Near Duke University/Downtown

Hampton Inn & Suites Durham/North I-85

Everything within 1 mile

Comfort Inn & Suites Durham near Duke University

The Lodge at Duke Medical Center

Unscripted Durham, Part of JDV by Hyatt

Curated & Caffeinated! Gem near Duke & Downtown • Espresso bar, Eco+, Fire Pit

Cottage with Yard, Mins to Duke

Frequently asked questions