The Best Hotels Closest to Duke Regional Hospital in Raleigh for 2026

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Our top choices for Duke Regional Hospital hotels

A breakfast area with a chalkboard menu, a sign indicating breakfast starts here, and a variety of food items like waffles, oatmeal, and fruits.

A Hampton Inn hotel with a modern facade, multiple floors, and a parking lot.

A narrow hallway with shelves stocked with snacks and beverages, leading to a room with a desk and chair.

A hotel room with a bed, a desk with a chair, a flat-screen TV, a microwave, and a mirror.

1. Hampton Inn & Suites Durham/North I-85

2.2 km from Duke Regional Hospital

Darrel

SAR 443

SAR 503 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with two beds, a flat-screen TV, a wooden headboard, and a carpeted floor.

A Holiday Inn Express hotel with a modern design, featuring a prominent sign, multiple windows, and a well-lit entrance.

A coffee station with two coffee machines, a coffee press, and various coffee-related items on a counter.

A breakfast buffet with a bakery section, a coffee station, and a sign indicating the availability of breakfast.

2. Holiday Inn Express Durham by IHG

2.4 km from Duke Regional Hospital

Kimberly R

SAR 428

SAR 486 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with a television on a wooden cabinet, a desk with a chair, and a lamp.

A Red Roof Cafe with a stone wall, a coffee machine, and two white chairs.

A hotel room with a bed, bedside tables, a nightstand, a mirror, and a bathroom with a sink and mirror.

A Red Roof Inn with a modern architectural design, featuring a prominent red sign and a well-maintained lawn.

3. Red Roof Inn Durham - Duke Univ Medical Center

2.3 km from Duke Regional Hospital

Luis

SAR 246

SAR 286 total

includes taxes & fees

19 Oct - 20 Oct

A stone fire pit surrounded by striped chairs and tables in an outdoor lounge area with a view of a building in the background.

A modern dining area with a long table, multiple chairs, and a sofa with red ottomans.

A modern hotel lobby with a reception desk, seating area, and a cityscape mural on the wall.

A Hampton Inn & Suites hotel with a modern facade, multiple windows, and a parking lot.

4. Hampton Inn & Suites Durham University Medical Center

5 km from Duke Regional Hospital

Nicole

SAR 468

SAR 531 total

includes taxes & fees

1 Nov - 2 Nov

A modern indoor space with multiple seating areas, including tables and chairs, a television, and decorative shelves.

An indoor swimming pool with clear blue water, surrounded by lounge chairs and a tiled floor.

5. Home2 Suites by Hilton Durham University Medical Center

5 km from Duke Regional Hospital

katey

SAR 520

SAR 590 total

includes taxes & fees

18 Oct - 19 Oct

An outdoor patio area with round tables and chairs, large umbrellas, and a glass door entrance.

A multi-story hotel with a brick facade, large windows, and a well-lit entrance.

A modern restaurant with round tables and yellow chairs, a bar area, and a 'Hello Fall' sign.

A hotel room with two beds, a desk, a chair, a sofa, and a TV.

6. Fairfield by Marriott Inn & Suites Durham

18.2 km from Duke Regional Hospital

Yolanda

SAR 432

SAR 490 total

includes taxes & fees

29 Oct - 30 Oct

A modern lobby with a central seating area, a TV screen, and a patterned wall.

A modern hotel room with a bed, bedside table, TV, and a small desk area.

An indoor swimming pool with clear water, surrounded by lounge chairs and potted plants.

A modern kitchen with a built-in refrigerator, a gray sofa, and a gray armchair.

7. Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek

18.2 km from Duke Regional Hospital

Maurice

SAR 443

SAR 502 total

includes taxes & fees

18 Oct - 19 Oct

A swimming pool with lounge chairs and a wooden fence.

A modern bar area with a refrigerated display, wooden bar counter, and seating.

A hotel room with a bed, a sofa, a desk with a chair, a television, and a painting on the wall.

A multi-story hotel with a modern design, featuring a prominent entrance with a glass canopy and an American flag.

8. Hyatt Place Durham Southpoint

16.1 km from Duke Regional Hospital

Stephen

SAR 507

SAR 575 total

includes taxes & fees

21 Oct - 22 Oct

An outdoor seating area with sofas, chairs, and a fire pit, adjacent to a modern building with large windows.

A modern living room with a fireplace, seating area, and a pool table.

A modern reception area with a marble counter, a wooden bench, and a unique chandelier.

A modern kitchen with a central island, bar stools, wooden cabinets, and pendant lighting.

9. JB Duke Hotel

6.2 km from Duke Regional Hospital

samantha

SAR 762

SAR 865 total

includes taxes & fees

11 Oct - 12 Oct

A reception area with two wooden reception desks, a potted plant, and a computer on the wall.

A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

A hotel room with a sofa, a small table, a desk, a chair, a TV, and a window with curtains.

10. Courtyard Raleigh-Durham Airport/Brier Creek

16.6 km from Duke Regional Hospital

eidy

SAR 503

SAR 570 total

includes taxes & fees

25 Oct - 26 Oct

An outdoor seating area with wicker chairs and a large umbrella, a fire feature, and a view of the interior through glass walls.

A large indoor swimming pool with a skylight ceiling, clear glass walls, and a tiled floor.

A kitchen with a microwave, coffee maker, and a dishwasher.

A hotel room with a large bed, a bedside table with a lamp, a TV mounted on the wall, and a window with curtains.

11. DoubleTree Suites by Hilton Raleigh - Durham

14.2 km from Duke Regional Hospital

Stephen

SAR 394

SAR 447 total

includes taxes & fees

2 Nov - 3 Nov

A brick pathway flanked by neatly trimmed hedges leading to a building with a red facade and a grey roof.

A modern living room with two sofas facing a glass coffee table, a large window with curtains, and a brick wall.

A spacious lobby with a long corridor, comfortable seating areas, and large windows providing natural light.

A restaurant with brick walls, wooden tables, and blue chairs.

12. Rizzo Center, a Destination by Hyatt Hotel

17 km from Duke Regional Hospital

Dale

SAR 732

SAR 831 total

includes taxes & fees

13 Oct - 14 Oct

An outdoor seating area with wicker furniture and a stone fire pit.

A conference room with a long table, chairs, and a modern chandelier.

A modern hotel lobby with seating areas, large windows, and a dining section.

A hotel lobby with a sofa, chairs, a table, and a large window offering a view of the building.

13. Residence Inn Raleigh-Durham Airport/Brier Creek

16.6 km from Duke Regional Hospital

Janet

SAR 523

SAR 593 total

includes taxes & fees

18 Oct - 19 Oct

A hotel entrance with a stone facade, large wooden doors, and a view into the interior.

A person performing a yoga pose outdoors with trees and a golf course in the background.

A dining area with a chandelier, tables, chairs, and a Christmas tree.

An indoor swimming pool with clear blue water, surrounded by lounge chairs and potted plants.

14. Washington Duke Inn & Golf Club

6.6 km from Duke Regional Hospital

Antonio

SAR 965

SAR 1,095 total

includes taxes & fees

27 Oct - 28 Oct

An outdoor seating area with a circular fire pit surrounded by wicker chairs and a table.

A multi-story hotel with a flat facade, large windows, and a clear sky.

An indoor swimming pool with a 3 FT depth marker, a wheelchair-accessible chair, a potted plant, and a view of the outside through large windows.

A modern hotel lobby with a mix of seating areas, a bar, and a large wall-mounted TV.

15. SpringHill Suites by Marriott Durham Chapel Hill

12.6 km from Duke Regional Hospital

Logan

SAR 480

SAR 545 total

includes taxes & fees

12 Oct - 13 Oct

A bar area with multiple shelves of bottles, glasses, and a bar counter.

A modern restaurant with long communal tables, hanging pendant lights, and geometric patterned walls.

An outdoor dining area with tables and chairs, large windows, and a view of greenery.

16. The Westin Raleigh-Durham Airport

18.2 km from Duke Regional Hospital

Dina

SAR 807

SAR 914 total

includes taxes & fees

18 Oct - 19 Oct

An indoor swimming pool with clear water, a no diving sign, and a seating area with chairs and tables.

A modern kitchen with built-in shelves, a glass backsplash, and a variety of kitchenware.

A modern hotel lobby with a long dining table, multiple chairs, a sofa, and a bar area.

A modern hotel lobby with a reception desk, several chairs, a large monitor, and pendant lighting.

17. Hyatt House Raleigh / RDU / Brier Creek

17.8 km from Duke Regional Hospital

Alton

SAR 413

SAR 468 total

includes taxes & fees

1 Nov - 2 Nov

A lobby with a green sofa, yellow chairs, a coffee table with drinks, and a window with plants.

A business center with wooden paneling, multiple workstations, and framed artwork on the walls.

An indoor swimming pool with clear glass walls, a tiled floor, and a seating area with chairs and a table.

A Hilton Garden Inn hotel with a modern design, featuring a large entrance and a parking area with a delivery van.

18. Hilton Garden Inn Durham/University Medical Center

9th Street District, 4 km from Duke Regional Hospital

Hal

SAR 517

SAR 586 total

includes taxes & fees

2 Nov - 3 Nov

A spacious lobby with high ceilings, a central fountain, and seating areas.

A modern bedroom with a large bed, a fireplace, a walk-in closet, and a bathroom with a round mirror and vanity.

A spacious lobby with a curved seating area, large windows, and a modern chandelier.

An outdoor patio area with wicker furniture, stone pillars, and string lights.

19. Embassy Suites by Hilton Raleigh Durham Airport Brier Creek

18.2 km from Duke Regional Hospital

Darren C.

SAR 597

SAR 676 total

includes taxes & fees

18 Oct - 19 Oct

An outdoor patio with wicker furniture, a stone fire pit, and a brick building in the background.

A multi-story brick building with a modern entrance and a parking lot.

A spacious lobby with a reception desk, seating area, and a beverage kiosk.

A hotel room with two beds, a desk, a TV, and a sofa.

20. Residence Inn Durham McPherson/Duke University Medical Cntr

Trinity Park, 4.1 km from Duke Regional Hospital

Patricia

SAR 591

SAR 671 total

includes taxes & fees

5 Nov - 6 Nov

View all properties

Compare popular hotels close to Duke Regional Hospital

Property	Property class	Guest rating
Hampton Inn & Suites Durham/North I-85	9.0 Wonderful 1,003 reviews	View
Holiday Inn Express Durham by IHG	8.8 Excellent 1,005 reviews	View
Red Roof Inn Durham - Duke Univ Medical Center	6.8 1,000 reviews	View
Hampton Inn & Suites Durham University Medical Center	9.6 Exceptional 570 reviews	View
Home2 Suites by Hilton Durham University Medical Center	9.6 Exceptional 357 reviews	View

Top Duke Regional Hospital Hotel Reviews

Courtyard Durham Near Duke University/Downtown

10/10 Excellent

"Great room, close to downtown. Wonderfully professional staff. Would stay there again."

Comfort Inn & Suites Durham near Duke University

10/10 Excellent

"This was a very good value for money stay. The hotel was clean, staff were friendly and helpful, the bed was very comfortable and the room was spacious. Breakfast was included and was a standard breakfast buffet. We would happily stay here again if visiting Durham."

Millennium Hotel Durham

10/10 Excellent

"Front desk couldn’t find my reservation. I called expedia and after more than an hour they emailed the hotel a new payment code. Gladly, Fernando, hotel front desk representative, was able to quickly make a new reservation and get me and my wife a room. Thanks Fernando (Millenium Hotel) for the great customer service."

Hampton Inn & Suites Durham/North I-85

10/10 Excellent

"Clean rooms and friendly staff"

Curated & Caffeinated! Gem near Duke & Downtown • Espresso bar, Eco+, Fire Pit

10/10 Excellent

"The house was absolutely immaculate and Kristin could not have nicer or more helpful. The location was just 25 minutes from RDU, 12 minutes from downtown Durham and about a half an hour from Chapel Hill. Comfortable living room for my small group, large screen TV with all the streaming channels and a very cool coffee grinder/maker for regular or espresso coffee. Highly recommend. John L"

Drexall Haven - Stylish + Peaceful Stay

8/10 Good

"The house is newly renovated so everything looks really nice. The only issue I have is a lack of dressers for our clothes. Otherwise the experience was great. Quiet neighborhood out of the way but accessible."

Everything within 1 mile

10/10 Excellent

"Perfect size and great location! The host has thought of everything and included so many extra thoughtful touches! So close to everything, quiet, clean, and stocked!"

Cottage with Yard, Mins to Duke

10/10 Excellent

"This was a cheerful home with comfortable beds and many thoughtful extras. We enjoyed our time here."

Durham Retreat: 10 mins from Duke & Downtown, 20 mins from RTP & RDU I Sleeps 8

10/10 Excellent

"!"

Frequently asked questions

What's the area like around Duke Regional Hospital?

Duke Regional Hospital is located in an area of Durham known for its stunning cathedral. If you're looking for a convenient place to stay, check out the 10 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Duke Regional Hospital?

Courtyard Durham Near Duke University/Downtown is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and free parking. It's located 2.2 mi (3.5 km) from Duke Regional Hospital. Other good choices within a few miles include Holiday Inn Express Durham by IHG and Red Roof Inn Durham - Duke Univ Medical Center.

How many hotels can I expect to find near Duke Regional Hospital?

Expedia has 10 hotels and other accommodations within a mile from Duke Regional Hospital.

If I need to cancel the hotel reservation for my stay near Duke Regional Hospital, will I receive a refund?

Yes! Most hotel room reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of booking. Add dates, click "Search", then you can filter by "fully refundable" to get the best deals near Duke Regional Hospital.

Where can I learn more about changing or cancelling my trip in the area near Duke Regional Hospital?

To find more details about changing or cancelling your stay near Duke Regional Hospital, click here.

What can I see and do near Duke Regional Hospital?

You might want to spend some time browsing the exhibits at Museum of Life and Science, Nasher Museum of Art at Duke University, or Bennett Place. While you're exploring, swing by American Tobacco Campus, Cameron Indoor Stadium, and Wallace Wade Stadium to learn a bit about the area. You can enjoy live performances at Carolina Theatre and Common Ground Theatre.

Find hotels near Duke Regional Hospital, Raleigh from SAR 286

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Treat yourself

Be picky

Check prices for these dates

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Our top choices for Duke Regional Hospital hotels

1. Hampton Inn & Suites Durham/North I-85

2. Holiday Inn Express Durham by IHG

3. Red Roof Inn Durham - Duke Univ Medical Center

4. Hampton Inn & Suites Durham University Medical Center

5. Home2 Suites by Hilton Durham University Medical Center

6. Fairfield by Marriott Inn & Suites Durham

7. Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek

8. Hyatt Place Durham Southpoint

9. JB Duke Hotel

10. Courtyard Raleigh-Durham Airport/Brier Creek

11. DoubleTree Suites by Hilton Raleigh - Durham

12. Rizzo Center, a Destination by Hyatt Hotel

13. Residence Inn Raleigh-Durham Airport/Brier Creek

14. Washington Duke Inn & Golf Club

15. SpringHill Suites by Marriott Durham Chapel Hill

16. The Westin Raleigh-Durham Airport

17. Hyatt House Raleigh / RDU / Brier Creek

18. Hilton Garden Inn Durham/University Medical Center

19. Embassy Suites by Hilton Raleigh Durham Airport Brier Creek

20. Residence Inn Durham McPherson/Duke University Medical Cntr

Compare popular hotels close to Duke Regional Hospital

Top Duke Regional Hospital Hotel Reviews

Courtyard Durham Near Duke University/Downtown

Comfort Inn & Suites Durham near Duke University

Millennium Hotel Durham

Hampton Inn & Suites Durham/North I-85

Curated & Caffeinated! Gem near Duke & Downtown • Espresso bar, Eco+, Fire Pit

Drexall Haven - Stylish + Peaceful Stay

Everything within 1 mile

Cottage with Yard, Mins to Duke

Durham Retreat: 10 mins from Duke & Downtown, 20 mins from RTP & RDU I Sleeps 8

Frequently asked questions