Photo by Bill Dillard

Find Historic Hotels in Southeast Missouri, MO

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Southeast Missouri Historic Hotels

Next weekend
In two weeks

Top Southeast Missouri Historic Hotels

⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4

2.0 star property
Ste. Genevieve
10.0 out of 10, Exceptional, (18)
"Great historic property!"
United States
Rhonda R.
The price is SAR 507
SAR 867 total
includes taxes & fees
12 Dec - 13 Dec
⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4

Beautiful Modern Loft In Wine Country!

Ste. Genevieve
10.0 out of 10, Exceptional, (271)
"Loved our stay here! Thoughtful amenities on a beautiful property. Great communication with host. "
United States
Elsie H.
The price is SAR 555
SAR 678 total
includes taxes & fees
18 Dec - 19 Dec
Beautiful Modern Loft In Wine Country!

The Weber Farm - Enjoy a beautiful 100 acre farm!

Frohna
10.0 out of 10, Exceptional, (32)
"Hosts were great. I just wish they had a second bath or atleast a larger bathroom. "
United States
Dennis H.
The price is SAR 422
SAR 692 total
includes taxes & fees
9 Dec - 10 Dec
The Weber Farm - Enjoy a beautiful 100 acre farm!

"Little Brick House on Main (1865)”

Ste. Genevieve
10.0 out of 10, Exceptional, (63)
"Great place to stay!"
United States
Lettitia B.
The price is SAR 446
SAR 596 total
includes taxes & fees
9 Dec - 10 Dec
"Little Brick House on Main (1865)”

Serenity South -- Gardens, River-Views, and Refreshing Space

Cape Girardeau
10.0 out of 10, Exceptional, (148)
"Such a great place and location"
United States
Tracy H.
The price is SAR 563
SAR 919 total
includes taxes & fees
9 Dec - 10 Dec
Serenity South -- Gardens, River-Views, and Refreshing Space

Country Inn Motel

2.0 star property
Licking
7.2 out of 10, Good, (330)
"Friendly staff and clean room"
United States
Peggy
The price is SAR 206
SAR 225 total
includes taxes & fees
9 Dec - 10 Dec
Country Inn Motel

Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Anna
10.0 out of 10, Exceptional, (403)
"Very clean, courteus staff. Beautiful area and quiet. Very relaxing."
United States
Tommy
The price is SAR 439
SAR 752 total
includes taxes & fees
11 Dec - 12 Dec
Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Charming cottage overlooking Lake Acre

Dongola
10.0 out of 10, Exceptional, (101)
"Location was great, everything was great for what we were there for. Already booked again for November. "
United States
carlton h.
The price is SAR 507
SAR 1,054 total
includes taxes & fees
12 Dec - 13 Dec
Charming cottage overlooking Lake Acre

Contemporary Glamping with Native American Appeal

Anna
9.8 out of 10, Exceptional, (155)
"Our 2nd time staying here and it was perfect"
United States
machelle p.
Contemporary Glamping with Native American Appeal

Peter Ray House

Maeystown
10.0 out of 10, Exceptional, (70)
"The house was wonderful, the town was delightful, and the people were very friendly! We can’t wait for our next trip!"
United States
Deborah
The price is SAR 507
SAR 831 total
includes taxes & fees
9 Dec - 10 Dec
Peter Ray House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Southeast Missouri Hotel Reviews

Explore a world of travel with Expedia