Find hotels in Serra Mesa, San Diego from SAR 287

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
22 Jul - 23 Jul
Tomorrow
23 Jul - 24 Jul
This weekend
25 Jul - 27 Jul
Next weekend
1 Aug - 3 Aug

Filter by

Guest rating
Guest rating
Star rating

Discover 8,841 Serra Mesa hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Sycuan Casino Resort
3 outdoor pools, cabanas (surcharge), pool umbrellas

Sycuan Casino Resort

4.0 star property
9.2 out of 10, Wonderful, (1417)
"Great place to stay beautiful casino! "
Sycuan Casino Resort
Days Inn by Wyndham San Diego-East/El Cajon
Standard Room, 1 King Bed, Smoking | Desk, laptop workspace, iron/ironing board, free WiFi

Days Inn by Wyndham San Diego-East/El Cajon

2.0 star property
7.6 out of 10, Good, (1008)
"Cozy bed, very quiet and convenient"
The price is SAR 416
SAR 459 total
includes taxes & fees
17 Aug - 18 Aug
Days Inn by Wyndham San Diego-East/El Cajon
Best Western Plus La Mesa San Diego
Lobby

Best Western Plus La Mesa San Diego

2.5 star property
8.2 out of 10, Very Good, (1010)
"Staff was friendly, hotel was clean and breakfast was great"
The price is SAR 462
SAR 508 total
includes taxes & fees
17 Aug - 18 Aug
Best Western Plus La Mesa San Diego
SpringHill Suites by Marriott Chula Vista Eastlake
Outdoor pool

SpringHill Suites by Marriott Chula Vista Eastlake

3.5 star property
9.6 out of 10, Exceptional, (377)
"Great place and location "
The price is SAR 611
SAR 674 total
includes taxes & fees
10 Aug - 11 Aug
SpringHill Suites by Marriott Chula Vista Eastlake
Ramada by Wyndham San Diego Poway Miramar
Exterior

Ramada by Wyndham San Diego Poway Miramar

2.0 star property
7.0 out of 10, Good, (844)
"Our stay went well, and the hotel is a good value"
The price is SAR 371
SAR 408 total
includes taxes & fees
17 Aug - 18 Aug
Ramada by Wyndham San Diego Poway Miramar
Sonesta ES Suites San Diego - Rancho Bernardo
Full-size fridge, microwave, stovetop, dishwasher

Sonesta ES Suites San Diego - Rancho Bernardo

3.0 star property
8.2 out of 10, Very Good, (1009)
"Very nice place for families "
The price is SAR 409
SAR 466 total
includes taxes & fees
13 Aug - 14 Aug
Sonesta ES Suites San Diego - Rancho Bernardo
Ayres Hotel San Diego South - Chula Vista
Lobby lounge

Ayres Hotel San Diego South - Chula Vista

3.0 star property
9.8 out of 10, Exceptional, (1085)
"The area was amazing, food & shopping options were right across the hotel which was very convenient. Amenities were great, complimentary breakfast had good options, and staff were friendly. "
The price is SAR 654
SAR 721 total
includes taxes & fees
3 Aug - 4 Aug
Ayres Hotel San Diego South - Chula Vista
Heritage Inn La Mesa
Outdoor pool, pool umbrellas, sun loungers

Heritage Inn La Mesa

2.0 star property
6.6 out of 10, (1047)
"Familiar stay"
The price is SAR 287
SAR 316 total
includes taxes & fees
28 Jul - 29 Jul
Heritage Inn La Mesa
La Quinta Inn by Wyndham San Diego - Miramar
Reception

La Quinta Inn by Wyndham San Diego - Miramar

3.0 star property
7.6 out of 10, Good, (1009)
"comfortable bed & clean rooms"
The price is SAR 449
SAR 516 total
includes taxes & fees
17 Aug - 18 Aug
La Quinta Inn by Wyndham San Diego - Miramar
Lamplighter Inn & Suites at SDSU
Outdoor pool, pool umbrellas, sun loungers

Lamplighter Inn & Suites at SDSU

2.5 star property
9.0 out of 10, Wonderful, (1215)
"Clean rooms, simple checkin, plenty of parking"
Lamplighter Inn & Suites at SDSU
Best Western Chula Vista/Otay Valley Hotel
Lobby

Best Western Chula Vista/Otay Valley Hotel

2.5 star property
7.8 out of 10, Good, (1462)
"Clean, great staff. "
The price is SAR 475
SAR 523 total
includes taxes & fees
3 Aug - 4 Aug
Best Western Chula Vista/Otay Valley Hotel
La Quinta Inn by Wyndham San Diego Chula Vista
Exterior

La Quinta Inn by Wyndham San Diego Chula Vista

3.0 star property
8.6 out of 10, Excellent, (1307)
"Love the breakfast and convenient location. "
The price is SAR 462
SAR 509 total
includes taxes & fees
29 Jul - 30 Jul
La Quinta Inn by Wyndham San Diego Chula Vista
Studio 6 Suites San Ysidro, CA -San Diego South Bay
Desk, blackout drapes, iron/ironing board, free WiFi

Studio 6 Suites San Ysidro, CA -San Diego South Bay

2.5 star property
7.8 out of 10, Good, (1144)
"Great stay"
The price is SAR 311
SAR 355 total
includes taxes & fees
3 Aug - 4 Aug
Studio 6 Suites San Ysidro, CA -San Diego South Bay
Valli Hi Motel
Desk, blackout drapes, soundproofing, free WiFi

Valli Hi Motel

2.5 star property
8.2 out of 10, Very Good, (1016)
"Staff was friendly hotel was clean and easy day trips back and forth throughout San Diego area."
Valli Hi Motel
Best Western Americana Inn
1 bedroom, pillowtop beds, in-room safe, desk

Best Western Americana Inn

2.5 star property
9.0 out of 10, Wonderful, (1118)
"It’s a very nice clean and friendly people in the property"
The price is SAR 492
SAR 559 total
includes taxes & fees
30 Jul - 31 Jul
Best Western Americana Inn
Chula Vista Inn
Exterior

Chula Vista Inn

2.5 star property
6.6 out of 10, (1005)
"Nice hotel "
Chula Vista Inn
Hotel Palmeras Chula Vista
Front of property

Hotel Palmeras Chula Vista

2.0 star property
7.0 out of 10, Good, (1781)
"Great rooms ,Awesome staff. And pet friendly!!! "
The price is SAR 288
SAR 317 total
includes taxes & fees
28 Jul - 29 Jul
Hotel Palmeras Chula Vista
Hercor Hotel - Urban Boutique
Deluxe Room, 1 King Bed | 1 bedroom, premium bedding, down comforters, pillowtop beds

Hercor Hotel - Urban Boutique

3.0 star property
8.6 out of 10, Excellent, (1208)
"Great place to stay!"
The price is SAR 379
SAR 417 total
includes taxes & fees
28 Jul - 29 Jul
Hercor Hotel - Urban Boutique
Howard Johnson by Wyndham National City/San Diego South
Hair dryer, towels

Howard Johnson by Wyndham National City/San Diego South

2.0 star property
7.4 out of 10, Good, (1006)
"Enjoyed our stay"
The price is SAR 409
SAR 451 total
includes taxes & fees
18 Aug - 19 Aug
Howard Johnson by Wyndham National City/San Diego South
SureStay Hotel by Best Western Chula Vista San Diego Bay
Outdoor pool

SureStay Hotel by Best Western Chula Vista San Diego Bay

3.0 star property
7.8 out of 10, Good, (1460)
"Great place"
The price is SAR 388
SAR 428 total
includes taxes & fees
29 Jul - 30 Jul
SureStay Hotel by Best Western Chula Vista San Diego Bay
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Serra Mesa

Find the best Serra Mesa areas and neighborhoods for the activities you enjoy most.
US Grant Hotel
Downtown San Diego map

Downtown San Diego

2 out of top 10 points of interest in this area

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Belmont Park showing rides and a garden
Mission Beach map

Mission Beach

Spanning nearly two miles of oceanfront, this sandbar community offers sunbathing, surfing, and beach volleyball, with nearby attractions like Belmont Park's Giant Dipper Roller Coaster and SeaWorld in Mission Bay Park.

Pacific Beach Park showing a beach
Pacific Beach map

Pacific Beach

Boasting a lively nightlife scene, Pacific Beach offers miles of sandy shores, a bustling 3.2-mile boardwalk, and attractions like Crystal Pier and Kate Sessions Park. Enjoy local shops, bars, and eateries along the vibrant walkway.

Gaslamp Quarter showing signage, night scenes and street scenes
Gaslamp Quarter map

Gaslamp Quarter

Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.

Ocean Beach
Ocean Beach map

Ocean Beach

Ocean Beach is known for its stunning beaches, and with sights like Ocean Beach Pier and Dog Beach, you won't get bored spending a day wandering around this part of San Diego.

Top Serra Mesa Hotel Reviews

Bay Club Hotel & Marina

Bay Club Hotel & Marina

10/10 Excellent
"Great location, clean rooms, helpful staff and good restaurant"
Clark 2-night trip
Posted 7 hours ago
Bay Club Hotel & Marina

Frequently asked questions

What's it like in Serra Mesa?

Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighborhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.

How many hotels will I be able to find in the Serra Mesa area?

Expedia has 35 hotels and other accommodations in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.

If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?

Yes, you'll find most hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Add your dates and click on "Search", then filter by "fully refundable" to view the top deals on offer in Serra Mesa.

Where can I learn more about changing or cancelling my trip to Serra Mesa?

For more information about picking new dates or cancelling your trip to Serra Mesa, click here.

What can I see and do in this San Diego neighborhood?

Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.