Find hotels in Otay Mesa, San Diego from SAR 287

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25 Jul - 26 Jul
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26 Jul - 27 Jul
This weekend
25 Jul - 27 Jul
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1 Aug - 3 Aug

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Discover 4,638 Otay Mesa hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Quality Suites San Diego Otay Mesa
Desk, laptop workspace, blackout drapes, iron/ironing board

Quality Suites San Diego Otay Mesa

2.5 star property
7.2 out of 10, Good, (1004)
"Great location and spacious room "
The price is SAR 446
SAR 508 total
includes taxes & fees
31 Jul - 1 Aug
Quality Suites San Diego Otay Mesa
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Exterior

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 star property
7.8 out of 10, Good, (1418)
"Great stay, close to the Cross Border Xpress "
The price is SAR 521
SAR 593 total
includes taxes & fees
10 Aug - 11 Aug
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Sycuan Casino Resort
3 outdoor pools, cabanas (surcharge), pool umbrellas

Sycuan Casino Resort

4.0 star property
9.2 out of 10, Wonderful, (1426)
"Great place to stay beautiful casino! "
Sycuan Casino Resort
Days Inn by Wyndham San Diego-East/El Cajon
Standard Room, 1 King Bed, Smoking | Desk, laptop workspace, iron/ironing board, free WiFi

Days Inn by Wyndham San Diego-East/El Cajon

2.0 star property
7.6 out of 10, Good, (1011)
"Cozy bed, very quiet and convenient"
The price is SAR 420
SAR 463 total
includes taxes & fees
17 Aug - 18 Aug
Days Inn by Wyndham San Diego-East/El Cajon
Super 8 by Wyndham El Cajon/San Diego
Lobby

Super 8 by Wyndham El Cajon/San Diego

2.0 star property
7.8 out of 10, Good, (1009)
"Great place "
The price is SAR 386
SAR 425 total
includes taxes & fees
25 Aug - 26 Aug
Super 8 by Wyndham El Cajon/San Diego
Best Western Plus La Mesa San Diego
Lobby

Best Western Plus La Mesa San Diego

2.5 star property
8.2 out of 10, Very Good, (1014)
"Staff was friendly, hotel was clean and breakfast was great"
The price is SAR 462
SAR 508 total
includes taxes & fees
17 Aug - 18 Aug
Best Western Plus La Mesa San Diego
SpringHill Suites by Marriott Chula Vista Eastlake
Outdoor pool

SpringHill Suites by Marriott Chula Vista Eastlake

3.5 star property
9.6 out of 10, Exceptional, (381)
"Clean property and great breakfast!"
The price is SAR 612
SAR 674 total
includes taxes & fees
10 Aug - 11 Aug
SpringHill Suites by Marriott Chula Vista Eastlake
Ayres Hotel San Diego South - Chula Vista
Lobby lounge

Ayres Hotel San Diego South - Chula Vista

3.0 star property
9.8 out of 10, Exceptional, (1088)
"Very nice hotel"
The price is SAR 598
SAR 659 total
includes taxes & fees
3 Aug - 4 Aug
Ayres Hotel San Diego South - Chula Vista
Heritage Inn La Mesa
Outdoor pool, pool umbrellas, sun loungers

Heritage Inn La Mesa

2.0 star property
6.6 out of 10, (1050)
"Familiar stay"
The price is SAR 287
SAR 316 total
includes taxes & fees
28 Jul - 29 Jul
Heritage Inn La Mesa
Lamplighter Inn & Suites at SDSU
Outdoor pool, pool umbrellas, sun loungers

Lamplighter Inn & Suites at SDSU

2.5 star property
9.0 out of 10, Wonderful, (1218)
"Clean rooms, simple checkin, plenty of parking"
Lamplighter Inn & Suites at SDSU
Best Western Chula Vista/Otay Valley Hotel
Lobby

Best Western Chula Vista/Otay Valley Hotel

2.5 star property
7.8 out of 10, Good, (1464)
"Clean, great staff. "
The price is SAR 443
SAR 488 total
includes taxes & fees
24 Aug - 25 Aug
Best Western Chula Vista/Otay Valley Hotel
La Quinta Inn by Wyndham San Diego Chula Vista
Exterior

La Quinta Inn by Wyndham San Diego Chula Vista

3.0 star property
8.6 out of 10, Excellent, (1316)
"Love the breakfast and convenient location. "
The price is SAR 456
SAR 501 total
includes taxes & fees
28 Jul - 29 Jul
La Quinta Inn by Wyndham San Diego Chula Vista
Studio 6 Suites San Ysidro, CA -San Diego South Bay
Desk, blackout drapes, iron/ironing board, free WiFi

Studio 6 Suites San Ysidro, CA -San Diego South Bay

2.5 star property
7.8 out of 10, Good, (1149)
"Nice hotel to stay in "
The price is SAR 311
SAR 355 total
includes taxes & fees
28 Jul - 29 Jul
Studio 6 Suites San Ysidro, CA -San Diego South Bay
Valli Hi Motel
Desk, blackout drapes, soundproofing, free WiFi

Valli Hi Motel

2.5 star property
8.2 out of 10, Very Good, (1022)
"Staff was friendly hotel was clean and easy day trips back and forth throughout San Diego area."
Valli Hi Motel
Best Western Americana Inn
1 bedroom, pillowtop beds, in-room safe, desk

Best Western Americana Inn

2.5 star property
9.0 out of 10, Wonderful, (1121)
"It’s a very nice clean and friendly people in the property"
The price is SAR 459
SAR 522 total
includes taxes & fees
24 Aug - 25 Aug
Best Western Americana Inn
Chula Vista Inn
Exterior

Chula Vista Inn

2.5 star property
6.6 out of 10, (1008)
"Nice hotel "
Chula Vista Inn
Quality Inn San Diego South - Chula Vista
Coffee service

Quality Inn San Diego South - Chula Vista

2.5 star property
7.8 out of 10, Good, (997)
"From now on this will be my Favorite place to stay on my Business Trips "
The price is SAR 368
SAR 405 total
includes taxes & fees
10 Aug - 11 Aug
Quality Inn San Diego South - Chula Vista
Days Inn by Wyndham Chula Vista/San Diego
Lobby

Days Inn by Wyndham Chula Vista/San Diego

2.0 star property
6.2 out of 10, (974)
"Easy going friendly staff and great room!"
The price is SAR 376
SAR 415 total
includes taxes & fees
27 Jul - 28 Jul
Days Inn by Wyndham Chula Vista/San Diego
Hotel Palmeras Chula Vista
Front of property

Hotel Palmeras Chula Vista

2.0 star property
7.0 out of 10, Good, (1793)
"It’s was good experience staying in hotel "
The price is SAR 298
SAR 327 total
includes taxes & fees
28 Jul - 29 Jul
Hotel Palmeras Chula Vista
Hercor Hotel - Urban Boutique
Deluxe Room, 1 King Bed | 1 bedroom, premium bedding, down comforters, pillowtop beds

Hercor Hotel - Urban Boutique

3.0 star property
8.6 out of 10, Excellent, (1213)
"Great place to stay!"
The price is SAR 379
SAR 417 total
includes taxes & fees
28 Jul - 29 Jul
Hercor Hotel - Urban Boutique
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most.
US Grant Hotel
Downtown San Diego map

Downtown San Diego

2 out of top 10 points of interest in this area

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Belmont Park showing rides and a garden
Mission Beach map

Mission Beach

Spanning nearly two miles of oceanfront, this sandbar community offers sunbathing, surfing, and beach volleyball, with nearby attractions like Belmont Park's Giant Dipper Roller Coaster and SeaWorld in Mission Bay Park.

Pacific Beach Park showing a beach
Pacific Beach map

Pacific Beach

Boasting a lively nightlife scene, Pacific Beach offers miles of sandy shores, a bustling 3.2-mile boardwalk, and attractions like Crystal Pier and Kate Sessions Park. Enjoy local shops, bars, and eateries along the vibrant walkway.

Gaslamp Quarter showing signage, night scenes and street scenes
Gaslamp Quarter map

Gaslamp Quarter

Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.

Ocean Beach
Ocean Beach map

Ocean Beach

Ocean Beach is known for its stunning beaches, and with sights like Ocean Beach Pier and Dog Beach, you won't get bored spending a day wandering around this part of San Diego.

Top Otay Mesa Hotel Reviews

The Dextro Hotel, BW Premier Collection

The Dextro Hotel, BW Premier Collection

10/10 Excellent
"Easy check-in, clean room. Staff and manager were kind and accommodating on a very busy comic-con weekend. Would definitely stay here again. "
Stephanie 2-night trip
Posted 7 hours ago
The Dextro Hotel, BW Premier Collection

Frequently asked questions

What's it like in Otay Mesa?

Otay Mesa is a neighborhood that travelers like for its beaches, restaurants, and shopping.

Where is the best hotel for a stay in Otay Mesa?

Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.

How many hotels will I be able to find in the Otay Mesa area?

Expedia has 5 Otay Mesa hotels and other accommodations, and one might make a good home base for venturing out into the greater San Diego area.

If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?

Yes! The majority of hotel reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Otay Mesa.

Where can I learn more about changing or cancelling my trip to Otay Mesa?

To find more details about changing or cancelling your trip to Otay Mesa, go to https://www.expedia.com/service/.

What is there to do in this San Diego neighborhood?

A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana, and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.