Otay Mesa, CA

San Diego

A city skyline with high-rise buildings and a bridge over a body of water.
An aerial view of a densely populated city with a mix of residential and commercial buildings, surrounded by greenery and a clear sky.
A hillside town with a winding road, a bridge in the distance, and a river in the foreground.

Stay near popular Otay Mesa attractions

Cross Border Xpress

Cross Border Xpress is just one of the places to see in San Diego, so why not enjoy the other things to explore during your travels? Visit the shops in this family-friendly area, or simply enjoy its restaurants.
See properties

Otay Mesa Hotel Deals

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
The price is SAR 571 per night from Nov 2 to Nov 3
SAR 571
SAR 793 total
2 Nov - 3 Nov
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Wyndham San Diego Bayside
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
The price is SAR 781 per night from Nov 1 to Nov 2
SAR 781
SAR 1,096 total
1 Nov - 2 Nov
includes taxes & fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
Paradise Point Resort & Spa
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
The price is SAR 417 per night from Nov 1 to Nov 2
SAR 417
SAR 480 total
1 Nov - 2 Nov
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (2,977 reviews)
"The room was dusty and had lots of spiderwebs the patio/ balcony was dirty full of leaves the carpet was not vacuumed and the bathroom tub was rusty"

Reviewed on 6 October 2026

Handlery Hotel
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
The price is SAR 522 per night from Nov 1 to Nov 2
SAR 522
SAR 790 total
1 Nov - 2 Nov
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
Sheraton San Diego Resort
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr San Diego CA
The price is SAR 591 per night from Nov 4 to Nov 5
SAR 591
SAR 680 total
4 Nov - 5 Nov
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a marina, and a health club. Our guests praise the breakfast and the restaurant in ...
9.2/10 Wonderful! (3,989 reviews)
"I would like to give special recognition to the gentleman at the reception who made such a wonderful impression on us. From the moment we spoke with him, he was incredibly kind, welcoming, and genuine. His name is Zijan. What impressed me most was how proudly and enthusiastically he spoke about the ..."

Reviewed on 6 October 2026

Bay Club Hotel & Marina
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
The price is SAR 679 per night from Nov 3 to Nov 4
SAR 679
SAR 968 total
3 Nov - 4 Nov
includes taxes & fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (4,490 reviews)
"Our room needs to updated. Bed was broken down, furniture"

Reviewed on 6 October 2026

Hard Rock Hotel San Diego
See all 4,962 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most.
A large stadium with the sign "Cobo Park" and palm trees around it.

Downtown San Diego

Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.

A pier extending into the ocean with buildings at the end, under a partly cloudy sky.

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.

A coastal cityscape with a long sandy beach, a pier, and dense urban buildings.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

A theater marquee with ornate designs and the name "Gaslamp Quarter".

Gaslamp Quarter

Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Nova SD is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.

An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.

Otay Mesa, CA

Choose two or more items and save on your trip: