Photo by Linda Cronan
Find 4 Star Hotels in Medical Center District, TX from SAR128
Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on Medical Center District 4 Star Hotels
Compare Medical Center District 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.
Riverwalk Plaza
Riverwalk Plaza
8.2 out of 10, Very Good, (3654)
The price is SAR 446
SAR 528 total
includes taxes & fees
9 Jum. II - 10 Jum. II
Canopy by Hilton San Antonio Riverwalk
Canopy by Hilton San Antonio Riverwalk
9.4 out of 10, Exceptional, (1323)
The price is SAR 717
SAR 838 total
includes taxes & fees
18 Jum. II - 19 Jum. II
JW Marriott San Antonio Hill Country Resort & Spa
JW Marriott San Antonio Hill Country Resort & Spa
8.8 out of 10, Excellent, (1017)
The price is SAR 1,240
SAR 1,633 total
includes taxes & fees
28 Jum. II - 29 Jum. II
Save an average of 15% on thousands of hotels when you're signed in
Hotel Contessa
Hotel Contessa
8.8 out of 10, Excellent, (2775)
The price is SAR 687
SAR 848 total
includes taxes & fees
8 Jum. II - 9 Jum. II
Hyatt Regency San Antonio Riverwalk
Hyatt Regency San Antonio Riverwalk
8.8 out of 10, Excellent, (1630)
The price is SAR 731
SAR 854 total
includes taxes & fees
15 Jum. II - 16 Jum. II
Hotel Gibbs Downtown Riverwalk
Hotel Gibbs Downtown Riverwalk
9.0 out of 10, Wonderful, (2911)
The price is SAR 435
SAR 494 total
includes taxes & fees
13 Jum. II - 14 Jum. II
Omni La Mansion del Rio
Omni La Mansion del Rio
9.2 out of 10, Wonderful, (2181)
The price is SAR 739
SAR 862 total
includes taxes & fees
23 Jum. II - 24 Jum. II
Hotel Valencia Riverwalk
Hotel Valencia Riverwalk
9.2 out of 10, Wonderful, (1756)
The price is SAR 596
SAR 701 total
includes taxes & fees
18 Jum. II - 19 Jum. II
Grand Hyatt San Antonio River Walk
Grand Hyatt San Antonio River Walk
8.8 out of 10, Excellent, (1094)
The price is SAR 710
SAR 831 total
includes taxes & fees
14 Jum. II - 15 Jum. II
The St. Anthony, A Luxury Collection Hotel, San Antonio
The St. Anthony, A Luxury Collection Hotel, San Antonio
9.0 out of 10, Wonderful, (1009)
The price is SAR 730
SAR 847 total
includes taxes & fees
30 Jum. II - 1 Raj.
The Westin San Antonio North
The Westin San Antonio North
8.4 out of 10, Very Good, (1011)
The price is SAR 416
SAR 479 total
includes taxes & fees
1 Raj. - 2 Raj.
La Cantera Resort & Spa
La Cantera Resort & Spa
8.8 out of 10, Excellent, (1070)
The price is SAR 1,328
SAR 1,670 total
includes taxes & fees
30 Jum. II - 1 Raj.
Element San Antonio Riverwalk
Element San Antonio Riverwalk
8.8 out of 10, Excellent, (275)
The price is SAR 458
SAR 527 total
includes taxes & fees
8 Raj. - 9 Raj.
AC Hotel by Marriott San Antonio Riverwalk
AC Hotel by Marriott San Antonio Riverwalk
8.4 out of 10, Very Good, (263)
The price is SAR 443
SAR 524 total
includes taxes & fees
16 Jum. II - 17 Jum. II
Plaza San Antonio Hotel & Spa, Autograph Collection
Plaza San Antonio Hotel & Spa, Autograph Collection
9.2 out of 10, Wonderful, (95)
The price is SAR 627
SAR 731 total
includes taxes & fees
6 Raj. - 7 Raj.
The Westin Riverwalk, San Antonio
The Westin Riverwalk, San Antonio
8.6 out of 10, Excellent, (1049)
The price is SAR 655
SAR 765 total
includes taxes & fees
30 Jum. II - 1 Raj.
Hyatt Regency Hill Country Resort & Spa
Hyatt Regency Hill Country Resort & Spa
8.8 out of 10, Excellent, (1006)
The price is SAR 976
SAR 1,309 total
includes taxes & fees
9 Jum. II - 10 Jum. II
Hilton Palacio Del Rio
Hilton Palacio Del Rio
8.8 out of 10, Excellent, (1582)
The price is SAR 634
SAR 734 total
includes taxes & fees
14 Jum. II - 15 Jum. II
Marriott San Antonio Airport
Marriott San Antonio Airport
8.2 out of 10, Very Good, (1004)
The price is SAR 443
SAR 513 total
includes taxes & fees
5 Raj. - 6 Raj.
Hilton San Antonio Hill Country
Hilton San Antonio Hill Country
8.0 out of 10, Very Good, (1103)
The price is SAR 507
SAR 577 total
includes taxes & fees
23 Jum. II - 24 Jum. II
Explore similar 5-star hotels
Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Medical Center District.
Thompson San Antonio - Riverwalk, by Hyatt
115 Lexington Avenue, San Antonio, TX
8.8/10 Excellent! (509 reviews)
Still don't see what you're looking for?
See all properties in Medical Center District.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent reviews of Medical Center District hotelsExpedia verified reviews
5/5 Excellent
"Great location and beautiful hotel. In walking distance to La Villita Historic Village and even the mall (and I’m pregnant)! Great breakfast and bar food in the hotel and in walking distance to some of the best restaurants in the city. "
A verified traveler stayed at Hotel Contessa
Posted 2 days ago
Medical Center District Hotels by Star Rating
Hotels in Medical Center District Neighborhoods
Stay near popular Medical Center District attractions
- USAA Corporate Office Headquarters
- South Texas Medical Center
- CHRISTUS Santa Rosa Hospital - Medical Center
- University of Texas Health and Science Center at San Antonio
- Oak Hills Country Club
- The San Antonio Art Institute
- Six Flags Fiesta Texas
- Lackland Air Force Base
- Alamo
- Alamodome
- Henry B. González Convention Center
- San Antonio Zoo and Aquarium
- Frost Bank Center
- River Walk
- The Shops of La Cantera
- San Antonio River
- The Rim Shopping Center
Explore more hotels
- Hotel Contessa
- Crockett Hotel
- Hotel Gibbs Downtown Riverwalk
- Hotel Valencia Riverwalk
- Canopy by Hilton San Antonio Riverwalk
- Drury Plaza Hotel San Antonio Riverwalk
- Hyatt Regency San Antonio Riverwalk
- Omni La Mansion del Rio
- La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
- JW Marriott San Antonio Hill Country Resort & Spa
- Drury Plaza Hotel San Antonio Airport
- Grand Hyatt San Antonio River Walk
- La Quinta Inn by Wyndham San Antonio I-35 N at Toepperwein
- Hyatt Vacation Club at Wild Oak Ranch, San Antonio
- Homewood Suites by Hilton San Antonio Riverwalk/Downtown
- Hampton Inn & Suites San Antonio Northwest/Medical Center
- The Gunter Hotel San Antonio Riverwalk
- La Quinta Inn & Suites by Wyndham San Antonio Downtown
- The Westin San Antonio North
- La Cantera Resort & Spa