Find Business Hotels in Portsmouth, OH
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Portsmouth Business Hotels
Top Portsmouth Business Hotels
Best Western River Cities
Russell
8.6 out of 10, Excellent, (425)
"Staff was nice. Scott helped us out as well as the lady that works overnights. The room was simple and clean. Breakfast was good for what it was. Stayed here last year and will stay next year for Thanksgiving and Christmas as well when we visit family. "
Lindsay
The price is SAR 383
SAR 434 total
includes taxes & fees
3 Jan - 4 January 2026
Greenbo Lake State Resort Park
Greenup
9.0 out of 10, Wonderful, (287)
"Very nice stay"
D
Super 8 by Wyndham Grayson
Grayson
8.0 out of 10, Very Good, (762)
"Great staff "
Missy
The price is SAR 233
SAR 264 total
includes taxes & fees
4 Jan - 5 January 2026
Quality Inn
Wheelersburg
8.2 out of 10, Very Good, (311)
"The breakfast was very good, there was a variety of items to enjoy. Our rooms were very clean, and check-in was very easy. The property is well taken care of and the staff is friendly."
Susanne L.
The price is SAR 334
SAR 372 total
includes taxes & fees
4 Jan - 5 January 2026
Super 8 by Wyndham Portsmouth
Portsmouth
7.0 out of 10, Good, (681)
"We loved it and returned each time we are back est."
Saundra
The price is SAR 252
SAR 280 total
includes taxes & fees
4 Jan - 5 January 2026
Quality Inn & Suites Portsmouth
Portsmouth
7.0 out of 10, Good, (564)
"Property in need of regular maintenance, breakfast was sub par, 4 out 10, however the bed was comfortable. Will try a different property next time I'm in town "
Don
The price is SAR 236
SAR 263 total
includes taxes & fees
4 Jan - 5 January 2026
Holiday Inn Portsmouth Downtown by IHG
Portsmouth
8.6 out of 10, Excellent, (461)
"Clean room, friendly staff. Love this hotel, i stay here every timeni visit family."
Cyndi
The price is SAR 432
SAR 481 total
includes taxes & fees
4 Jan - 5 January 2026
Red Roof Inn Wheelersburg
Wheelersburg
7.0 out of 10, Good, (291)
"was very nice"
garrett
The price is SAR 338
SAR 376 total
includes taxes & fees
7 Dec - 8 Dec
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Portsmouth Hotel Reviews
Ramada by Wyndham Catlettsburg/Ashland
10/10 Excellent
Explore a world of travel with Expedia
Find More Hotels near Portsmouth
More Hotel Options in Portsmouth
- Cheap Hotels in Portsmouth
- Family Hotels in Portsmouth
- Golf Hotels in Portsmouth
- Historic Hotels in Portsmouth
- Hotel Wedding Venues in Portsmouth
- Hotel with a Concierge in Portsmouth
- Hotels with Bars in Portsmouth
- Hotels with Free Parking in Portsmouth
- Hotels with Hot Tubs in Portsmouth
- Hotels with WiFi in Portsmouth
- Hotels with a Pool in Portsmouth
- Hotels with an Indoor Pool in Portsmouth
- Luxury Hotels in Portsmouth
- Pet-friendly Hotels in Portsmouth
- Resorts & Hotels with Spas in Portsmouth
- Shopping Hotels in Portsmouth
More Accommodation Types in Portsmouth
- Vacation Homes in Ohio
- Apartments in Ohio
- Cabin Rentals in Ohio
- Cottages in Ohio
- Condo Rentals in Ohio
- Motels in Ohio
- Farmstay in Ohio
- Lodges in Ohio
- B&B in Ohio
- Aparthotels in Ohio
- RV Parks in Ohio
- Villas in Ohio
- Guest Houses in Ohio
- Chalets in Ohio
- Resorts in Ohio
- Inns in Ohio
- Town Houses in Ohio
- Houseboats in Ohio
- Castles in Ohio
- Treehouses in Ohio
- Hostels in Ohio
- Residences in Ohio
Hotels near popular Portsmouth Attractions
- Hotels near Shawnee State University
- Hotels near Portsmouth Floodwall Mural
- Hotels near Boneyfiddle Commercial District
- Hotels near Mound Park
- Hotels near Ohio River
- Hotels near Ohio River Valley
- Hotels near Dogwood Pass
- Hotels near Greenbo Lake State Resort Park
- Hotels near Shawnee State Park
- Hotels near Ohio University Southern Campus
Portsmouth Hotels by Star Rating
Explore more hotels
- Days Inn by Wyndham Jackson
- Delta Hotels by Marriott Ashland Downtown
- Knights Inn Ashland
- Holiday Inn Express & Suites Ironton by IHG
- Days Inn by Wyndham Ashland
- Holiday Inn Express & Suites Ashland by IHG
- TownePlace Suites by Marriott Ironton
- Ramada by Wyndham Catlettsburg/Ashland
- Red Roof Inn Jackson, OH
- Rodeway Inn
- Comfort Inn
- Days Inn by Wyndham Grayson
- Best Western River Cities
- Quality Inn
- SureStay by Best Western Grayson
- Super 8 by Wyndham Grayson
- Quality Inn
- Americas Best Value Inn Grayson
- Greenbo Lake State Resort Park
- Country Nights Inn