The Best Hotels Closest to Cherokee Street in St. Louis for 2026

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Our top choices for Cherokee Street hotels

A room with a green armchair, a round table, a lamp, and a mirror on the wall.

A two-story building with a dark entrance, large windows, and a brick facade.

A bar area with a neon sign, a lamp, and various food and drink items.

A room with a bed, a nightstand with a lamp, a painting on the wall, and a radiator.

1. Truitt Hotel

Lafayette Square, 2.4 km from Cherokee Street

Gabrielle

SAR 630

SAR 765 total

includes taxes & fees

19 Oct - 20 Oct

A Comfort Inn & Suites hotel with a modern design, featuring a covered entrance and a brick facade.

A modern hotel room with a bed, bedside tables, a desk, and a chair.

2. Comfort Inn & Suites Saint Louis Lafayette Square

The Gate, 2.5 km from Cherokee Street

greg

SAR 411

SAR 481 total

includes taxes & fees

29 Oct - 30 Oct

A spacious lobby with a high ceiling, modern lighting fixtures, a seating area with sofas and chairs, and a bar area with stools.

A gym with treadmills, exercise bikes, and a mirror.

A modern kitchen with a sink, dishwasher, and microwave. There is a large mirror above the sink and a countertop with various items. The room has a neutral color scheme and a view of a living area with a couch and a TV.

3. Hampton Inn & Suites St. Louis/South I-55

16.2 km from Cherokee Street

Kevin

SAR 411

SAR 473 total

includes taxes & fees

25 Oct - 26 Oct

A restaurant with multiple tables and booths, large windows, and a modern interior design.

A hotel named "The Principal Hotel" with a brick facade, multiple windows, and a parking lot in front.

A wooden wall with the sign "THE PRINCIPAL HOTEL" and a row of books below.

A neatly made bed with white linens and a dark headboard, flanked by two bedside tables with lamps.

4. The Principal Hotel

17.1 km from Cherokee Street

Jeffrey

SAR 335

SAR 372 total

includes taxes & fees

25 Oct - 26 Oct

The Clayton Plaza Hotel sign with a stone wall and plants in front.

A lobby with a chandelier, a round table with a floral arrangement, and a painting on the wall.

A large conference room with rows of tables and chairs, a podium, and a buffet table with plates and napkins.

A living room with a brown leather sofa, a small table, and a chair. There is a window with curtains, a lamp, and a framed picture on the wall.

5. Clayton Plaza Hotel & Extended Stay

11.2 km from Cherokee Street

Sarah

SAR 347

SAR 405 total

includes taxes & fees

1 Nov - 2 Nov

A modern living room with a sofa set, a coffee table, and a TV mounted on the wall.

A reception area with a wooden wall and a large decorative piece. There are two reception counters and a sign on the wall.

A Marriott Fairfield hotel with a covered entrance, stone facade, and a clear sky.

A hotel room with two beds, a flat-screen TV mounted on the wall, a minibar, and a wooden wardrobe.

6. Fairfield Inn & Suites by Marriott St. Louis South

16.5 km from Cherokee Street

Megan

SAR 436

SAR 501 total

includes taxes & fees

1 Nov - 2 Nov

A long bar with multiple tables and chairs, wooden floors, and ornate chandeliers.

A large hotel with a prominent "RIVER CITY" sign.

A spacious hotel lobby with a central seating area, multiple armchairs, and a bar.

A luxurious hotel lobby with a grand stage, elegant seating, and a large chandelier.

7. River City Casino & Hotel

7.7 km from Cherokee Street

jodi

SAR 340

SAR 454 total

includes taxes & fees

18 Nov - 19 Nov

An indoor pool area with a hot tub, seating, and a stone wall.

A reception desk with a marble top, wooden paneling, and a sign indicating it's the Drury Inn.

8. Drury Plaza Hotel St. Louis Union Station

Downtown West, 4.2 km from Cherokee Street

James A.

SAR 424

SAR 504 total

includes taxes & fees

1 Nov - 2 Nov

A rooftop terrace with wicker furniture, offering a city view.

A modern hotel lobby with a bar area, seating arrangements, and a large chandelier.

A spacious lobby with a blue sofa, a glass coffee table, and a chandelier.

A lobby with seating areas, a chandelier, and a large pillar.

9. Drury Plaza Hotel St. Louis at the Arch

Downtown St. Louis, 4.9 km from Cherokee Street

Theresa

SAR 507

SAR 592 total

includes taxes & fees

25 Oct - 26 Oct

A modern living area with a sofa, armchairs, a coffee table, and a kitchen in the background.

A hotel room with a large bed, a desk, a chair, a TV, and a window with curtains.

A modern living room with a sectional sofa, a round coffee table, and large windows offering a view of the city.

A large indoor pool with clear glass walls, a tiled edge, and a seating area with chairs and tables.

10. Best Western St. Louis Inn

19.1 km from Cherokee Street

Harold

SAR 255

SAR 293 total

includes taxes & fees

25 Oct - 26 Oct

A hotel room with a minibar, a shoe rack, a coat rack, and a TV.

11. Holiday Inn Express & Suites St. Louis South - I-55 by IHG

16.3 km from Cherokee Street

Thomas

SAR 428

SAR 492 total

includes taxes & fees

25 Oct - 26 Oct

A hot tub with a wooden deck, surrounded by a bamboo fence, and string lights.

A spacious dining area with marble tables and chairs, a kitchen in the background, and a modern ceiling design.

A building with a brick facade, a covered entrance, and a tree adorned with string lights.

A reception area with a Christmas tree, a neon sign, and a Santa Claus figure.

12. The West End

Central West End, 5.5 km from Cherokee Street

Trevor

SAR 352

SAR 487 total

includes taxes & fees

25 Oct - 26 Oct

An outdoor patio with a fire pit, seating, and a building in the background.

A modern bar area with a wooden counter, a beverage dispenser, and a menu board.

A modern bar area with a digital menu display, a seating area with a long table and chairs, and a wall with a colorful abstract design.

A Courtyard by Marriott hotel with a modern facade, multiple floors, and a well-lit entrance.

13. Courtyard by Marriott St. Louis Brentwood

9.9 km from Cherokee Street

Anna

SAR 443

SAR 541 total

includes taxes & fees

1 Nov - 2 Nov

A multi-story wooden building with balconies and outdoor seating, likely a lodge or hotel.

A cozy bedroom with a stone fireplace, a bed with a patterned bedspread, and a television on a wooden stand.

A rustic wooden bed with a quilt, a chair, and a view of the outdoors through a door.

A rustic wooden interior with a wooden bench displaying various animal carvings and a stone wall.

14. The Lodge at Grant's Trail

8.5 km from Cherokee Street

Sherri

SAR 660

SAR 765 total

includes taxes & fees

25 Oct - 26 Oct

A modern dining area with a long table and four chairs, a flat-screen TV mounted on the wall, and three pendant lights above.

A swimming pool with a clear blue interior, surrounded by a blue wall, and equipped with a metal ladder.

A hotel room with a flat-screen TV, a round mirror, a desk with a lamp, a microwave, and a chair.

An outdoor patio with two tables and chairs, two umbrellas, and a brick building in the background.

15. Hampton Inn St. Louis - Columbia

16.9 km from Cherokee Street

Jacob

SAR 411

SAR 457 total

includes taxes & fees

1 Nov - 2 Nov

A modern living room with a built-in fireplace, a large flat-screen TV, a unique hexagonal pendant light, and a patterned rug.

A modern dining area with a long table, multiple chairs, and a unique chandelier.

A corridor with snack bags, a refrigerator stocked with Mountain Dew, and a view into a room with a ceiling fan.

A multi-story hotel with a stone facade, a covered entrance, and a parking lot.

16. Hyatt Select St. Louis Airport

19.2 km from Cherokee Street

Daisy

SAR 413

SAR 512 total

includes taxes & fees

26 Oct - 27 Oct

A bar area with a long counter displaying numerous bottles of alcohol and several empty wine glasses lined up.

A modern lobby with a grey sofa, two armchairs, a round table, and a chandelier. There are two posters on the wall and a reception desk in the background.

A gym with various exercise equipment, large windows, and a skylight.

17. Holiday Inn St Louis SW - Route 66 by IHG

16.1 km from Cherokee Street

Eric

SAR 417

SAR 496 total

includes taxes & fees

15 Nov - 16 Nov

A hotel room with a large bed, a desk, a chair, a TV, and a view of the city.

A room with a blue sofa, two cushions, a small table, and a wall-mounted light fixture.

A gym with exercise equipment, dumbbells, and motivational wall art.

A hotel entrance with a covered walkway, stone facade, and a parking lot with marked spaces.

18. Comfort Suites St. Louis - Sunset Hills

16 km from Cherokee Street

John

SAR 443

SAR 515 total

includes taxes & fees

25 Oct - 26 Oct

A swimming pool with a 40 ft depth marker, lounge chairs, and a brick wall.

A spacious kitchen with granite countertops, wooden cabinets, stainless steel appliances, and pendant lighting.

A hotel room with two beds, a chair, a lamp, and a heater.

A Drury Inn & Suites building with a brick facade, multiple windows, and a parking lot with several cars.

19. Drury Inn & Suites St. Louis Forest Park

5.8 km from Cherokee Street

Tammy

SAR 507

SAR 592 total

includes taxes & fees

1 Nov - 2 Nov

A courtyard with outdoor seating, a central fountain, and a view of a tower.

The exterior of the Charles F. Knight Center with a stone facade, large arched entrance, and a sign above the doors.

A hotel room with two beds, a desk, and a chair.

A spacious lobby with a bar area, seating arrangements, and a clock on the wall.

20. The Knight Center at Washington University

9.5 km from Cherokee Street

Rosalyn

SAR 552

SAR 635 total

includes taxes & fees

1 Nov - 2 Nov

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Compare popular hotels close to Cherokee Street

Property	Property class	Guest rating
Truitt Hotel	9.8 Exceptional 20 reviews	View
Comfort Inn & Suites Saint Louis Lafayette Square	8.2 Very good 422 reviews	View
Hampton Inn & Suites St. Louis/South I-55	9.6 Exceptional 1,000 reviews	View
Clayton Plaza Hotel & Extended Stay	8.8 Excellent 3,491 reviews	View
Fairfield Inn & Suites by Marriott St. Louis South	9.6 Exceptional 396 reviews	View

Top Cherokee Street Hotel Reviews

Spacious 2 bedroom apartment with 3 queen beds and 2 full baths

10/10 Excellent

"Great property. Close to everything and so spacious. Read up on the Lemp Brewery if you go. Fascinating story!Host was extremely responsive, space was clean and uncluttered. We loved it"

Large Executive 1st Floor Apartment with Chefs Kitchen!

10/10 Excellent

"Loved it"

Historic Tower Grove Retreat • Game Room • Deck • Sleeps 7

10/10 Excellent

"Lots of room to move about. Conveniently located without being in the middle of overly congested areas. We loved our stay in St Louis. Thank you for hosting us."

Centrally located in the Tower Grove East neighborhood!

10/10 Excellent

"Beautiful little space that was maybe 10-15 minutes from everything we needed to do. It was a fast trip and this was a lovely landing pad."

St. Louis Modern Retreat - Spacious, Family-Friendly, Convenient Location!

10/10 Excellent

"Great place and location! The home is large and spacious and was perfect for our family to hang out in between other events. We made the best of it using the kitchen, living room, and back eating area. Great place for a bunch of adults who need their space. The neighborhood is very peaceful with lots of good restaurants nearby. If there is one I will absolutely be going back to, it is Milque Toast on Jefferson Ave—best food we had all weekend and I highly recommend it. The beds have memory foam mattresses, which I am usually not a fan of, but these were surprisingly comfortable. Next time we are in town with a group, we will be staying here."

Chateau St. Louis ~New~ Historic Home ~ 9min > DT

10/10 Excellent

"Great property, great location, and awesome upgrades."

Charming Cottage Loft near Soulard Free Parking Pet Friendly

10/10 Excellent

"Hard to find, but once found it was a nice stay"

House in Soulard near Downtown, Arch, Busch Stadium and anheuser busch brewery

10/10 Excellent

"Love the space. Clean and spaciousAshley was so helpful and caring. Thank you for everything!!!"

King Bed/Cherokee St Art District/Fast WiFi + W/D

10/10 Excellent

"It was in a lovely part of historical St. Louis, within walking distance of multiple cute shops and places to eat! We felt super safe staying there and it was a great experience, 10/10 would recommend!!"

Other attractions near Cherokee Street

Casa Loma Ballroom

After visiting Casa Loma Ballroom, make a plan to see the other sights and activities in St. Louis.

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The Golden Record

The Golden Record is just one of the places to see in St. Louis, so why not enjoy the other things to explore during your travels?

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2720 Cherokee Performing Arts Center

Enjoy an outing to 2720 Cherokee Performing Arts Center during your stay in St. Louis.

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Transgender Memorial Garden

After visiting Transgender Memorial Garden, make a plan to see the other sights and activities in St. Louis.

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The Luminary

You can spend time browsing the exhibits at The Luminary during your travels in St. Louis.

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MoshMellow

MoshMellow is just one of the places to see in St. Louis, so why not enjoy the other things to explore during your travels?

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Off Broadway Nightclub

Off Broadway Nightclub is just one of the places to see in St. Louis, so why not enjoy the other things to explore during your travels?

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Off Broadway

You can enjoy a show at Off Broadway during your trip to St. Louis.

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Frequently asked questions

What's the area like around Cherokee Street?

Cherokee Street is located in St. Louis. If you're looking for a convenient place to stay, check out the 150 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Cherokee Street?

Benton Park Inn is one of the top choices for your stay based on our traveler data, and this B&B offers free breakfast and free parking. It's located just a short 0.5 mi (0.9 km) from Cherokee Street. Another good choice is Hyatt Regency St. Louis at The Arch, located 3.2 mi (5.1 km) away.

How many hotels will I be able to find near Cherokee Street?

Expedia has 150 hotels and other accommodations within a mile from Cherokee Street.

If I need to cancel the hotel reservation for my stay near Cherokee Street, will I receive a refund?

Yes, the majority of room reservations are refundable if you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your check-in date. If your reservation is non-refundable, you may still be able to cancel and receive a refund within 24 hours of your booking. Enter dates in and click on "Search", then use the "fully refundable" filter to view the best options available near Cherokee Street.

Where can I learn more about changing or cancelling my trip in the area near Cherokee Street?

To access more information about updating your stay near Cherokee Street or cancelling it, go to https://www.expedia.com/service/.

What can I see and do near Cherokee Street?

Study the collections at City Museum, St. Louis Science Center, or Cathedral Basilica of St. Louis. St. Louis Union Station, Anheuser-Busch Brewery, and Washington Avenue Historic District are notable landmarks to explore if you're in the area. You can check out the local talent at Fox Theater, St. Louis Symphony Orchestra, and Powell Symphony Hall.

Find hotels near Cherokee Street, St. Louis from SAR 293

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Treat yourself

Be picky

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Our top choices for Cherokee Street hotels

1. Truitt Hotel

2. Comfort Inn & Suites Saint Louis Lafayette Square

3. Hampton Inn & Suites St. Louis/South I-55

4. The Principal Hotel

5. Clayton Plaza Hotel & Extended Stay

6. Fairfield Inn & Suites by Marriott St. Louis South

7. River City Casino & Hotel

8. Drury Plaza Hotel St. Louis Union Station

9. Drury Plaza Hotel St. Louis at the Arch

10. Best Western St. Louis Inn

11. Holiday Inn Express & Suites St. Louis South - I-55 by IHG

12. The West End

13. Courtyard by Marriott St. Louis Brentwood

14. The Lodge at Grant's Trail

15. Hampton Inn St. Louis - Columbia

16. Hyatt Select St. Louis Airport

17. Holiday Inn St Louis SW - Route 66 by IHG

18. Comfort Suites St. Louis - Sunset Hills

19. Drury Inn & Suites St. Louis Forest Park

20. The Knight Center at Washington University

Compare popular hotels close to Cherokee Street

Top Cherokee Street Hotel Reviews

Spacious 2 bedroom apartment with 3 queen beds and 2 full baths

Large Executive 1st Floor Apartment with Chefs Kitchen!

Historic Tower Grove Retreat • Game Room • Deck • Sleeps 7

Centrally located in the Tower Grove East neighborhood!

St. Louis Modern Retreat - Spacious, Family-Friendly, Convenient Location!

Chateau St. Louis ~New~ Historic Home ~ 9min > DT

Charming Cottage Loft near Soulard Free Parking Pet Friendly

House in Soulard near Downtown, Arch, Busch Stadium and anheuser busch brewery

King Bed/Cherokee St Art District/Fast WiFi + W/D

Other attractions near Cherokee Street

Casa Loma Ballroom

The Golden Record

2720 Cherokee Performing Arts Center

Transgender Memorial Garden

The Luminary

MoshMellow

Off Broadway Nightclub

Off Broadway

Frequently asked questions