Take advantage of a free breakfast buffet, a grocery/convenience store, and dry cleaning/laundry services at Hampton Inn & Suites St. Louis/South I-55. Free in-room WiFi is available to all guests, along with a fireplace in the lobby and a gym.
St. Louis is home to Hampton Inn & Suites St. Louis/South I-55. The area's natural beauty can be seen at Mississippi River and Forest Park, while Missouri Botanical Garden and St. Louis Zoo are popular area attractions. BounceU of St. Louis and Kennedy Rink are also worth visiting. Visit our St. Louis travel guide
4200 Midamerica Lane, St. Louis, MO, 63129
What's nearby
Busch Stadium
16 min drive - 28.2 km
Gateway Arch
17 min drive - 28.9 km
Enterprise Center
17 min drive - 29.3 km
St. Louis Union Station
18 min drive - 28.3 km
St. Louis Zoo
23 min drive - 35.7 km
Getting around
Kirkwood Station
14 min drive
St. Louis Lambert Intl. Airport (STL)
31 min drive
Restaurants
McDonald's
3 min drive
Burger King
10 min walk
Hardee's / Red Burrito
10 min walk
Subway
3 min drive
Rich & Charlie's Italian Restaurant
3 min drive
About this property
Hampton Inn & Suites St. Louis/South I-55
Hotel near Mississippi River
At Hampton Inn & Suites St. Louis/South I-55, you can look forward to a free breakfast buffet, a grocery/convenience store, and dry cleaning/laundry services. Free in-room WiFi is available to all guests, along with a fireplace in the lobby and a gym.
Additional perks include:
An indoor pool
Free self parking
Express check-in, 1 meeting room, and luggage storage
Free newspapers, ATM/banking services, and a front-desk safe
Guest reviews speak highly of the breakfast and helpful staff
Room features
All 92 rooms offer comforts such as air conditioning, as well as perks like free WiFi and safes. Guest reviews speak positively of the clean rooms at the property.
Does Hampton Inn & Suites St. Louis/South I-55 have a pool?
Yes, this property has an indoor pool. Pool access is from 8 AM–10 PM.
How much does it cost to stay at Hampton Inn & Suites St. Louis/South I-55?
As of 24 Shawwal 2026, prices found for a 1-night stay for 2 adults at Hampton Inn & Suites St. Louis/South I-55 on 30 Shawwal 2026 start from SAR 412, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.
Is Hampton Inn & Suites St. Louis/South I-55 pet-friendly?
Yes, Hampton Inn & Suites St. Louis/South I-55 allows cats and dogs (limit 2 total). There's a fee of USD 75 per accommodation, per stay. Service animals are exempt from fees.
How much is parking?
Self parking is free at this property.
What time is check-in at Hampton Inn & Suites St. Louis/South I-55?
Check-in start time: 3 PM; Check-in end time: midnight.
What time is check-out at Hampton Inn & Suites St. Louis/South I-55?
Check-out is at 11 AM.
Where is Hampton Inn & Suites St. Louis/South I-55 located?
Situated in St. Louis, this hotel is 0.3 mi (0.6 km) from Barnes Jewish South Campus and within 3 mi (5 km) of BounceU of St. Louis and St Anthony's. Suson Park and Kindred Hospital St. Louis South are also within 3 mi (5 km).
Can I cancel my reservation for free and receive a full refund?
Yes, this property offers free cancellation on select room rates, because flexibility matters! Please refer to the property cancellation policy on our site for more details about any exclusions or requirements.
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Reviews
Hampton Inn & Suites St. Louis/South I-55 Reviews
9.6
Exceptional
All reviews shown are from real guest experiences. Only travelers who have booked a stay with us can submit a review. We verify reviews according to our guidelines and publish all reviews, positive or negative.
Room was clean and breakfast was excellent. But bed was older and squeezing and pillows need to be replaced and the A/C only went to 68 would be the only negative.
Kudos to both the housecleaning staff for such a clean room & the breakfast attendants that were supervising the breakfast. They were all super friendly & helpful!
Bed was comfy, loved the shower, breakfast was good, & so very happy that y'all allow dogs!!! I wish the pet fee was a little cheaper, though.
We have stayed there before & will definitely stay again!
We stayed one night on our way back from Tulsa OK to Indianapolis. We were traveling with a small dog and needed space to walk her. We drove to area restaurants and stores and found them easily accessible without using the Interstate. The hotel was quiet and well kept, and the staff took care of our rather minor needs.
The front desk attendant was very helpful and welcoming. I was impressed wit the cleanliness of our room and the hot breakfast options. Would definitely stay there again!
Staff and room was GREAT!!! Parking was great!! Room was clean and well stocked. Breakfast was good as always. Nice comfortable environment that makes you feel home away from home. We will be returning.
My cousins and I were in town to see the Chicago Cubs play the St Louis Cardinals. This Hampton Inn & Suites was the perfect place to stay for the night. It is about a 20-minute Uber ride to the park but worked really well for us. It was very clean. The room was clean. The lobby was clean. The breakfast in the morning was very good and quite delicious. The lady who worked at breakfast, I did not catch her name, was so kind and sweet. I always look for clean hotels and this one definitely was great!