The Best Hotels Closest to Mayo Clinic in Rochester for 2026

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Our top choices for Mayo Clinic hotels

A spacious living area with a modern staircase, leather sofas, and contemporary lighting.

A modern pool table in a spacious, well-lit room with large windows and a bar area.

A rooftop pool area with lounge chairs and umbrellas, surrounded by a modern building with a brick facade.

A modern interior with a large dining table, sofas, and a kitchen area.

1. The Berkman

Folwell, 1.4 km from Mayo Clinic

Suzette

SAR 585

SAR 681 total

includes taxes & fees

1 Oct - 2 Oct

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.

A modern hotel room with a bed, desk, and kitchenette.

A modern restaurant with a counter, seating area, and a TV screen.

2. Home2 Suites by Hilton Rochester Mayo Clinic Area

2.6 km from Mayo Clinic

Vickie

SAR 459

SAR 528 total

includes taxes & fees

24 Oct - 25 Oct

A coffee shop interior with a wooden counter, menu boards, and seating area.

A hotel exterior with a 'Townplace Suites' sign, outdoor seating area, and 'OPEN' signage.

A hotel room with a bed, bedside table, and a window with curtains.

An outdoor seating area with tables and chairs, a neon sign, and flower arrangements.

3. TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park, 0.4 km from Mayo Clinic

Hafsa

SAR 514

SAR 592 total

includes taxes & fees

3 Oct - 4 Oct

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

An outdoor patio area with wicker furniture, a central fire feature, and a stone building in the background.

A modern reception area with a brick-patterned wall, two reception desks, a flat-screen TV, and seating arrangements including a sofa and chairs.

A modern hotel with a flat roof, multiple windows, and a covered outdoor seating area.

4. Residence Inn by Marriott Rochester Mayo Clinic Area South

2.4 km from Mayo Clinic

Chee

SAR 496

SAR 571 total

includes taxes & fees

17 Oct - 18 Oct

A modern living room with a flat-screen TV, a fireplace, comfortable seating, and a large window with a city view.

A modern indoor swimming pool with seating areas and a city view.

A modern hotel lobby with a curved staircase, seating areas, and large windows.

A spacious lobby with modern furniture, a spiral staircase, and large windows offering views of the outdoors.

5. Hilton Rochester Mayo Clinic Area

Downtown Rochester, 0.3 km from Mayo Clinic

Raymond

SAR 674

SAR 776 total

includes taxes & fees

17 Oct - 18 Oct

A modern indoor patio with a fire feature, seating, and large windows.

A reception area with a curved reception desk, wooden shelving, and a green moss wall with the text "I ♥ EVEN".

A modern living room with a fireplace, large windows, and a flat-screen TV mounted on the wall.

A modern interior with a seating area, a bookshelf, and a window with a view of trees.

6. EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

Rici

SAR 458

SAR 578 total

includes taxes & fees

2 Oct - 3 Oct

A modern outdoor seating area with a built-in fireplace, two wooden chairs, a table, and a sofa.

A hotel room with a kitchenette, a bed, a sofa, a small table, and a window with curtains.

A modern kitchen with a central island, bar stools, and pendant lighting. A living area with a sofa, ottoman, and a view of the outdoors is visible.

A gym with various exercise equipment, including treadmills, stationary bikes, and weight machines.

7. Staybridge Suites Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

Sheri

SAR 402

SAR 470 total

includes taxes & fees

25 Oct - 26 Oct

A modern kitchen with a dark countertop, black cabinets, a microwave, and a refrigerator. There are two pendant lights above the counter.

A hotel gym with treadmills, elliptical machines, and free weights.

A hotel room with a large round table, two sofas, a TV, and a bed.

Two armchairs with striped pillows, a small round table, a clock, and a phone on a counter.

8. Candlewood Suites Rochester Mayo Clinic Area by IHG

2.6 km from Mayo Clinic

Sean

SAR 436

SAR 501 total

includes taxes & fees

2 Oct - 3 Oct

An outdoor patio with a brick floor, stone fireplace, and wooden pergola.

A conference room with multiple tables and chairs, ceiling fans, and artwork on the walls.

An indoor swimming pool with clear pool rules posted on the wall, a lifeguard chair, and a pool lift sign.

A gym with exercise equipment, a clock, and a window with blinds.

9. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

SAR 428

SAR 493 total

includes taxes & fees

24 Oct - 25 Oct

A Courtyard Marriott hotel with multiple floors, a brick facade, and illuminated signage.

A hotel room with a sofa, armchairs, a small kitchenette, a flat-screen TV, and a large window.

A modern living room with a sofa, a round coffee table, and a side table. There are large windows with a view of the outside.

A hotel room with a bed, a sofa, a desk, a TV, and a wall art piece.

10. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

MATTHEW

SAR 460

SAR 530 total

includes taxes & fees

3 Oct - 4 Oct

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

A modern dining area with round tables and chairs, a large painting on the wall, and a flat-screen TV mounted above a geometric-patterned wall.

A modern indoor pool area with lounge chairs and a pool.

A modern Hyatt House hotel with a prominent 'Hyatt House' sign, multiple floors, and a parking garage.

11. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester, 0.5 km from Mayo Clinic

Kathy

SAR 443

SAR 510 total

includes taxes & fees

17 Oct - 18 Oct

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

A reception area with a wooden reception desk, a red doormat, and framed awards on the wall.

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

A hotel lobby with leather sofas, a stone fireplace, and a patterned carpet.

12. Econo Lodge Mayo Clinic Area

3.1 km from Mayo Clinic

Ashley

SAR 265

SAR 305 total

includes taxes & fees

25 Oct - 26 Oct

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A hotel room with a bed, a desk, a chair, a TV, and a bathroom visible through an open door.

A modern lounge area with seating arrangements, a reception desk, and a patterned wall.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

13. Hampton Inn Rochester-South

2.9 km from Mayo Clinic

dennis

SAR 397

SAR 457 total

includes taxes & fees

11 Oct - 12 Oct

A hotel entrance with a stone facade, a glass door, and a metal roof structure.

An outdoor patio area with brick walls, a large arched window, and outdoor seating.

A spa area with a hot tub, exercise equipment, and a seating area with chairs and a table.

A hotel lobby with striped armchairs, a sofa, a fireplace, and a clock on the wall.

14. Aspen Suites

1.2 km from Mayo Clinic

Dana

SAR 504

SAR 609 total

includes taxes & fees

3 Oct - 4 Oct

A room with a fireplace, two leather armchairs, a sofa, and a large window providing a view of the outdoors.

A hotel room with a bed, a sink, a microwave, and a window with curtains.

A long, narrow hotel corridor with a carpeted floor, light fixtures along the walls, and a ceiling with recessed lighting.

A reception area with a curved counter, ceiling lights, and a potted plant.

15. Brentwood Inn & Suites

Downtown Rochester, 0.3 km from Mayo Clinic

Daniel

SAR 352

SAR 405 total

includes taxes & fees

2 Oct - 3 Oct

A spacious outdoor dining area with modern furniture and large windows offering views of the city.

A modern interior with a wooden ceiling, a large black shelving unit, and a refrigerator stocked with beverages.

A reception desk with a modern design, featuring a wooden panel and a wall adorned with framed botanical artwork.

A modern hotel room with a large bed, a sofa, a small table, a desk, and a wardrobe.

16. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester, 0.4 km from Mayo Clinic

thomas

SAR 402

SAR 463 total

includes taxes & fees

24 Oct - 25 Oct

A spacious hotel lobby with multiple seating areas, including sofas and round tables, and a large dining area with yellow chairs.

A hotel room with a blue sofa, a wooden bench, a small table with a lamp, a painting of a flower, and a kitchenette in the background.

A reception area with two counters, a patterned wall, and a wooden floor.

A spacious lobby with a large seating area, a fireplace, and large windows providing natural light.

17. Hilton Garden Inn Rochester Downtown, MN

Downtown Rochester, 0.3 km from Mayo Clinic

John

SAR 428

SAR 493 total

includes taxes & fees

23 Oct - 24 Oct

A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.

A hotel room with a large bed, bedside tables, a mirror, and a patterned carpet.

A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

A hotel lobby with a patterned carpet, two beige armchairs, a small table, a clock, a fire extinguisher, and a staircase.

18. Quality Inn & Suites Mayo Clinic Area

2.6 km from Mayo Clinic

Edward

SAR 287

SAR 335 total

includes taxes & fees

25 Oct - 26 Oct

An outdoor patio area with yellow umbrellas, wicker furniture, and a sign for Centerstone Plaza Hotel.

A modern reception area with a wooden reception desk, glass pendant lights, and a long hallway with seating.

A garden with a water feature, rocks, and yellow umbrellas.

A restaurant interior with wooden tables, chairs, and a stone wall.

19. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Historic Southwest, 0.6 km from Mayo Clinic

Carrie

SAR 378

SAR 435 total

includes taxes & fees

12 Oct - 13 Oct

A modern hotel lobby with multiple seating areas, including a central dining table with chairs, a bar area, and a seating section with cushioned chairs.

A modern conference room with a long table, multiple chairs, and a wooden partition.

A modern hotel room with a large bed, two bedside tables, and built-in lighting.

A modern lounge area with a curved sofa, a round table, and a seating area with chairs.

20. SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

Kutzky Park, 1.1 km from Mayo Clinic

Jackie

SAR 428

SAR 493 total

includes taxes & fees

2 Oct - 3 Oct

View all properties

Compare popular hotels close to Mayo Clinic

Property	Property class	Guest rating
The Berkman	9.6 Exceptional 444 reviews	View
Home2 Suites by Hilton Rochester Mayo Clinic Area	9.6 Exceptional 1,005 reviews	View
TownePlace Suites by Marriott Rochester Mayo Clinic Area	9.6 Exceptional 562 reviews	View
Residence Inn by Marriott Rochester Mayo Clinic Area South	9.6 Exceptional 311 reviews	View
Hilton Rochester Mayo Clinic Area	9.6 Exceptional 647 reviews	View

Top Mayo Clinic Hotel Reviews

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

10/10 Excellent

"Had an amazing stay while we were in Rochester for Mayo. The staff was very helpful. Had an excellent breakfast every morning and the attached restaurant Twigs is top notch. The rooms were clean and restocked every morning for our five day stay. The shuttle service is amazing. We don’t know what we would’ve done without it. The drivers were amazing. Very friendly and respectful. I will definitely stay he whenever we come back to Rochester. Thank you for a stress free stay during a difficult time for our family."

EVEN Hotel Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"One of the cleanest hotels I’ve ever stayed in."

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

10/10 Excellent

"Had great help from staff."

Aspen Select

8/10 Good

"Really close to the st Mary's hospital. Parking was great"

AmericInn by Wyndham Rochester Near Mayo Clinic

8/10 Good

"very good restaurant attached with good food at a good price...and you get a 15% discount if you are also staying at the hotel."

Hotel Indigo Rochester – Mayo Clinic Area by IHG

8/10 Good

"Rooms were very clean and easy to manage. find the hotel was difficult"

Hilton Garden Inn Rochester Downtown, MN

8/10 Good

"The beds were great! The staff very friendly. We stayed for just one night so didn't use many of the amenities. We were disappointed that there was a charge for breakfast...a simple continental breakfast was $12! Whereas the other hotels where we had stayed on previous visits to Rochester had free breakfast! They also had free parking whereas we had to pay for parking at a nearby parking ramp at this hotel."

Brentwood Inn & Suites

8/10 Good

"Walking distance to Mayo—very handy amidst construction."

Kahler Grand Hotel

10/10 Excellent

"Love the 40’s vibes that this modern hotel has."

Frequently asked questions

What's the area like around Mayo Clinic?

Mayo Clinic is located in a welcoming area of Rochester known for its major shopping area. If you're looking for a convenient place to stay, check out the 152 hotels and other accommodations you'll find within a mile.

What's the best place to stay close to Mayo Clinic?

Adjacent to Mayo Clinic, Kahler Grand Hotel is one of the top choices for your stay based on our traveler data, and this hotel offers 2 restaurants and an indoor pool. Other good options close by include Kahler Inn and Suites - Mayo Clinic Area and Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area.

How many hotels will I be able to find near Mayo Clinic?

Expedia has 152 hotels and other accommodations within a mile from Mayo Clinic.

If I need to cancel the hotel reservation for my stay near Mayo Clinic, will I receive a refund?

Yes, you'll find most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best deals near Mayo Clinic.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic?

For additional details about rescheduling or cancelling your stay near Mayo Clinic, head over to our customer service page.

What can I see and do near Mayo Clinic?

You'll want to browse the exhibits at Mayowood Mansion and History Center of Olmsted County. Learn about local history at Plummer House and Assisi Heights. You can enjoy live performances at Rochester Civic Theater and Marcus Rochester Cinema.

Find hotels near Mayo Clinic, Rochester from SAR 305

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Our top choices for Mayo Clinic hotels

1. The Berkman

2. Home2 Suites by Hilton Rochester Mayo Clinic Area

3. TownePlace Suites by Marriott Rochester Mayo Clinic Area

4. Residence Inn by Marriott Rochester Mayo Clinic Area South

5. Hilton Rochester Mayo Clinic Area

6. EVEN Hotel Rochester - Mayo Clinic Area by IHG

7. Staybridge Suites Rochester - Mayo Clinic Area by IHG

8. Candlewood Suites Rochester Mayo Clinic Area by IHG

9. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

10. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

11. Hyatt House Rochester/Mayo Clinic Area

12. Econo Lodge Mayo Clinic Area

13. Hampton Inn Rochester-South

14. Aspen Suites

15. Brentwood Inn & Suites

16. Hotel Indigo Rochester – Mayo Clinic Area by IHG

17. Hilton Garden Inn Rochester Downtown, MN

18. Quality Inn & Suites Mayo Clinic Area

19. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

20. SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

Compare popular hotels close to Mayo Clinic

Top Mayo Clinic Hotel Reviews

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

EVEN Hotel Rochester - Mayo Clinic Area by IHG

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

Aspen Select

AmericInn by Wyndham Rochester Near Mayo Clinic

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hilton Garden Inn Rochester Downtown, MN

Brentwood Inn & Suites

Kahler Grand Hotel

Frequently asked questions