The Best Hotels Closest to Mayo Clinic in Rochester for 2026

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Our top choices for Mayo Clinic hotels

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

A modern lounge area with a sofa, chairs, and tables.

An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.

A modern hotel room with a bed, desk, and kitchenette.

1. Home2 Suites by Hilton Rochester Mayo Clinic Area

2.6 km from Mayo Clinic

howard

SAR 443

SAR 510 total

includes taxes & fees

12 Nov - 13 Nov

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

An outdoor patio area with wicker furniture, a central fire feature, and a stone building in the background.

A modern lounge area with seating, a fireplace, and a bar area.

A modern hotel with a flat roof, multiple windows, and a covered outdoor seating area.

2. Residence Inn by Marriott Rochester Mayo Clinic Area South

2.4 km from Mayo Clinic

Chee

SAR 495

SAR 570 total

includes taxes & fees

13 Nov - 14 Nov

An outdoor patio area with a concrete floor, wooden fence, and string lights.

A Fairfield Inn & Suites hotel with a modern design, featuring a prominent entrance and a parking area.

A modern living room with a stone fireplace, a blue armchair, a round coffee table, and a large window offering a view of the outdoors.

A breakfast bar with a wooden counter, a coffee machine, and a refrigerator.

3. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park, 1.8 km from Mayo Clinic

Jon

SAR 469

SAR 540 total

includes taxes & fees

24 Oct - 25 Oct

A coffee shop interior with a wooden counter, menu boards, and seating area.

A hotel room with a bed, bedside table, and a window with curtains.

An outdoor seating area with tables and chairs, a neon sign, and flower arrangements.

4. TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park, 0.4 km from Mayo Clinic

Cory

SAR 514

SAR 592 total

includes taxes & fees

6 Nov - 7 Nov

A rooftop terrace with outdoor seating and a city skyline in the background.

A gym with treadmills, elliptical machines, and weightlifting equipment.

A bathroom with a granite countertop, a sink, a mirror, and a coffee maker.

A bar area with red bar stools, a wooden floor, and a wall of wine bottles.

5. Hilton Rochester Mayo Clinic Area

Downtown Rochester, 0.3 km from Mayo Clinic

Raymond

SAR 667

SAR 768 total

includes taxes & fees

7 Nov - 8 Nov

A spacious living area with a modern staircase, leather sofas, and contemporary lighting.

A modern interior with a large dining table, sofas, and a kitchen area.

A rooftop pool area with lounge chairs and umbrellas, surrounded by a modern building with a brick facade.

A modern pool table in a spacious, well-lit room with large windows and a bar area.

6. The Berkman

Folwell, 1.4 km from Mayo Clinic

Suzette

SAR 763

SAR 887 total

includes taxes & fees

22 Oct - 23 Oct

A modern outdoor seating area with a built-in fireplace, two wooden chairs, a table, and a sofa.

A hotel room with a kitchenette, a bed, a sofa, a small table, and a window with curtains.

A modern kitchen with a central island, bar stools, and pendant lighting. A living area with a sofa, ottoman, and a view of the outdoors is visible.

A gym with various exercise equipment, including treadmills, stationary bikes, and weight machines.

7. Staybridge Suites Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

Amanda

SAR 428

SAR 500 total

includes taxes & fees

1 Nov - 2 Nov

A modern indoor patio with a fire feature, seating, and large windows.

A modern living room with a fireplace, large windows, and a flat-screen TV mounted on the wall.

A modern interior with a seating area, a bookshelf, and a window with a view of trees.

A reception area with a curved reception desk, wooden shelving, and a green moss wall with the text "I ♥ EVEN".

8. EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

James

SAR 428

SAR 543 total

includes taxes & fees

23 Oct - 24 Oct

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

A hotel lobby with leather sofas, a stone fireplace, and a patterned carpet.

A compact laundry area with a washing machine, dryer, and a water fountain.

9. Econo Lodge Mayo Clinic Area

3.1 km from Mayo Clinic

Ashley

SAR 250

SAR 288 total

includes taxes & fees

8 Nov - 9 Nov

An outdoor patio with a brick floor, stone fireplace, and wooden pergola.

A gym with exercise equipment, a clock, and a window with blinds.

A conference room with multiple tables and chairs, ceiling fans, and artwork on the walls.

A modern hotel lobby with a stone wall fireplace, comfortable seating, and a chandelier.

10. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

Lin

SAR 443

SAR 510 total

includes taxes & fees

7 Nov - 8 Nov

A modern kitchen with a dark countertop, black cabinets, a microwave, and a refrigerator. There are two pendant lights above the counter.

A storage cabinet with multiple shelves containing kitchen appliances, glassware, and board games.

A person at a checkout counter in a store, with various snack items and a sign indicating a price of $1.50.

A reception area with a clock, a counter, and a nameplate.

11. Candlewood Suites Rochester Mayo Clinic Area by IHG

2.6 km from Mayo Clinic

Kevin

SAR 454

SAR 523 total

includes taxes & fees

27 Oct - 28 Oct

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A modern lounge area with seating arrangements, a reception desk, and a patterned wall.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

A pool area with a table and chairs, a lifeguard chair, and a pool lift.

12. Hampton Inn Rochester-South

2.9 km from Mayo Clinic

dennis

SAR 396

SAR 455 total

includes taxes & fees

24 Oct - 25 Oct

A Courtyard Marriott hotel with multiple floors, a brick facade, and illuminated signage.

A modern living room with a sofa, a round coffee table, and a side table. There are large windows with a view of the outside.

A conference room with a long table, multiple chairs, and decorative wall art.

A hotel room with a bed, a sofa, a desk, a TV, and a wall art piece.

13. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

MATTHEW

SAR 424

SAR 488 total

includes taxes & fees

6 Nov - 7 Nov

A bedroom with a large bed, a TV on a dresser, and a view of the city through large windows.

A modern kitchen with wooden cabinets, a granite countertop, and a stainless steel stove.

A multi-story building with the sign 'Broadway Plaza' indicating a commercial or hotel property.

14. Broadway Plaza, Trademark Collection by Wyndham

Downtown Rochester, 0.3 km from Mayo Clinic

Danny

SAR 635

SAR 731 total

includes taxes & fees

24 Oct - 25 Oct

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

A modern indoor pool area with lounge chairs and a pool.

A modern dining area with round tables and chairs, a large painting on the wall, and a flat-screen TV mounted above a geometric-patterned wall.

A modern bar area with seating and a counter.

15. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester, 0.5 km from Mayo Clinic

Elsie

SAR 443

SAR 510 total

includes taxes & fees

24 Oct - 25 Oct

A hotel entrance with a stone facade, a glass door, and a metal roof structure.

A hotel room with a kitchenette, a dining area with striped chairs, a sofa, a TV, and a window with curtains.

An outdoor patio area with brick walls, a large arched window, and outdoor seating.

A spa area with a hot tub, exercise equipment, and a seating area with chairs and a table.

16. Aspen Suites

1.2 km from Mayo Clinic

Dana

SAR 425

SAR 514 total

includes taxes & fees

5 Nov - 6 Nov

A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.

A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

A hotel room with a large bed, bedside tables, a mirror, and a patterned carpet.

A compact kitchen with a microwave, refrigerator, and coffee maker. A small bar stool is near the counter.

17. Quality Inn & Suites Mayo Clinic Area

2.6 km from Mayo Clinic

Jessica

SAR 253

SAR 295 total

includes taxes & fees

13 Nov - 14 Nov

A spacious outdoor dining area with modern furniture and large windows offering views of the city.

A modern interior with a wooden ceiling, a large black shelving unit, and a refrigerator stocked with beverages.

An outdoor dining area with wooden beams, tables, and chairs.

A reception desk with a modern design, featuring a wooden panel and a wall adorned with framed botanical artwork.

18. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester, 0.4 km from Mayo Clinic

Hernan

SAR 402

SAR 462 total

includes taxes & fees

23 Oct - 24 Oct

A room with a fireplace, two leather armchairs, a sofa, and a large window providing a view of the outdoors.

A long, narrow hotel corridor with a carpeted floor, light fixtures along the walls, and a ceiling with recessed lighting.

A hotel room with a bed, a sink, a microwave, and a window with curtains.

A reception area with a curved counter, ceiling lights, and a potted plant.

19. Brentwood Inn & Suites

Downtown Rochester, 0.3 km from Mayo Clinic

Elaine

SAR 469

SAR 540 total

includes taxes & fees

5 Nov - 6 Nov

A spacious hotel lobby with multiple seating areas, including sofas and round tables, and a large dining area with yellow chairs.

A hotel room with a blue sofa, a wooden bench, a small table with a lamp, a painting of a flower, and a kitchenette in the background.

A reception area with two counters, a patterned wall, and a wooden floor.

A spacious lobby with a large seating area, a fireplace, and large windows providing natural light.

20. Hilton Garden Inn Rochester Downtown, MN

Downtown Rochester, 0.3 km from Mayo Clinic

Richard

SAR 443

SAR 510 total

includes taxes & fees

24 Oct - 25 Oct

View all properties

Compare popular hotels close to Mayo Clinic

Property	Property class	Guest rating
Home2 Suites by Hilton Rochester Mayo Clinic Area	9.6 Exceptional 1,002 reviews	View
Residence Inn by Marriott Rochester Mayo Clinic Area South	9.6 Exceptional 316 reviews	View
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys	9.6 Exceptional 746 reviews	View
TownePlace Suites by Marriott Rochester Mayo Clinic Area	9.6 Exceptional 569 reviews	View
Hilton Rochester Mayo Clinic Area	9.6 Exceptional 650 reviews	View

Top Mayo Clinic Hotel Reviews

Kahler Grand Hotel

10/10 Excellent

"Very close to the clinic, great place to rest!"

Hilton Garden Inn Rochester Downtown, MN

10/10 Excellent

"The staff was very helpful. Our room was very clean. Loved how easy it was to get to the Mayo Clinic."

EVEN Hotel Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"This was my third time staying at the Even hotel Rochester. It appears new and fresh and was nice and quiet at night (and I stayed on a weekend). I also appreciated the gym on-site- that was helpful! Will be staying there again. Very good deal for the price. The pool and hot tub were also great. The only drawback was there was extensive construction going on so the streets around the hotel were detoured and sometimes blocked, hopefully that will end soon."

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

10/10 Excellent

"the shuttle service is incredible, helps to make my stay stress free from driving and gets me to my appointments ahead of time too. Food is always great and a good selection of it. nice to eat then walk up to my room and relax. stayed many times and always had a great experience."

Kahler Inn and Suites - Mayo Clinic Area

8/10 Good

"Overall, it was a good experience, very convenient to Mayo Clinic and Methodist Hospital. The woman who checked us in this time was not very welcoming, don’t think she wanted to be there."

Brentwood Inn & Suites

10/10 Excellent

"Everyone was very helpful even the guests. Breakfast was good. Parking was great."

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

10/10 Excellent

"'staff was very good"

Aspen Select

10/10 Excellent

"Great"

Hilton Rochester Mayo Clinic Area

10/10 Excellent

"Very nice hotel that’s in an excellent location. It has a good restaurant. Nice toiletries. Towels were thin and need replacement."

Frequently asked questions

What's the area like around Mayo Clinic?

Mayo Clinic is located in a welcoming area of Rochester known for its major shopping area. If you're looking for a convenient place to stay, check out the 153 hotels and other accommodations you'll find within a mile.

What's the best place to stay close to Mayo Clinic?

Adjacent to Mayo Clinic, Kahler Grand Hotel is one of the top choices for your stay based on our traveler data, and this hotel offers 2 restaurants and an indoor pool. Other good options close by include Kahler Inn and Suites - Mayo Clinic Area and Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area.

How many hotels will I be able to find near Mayo Clinic?

Expedia has 153 hotels and other accommodations within a mile from Mayo Clinic.

If I need to cancel the hotel reservation for my stay near Mayo Clinic, will I receive a refund?

Yes, you'll find most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best deals near Mayo Clinic.

Where can I learn more about changing or cancelling my trip in the area near Mayo Clinic?

For additional details about rescheduling or cancelling your stay near Mayo Clinic, head over to our customer service page.

What can I see and do near Mayo Clinic?

You'll want to browse the exhibits at Mayowood Mansion and History Center of Olmsted County. Learn about local history at Assisi Heights and Plummer House. You can enjoy live performances at Rochester Civic Theater and Marcus Rochester Cinema.

Find hotels near Mayo Clinic, Rochester from SAR 288

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Be picky

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Our top choices for Mayo Clinic hotels

1. Home2 Suites by Hilton Rochester Mayo Clinic Area

2. Residence Inn by Marriott Rochester Mayo Clinic Area South

3. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

4. TownePlace Suites by Marriott Rochester Mayo Clinic Area

5. Hilton Rochester Mayo Clinic Area

6. The Berkman

7. Staybridge Suites Rochester - Mayo Clinic Area by IHG

8. EVEN Hotel Rochester - Mayo Clinic Area by IHG

9. Econo Lodge Mayo Clinic Area

10. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

11. Candlewood Suites Rochester Mayo Clinic Area by IHG

12. Hampton Inn Rochester-South

13. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

14. Broadway Plaza, Trademark Collection by Wyndham

15. Hyatt House Rochester/Mayo Clinic Area

16. Aspen Suites

17. Quality Inn & Suites Mayo Clinic Area

18. Hotel Indigo Rochester – Mayo Clinic Area by IHG

19. Brentwood Inn & Suites

20. Hilton Garden Inn Rochester Downtown, MN

Compare popular hotels close to Mayo Clinic

Top Mayo Clinic Hotel Reviews

Kahler Grand Hotel

Hilton Garden Inn Rochester Downtown, MN

EVEN Hotel Rochester - Mayo Clinic Area by IHG

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

Brentwood Inn & Suites

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

Aspen Select

Hilton Rochester Mayo Clinic Area

Frequently asked questions