Photo by Jessica Richter
Search Vacation Homes in Southeast Missouri
Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Check availability on Vacation Homes in Southeast Missouri
Compare 141 Vacation Homes in Southeast Missouri with updated reviews, rates, and availability.
Unique cabins in the woods<br>Not friendly for Street Bikes. Beautifulin FALL!
Unique cabins in the woods<br>Not friendly for Street Bikes. Beautifulin FALL!
10.0 out of 10, Exceptional, (68)
Cozy Three bedroom home in Central Farmington
Cozy Three bedroom home in Central Farmington
9.6 out of 10, Exceptional, (7)
Quiet, Cozy Cabin!
Quiet, Cozy Cabin!
8.6 out of 10, Excellent, (4)
The price is SAR 364
SAR 705 total
includes taxes & fees
28 Jum. I - 29 Jum. I
Save an average of 15% on thousands of hotels when you're signed in
Cozy town house - 3 Queen beds
Cozy town house - 3 Queen beds
10.0 out of 10, Exceptional, (2)
RIVER FRONT HOUSE
RIVER FRONT HOUSE
9.8 out of 10, Exceptional, (24)
Serenity South -- Gardens, River-Views, and Refreshing Space
Serenity South -- Gardens, River-Views, and Refreshing Space
10.0 out of 10, Exceptional, (114)
The price is SAR 563
SAR 915 total
includes taxes & fees
28 Jum. I - 29 Jum. I
Beautiful historical two story stone farmhouse
Beautiful historical two story stone farmhouse
10.0 out of 10, Exceptional, (42)
Your home away from home in downtown, historic Farmington!
Your home away from home in downtown, historic Farmington!
10.0 out of 10, Exceptional, (5)
The 1801 House: A beautiful historic home in the Ste Genevieve Historic District
The 1801 House: A beautiful historic home in the Ste Genevieve Historic District
10.0 out of 10, Exceptional, (97)
"Little Brick House on Main (1865)”
"Little Brick House on Main (1865)”
10.0 out of 10, Exceptional, (26)
Guests enjoy their own one bedroom apartment in the Ozarks
Guests enjoy their own one bedroom apartment in the Ozarks
10.0 out of 10, Exceptional, (54)
Rustic Lodge for 14 near Current River on private 35 acres
Rustic Lodge for 14 near Current River on private 35 acres
10.0 out of 10, Exceptional, (12)
The price is SAR 1,684
SAR 2,882 total
includes taxes & fees
28 Jum. I - 29 Jum. I
Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE
Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE
10.0 out of 10, Exceptional, (51)
40-Acre Poplar Bluff Nature Lovers Paradise!
40-Acre Poplar Bluff Nature Lovers Paradise!
9.4 out of 10, Exceptional, (23)
Newly renovated early 1900’s farmhouse
Newly renovated early 1900’s farmhouse
10.0 out of 10, Exceptional, (8)
The price is SAR 634
SAR 990 total
includes taxes & fees
27 Jum. II - 28 Jum. II
Secluded Cabin with Heated Pool, hot tub, fireplace & so much more
Secluded Cabin with Heated Pool, hot tub, fireplace & so much more
10.0 out of 10, Exceptional, (62)
Gabouri Place ~ Completely Renovated Victorian in Ste. Genevieve's Historic Dist
Gabouri Place ~ Completely Renovated Victorian in Ste. Genevieve's Historic Dist
10.0 out of 10, Exceptional, (148)
Dexter Homestead. VERY Cozy & Clean 7 Bed home.
Dexter Homestead. VERY Cozy & Clean 7 Bed home.
8.6 out of 10, Excellent, (15)
Gorgeous large rental home in Lesterville MO just minutes from Blackwater River.
Gorgeous large rental home in Lesterville MO just minutes from Blackwater River.
10.0 out of 10, Exceptional, (4)
The price is SAR 1,125
SAR 1,905 total
includes taxes & fees
28 Jum. I - 29 Jum. I
Private lake, beach & hot tub, romantic getaway or family vaca
Private lake, beach & hot tub, romantic getaway or family vaca
10.0 out of 10, Exceptional, (14)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Other property types in Southeast Missouri
Holiday Inn Club Vacations Timber Creek Resort at De Soto, an IHG Hotel
Holiday Inn Club Vacations Timber Creek Resort at De Soto, an IHG Hotel
9.4 out of 10, Exceptional, (126)
The price is SAR 671
SAR 748 total
includes taxes & fees
9 Jum. II - 10 Jum. II
Secluded Ozarks Tiny House cabin in Eminence, MO
Secluded Ozarks Tiny House cabin in Eminence, MO
10.0 out of 10, Exceptional, (78)
RIVER FRONT HOUSE
RIVER FRONT HOUSE
9.8 out of 10, Exceptional, (24)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Recent reviews of Southeast Missouri hotelsExpedia verified reviews
5/5 Excellent
"Have stayed several times. Would stay again"
A verified traveler stayed at Auburn Place Hotel And Suites
Posted 2 days ago
Popular Destinations
- Vacation Homes in Dexter
- Vacation Homes in Van Buren
- Vacation Homes in Eminence
- Vacation Homes in Lesterville
- Vacation Homes in Poplar Bluff
- Vacation Homes in Hayti
- Vacation Homes in Perryville
- Vacation Homes in Ironton
- Vacation Homes in Fredericktown
- Vacation Homes in Festus
- Vacation Homes in Sikeston
- Vacation Homes in Potosi
- Vacation Homes in Ste Genevieve
- Vacation Homes in Farmington
Top Vacation Homes in Other Destinations
More Accommodation Types in Southeast Missouri
- Cabin Rentals in Southeast Missouri (78)
- Apartments in Southeast Missouri (39)
- Cottages in Southeast Missouri (35)
- Motels in Southeast Missouri (23)
- Farmstay in Southeast Missouri (14)
- Resorts in Southeast Missouri (12)
- Lodges in Southeast Missouri (10)
- Condo Rentals in Southeast Missouri (4)
- RV Parks in Southeast Missouri (3)
- Aparthotels in Southeast Missouri (2)
- B&B in Southeast Missouri (1)
- Villas in Southeast Missouri (1)
- Hotels (570)