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27 Sep - 28 Sep
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2 Oct - 4 Oct
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Our top choices for Southeast Missouri hotels

1. Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
Sikeston
United States
Scott
SAR 353
SAR 406 total
includes taxes & fees
4 Oct - 5 Oct
Drury Inn & Suites Sikeston, MO

2. Shepherd Mountain Inn

Shepherd Mountain Inn
Ironton
United States
Michael
SAR 463
SAR 506 total
includes taxes & fees
29 Sep - 30 Sep
Shepherd Mountain Inn

3. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
United States
Sandra
SAR 375
SAR 424 total
includes taxes & fees
4 Oct - 5 Oct
Drury Plaza Hotel Cape Girardeau Conference Center

4. Madison Inn Lodge

Madison Inn Lodge
Fredericktown
United States
Bawan
SAR 329
SAR 359 total
includes taxes & fees
29 Sep - 30 Sep
Madison Inn Lodge

5. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
United States
Elaine
SAR 316
SAR 342 total
includes taxes & fees
30 Sep - 1 Oct
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

6. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
Poplar Bluff
United States
Rhonda
SAR 329
SAR 369 total
includes taxes & fees
18 Oct - 19 Oct
Hampton Inn Poplar Bluff

7. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
Poplar Bluff
United States
Vicki
SAR 380
SAR 429 total
includes taxes & fees
4 Oct - 5 Oct
Fairfield Inn & Suites by Marriott Poplar Bluff

8. Fort Davidson Hotel

Fort Davidson Hotel
Ironton
United States
richard
SAR 469
SAR 513 total
includes taxes & fees
1 Oct - 2 Oct
Fort Davidson Hotel

9. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
Sikeston
United States
Allen
SAR 379
SAR 429 total
includes taxes & fees
4 Oct - 5 Oct
Fairfield Inn & Suites by Marriott Sikeston

10. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
United States
ELAINE
SAR 379
SAR 432 total
includes taxes & fees
4 Oct - 5 Oct
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

11. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson
United States
Thomas
SAR 315
SAR 333 total
includes taxes & fees
11 Oct - 12 Oct
Drury Inn & Suites Jackson MO

12. Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington
Farmington
United States
Marisa
SAR 223
SAR 243 total
includes taxes & fees
4 Oct - 5 Oct
Super 8 by Wyndham Farmington

13. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
Cape Girardeau
United States
Shannon
SAR 336
SAR 382 total
includes taxes & fees
4 Oct - 5 Oct
Tru By Hilton Cape Girardeau

14. Hampton Inn Sikeston

Hampton Inn Sikeston
Sikeston
United States
John
SAR 382
SAR 432 total
includes taxes & fees
4 Oct - 5 Oct
Hampton Inn Sikeston

15. The Riverview

The Riverview
Cape Girardeau
United States
Alyssa
SAR 395
SAR 445 total
includes taxes & fees
30 Sep - 1 Oct
The Riverview

16. Hampton Inn & Suites By Hilton Festus

Hampton Inn & Suites By Hilton Festus
Festus
United States
Abram
SAR 336
SAR 384 total
includes taxes & fees
15 Oct - 16 Oct
Hampton Inn & Suites By Hilton Festus

17. Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
Farmington
United States
Susan
SAR 412
SAR 448 total
includes taxes & fees
4 Oct - 5 Oct
Crown Pointe Lodge, BW Signature Collection

18. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau
United States
Elizabeth
SAR 270
SAR 305 total
includes taxes & fees
4 Oct - 5 Oct
Pear Tree Inn Cape Girardeau West

19. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
United States
Carlos
SAR 380
SAR 428 total
includes taxes & fees
4 Oct - 5 Oct
Fairfield Inn & Suites by Marriott Cape Girardeau

20. Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
Sikeston
United States
Melissa
SAR 357
SAR 404 total
includes taxes & fees
25 Oct - 26 Oct
Holiday Inn Express & Suites Sikeston Southwest by IHG
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Vacation Rentals in Southeast Missouri

Cabin

Sam A Baker State Park

Sam A Baker State Park
Patterson
"Pet friendly, great staff. "
Sam A Baker State Park
Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
French Village
"I really enjoyed my time at the stay !"
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Vacation Home

Tiny Houses of French Village

Tiny Houses of French Village
French Village
"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "
Tiny Houses of French Village
Cottage

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

'turtle Rock' - Ironton Cabin w/ Furnished Patio!
Ironton
"Stroller, pack n play and high chair. This was amazing "
'turtle Rock' - Ironton Cabin w/ Furnished Patio!
Cabin

Lake Wappapello

Lake Wappapello
Williamsville
"Pet friendly. Family-friendly "
Lake Wappapello
Aparthotel

The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel
Perryville
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."
The Atrium - A Boutique Hotel
Aparthotel

Urban Lofts

Urban Lofts
Perryville
"Beautiful place and staff was amazing!"
Urban Lofts
Cottage

Walk to Current River: Ozarks Adventure Home!

Walk to Current River: Ozarks Adventure Home!
Van Buren
"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."
Walk to Current River: Ozarks Adventure Home!
Cottage

Cozy Belgrade Cottage w/ Wood-burning Stove!

Cozy Belgrade Cottage w/ Wood-burning Stove!
Belgrade
Cozy Belgrade Cottage w/ Wood-burning Stove!
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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.
Photo by Pat Long

Elephant Rocks State Park

9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
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A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
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A sunset over a lake with boats and ducks.
Photo by JG Morris

Lake Wappapello

8.8/10 (54 reviews)
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)
Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.
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Century Casino Caruthersville

7.0/10 (57 reviews)
Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.
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Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri
A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.
Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

8/10 Good
"Not enough towels"
LATASHA 1-night trip
Posted 1 hour ago
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

10/10 Excellent
"Staff were helpful."
Joseph 1-night trip
Posted 2 hours ago
Baymont Inn and Suites by Wyndham Farmington, MO
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

10/10 Excellent
"Difficult to communicate with person setting up and maintaining breakfast area as they did not speak English"
Terry 1-night trip
Posted 5 hours ago
Comfort Inn Festus - St Louis South
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent
"Staff was kind and courteous, Very clean hotel , breakfast was excellent. We came for SEMO daily weekend and we had a great experience at this hotel . We would love to stay here again when we attend more SEMO events . Thank you !"
Lisa 2-night trip
Posted 8 hours ago
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

10/10 Excellent
"This hotel is exceptionally nice. Definitely staying here again when I come to town. Well done!"
Fran 2-night trip
Posted 9 hours ago
Hampton Inn Poplar Bluff
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

10/10 Excellent
"Great experience. Staff was welcoming. Rooms were clean."
yolanda 2-night trip
Posted 11 hours ago
Drury Inn & Suites Hayti Caruthersville
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

10/10 Excellent
"The staff is so friendly and helpful! They’re the gems of the hotel!"
Elizabeth 3-night trip
Posted 11 hours ago
Pear Tree Inn Cape Girardeau West
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

10/10 Excellent
"Debbie at the desk was super nice and helpful."
Nancy 1-night trip
Posted 1 day ago
Holiday Inn Poplar Bluff by IHG
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

10/10 Excellent
"I loved everything about this cabin and I was on a high from this experience."
Paris 1-night trip
Posted 1 day ago
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO
SAR 213
SAR 232 total
4 Oct - 5 Oct
includes taxes & fees
8/10 Very Good! (1,010 reviews)
Baymont Inn and Suites by Wyndham Farmington, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO
SAR 249
SAR 284 total
30 Sep - 1 Oct
includes taxes & fees
Days Inn and Suites by Wyndham Sikeston
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO
SAR 270
SAR 305 total
4 Oct - 5 Oct
includes taxes & fees
9.2/10 Wonderful! (1,004 reviews)
Pear Tree Inn Cape Girardeau West
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO
SAR 278
SAR 311 total
29 Sep - 30 Sep
includes taxes & fees
8/10 Very Good! (1,001 reviews)
Motel 6 Poplar Bluff, MO
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO
SAR 267
SAR 312 total
25 Oct - 26 Oct
includes taxes & fees
7.8/10 Good! (1,004 reviews)
Comfort Inn Festus - St Louis South
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO
SAR 329
SAR 369 total
18 Oct - 19 Oct
includes taxes & fees
9.4/10 Exceptional! (954 reviews)
Hampton Inn Poplar Bluff

Hotels in Southeast Missouri with star-rating

Find out more about Southeast Missouri

Top reasons to visit Southeast Missouri

  • Outdoor Adventures: Southeast Missouri is perfect for outdoor enthusiasts, featuring urban parks, scenic state parks, and recreational activities.
  • Charming Towns: Explore friendly towns like Cape Girardeau and Sikeston, offering local charm and hospitality.
  • Mississippi River Views: Enjoy leisurely strolls along the picturesque Mississippi River, taking in the scenic beauty.
  • Family-Friendly Attractions: The region boasts a variety of attractions suitable for families, making it a fun vacation spot.
  • Diverse Accommodations: From cozy lodges to modern hotels, Southeast Missouri offers a range of lodging options for every traveler.

Find great hotels near Southeast Missouri

In Southeast Missouri, you'll discover a diverse selection of accommodations, from cozy lodges to well-appointed hotels, catering to both business and leisure travelers. Whether you seek family-friendly options, an adventure-packed getaway, or proximity to local attractions, this region offers a variety of choices. Explore the best hotels, read reviews, and find the perfect place to unwind during your visit to this charming corner of the United States.

  • Madison Inn Lodge: A cozy motel that caters to both business travelers and pet enthusiasts. Situated 25.7km from Southeast Missouri, Madison Inn Lodge offers a welcoming atmosphere where pets are permitted, making it an ideal choice for those traveling with furry companions. The property features essential amenities suitable for business stays, ensuring a comfortable experience for all guests. With a pet-friendly policy that includes some restrictions and a waiver for service animals, this lodge strikes a balance between convenience and comfort.
  • Shepherd Mountain Inn: Located 33.8km from Southeast Missouri, Shepherd Mountain Inn is a classic hotel designed for the business traveler. With its straightforward amenities and comfortable accommodations, this property provides a functional base for those visiting the area for work. Guests appreciate the inn's professional environment, which promotes productivity and relaxation after a busy day. Its proximity to local businesses and attractions makes it a pragmatic choice for anyone looking to blend work with leisure.
  • Alpaca Farm Stay: Nestled just 12.9km from Southeast Missouri, Alpaca Farm Stay offers a unique experience for adventure seekers and families. This lodge features various outdoor activities, including motorboating, hiking, kayaking, fishing, and birdwatching, making it perfect for those who love the great outdoors. Families will enjoy amenities like a shared playground, while couples can take advantage of special romance packages. With picturesque views of the lake and mountains, this property invites guests to unwind and create lasting memories in a serene setting.

Where to stay near Southeast Missouri

For an unforgettable vacation, Southeast Missouri offers a perfect blend of scenic retreats and family-friendly adventures. Explore the charming towns like Cape Girardeau and Sikeston, where friendly locals welcome you. Enjoy leisurely strolls along the scenic Mississippi River or immerse yourself in outdoor activities in the lush parks. With its convenient location and vibrant atmosphere, Southeast Missouri is an ideal destination for families seeking recreation and relaxation, making it a memorable getaway.

  • Annapolis: Nestled 22.5km from Southeast Missouri, Annapolis is a charming city that attracts visitors year-round, with peak arrivals during June to July and September. Known for its stunning outdoor scenery and adventurous spirit, Annapolis offers a range of recreational activities, including access to a national state park and beautiful riverside parks. Whether you're hiking, picnicking, or simply enjoying the fresh air, Annapolis promises an invigorating experience for nature lovers and adventure seekers alike.
  • Central Fredericktown: Located just 16.1km from Southeast Missouri, Central Fredericktown is a delightful village perfect for family adventures and city-themed exploration. With visitor numbers peaking from June to August, this vibrant area features a variety of attractions, including a shopping mall and educational centers. Families will enjoy the local history museum and parks, making it an excellent destination for learning and leisure. Central Fredericktown blends small-town charm with engaging activities for all ages.
  • Des Arc: A mere 17.7km away from Southeast Missouri, Des Arc is a lively city known for its seasonal tourism, with visitors flocking in from June to August. This city offers a wealth of outdoor activities, including access to a water park and national state parks, making it ideal for those seeking adventure and stunning natural scenery. With its picturesque lakes and rivers, Des Arc invites you to explore its recreational areas while unwinding in a serene setting, ensuring a memorable getaway.

Things to do near Southeast Missouri

Southeast Missouri offers a wealth of outdoor adventures and scenic beauty, making it an ideal vacation spot. Visitors can enjoy a variety of activities including campus tours, recreational areas, sports tournaments, brewery tours, and educational experiences. The region is also home to an arena entertainment facility, ensuring a fun-filled trip for all. Whether you're looking for relaxation or excitement, Southeast Missouri has something for everyone.

Shopping

For a unique shopping experience in Southeast Missouri, visit Red's Flea Market, located 41.8km away, offering a vibrant atmosphere filled with local treasures. Alternatively, head to Farmington Mineral Area Shopping Center, 48.3km away, where you'll find a variety of shops perfect for family fun and entertainment.

Recreation

At Crane Lake Recreation Area, enjoy serene nature trails and peaceful surroundings that promote relaxation. Arcadia Valley Golf Club offers invigorating outdoor experiences with scenic views while you play golf. Silver Mine Recreation Area provides a tranquil environment perfect for unwinding amidst beautiful landscapes.

Adventure

Shepherd Mountain Bike Park and Hiking Trails, located 33.8km from Southeast Missouri, offers thrilling mountain biking and scenic hiking trails. Experience the stunning landscapes, immerse yourself in nature, and enjoy the exhilarating outdoor adventure vibes that this destination has to offer.

Nightlife

Southeast Missouri offers a vibrant nightlife scene. Enjoy live music at The Blue Note in Columbia or dance the night away at The Loft in Cape Girardeau. For a laid-back vibe, grab drinks at The Tap Room, where locals gather for good conversation and a friendly atmosphere.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Southeast Missouri

To save money on your trip to Southeast Missouri, consider visiting between November and January when prices are lower. Tuesdays offer the best hotel rates, while Saturdays are the most expensive. Use Expedia to refine your hotel search by budget and location, and try combining your hotel, flights, and activities for better deals. Look for hotel packages and compare room rates to find the best bargains. Additionally, explore free local attractions and utilize public transport to keep your expenses down.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around Southeast Missouri are November to January, where the prices are slightly lower. This is in comparison to April, June and August, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around Southeast Missouri is Tuesday. The most expensive day to stay around Southeast Missouri is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia's search tool to refine your preferences, such as budget, desired location, and the type of hotel you prefer. To find the best prices and deals, simply arrange the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your hotel reservations in Southeast Missouri with your flights and activities through an Expedia package.

Find the best attractions near Southeast Missouri

For an exciting vacation in Southeast Missouri, outdoor enthusiasts will find plenty to explore, from urban parks to scenic state parks and historic civic buildings. Perfect for family experiences, the area offers a variety of attractions, including nearby sites and the Southeast Missouri State University. Whether you're seeking adventure or simply enjoying nature's beauty, Southeast Missouri has something for everyone.

  • Walnut Hollow Lake: Located 20.9km from Southeast Missouri, Walnut Hollow Lake offers a romantic atmosphere with beautiful beaches and scenic views, perfect for outdoor enthusiasts looking to relax by the water.
  • K Bridge Recreation Area: Situated 27.4km away, this urban park is ideal for families, featuring expansive outdoor spaces where city vibes meet nature, making it a great spot for picnics and leisurely strolls.
  • Millstream Gardens Conservation Area: Just 24.1km from Southeast Missouri, this preserve is known for its friendly atmosphere and adventurous trails, perfect for families seeking relaxation alongside historical insights.

Best time to go to Southeast Missouri

The best time to visit Southeast Missouri is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are slightly high and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are slightly low and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January34.9°F (1.6°C)Light RainMostly SunnySlightly LowSlightly Low
February38.1°F (3.4000000000000004°C)Light RainMostly SunnySlightly LowAverage
March48.0°F (8.9°C)Light RainMostly SunnyAverageAverage
April57.6°F (14.2°C)Light RainMostly SunnyAverageSlightly High
May67.3°F (19.6°C)Light RainMostly SunnyAverageAverage
June76.5°F (24.700000000000003°C)Light RainMostly SunnySlightly HighSlightly High
July79.2°F (26.200000000000003°C)Light RainMostly SunnySlightly HighAverage
August77.2°F (25.1°C)Light RainMostly SunnySlightly HighSlightly High
September71.6°F (22.0°C)Light RainMostly SunnyAverageAverage
October59.9°F (15.5°C)Light RainMostly SunnyAverageAverage
November47.5°F (8.6°C)Light RainMostly SunnyAverageSlightly Low
December39.4°F (4.1000000000000005°C)Light RainMostly SunnySlightly LowSlightly Low

The nearest major airports for your trip to Southeast Missouri

For your visit to Southeast Missouri, you can fly into several nearby airports. St. Louis Lambert International Airport (STL) is 154.5km away, with hotels like The Ritz-Carlton, St. Louis, a 5-star hotel 11.3km from the airport, and Ameristar Casino Resort and Spa, also 11.3km away. Fort Leonard Wood Regional Airport (TBN) is another option, 154.5km away, featuring Z Loft Extended Stay Hotel, just 9.7km from the airport. Finally, Paducah Barkley Regional Airport (PAH) is 152.9km away, with The Respite Bed and Breakfast, a 4.5-star option 14.5km from the airport. Each airport provides convenient access to comfortable accommodations.