A pier extending into calm waters with a small boat docked at the end.

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19 Sep - 20 Sep
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Our top choices for Panacea hotels

1. The Panacea Motel

The Panacea Motel
Panacea
United States
Dashawn
SAR 416
SAR 464 total
includes taxes & fees
21 Sep - 22 Sep
The Panacea Motel

2. Best Western Wakulla Inn & Suites

Best Western Wakulla Inn & Suites
Crawfordville
United States
James
SAR 418
SAR 466 total
includes taxes & fees
11 Oct - 12 Oct
Best Western Wakulla Inn & Suites

3. Wildwood Inn

Wildwood Inn
Crawfordville
United States
Kizzy
SAR 436
SAR 501 total
includes taxes & fees
11 Oct - 12 Oct
Wildwood Inn

4. The Lodge at Wakulla Springs

The Lodge at Wakulla Springs
Crawfordville
United States
Joy
SAR 305
SAR 340 total
includes taxes & fees
30 Sep - 1 Oct
The Lodge at Wakulla Springs

5. St James Bay Golf & Pickleball Resort

St James Bay Golf & Pickleball Resort
Carrabelle
United States
jamie
SAR 360
SAR 534 total
includes taxes & fees
20 Sep - 21 Sep
St James Bay Golf & Pickleball Resort

6. Franklin Inn

Franklin Inn
Carrabelle
United States
Nathan
SAR 353
SAR 390 total
includes taxes & fees
20 Sep - 21 Sep
Franklin Inn

7. The Old Carrabelle Hotel

The Old Carrabelle Hotel
Carrabelle
United States
Christy
SAR 396
SAR 437 total
includes taxes & fees
1 Oct - 2 Oct
The Old Carrabelle Hotel

8. The Moorings Hotel and Marina

The Moorings Hotel and Marina
Carrabelle
United States
Tina
SAR 482
SAR 533 total
includes taxes & fees
1 Oct - 2 Oct
The Moorings Hotel and Marina
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Stay near popular Panacea attractions

Alligator Point Beach

8.8/10 (10 reviews)
Escape to this pristine stretch of old coastal Florida with white sands and shallow, clear waters. Spot dolphins and sea turtles while enjoying the serenity of an undeveloped shoreline.
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Bald Point State Park

8.6/10 (20 reviews)
Where Ochlockonee Bay meets Apalachee Bay, this coastal park showcases diverse ecosystems from beaches to pine flatwoods. Spot migrating raptors and monarch butterflies while hiking through pristine natural habitats.
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Mashes Sand Beach

8.8/10 (3 reviews)
Mashes Sands Beach offers serene shallow waters and expansive sandbars perfect for peaceful exploration. Wade through the tea-colored Gulf waters while spotting hermit crabs and enjoying spectacular sunset views.
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Wilson Beach

Wilson Beach offers a serene Gulf Coast escape with pristine shores and gentle waves far from tourist crowds. Bring supplies and enjoy peaceful beachcombing along this unspoiled natural sanctuary.
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Public Beach Access

Mashes Sands Beach features tranquil white-sand shores and shallow waters ideal for families. Wade in the gentle surf, cast a fishing line, or enjoy a peaceful picnic away from tourist crowds.
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Silver Lake

Swim in crystal-clear waters along a pristine 250-foot white sand beach surrounded by longleaf pines. The mile-long interpretive trail offers peaceful wildlife encounters with bald eagles and turtles.
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Gulf Specimen Public Aquarum

Take the kids to visit the sea life you'll find at Gulf Specimen Public Aquarum during your trip to Panacea. Stroll along the beaches in this relaxing area, or seek out the fishing spots.
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Panacea Springs

Once a popular health resort, these historic mineral springs were believed to possess healing properties in the early 1900s. Explore the remnants of spa structures while imagining the therapeutic rituals of a bygone era.
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Learn more about Panacea

Kayak through pristine coastal marshes at Panacea's Woolley Park, where fishing piers and boardwalks offer prime spots for catching redfish. Nearby St. Marks National Wildlife Refuge invites visitors to spot migratory birds and explore the historic lighthouse along scenic hiking trails.

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A sunset over a calm body of water with silhouettes of birds flying and a distant tree line.

Top Panacea Hotel Reviews

Coastal Getaway on canal-steps to the beach

Coastal Getaway on canal-steps to the beach

10/10 Excellent
"Awesome weekend staying at this location. We was within walking distance to the beach and fishing. Loved that it had a complete bathroom downstairs when we came in from fishing all day and night. Great communication with the host. Very prompt responding to questions. Will recommend to family and friends!!"
Allyson G. 2-night trip
Posted 6 days ago
Coastal Getaway on canal-steps to the beach
Hideaway Beach Cottage on waterfront with amazing views.

Hideaway Beach Cottage on waterfront with amazing views.

8/10 Good
"Overall good"
Terri M. 10-night trip
Posted 6 days ago
Hideaway Beach Cottage on waterfront with amazing views.
Lighthouse- enjoy the water, bask in the view

Lighthouse- enjoy the water, bask in the view

8/10 Good
"House and property were great. The only real problem was that the dishwasher did not work. I thought I had done something wrong after the first cycle and ran it again. Same result, the dishes weren’t clean. Send a message to the realty company (host) and they sent a plumber. He worked on the plumbing side of the unit and corrected a couple of issues but said the dishwasher needed replacing. For two days I messaged the host asking for an update and for the most part they didn’t answer at all. That is my biggest complaint. I know things break but I don’t like that they don’t answer my requests to be informed as to next steps. Found out the night before we left that they would be replacing the dishwasher after we left. Good news for the next guest but not for us. Again the real problem for us was lack of communication. A simple, we’re on it or an acknowledgment of my message would have gone a long way towards making the situation a bit more palatable."
Paul O. 7-night trip
Posted 2 weeks ago
Lighthouse- enjoy the water, bask in the view
Private Beachfront w/ Sauna, Hottub, Golf Cart, Kayaks, Paddle Boards & Bikes +

Private Beachfront w/ Sauna, Hottub, Golf Cart, Kayaks, Paddle Boards & Bikes +

10/10 Excellent
"The property was exactly as described, and then some! This was the most peaceful beach vacation we've ever had! We saw dolphins every day, as well as sting rays, many different birds, crabs, and more. The house was well equipped with everything we needed. The golf cart was fun to ride around on and explore the state parks in the area. The host was quick to respond and the personal touches were very appreciated. If you're looking for a quiet, peaceful beach vacation, this is your place!"
Denise P. 8-night trip
Posted 3 weeks ago
Private Beachfront w/ Sauna, Hottub, Golf Cart, Kayaks, Paddle Boards & Bikes +
Waterfront Home: Spectacular On-Site Fishing!

Waterfront Home: Spectacular On-Site Fishing!

10/10 Excellent
"Great stay!"
Robin B. 2-night trip
Posted 3 weeks ago
Waterfront Home: Spectacular On-Site Fishing!
Great sunrise view from dining area and decks. Easy beach access.

Great sunrise view from dining area and decks. Easy beach access.

10/10 Excellent
"We had a very nice time at the Snail's Pace! It is a very peaceful and quiet area with direct beach access and the Bold Point State Park beach just a couple of minutes' drive from the house. The house was clean and welcoming. It had everything needed for a beach vacation. There were beach umbrellas, towels, chairs, and a big box full of beach toys for kids. There was a small grill outside and an outside shower, which we found very convenient. The dining area has a beautiful view of the Gulf. There were two porches: the upstairs one with the same view as the dining room and the downstairs one, which is screened in. The owners organized the house very well and thought of all the essentials for a great beach vacation. Kevin (the host) was very responsive and welcoming, and he made sure that the house and the beach treated us well :) One piece of advice: there are rocks on the beach next to the house that you cannot see during the high tide. Be careful in the water. We had a 3-year-old son, so we chose to go to the Bold Point State Park Beach for swimming. But we had a great time playing and walking on the beach that was next to the house. It felt so relaxing! Thank you, Barbara and Kevin, for your hospitality!"
Anna Y. 3-night trip
Posted 3 weeks ago
Great sunrise view from dining area and decks. Easy beach access.
7 Bedroom Beach House with POOL!! Gulf Front and Bay Front

7 Bedroom Beach House with POOL!! Gulf Front and Bay Front

10/10 Excellent
"We had an amazing week. Best equipped home we have ever stayed. The privacy and peacefulness was just want we needed. Host was very responsive."
Tracy G. 7-night trip
Posted 1 month ago
7 Bedroom Beach House with POOL!! Gulf Front and Bay Front
Happy Shack BEACH & BAY! Kayak, paddle boards, tiki hut, firepit, grille, wifi

Happy Shack BEACH & BAY! Kayak, paddle boards, tiki hut, firepit, grille, wifi

10/10 Excellent
"I just want to express my deepest gratitude for allowing us to stay in your beautiful home. From the moment we arrived, it brought such a sense of peace, calm, and relaxation — exactly what our family needed.Being able to paddleboard alongside the dolphins was absolutely incredible. It felt like we were in our own little world, surrounded by so much beauty and tranquility. The breathtaking sunrises, sunsets, and the precious quality time we shared together are memories we will cherish forever.Thank you again from the bottom of our hearts for opening your home to us and creating such a special place where we could reconnect, unwind, and enjoy every moment. We truly enjoyed our stay and are so grateful for this amazing experience."
Sabrina P. 4-night trip
Posted 2 months ago
Happy Shack BEACH & BAY! Kayak, paddle boards, tiki hut, firepit, grille, wifi
Skipper-extends from Beach Front to Harbor with Kayaks, Pickleball & Dock

Skipper-extends from Beach Front to Harbor with Kayaks, Pickleball & Dock

10/10 Excellent
"Great place to stay. The fridge had a small leak coming from the bottom that needs addressed. We loved our stay."
Steven W. 7-night trip
Posted 2 months ago
Skipper-extends from Beach Front to Harbor with Kayaks, Pickleball & Dock

More cheap stays in Panacea

Franklin Inn

Franklin Inn

1589 US-98 Carrabelle FL
SAR 353
SAR 390 total
20 Sep - 21 Sep
includes taxes & fees
7.8/10 Good! (509 reviews)
Franklin Inn
The Old Carrabelle Hotel

The Old Carrabelle Hotel

201 Tallahassee St Carrabelle FL
SAR 396
SAR 437 total
1 Oct - 2 Oct
includes taxes & fees
The Old Carrabelle Hotel
The Panacea Motel

The Panacea Motel

1545 Coastal Hwy Panacea FL
SAR 416
SAR 464 total
21 Sep - 22 Sep
includes taxes & fees
9/10 Wonderful! (193 reviews)
The Panacea Motel
Best Western Wakulla Inn & Suites

Best Western Wakulla Inn & Suites

3292 Coastal Hwy 98 Crawfordville FL
SAR 418
SAR 466 total
11 Oct - 12 Oct
includes taxes & fees
Best Western Wakulla Inn & Suites
The Moorings Hotel and Marina

The Moorings Hotel and Marina

1000 Hwy 98 Carrabelle FL
SAR 482
SAR 533 total
1 Oct - 2 Oct
includes taxes & fees
8.6/10 Excellent! (54 reviews)
The Moorings Hotel and Marina
Cozy Waterfront 'island House' on Live Oak Island!

Cozy Waterfront 'island House' on Live Oak Island!

Crawfordville FL
Get ratesCozy Waterfront 'island House' on Live Oak Island!

Find out more about Panacea

Top reasons to visit Panacea

  • Stunning Beaches: Panacea boasts beautiful, tranquil beaches perfect for relaxation and enjoying picturesque sunsets.
  • Outdoor Adventures: The area offers numerous outdoor activities, including hiking, fishing, and golf for adventure enthusiasts.
  • Scenic State Parks: Explore nearby state parks that showcase the natural beauty and wildlife of the Florida coast.
  • Charming Accommodations: Enjoy a range of cozy motels and guesthouses that provide a welcoming atmosphere.
  • Warm Local Hospitality: Experience the friendly vibe of Panacea, where locals are eager to share their coastal charm.

Find great hotels near Panacea

Experience a relaxing getaway in Panacea, Florida, where you can choose from a variety of accommodations, including cozy motels and welcoming guesthouses. Ideal for adventure seekers and golf enthusiasts, many hotels in the area offer pet-friendly options and easy access to the beach. Whether you're looking for a charming beachside motel or a comfortable hotel, you'll find the perfect place to unwind and explore the beauty of this coastal destination.

  • Hyatt House Tallahassee Capitol – University: This 3-star hotel is an excellent choice for travelers seeking a blend of comfort and convenience. Located 46.7km from Panacea, the Hyatt House Tallahassee Capitol – University offers a welcoming atmosphere for families, business travelers, and pet owners alike. The hotel features family-friendly amenities, including a complimentary crib service and child safety features like window guards. For pet lovers, the property allows pets with certain restrictions, ensuring your furry friends can accompany you on your travels. Guests appreciate the thoughtful amenities and the hotel's prime location for both business and leisure activities.
  • Best Western Wakulla Inn & Suites: Situated just 9.7km from Panacea, the Best Western Wakulla Inn & Suites caters to adventure seekers and business travelers. This hotel is perfect for those looking to explore the great outdoors with opportunities for kayaking, snorkeling, and hiking available nearby. The property provides a comfortable and inviting atmosphere, making it a great base for your adventures in Wakulla County. With its strategic location and range of recreational activities, guests often find themselves returning for the exciting experiences that await just outside their door.
  • Wildwood Inn: Located 11.3km from Panacea, the Wildwood Inn is a charming 3-star hotel that combines adventure with a pet-friendly environment. Ideal for business travelers and outdoor enthusiasts, guests can enjoy activities like fishing, sailing, and kayaking in the surrounding area. The hotel’s warm and inviting ambiance, along with its policies welcoming pets, makes it a popular choice for families and adventurers alike. With easy access to nearby attractions and recreational options, Wildwood Inn provides a memorable stay for all types of travelers.

Where to stay in and around Panacea

Panacea, Florida, is a hidden gem perfect for a serene beach getaway. Surrounded by charming coastal scenery, visitors can unwind on tranquil shores and explore nearby family-friendly neighborhoods. Enjoy outdoor adventures or simply relax in the soothing atmosphere that Panacea offers. With its oceanfront charm and secluded vibe, this destination promises a delightful escape for those looking to connect with nature and experience the warm hospitality of friendly locals.

  • Saint Teresa: Nestled in the heart of the Panacea area, Saint Teresa is a charming village that beckons travelers with its stunning beaches and outdoor adventures. The village experiences a moderate influx of visitors, particularly during March and the summer months. Here, you can enjoy a relaxed atmosphere while exploring the nearby national state park and the unique nudist beach. With a variety of recreational areas and golf courses, Saint Teresa offers a delightful mix of leisure and natural beauty for those seeking a scenic getaway.
  • Sopchoppy: Located just 9.7km from Panacea, Sopchoppy is a vibrant city known for its outdoor activities and breathtaking landscapes. The city attracts visitors mainly during the spring and summer months, making it a great destination for adventurers. Explore the lush trails of the national state park, unwind by the lake, or indulge in local recreational venues. Sopchoppy is perfect for those looking to immerse themselves in nature while enjoying a quaint, small-town atmosphere.
  • Crawfordville: Situated 16.1km from Panacea, Crawfordville offers a mix of outdoor adventures and cultural experiences. The city sees a steady number of visitors year-round, with peak times in spring and fall. Crawfordville is a gateway to beautiful beaches and the expansive national state park, making it ideal for beach lovers and adventure enthusiasts alike. Visitors can also explore educational venues, including a historic college university, adding a unique dimension to their travel experience.

Things to do in and around Panacea

Panacea, Florida, is perfect for beach and outdoor enthusiasts seeking scenic beauty. Enjoy a variety of activities such as relaxing at resorts, playing golf, and exploring recreational areas. With ample outdoor seating and experiences, visitors can immerse themselves in the area's natural charm while discovering the best local attractions. Whether you're lounging on the beach or enjoying a round of golf, Panacea offers memorable experiences for every traveler.

Shopping

In Panacea, you can explore local shops and markets for unique souvenirs. If you're up for a drive, check out the Tallahassee Downtown Market and Flea Market Tallahassee, both offering vibrant city vibes. The Governor's Square Mall is also a great option for a more extensive shopping experience.

Recreation

Experience a round of golf at St. James Bay Golf Club, where you can enjoy the beautiful outdoor scenery. For relaxation, visit Woolley Park or Myron B Hodge City Park, both offering serene environments perfect for unwinding and connecting with nature.

Adventure

Explore the Tallahassee-Saint Marks Historic Railroad Trail State Park, a scenic 43.5km from Panacea, perfect for hiking enthusiasts seeking outdoor adventure. The nearby Saint Marks Trail, located 45.1km away, also offers beautiful scenery. For a different thrill, visit the Tom Brown Tennis Center, 49.9km from Panacea, for some exciting tennis matches.

Nightlife

In Panacea, enjoy the vibrant nightlife at Theatre Tallahassee, located 49.9km away. This venue offers a mix of romance and culture, showcasing entertaining performances that capture the essence of the local arts scene. Experience a delightful evening filled with captivating shows and a lively atmosphere.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Panacea

To save money on your trip to Panacea, consider visiting during the cheaper months of July or December to January, and avoid Fridays for accommodations as they tend to be pricier. Utilize Expedia to find great deals by sorting hotel prices from lowest to highest and consider booking a package deal that combines your hotel, flights, and activities for additional savings. Public transport is an affordable option, but exploring on foot can also help you save while enjoying the scenery. Remember, Mondays are the best days to book your stay for the lowest rates.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Panacea are July and December to January, where the prices are slightly lower. This is in comparison to May and September to October, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Panacea is Monday. The most expensive day to stay in Panacea is Friday.
  • Find cheap hotels on Expedia: Utilize Expedia’s search tool to narrow down your options based on your budget, desired location, and the type of hotel you prefer. To find the best prices and deals available, simply sort the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your Panacea hotel reservation with your flights and activities through an Expedia package deal.

Find the best attractions in and around Panacea

Panacea, Florida, is a delightful destination for beach and outdoor enthusiasts, offering stunning scenery and various attractions. Visitors can enjoy the beautiful beaches, explore nearby state parks, and take in the natural beauty of the surrounding islands. Whether you're looking to relax by the shore or engage in outdoor activities, Panacea provides an ideal backdrop for a memorable vacation experience.

  • Bald Point State Park: Experience the beauty of nature at Bald Point State Park, where you can enjoy scenic views, hiking trails, and the chance to observe diverse wildlife. This park is perfect for outdoor enthusiasts and offers a tranquil escape with its picturesque landscapes.
  • USS Mohawk CGC Veterans Memorial Reef: Dive into history at the USS Mohawk CGC Veterans Memorial Reef, an artificial reef created from a decommissioned Coast Guard ship. This site not only honors veterans but also provides a unique spot for snorkeling and diving, showcasing vibrant marine life.
  • Ochlockonee River State Park: Just 8.0km from Panacea, Ochlockonee River State Park offers outdoor adventures like kayaking, fishing, and hiking. This park features beautiful river views and lush surroundings, perfect for those seeking a peaceful retreat in nature.

Best time to go to Panacea

The best time to visit Panacea is dependent on what kind of holiday you are seeking. July and August are its hottest month on average. At the time of August, visitor numbers are average and weather is mostly sunny. January is its coolest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January53.6°F (12.0°C)Light RainMostly SunnyAverageSlightly Low
February57.6°F (14.2°C)Light RainMostly SunnyAverageAverage
March62.4°F (16.9°C)Light RainMostly SunnyAverageAverage
April68.2°F (20.1°C)Light RainMostly SunnyModerately HighAverage
May74.8°F (23.8°C)Light RainMostly SunnyAverageSlightly High
June80.4°F (26.9°C)Moderate RainMostly SunnyModerately HighAverage
July81.7°F (27.6°C)Moderate RainMostly SunnyModerately HighSlightly Low
August81.7°F (27.6°C)Moderate RainMostly SunnyAverageAverage
September78.4°F (25.8°C)Light RainMostly SunnyAverageSlightly High
October71.1°F (21.7°C)Light RainMostly SunnyModerately LowSlightly High
November61.9°F (16.6°C)Light RainMostly SunnyModerately LowAverage
December57.6°F (14.2°C)Light RainMostly SunnyModerately LowSlightly Low

The nearest major airports for your trip to Panacea

For your visit to Panacea, Florida, the nearest major airport is Tallahassee International Airport (TLH), situated 41.8km away. A few excellent hotel options nearby include the DoubleTree by Hilton Hotel Tallahassee and Hotel Duval, Autograph Collection, both rated 4 stars and located 8.0km from the airport, offering convenient shuttle services. Additionally, Hotel Indigo Tallahassee - Collegetown by IHG, a 3.5-star hotel, is just 6.4km from TLH. These hotels provide easy access to the airport, ensuring a smooth start to your vacation in Panacea.

Frequently asked questions

Where is the best place to stay in Panacea?
Based on Expedia's traveler preferences, The Panacea Motel is a top place to stay in Panacea. Other good choices for your visit include Your Fall Escape: FSU Football & Scalloping and Coastal Getaway on canal-steps to the beach. See all available top hotels, or vacation rentals in Panacea.
What's the top vacation rental in Panacea?
BEACH FRONT to BAY with boatdock, swimming pool, pickleball courts and kayaks.: Visitors give good reviews to this Panacea vacation home rental, which is located on the beach and has an outdoor pool, a balcony, and air-conditioning to put you at ease in your new surroundings. It has 6 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You can relax into your vacation with a garden and a selection of games. Other favorite homes for rent in Panacea are Your Fall Escape: FSU Football & Scalloping and Coastal Getaway on canal-steps to the beach. See all vacation rentals in Panacea.
If I need to cancel my hotel reservation in Panacea, will I receive a refund?
Yes! Most hotel bookings are refundable provided that you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Panacea.
Where can I learn more about changing or cancelling my trip to Panacea?
For more details about changing or cancelling your trip to Panacea, click here.
What's the best pet-friendly place to stay in Panacea?
The Panacea Motel is a top pet-friendly option for your stay. See more pet-friendly hotel accommodations in Panacea.
What are some accommodations with pools in Panacea?
What's the best hotel for staying near Tallahassee Regional Airport (TLH)?
Tallahassee Sun & Moon is one of the top choices for your stay and is a popular property, featuring free WiFi and free parking. It's located 3.5 mi (5.7 km) from Tallahassee Regional Airport. Other options close to the airport include Hampton Inn & Suites Tallahassee Capitol-University and Governors Inn.
What's it like to stay in Panacea?
Nature enthusiasts will enjoy exploring Panacea, and many visitors are sure to appreciate the beaches and seafood restaurants. The relaxing and tucked away setting also entices those visiting the city. In Panacea, there are 227 hotels and other accommodations to choose from. Find out more about Panacea.
What are the top places to visit in Panacea?
Natural beauty is on display at Mashes Sand Beach, Alligator Point Beach, and Bald Point State Park. Dolphin watching is a great activity, and Bayside Marina is one place to visit. A couple of additional sights to add to your agenda are Wilson Beach and Gulf Specimen Public Aquarum. Check out what more to see and do in Expedia's Panacea guide.
What's the seasonal weather like in Panacea?
The hottest months are usually July and August with an average temp of 81°F, while the coldest months are January and February with an average of 58°F. The rainiest months in Panacea are August, July, June, and September, with each month seeing an average of 8 inches of rainfall.