The Best Hotels Closest to Mission Hope Cancer Center in Santa Maria for 2026

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Our top choices for Mission Hope Cancer Center hotels

Standard Room, 1 King Bed, Non Smoking, Refrigerator & Microwave | Private kitchen | Coffee/tea maker, fridge, microwave

Standard Room, 2 Queen Beds, Non Smoking, Refrigerator & Microwave | Premium bedding, desk, laptop workspace, blackout drapes

Suite, 1 King Bed, Non Smoking, Refrigerator & Microwave (with Sofabed) | Premium bedding, desk, laptop workspace, blackout drapes

Suite, 1 King Bed, Non Smoking (Oversized Room;with Sofabed) | Premium bedding, desk, laptop workspace, blackout drapes

1. Best Western Plus Big America

2.8 km from Mission Hope Cancer Center

Marivic

SAR 413

SAR 465 total

includes taxes & fees

25 Oct - 26 Oct

2 Queen Designer | Premium bedding, down comforters, desk, blackout drapes

1 King Designer | Premium bedding, down comforters, desk, blackout drapes

2. Hotel Avanti

2.3 km from Mission Hope Cancer Center

Vanessa

SAR 281

SAR 317 total

includes taxes & fees

27 Sep - 28 Sep

3. Historic Santa Maria Inn

2.2 km from Mission Hope Cancer Center

Britney

SAR 399

SAR 449 total

includes taxes & fees

27 Sep - 28 Sep

Deluxe Room | Bathroom | Soap, shampoo, toilet paper

4. Villa Motel

2.4 km from Mission Hope Cancer Center

Tina

SAR 210

SAR 236 total

includes taxes & fees

25 Oct - 26 Oct

Premium bedding, pillowtop beds, in-room safe, blackout drapes

Outdoor pool, open 9:00 AM to 9 PM, pool umbrellas, sun loungers

5. Quality Inn & Suites Santa Maria

2.9 km from Mission Hope Cancer Center

michael

SAR 389

SAR 437 total

includes taxes & fees

4 Oct - 5 Oct

Standard Room, 2 Double Beds | Desk, iron/ironing board, cribs (free), WiFi (free)

Shower, free toiletries, hair dryer, towels

Desk, iron/ironing board, cribs (free), WiFi (free)

6. Days Inn by Wyndham Santa Maria

0.8 km from Mission Hope Cancer Center

David

SAR 278

SAR 312 total

includes taxes & fees

4 Oct - 5 Oct

7. Motel 6 Santa Maria, CA - South

0.5 km from Mission Hope Cancer Center

Chrisj

SAR 335

SAR 376 total

includes taxes & fees

7 Oct - 8 Oct

8. Wine Stone Inn

10.2 km from Mission Hope Cancer Center

DALLAS Cooper

SAR 571

SAR 680 total

includes taxes & fees

27 Sep - 28 Sep

Studio Suite, 2 Queen Beds (Full Kitchen) | Hypo-allergenic bedding available, in-room safe, desk, laptop workspace

9. Homewood Suites by Hilton Santa Maria

3.5 km from Mission Hope Cancer Center

Katrina

SAR 558

SAR 629 total

includes taxes & fees

4 Oct - 5 Oct

10. Fairfield Inn & Suites by Marriott Santa Maria

3.3 km from Mission Hope Cancer Center

Zenny

SAR 421

SAR 475 total

includes taxes & fees

4 Oct - 5 Oct

Suite, 1 Bedroom (1 Queen Bed) | Desk, blackout drapes, iron/ironing board, cribs (free)

11. Candlewood Suites Santa Maria by IHG

3.3 km from Mission Hope Cancer Center

Leighanna

SAR 428

SAR 482 total

includes taxes & fees

28 Sep - 29 Sep

Standard Room, 2 Double Beds, Non Smoking | Premium bedding, pillowtop beds, desk, iron/ironing board

12. Solaire Inn & Suites

3.7 km from Mission Hope Cancer Center

Eduardo

SAR 218

SAR 245 total

includes taxes & fees

27 Sep - 28 Sep

13. Motel 6 Santa Maria, CA - North

3.4 km from Mission Hope Cancer Center

Tracy

SAR 223

SAR 251 total

includes taxes & fees

4 Oct - 5 Oct

Corner Suite 1 King Bed, Non Smoking | Premium bedding, memory foam beds, in-room safe, desk

14. Radisson Hotel Santa Maria

6.8 km from Mission Hope Cancer Center

Teresa

SAR 571

SAR 643 total

includes taxes & fees

4 Oct - 5 Oct

Standard Room, 1 King Bed | Desk, WiFi (free), bed sheets

Standard Room, 2 Double Beds | Desk, WiFi (free), bed sheets

15. Colonial Motel

3.4 km from Mission Hope Cancer Center

Darren

SAR 279

SAR 314 total

includes taxes & fees

25 Oct - 26 Oct

View all properties

Compare popular hotels close to Mission Hope Cancer Center

Property	Property class	Guest rating
Best Western Plus Big America	8.8 Excellent 1,001 reviews	View
Hotel Avanti	8.6 Excellent 479 reviews	View
Historic Santa Maria Inn	8.4 Very good 2,334 reviews	View
Villa Motel	8.0 Very good 447 reviews	View
Quality Inn & Suites Santa Maria	8.0 Very good 1,008 reviews	View

Top Mission Hope Cancer Center Hotel Reviews

Oxford Suites Pismo Beach

8/10 Good

"We go here almost every summer. Such a quaint property. It’s dated but well kept and great staff! Awesome breakfast, lots of parking. Amazing happy hour. Very family friendly."

Hampton Inn & Suites Arroyo Grande/Pismo Beach Area, CA

10/10 Excellent

"Very clean room and friendly staff."

Homewood Suites by Hilton Santa Maria

10/10 Excellent

"Nice and clean"

Aloha Inn

10/10 Excellent

"Clean"

Hotel Avanti

8/10 Good

"Everything is great, except for the hanging barn doors. It feels really weird to use the bathroom with door gaps both sides!"

The Agrarian Hotel, BW Signature Collection

10/10 Excellent

"Complimentary wine bottle was a nice touch. The high ceilings made the room feel much larger. It was nice to see wooden floors instead of usual carpet. At night, super quiet and peaceful patio..looking out to beautiful greenery. Super close location to the Village, my kids enjoyed this hotel. Staff very friendly, we definitely would stay here again."

Days Inn by Wyndham Arroyo Grande/Pismo Beach

10/10 Excellent

"Great for a 1 night stay. Rooms are relatively updated."

Solaire Inn & Suites

10/10 Excellent

"Todo excelente gracias"

Frequently asked questions

What's the area like around Mission Hope Cancer Center?

Mission Hope Cancer Center is located in a family-friendly area of Santa Maria known for its array of dining options. If you're looking for a convenient place to stay, check out the 10 hotels and other accommodations you'll find within a mile.

What's the best place to stay near Mission Hope Cancer Center?

Historic Santa Maria Inn is one of the top choices for your stay based on our traveler data, and this hotel offers 2 bars and a restaurant. It's located 1.4 mi (2.2 km) from Mission Hope Cancer Center. Other good options within 5 miles include Villa Motel and Homewood Suites by Hilton Santa Maria.

How many hotels are there near Mission Hope Cancer Center?

Expedia has 10 hotels and other accommodations within a mile from Mission Hope Cancer Center.

If I need to cancel the hotel reservation for my stay near Mission Hope Cancer Center, will I receive a refund?

Yes! The majority of hotel bookings are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of your booking. Put your dates in and click on "Search", then use the "fully refundable" filter to review the top deals on offer near Mission Hope Cancer Center.

Where can I learn more about changing or cancelling my trip in the area near Mission Hope Cancer Center?

For more details about changing or cancelling your stay near Mission Hope Cancer Center, head over to our customer service page.

What can I see and do near Mission Hope Cancer Center?

Study the collections at Santa Maria Valley Historical Society, Natural History Museum, or Santa Maria Museum of Flight. You can enjoy live performances at Pacific Conservatory Theatre and Santa Maria Civic Theatre. Children's Resource & Referral (CRR) Discovery Museum, Rancho Bowl, and Santa Maria Fairpark are fun stops for the whole family while you're in town.

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Our top choices for Mission Hope Cancer Center hotels

1. Best Western Plus Big America

2. Hotel Avanti

3. Historic Santa Maria Inn

4. Villa Motel

5. Quality Inn & Suites Santa Maria

6. Days Inn by Wyndham Santa Maria

7. Motel 6 Santa Maria, CA - South

8. Wine Stone Inn

9. Homewood Suites by Hilton Santa Maria

10. Fairfield Inn & Suites by Marriott Santa Maria

11. Candlewood Suites Santa Maria by IHG

12. Solaire Inn & Suites

13. Motel 6 Santa Maria, CA - North

14. Radisson Hotel Santa Maria

15. Colonial Motel

Compare popular hotels close to Mission Hope Cancer Center

Top Mission Hope Cancer Center Hotel Reviews

Oxford Suites Pismo Beach

Hampton Inn & Suites Arroyo Grande/Pismo Beach Area, CA

Homewood Suites by Hilton Santa Maria

Aloha Inn

Hotel Avanti

The Agrarian Hotel, BW Signature Collection

Days Inn by Wyndham Arroyo Grande/Pismo Beach

Solaire Inn & Suites

Frequently asked questions

Find hotels near Mission Hope Cancer Center, Santa Maria from SAR 236

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Mission Hope Cancer Center hotels

1. Best Western Plus Big America

2. Hotel Avanti

3. Historic Santa Maria Inn

4. Villa Motel

5. Quality Inn & Suites Santa Maria

6. Days Inn by Wyndham Santa Maria

7. Motel 6 Santa Maria, CA - South

8. Wine Stone Inn

9. Homewood Suites by Hilton Santa Maria

10. Fairfield Inn & Suites by Marriott Santa Maria

11. Candlewood Suites Santa Maria by IHG

12. Solaire Inn & Suites

13. Motel 6 Santa Maria, CA - North

14. Radisson Hotel Santa Maria

15. Colonial Motel

Compare popular hotels close to Mission Hope Cancer Center

Top Mission Hope Cancer Center Hotel Reviews

Oxford Suites Pismo Beach

Hampton Inn & Suites Arroyo Grande/Pismo Beach Area, CA

Homewood Suites by Hilton Santa Maria

Aloha Inn

Hotel Avanti

The Agrarian Hotel, BW Signature Collection

Days Inn by Wyndham Arroyo Grande/Pismo Beach

Solaire Inn & Suites

Frequently asked questions