Find hotels in South Main, Houston from SAR 262
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Our top choices for South Main hotels
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.2 out of 10, Good, (1,288 reviews)
"Would stay again!"
Austin
The price is SAR 372
SAR 435 total
includes taxes & fees
31 May - 1 Jun
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,000 reviews)
"Good parking"
joseph
The price is SAR 282
SAR 330 total
includes taxes & fees
4 Jun - 5 Jun
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,000 reviews)
"Clean & comfortable, super nice staff, good breakfast options, convenient to MDA."
Cleota
The price is SAR 379
SAR 443 total
includes taxes & fees
31 May - 1 Jun
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,003 reviews)
"Very clean rooms and excellent staff"
Efrain
The price is SAR 289
SAR 338 total
includes taxes & fees
1 Jun - 2 Jun
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (865 reviews)
"My stay was perfect "
Fredrick
The price is SAR 394
SAR 461 total
includes taxes & fees
8 Jun - 9 Jun
Studio 6 Houston, TX – Pearland/Medical Center
Studio 6 Houston, TX – Pearland/Medical CenterSoutheast Houston, 12.9 km from South Main
9.6 out of 10, Exceptional, (87 reviews)
"The property was very clean and the staff was great. I would stay here again when back in town."
Cruz
The price is SAR 224
SAR 262 total
includes taxes & fees
8 Jun - 9 Jun
Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (258 reviews)
"Clean room, and very helpful staff actually enjoyed our stay"
Jessica
The price is SAR 345
SAR 404 total
includes taxes & fees
31 May - 1 Jun
Courtyard by Marriott Houston Intercontinental Airport
Courtyard by Marriott Houston Intercontinental Airport31.8 km from South Main
9.0 out of 10, Wonderful, (1,214 reviews)
"Wonderful place to stay!"
Lisa
The price is SAR 443
SAR 519 total
includes taxes & fees
7 Jun - 8 Jun
Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical CenterTexas Medical Center, 4.4 km from South Main
8.4 out of 10, Very Good, (1,938 reviews)
"Breakfast was wonderful and the front desk staff were very helpful."
Reta
The price is SAR 459
SAR 542 total
includes taxes & fees
7 Jun - 8 Jun
Palace Inn Blue Edgebrook
Palace Inn Blue Edgebrook16.8 km from South Main
9.4 out of 10, Exceptional, (174 reviews)
"It was very clean"
Jesus
The price is SAR 373
SAR 450 total
includes taxes & fees
7 Jun - 8 Jun
Crystal Inn Northeast Houston Downtown I-610
Crystal Inn Northeast Houston Downtown I-610Northside, 18.9 km from South Main
8.4 out of 10, Very Good, (205 reviews)
"Great price and nice rooms"
Armando
The price is SAR 253
SAR 296 total
includes taxes & fees
5 Jun - 6 Jun
Hampton Inn & Suites Houston-Bush Intercontinental Aprt
Hampton Inn & Suites Houston-Bush Intercontinental Aprt31.8 km from South Main
8.8 out of 10, Excellent, (1,910 reviews)
"Nice overnight stay. Great for close to airport!!!"
Jaime
The price is SAR 344
SAR 404 total
includes taxes & fees
7 Jun - 8 Jun
Palace Inn Blue 290 W 43rd & Bingle Rd
Palace Inn Blue 290 W 43rd & Bingle Rd19.4 km from South Main
9.0 out of 10, Wonderful, (68 reviews)
"We loved it, very nice employees and very clean."
Jorge
The price is SAR 331
SAR 387 total
includes taxes & fees
7 Jun - 8 Jun
Tru by Hilton Houston Webster NASA
Tru by Hilton Houston Webster NASA30.7 km from South Main
9.0 out of 10, Wonderful, (1,000 reviews)
"Clean hotel and the staff are great. "
Mary S
The price is SAR 431
SAR 504 total
includes taxes & fees
30 Jun - 1 Jul
Best Western Plus Manvel Inn & Suites
Best Western Plus Manvel Inn & Suites22.6 km from South Main
8.8 out of 10, Excellent, (792 reviews)
"Very nice day very clean never been in a room with a hot tub nice and convenient. Lovely stay"
emira
The price is SAR 300
SAR 339 total
includes taxes & fees
11 Jun - 12 Jun
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
La Quinta Inn & Suites by Wyndham Houston Bush IAH South31.2 km from South Main
8.2 out of 10, Very Good, (2,046 reviews)
"Clean convenient close to airport and food"
Brian
The price is SAR 274
SAR 321 total
includes taxes & fees
2 Jun - 3 Jun
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG30.8 km from South Main
9.0 out of 10, Wonderful, (1,001 reviews)
"Wonderful enjoyed the stay and breakfast clean rooms"
Albert
The price is SAR 394
SAR 461 total
includes taxes & fees
8 Jun - 9 Jun
Spark by Hilton Houston Bush Intercontinental Airport
Spark by Hilton Houston Bush Intercontinental Airport31.2 km from South Main
8.6 out of 10, Excellent, (1,002 reviews)
"Great option close to the airport! "
Lisa
The price is SAR 335
SAR 392 total
includes taxes & fees
6 Jun - 7 Jun
Hotel Royale
Hotel Royale20.9 km from South Main
9.2 out of 10, Wonderful, (40 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
Jerome
The price is SAR 287
SAR 336 total
includes taxes & fees
5 Jun - 6 Jun
Hyatt Place Houston/Sugar Land
Hyatt Place Houston/Sugar Land21.4 km from South Main
8.8 out of 10, Excellent, (1,900 reviews)
"Great location and nice walking trail behind the property!"
michael
The price is SAR 366
SAR 421 total
includes taxes & fees
31 May - 1 Jun
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.6 Excellent 1,000 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 865 reviews | View | ||||||
 Wyndham Houston near NRG Park/Medical Center | 7.2 Good 1,288 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,000 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,003 reviews | View |
Where to stay in South Main
Find the best South Main areas and neighborhoods for the activities you enjoy most.
Downtown Houston
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.
The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Gerald D. Hines Waterwall Park.
Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews
Club Quarters Hotel Downtown, Houston
10/10 Excellent
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