Photo by Jessica King
Find hotels in De Soto, MO from SAR 191
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Go beyond your typical stay in De Soto
Pet friendly
Check prices for these dates
Compare 167 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
9.4 out of 10, Exceptional, (144)
cleanliness Families find a perfect lakeside retreat at this resort where fishing, mini golf, and playground activities create endless fun for all ages.
The price is SAR 596
SAR 687 total
includes taxes & fees
29 Jun - 30 Jun

The Conner House B&B
The Conner House B&B
10.0 out of 10, Exceptional, (13)
cleanliness Travelers start their day with a full breakfast at The Conner House B&B, stay connected with in-room WiFi, and unwind in the lobby with coffee or tea
The price is SAR 481
SAR 533 total
includes taxes & fees
29 Jun - 30 Jun

Corner George Inn Bed & Breakfast
Corner George Inn Bed & Breakfast
9.0 out of 10, Wonderful, (151)
cleanliness This welcoming B&B balances relaxation and exploration, offering a hearty breakfast before guests visit the on-site gift shop for unique finds.
The price is SAR 434
SAR 482 total
includes taxes & fees
4 Jul - 5 Jul

Postcard Cabins St. Francois
Postcard Cabins St. Francois
10.0 out of 10, Exceptional, (11)
The price is SAR 409
SAR 581 total
includes taxes & fees
30 Jun - 1 Jul

Tiny Houses of French Village
Tiny Houses of French Village
10.0 out of 10, Exceptional, (2)

Drury Inn & Suites St. Louis Arnold
Drury Inn & Suites St. Louis Arnold
9.6 out of 10, Exceptional, (1001)
cleanliness Travelers can choose between indoor and outdoor pools at this Arnold hotel, where high-speed internet keeps everyone connected even while relaxing
The price is SAR 446
SAR 516 total
includes taxes & fees
6 Jul - 7 Jul
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Cabins in De Soto you'll enjoy

82 Acre Hobby Farm with Lincoln Log Cabin
82 Acre Hobby Farm with Lincoln Log Cabin
10.0 out of 10, Exceptional, (37)
The price is SAR 563
SAR 1,047 total
includes taxes & fees
26 Jul - 27 Jul
These pet-friendly hotels in De Soto may fit your trip

Homestead Hideaway + Hot Tub
Homestead Hideaway + Hot Tub
10.0 out of 10, Exceptional, (27)
The price is SAR 435
SAR 813 total
includes taxes & fees
22 Jul - 23 Jul
Check out hotels with a pool in De Soto

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
9.4 out of 10, Exceptional, (144)
The price is SAR 596
SAR 687 total
includes taxes & fees
29 Jun - 30 Jun
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Learn more about De Soto
Get away to De Soto! Enjoy the local cuisine and more.

Photo by Jessica King
Open Photo by Jessica King
More cheap stays in De Soto
More cheap stays in De Soto

Pear Tree Inn St. Louis Arnold
1201 Drury Ln, Arnold, MO
The price is SAR 354 per night from Jul 6 to Jul 7
SAR 354
SAR 410 total
6 Jul - 7 Jul
includes taxes & fees
9.2/10 Wonderful! (1,007 reviews)
Hotels in De Soto with star-rating
Hotels in De Soto with star-rating

3 Star Hotels
9 properties

2 Star Hotels
30 properties
Stay near popular De Soto attractions
Stay near popular De Soto attractions
Recent reviews of De Soto hotels
Recent reviews of De Soto hotels

Hampton Inn Farmington
5/5 Excellent
"Nothing I didnt like. "
A verified traveler stayed at Hampton Inn Farmington
Posted 12 hours ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Stay near popular De Soto attractions
- Hotels near Mississippi River
- Hotels near Meramec State Park
- Hotels near Meramec River
- Hotels near Bonne Terre Mine
- Hotels near Pickle Springs Natural Area
- Hotels near St. Joe State Park
- Hotels near St. Francois State Park
- Hotels near Hawn State Park
- Hotels near Big River
- Hotels near Washington State Park
- Hotels near Villa Antonio Winery
- Hotels near Crown Pointe Golf Club
Hotels near De Soto Airports
De Soto Hotels by Brand
Other Hotels near De Soto, Missouri
- Fenton Hotels
- Eureka Hotels
- Ozarks Hotels
- Farmington Hotels
- Arnold Hotels
- Festus Hotels
- Southern Illinois Hotels
- Sullivan Hotels
- Ste Genevieve Hotels
- Pacific Hotels
- St. Clair Hotels
- Union Hotels
- Potosi Hotels
- Bonne Terre Hotels
- Bourbon Hotels
- Waterloo Hotels
- Tesson Ferry Hotels
- Imperial Hotels
- Pevely Hotels
- Hillsboro Hotels
Explore more hotels
- Postcard Cabins St. Francois
- La Quinta Inn & Suites by Wyndham Festus - St. Louis South
- Quality Inn Farmington
- Super 8 by Wyndham Bonne Terre
- Crown Pointe Lodge, BW Signature Collection
- Festus Inn
- Treehouse and Hot Tub on 10acres - Pet Friendly!
- Hampton Inn Farmington
- WoodSpring Suites St. Louis Arnold
- Holiday Inn Express & Suites Farmington by IHG
- Super 8 by Wyndham Potosi
- Charming 1-bedroom house in nice Imperial with AC. Attn! Traveling Contractors