Find 5 Star Hotels in Defiance, MO from SAR 542

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Defiance 5 Star Hotels

Tonight
8 May - 9 May
Tomorrow
9 May - 10 May
This weekend
8 May - 10 May
Next weekend
15 May - 17 May
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Defiance.
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO
The price is SAR 597 per night from May 25 to May 26
SAR 597
SAR 760 total
25 May - 26 May
includes taxes & fees
8.6/10 Excellent! (1,006 reviews)
Still don't see what you're looking for?
See all properties in Defiance.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Defiance?
The amount you pay for a 5-star hotel in Defiance depends on things such as when you want to go and the length of your vacation. Our insider tip for scoring an awesome deal? Use our pricing filters to check out the available hotels for your preferred dates.

  • Search for the lowest price per night from SAR 542

What makes a hotel 5 stars in Defiance?
In Defiance, a hotel must provide a specific number of upscale conveniences to earn 5 stars. These can include gourmet restaurants, on-site gyms, saunas and spas, luxury bathroom products, premium bedding and more. What also sets 5-star hotels apart is their outstanding standard of service. You can look forward to things like in-room massages, nightly turn-down services and concierge services. Some may even offer extra touches like welcome gifts.
Are there any 5-star all-inclusive resorts in Defiance?
Our handy filters are the best way to find exactly what you're looking for. Check the "All inclusive" and "5-star" boxes to see the most upscale resorts in Defiance where your accommodations, meals, entertainment and activities are included in the upfront price. At these escapes, your trip is pure relaxation and indulgence from the moment you pull up to the entrance.

Explore a world of travel with Expedia