Find 5 Star Hotels in Affton, MO
Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
Compare Affton 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.
Frequently asked questions
Affton Hotels by Star Rating
Stay near popular Affton attractions
- Enterprise Center
- St. Louis Union Station
- Busch Stadium
- St. Louis Zoo
- Gateway Arch
- Six Flags St. Louis
- Washington University in St. Louis
- Forest Park
- Hollywood Casino Amphitheatre
- City Museum
- Dome at America’s Center
- Ameristar Casino St. Charles
- Barnes Jewish Hospital
- St. Louis University
- Magic House - St. Louis Children's Museum
- America's Center Convention Complex
- Mississippi River
- Missouri Botanical Gardens and Arboretum
- Fox Theater
- Westport Plaza
More Accommodation Types in Affton
- Vacation Homes in Affton (618)
- Apartments in Affton (514)
- Condo Rentals in Affton (55)
- Cottages in Affton (27)
- Motels in Affton (21)
- Aparthotels in Affton (8)
- Villas in Affton (5)
- B&B in Affton (4)
- Guest Houses in Affton (4)
- Cabin Rentals in Affton (2)
- RV Parks in Affton (2)
- Town Houses in Affton (2)
- Farmstay in Affton (1)
- Lodges in Affton (1)
Explore more hotels
- Renaissance St. Louis Airport Hotel
- Hilton St. Louis Airport
- Hilton St. Louis at the Ballpark
- Casino Queen Hotel
- Moonrise Hotel
- Forest Park Hotel by MDR
- Angad Arts Hotel
- Live by Loews - St.Louis
- Drury Inn & Suites St. Louis Union Station
- St. Louis Union Station Hotel, Curio Collection by Hilton
- Le Méridien St. Louis Clayton
- DoubleTree by Hilton St. Louis Airport
- Hampton Inn St. Louis-Downtown (At the Gateway Arch)
- The Wildwood Hotel
- La Quinta Inn & Suites by Wyndham St. Louis Westport
- Marriott St. Louis Grand
- River City Casino & Hotel
- Residence Inn by Marriott St Louis Downtown
- Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
- Aviator Hotel & Suites South I-55, BW Signature Collection