Photo by Jessica King
Find hotels in De Soto, MO from SAR 204
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Go beyond your typical stay in De Soto
Cabin
Family friendly
Check prices for these dates
Compare 174 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
9.4 out of 10, Exceptional, (148)
The price is SAR 525
SAR 611 total
includes taxes & fees
29 Jul - 30 Jul

The Conner House B&B
The Conner House B&B
10.0 out of 10, Exceptional, (14)
The price is SAR 475
SAR 527 total
includes taxes & fees
5 Aug - 6 Aug

Corner George Inn Bed & Breakfast
Corner George Inn Bed & Breakfast
9.0 out of 10, Wonderful, (152)
The price is SAR 425
SAR 471 total
includes taxes & fees
28 Jul - 29 Jul

Postcard Cabins St. Francois
Postcard Cabins St. Francois
10.0 out of 10, Exceptional, (20)
The price is SAR 334
SAR 501 total
includes taxes & fees
27 Jul - 28 Jul

Tiny Houses of French Village
Tiny Houses of French Village
10.0 out of 10, Exceptional, (2)

Drury Inn & Suites St. Louis Arnold
Drury Inn & Suites St. Louis Arnold
9.6 out of 10, Exceptional, (1003)
The price is SAR 431
SAR 499 total
includes taxes & fees
17 Aug - 18 Aug
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Learn more about De Soto
Get away to De Soto! Enjoy the local cuisine and more.

Photo by Jessica King
Open Photo by Jessica King
Top De Soto Hotel Reviews

Drury Inn & Suites St. Louis Arnold
10/10 Excellent
More cheap stays in De Soto
More cheap stays in De Soto

Pear Tree Inn St. Louis Arnold
1201 Drury Ln, Arnold, MO
The price is SAR 338 per night from Jul 29 to Jul 30
SAR 338
SAR 390 total
29 Jul - 30 Jul
includes taxes & fees
9.2/10 Wonderful! (1,008 reviews)
Hotels in De Soto with star-rating
Hotels in De Soto with star-rating

3 Star Hotels
11 properties

2 Star Hotels
35 properties
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Stay near popular De Soto attractions
- Hotels near Mississippi River
- Hotels near Meramec State Park
- Hotels near Meramec River
- Hotels near Bonne Terre Mine
- Hotels near Washington State Park
- Hotels near Hawn State Park
- Hotels near Big River
- Hotels near Pickle Springs Natural Area
- Hotels near St. Francois State Park
- Hotels near Mastodon State Historic Site
- Hotels near Villa Antonio Winery
- Hotels near St. Joe State Park
Hotels near De Soto Airports
De Soto Hotels by Brand
Other Hotels near De Soto, Missouri
- Fenton Hotels
- Ozarks Hotels
- Eureka Hotels
- Farmington Hotels
- Southern Illinois Hotels
- Arnold Hotels
- Sullivan Hotels
- Festus Hotels
- Ste Genevieve Hotels
- St. Clair Hotels
- Pacific Hotels
- Potosi Hotels
- Union Hotels
- Bourbon Hotels
- Bonne Terre Hotels
- Waterloo Hotels
- Tesson Ferry Hotels
- Imperial Hotels
- Pevely Hotels
- Hillsboro Hotels
Explore more hotels
- Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
- Postcard Cabins St. Francois
- Super 8 by Wyndham Farmington
- Super 8 by Wyndham Bonne Terre
- Quality Inn Farmington
- Hampton Inn Farmington
- Charming 1-bedroom house in nice Imperial with AC. Attn! Traveling Contractors
- WoodSpring Suites St. Louis Arnold
- Festus Inn
- Crown Pointe Lodge, BW Signature Collection
- Treehouse and Hot Tub on 10acres - Pet Friendly!
- Super 8 by Wyndham Potosi