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Our top choices for Southwest Illinois hotels

A hotel kitchen with wooden cabinets, a coffee station, and a dining area with tables and chairs.

1. Best Western U. S. Inn

Nashville

Steven

SAR 491 total

includes taxes & fees

29 Oct - 30 Oct

A multi-story hotel with a central entrance, illuminated by exterior lights, and a clear sky in the background.

2. Best Western Plus Centralia Hotel & Suites

Centralia

Jeremy

SAR 584 total

includes taxes & fees

29 Oct - 30 Oct

A hotel lobby with a Kitchen+Bar area, seating arrangements, and a view to the outside.

3. Drury Plaza Hotel Mt. Vernon

Mount Vernon

Richard

SAR 470 total

includes taxes & fees

1 Nov - 2 Nov

A hotel with a covered entrance, stone pillars, and a modern design.

4. Holiday Inn Express & Suites Mount Vernon by IHG

Mount Vernon

Doug

SAR 482 total

includes taxes & fees

31 Oct - 1 Nov

An indoor swimming pool with a view of the outside, a hot tub, and a seating area with tables and chairs.

5. DoubleTree by Hilton Mt. Vernon

Mount Vernon

Kenneth

SAR 502 total

includes taxes & fees

30 Oct - 31 Oct

A hotel lobby with a large sofa, armchairs, a Christmas tree, and a patterned carpet.

6. Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

Mount Vernon

Susan

SAR 425 total

includes taxes & fees

15 Nov - 16 Nov

A hotel lobby with a reception desk, seating area, and a large screen TV.

7. Comfort Suites Mount Vernon

Mount Vernon

Bruce and Robin

SAR 502 total

includes taxes & fees

1 Nov - 2 Nov

An outdoor patio with stone fire pit, colorful striped sofas, and blue chairs.

8. Home2 Suites by Hilton Carbondale

Carbondale

Margaret

SAR 517 total

includes taxes & fees

17 Nov - 18 Nov

A spacious lobby with a stone fireplace, a seating area with a sofa and chairs, and a television mounted on the wall.

9. SureStay Hotel by Best Western Whittington Rend Lake

Whittington

Tad

SAR 337 total

includes taxes & fees

3 Nov - 4 Nov

A neatly made bed with white linens and a dark headboard, flanked by two bedside tables with lamps.

10. The Principal Hotel

Columbia

Jeffrey

SAR 347 total

includes taxes & fees

1 Nov - 2 Nov

A restaurant with a brick exterior and a sign that reads "RESTAURANT."

11. Powhatan Motel

Pocahontas

Bob

SAR 385 total

includes taxes & fees

29 Oct - 30 Oct

A modern dining area with multiple tables and chairs, a kitchen area with appliances, and a ceiling with recessed lighting and a circular light fixture.

12. Best Western Plus MidAmerica Hotel

Mascoutah

Alice

SAR 431 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a window with curtains.

13. Drury Inn & Suites St. Louis O'Fallon, IL

O'Fallon

Karissa

SAR 439 total

includes taxes & fees

9 Nov - 10 Nov

A hotel reception desk with a digital display, a desk phone, and a computer. There is a sign indicating the hotel's name and services.

14. Holiday Inn Express Hotel & Suites Sparta by IHG

Sparta

Jo Ann

SAR 417 total

includes taxes & fees

1 Nov - 2 Nov

A modern kitchen with wooden cabinets, a refrigerator, a coffee machine, and a microwave. There are red chairs and a table in the dining area.

15. Quality Inn Mount Vernon, IL

Mount Vernon

Ryan

SAR 307 total

includes taxes & fees

15 Nov - 16 Nov

A modern living room with a fireplace, a bookshelf, a large wall clock, and a cozy seating area.

16. Country Inn & Suites by Radisson, Marion, IL

Marion

Lisa

SAR 427 total

includes taxes & fees

8 Nov - 9 Nov

A modern indoor pool area with a blue ceiling, large windows, and a pool with a metal ladder.

17. Hampton Inn O'Fallon

O'Fallon

Edmond

SAR 496 total

includes taxes & fees

8 Nov - 9 Nov

A hotel room with two beds, a desk, a television, and a window with a view of the outdoors.

18. Red Bud Country Inn

Red Bud

James

SAR 329 total

includes taxes & fees

12 Nov - 13 Nov

A hotel room with a bed, a desk, a chair, a TV, and a window with curtains.

19. Super 8 by Wyndham Mt. Vernon IL

Mount Vernon

Leslie

SAR 312 total

includes taxes & fees

1 Nov - 2 Nov

A Comfort Inn & Suites hotel with a covered entrance, multiple floors, and a landscaped front yard.

20. Comfort Inn & Suites Marion I-57

Marion

Suzan

SAR 466 total

includes taxes & fees

8 Nov - 9 Nov

View all properties

Hotels recommended for families in Southwest Illinois

Best Western U. S. Inn

Nashville

SAR 491 total

includes taxes & fees

29 Oct - 30 Oct

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Stay near popular Southwest Illinois attractions

O'Fallon Family Sports Park

8.6/10 (137 reviews)

Explore the great outdoors at O'Fallon Family Sports Park, a lovely green space in O'Fallon. Check out the shops and top-notch restaurants in this family-friendly area.

See properties

Learn more about Southwest Illinois

Find lots to see and do in Southwest Illinois—live music, sports teams, and sights from Pyramid State Recreation Area to DuQuoin State Fairgrounds.

See all hotels in Southwest Illinois

A tall, cylindrical structure with a red and white striped pattern and a label reading "Brock's Old Original Catsup."

Top Southwest Illinois Hotel Reviews

Country Inn & Suites by Radisson, Marion, IL

10/10 Excellent

"This was a wonderful hotel that went the extra mile, with fall decorations in the lobby, fresh cookies at check-in, and every space so clean and fresh smelling. Our room, bed, and shower were great as was the breakfast. I would have loved for the ac/fan to stay on all night, but other than that, it was a great stay."

Quality Inn O'Fallon - St. Louis - Shiloh

8/10 Good

"The staff was awesome! The bathroom however had some stains on the shower curtain. It should have been washed . The bed was so very comfortable! We slept great! Thank you… The staff came right to the room when we couldn’t get the tv remote to work. Asked if we needed anything else.."