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Vacation Homes in Southeast Jacksonville

Fridge, microwave, oven, stovetop
Central 2BR Near Mayo Clinic with Fenced Yard and Patio!

Central 2BR Near Mayo Clinic with Fenced Yard and Patio!

2.0 star property
Southside
9.6 out of 10, Exceptional, (5)
"Location was perfect, house was exactly as advertised and was just right for our needs. Will definitely stay here again if we return to Jacksonville. "
United States
Steven Z.
The price is SAR 317
SAR 865 total
includes taxes & fees
2 Dec - 3 Dec
Central 2BR Near Mayo Clinic with Fenced Yard and Patio!
Fridge, microwave, stovetop, coffee/tea maker
La Casita by Amarelys and lazaro

La Casita by Amarelys and lazaro

Southside
10.0 out of 10, Exceptional, (5)
"Great location, easy access to route 95. Nice neighborhood ."
United States
herman c.
The price is SAR 195
SAR 914 total
includes taxes & fees
15 Dec - 16 Dec
La Casita by Amarelys and lazaro
Microwave, oven, stovetop, dishwasher
Charming 2-bedroom house close to stadium and hospitals

Charming 2-bedroom house close to stadium and hospitals

2.0 star property
South Riverside
10.0 out of 10, Exceptional, (2)
"This house was very clean and stocked with almost everything you need for a comfortable stay. Check in was a breeze and checking out was even easier. All they ask you to do when leaving is to lock the door on your way out! It's in a quiet neighborhood and convenient to the downtown San Marco area. "
United States
Derrel M.
The price is SAR 352
SAR 1,125 total
includes taxes & fees
1 Jan - 2 January 2026
Charming 2-bedroom house close to stadium and hospitals
Private kitchen
Spacious 3BR and Boat parking@ Central River Golf Club

Spacious 3BR and Boat parking@ Central River Golf Club

Southside
10.0 out of 10, Exceptional, (1)
"It was great, quick checkin, clean space, and amazing communication!"
United States
Aiden J.
Spacious 3BR and Boat parking@ Central River Golf Club
Paper towels
Prime Urban Home Close To Downtown Jacksonville

Prime Urban Home Close To Downtown Jacksonville

Spring Park
9.6 out of 10, Exceptional, (8)
"Had a business trip to Jax and staying her made it a great time I felt like I was home. Will recommend "
United States
Angelica P.
The price is SAR 638
SAR 1,332 total
includes taxes & fees
28 Dec - 29 Dec
Prime Urban Home Close To Downtown Jacksonville
Exterior
Spacious 4-Bedroom Retreat Near Downtown & San Marco – Jacksonville Charm

Spacious 4-Bedroom Retreat Near Downtown & San Marco – Jacksonville Charm

2.0 star property
Spring Park
10.0 out of 10, Exceptional, (1)
"Very clean and great "
United States
Nahjai T.
The price is SAR 327
SAR 1,007 total
includes taxes & fees
24 Dec - 25 Dec
Spacious 4-Bedroom Retreat Near Downtown & San Marco – Jacksonville Charm
Fridge, microwave, oven, stovetop
AWESOME/LUXURY/PERFECT LOCATION/PVT HOME @SE/Mandarin

AWESOME/LUXURY/PERFECT LOCATION/PVT HOME @SE/Mandarin

Del Rio
10.0 out of 10, Exceptional, (44)
"This was an overnight stop. Great location, easy to get back on the road. Nice fenced yard, spacious home, quiet neighborhood!We will be staying here again."
United States
Richard G.
The price is SAR 422
SAR 1,103 total
includes taxes & fees
2 Dec - 3 Dec
AWESOME/LUXURY/PERFECT LOCATION/PVT HOME @SE/Mandarin
Microwave, oven, stovetop, dishwasher
Beautiful Luxury House Great Location Near Beaches Mayo Clinic Shops Restaurants

Beautiful Luxury House Great Location Near Beaches Mayo Clinic Shops Restaurants

Jacksonville
Beautiful Luxury House Great Location Near Beaches Mayo Clinic Shops Restaurants
TV
Stylish Remodeled Townhouse – Entire Home - Great Location!

Stylish Remodeled Townhouse – Entire Home - Great Location!

2.0 star property
Southside
Stylish Remodeled Townhouse – Entire Home - Great Location!
Private kitchen
Be A Nomad | Spacious 4 BR Close to Mayo & Beaches

Be A Nomad | Spacious 4 BR Close to Mayo & Beaches

2.0 star property
Beach Haven
Be A Nomad | Spacious 4 BR Close to Mayo & Beaches
Smart TV
Fancy private pool home in Jax beach

Fancy private pool home in Jax beach

Isle of Palms
9.6 out of 10, Exceptional, (31)
"Really enjoyed our trip. Everything was very close by to our location. Would definitely stay again "
United States
Judy P.
The price is SAR 506
SAR 1,367 total
includes taxes & fees
2 Dec - 3 Dec
Fancy private pool home in Jax beach
Fridge, microwave, oven, stovetop
privacy paradise

privacy paradise

Southside
10.0 out of 10, Exceptional, (5)
"We enjoyed the patio and property on the beautiful day we had. Great location for us close to the stadium."
United States
Dawn H.
privacy paradise
Living area
Central Avenues Central Cozy 3BR@ Water

Central Avenues Central Cozy 3BR@ Water

Jacksonville
10.0 out of 10, Exceptional, (1)
"Great space, we only stayed 1 night but it was comfy! Hosts communicate great! "
United States
Carolyne H.
Central Avenues Central Cozy 3BR@ Water
Terrace/patio
Charming San Marco Bungalow, Close to Everything

Charming San Marco Bungalow, Close to Everything

San Marco
9.0 out of 10, Wonderful, (7)
"We stayed here for almost a month and it was exactly what we needed. The beds were so comfortable, and the fenced in backyard was perfect for our puppy to run around in. We really liked the location and the walkability to Publix and downtown San Marco. The owner is very responsive and instantly addressed our 2 questions throughout our stay. We will definitely stay here again when we are back in Jacksonville."
United States
Anonymous traveler
Charming San Marco Bungalow, Close to Everything
Outdoor dining
Fun 5 Star Hot Tub/Beaches getaway Near MAYO!

Fun 5 Star Hot Tub/Beaches getaway Near MAYO!

Beach Haven
7.8 out of 10, Good, (8)
"Great property and very convenient location. "
United States
Caylie W.
The price is SAR 589
SAR 1,238 total
includes taxes & fees
23 Dec - 24 Dec
Fun 5 Star Hot Tub/Beaches getaway Near MAYO!
Microwave, oven, stovetop, dishwasher
New Build - Beach - Town Center - 3Bed 2 Bath

New Build - Beach - Town Center - 3Bed 2 Bath

2.0 star property
Sans Pareil
New Build - Beach - Town Center - 3Bed 2 Bath
Pool
Beautiful 3 bedroom, 2 bathroom Beach Bungalow in Jacksonville Beach!

Beautiful 3 bedroom, 2 bathroom Beach Bungalow in Jacksonville Beach!

Beach Haven
8.6 out of 10, Excellent, (13)
"Worked perfect for us. "
United States
Jason P.
The price is SAR 638
SAR 1,513 total
includes taxes & fees
2 Dec - 3 Dec
Beautiful 3 bedroom, 2 bathroom Beach Bungalow in Jacksonville Beach!
Outdoor dining
New 2 miles 2Mayo Clinic Intracoastal water views Mins to JaxBeach

New 2 miles 2Mayo Clinic Intracoastal water views Mins to JaxBeach

Isle of Palms
10.0 out of 10, Exceptional, (5)
"Impressive house with plenty of space. Very large master bathroom and the generous shower with 2 shower heads was the highlight. Great kitchen and view on the back patio. Host was extremely responsive. There were minor housekeeping issues but all things considered, great place to stay. "
United States
Dedrix D.
The price is SAR 615
SAR 1,670 total
includes taxes & fees
1 Jan - 2 January 2026
New 2 miles 2Mayo Clinic Intracoastal water views Mins to JaxBeach
Fridge, microwave, oven, stovetop
Southside Jax great home parking large enough for RV

Southside Jax great home parking large enough for RV

Southside
The price is SAR 657
SAR 1,905 total
includes taxes & fees
22 Dec - 23 Dec
Southside Jax great home parking large enough for RV
Property grounds
Adorable 1-Bd Retreat Near Downtown Jax – Ideal for Professionals & Travelers

Adorable 1-Bd Retreat Near Downtown Jax – Ideal for Professionals & Travelers

2.0 star property
Spring Park
Adorable 1-Bd Retreat Near Downtown Jax – Ideal for Professionals & Travelers
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southeast Jacksonville Hotel Reviews

Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic

10/10 Excellent
"Overall my stay was wonderful. Any concerns that I needed was addressed ASAP. Staff was friendly and helpful. I will stay here again. "
Jermaine 1-night trip
Posted 1 day ago
Hilton Jacksonville At Mayo Clinic