Photo by Mike McClain

Find hotels in Puxico, MO from SARĀ 190

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Go beyond your typical stay in Puxico

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Check prices for these dates

Tonight
8 Nov - 9 Nov
Tomorrow
9 Nov - 10 Nov
Next weekend
13 Nov - 15 Nov
In two weeks
20 Nov - 22 Nov

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Our top choices for Puxico hotels

A modern hotel lobby with a central dining area, a minibar, and a view of the outdoors.

1. Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
2.5 star property
Dexter
9.6 out of 10, Exceptional, (82 reviews)
"This place is Brand new and really great!"
United States
Bryan
The price is SARĀ 366
SARĀ 415 total
includes taxes & fees
15 Nov - 16 Nov
Hampton Inn By Hilton Dexter
A spacious lobby with a reception desk, seating area, and large windows.

2. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,001 reviews)
"Clean, great food, excellent staff."
United States
Dean
The price is SARĀ 338
SARĀ 382 total
includes taxes & fees
13 Nov - 14 Nov
Drury Inn & Suites Poplar Bluff
A diner with booth seating, a checkered floor, and a counter with a cash register.

3. Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter
2.0 star property
Dexter
7.6 out of 10, Good, (425 reviews)
"Staff was very friendly"
United States
Steven
The price is SARĀ 332
SARĀ 376 total
includes taxes & fees
15 Nov - 16 Nov
Travelodge by Wyndham Dexter
A hotel room with a bed, a desk, a chair, a bathroom with a bathtub, and a patterned floor.

4. Econo Lodge Dexter

Econo Lodge Dexter
2.0 star property
Dexter
6.8 out of 10, (290 reviews)
"The place was okay for a night"
United States
Herman
The price is SARĀ 191
SARĀ 217 total
includes taxes & fees
7 Dec - 8 Dec
Econo Lodge Dexter
A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

5. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (977 reviews)
"Everything was great- breakfast, cleanliness, priceā€” will stay there again"
United States
ELAINE
The price is SARĀ 364
SARĀ 411 total
includes taxes & fees
15 Nov - 16 Nov
Fairfield Inn & Suites by Marriott Poplar Bluff
A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

6. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,013 reviews)
"Everything was great about the stay!"
United States
Denise
The price is SARĀ 335
SARĀ 375 total
includes taxes & fees
6 Dec - 7 Dec
Hampton Inn Poplar Bluff
A coffee shop with a coffee machine, espresso cups, a sink, and a trash bin.

7. Dexter Inn

Dexter Inn
2.5 star property
Dexter
7.0 out of 10, Good, (373 reviews)
"breakfast was good, staff friendly, pool area needs work"
United States
Edward
The price is SARĀ 243
SARĀ 276 total
includes taxes & fees
9 Dec - 10 Dec
Dexter Inn
A spacious cafe with wooden tables and chairs, large windows, and a bar area.

8. Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (806 reviews)
"Always an enjoyable stay"
United States
Nathan
The price is SARĀ 282
SARĀ 318 total
includes taxes & fees
6 Dec - 7 Dec
Holiday Inn Poplar Bluff by IHG
A hotel room with two beds, a TV, a mirror, a wardrobe, and a desk.

9. OYO Hickory House Inn

OYO Hickory House Inn
2.5 star property
Dexter
5.6 out of 10, (147 reviews)
"Great staff! Clean rooms and convinient"
United States
DIEGO
The price is SARĀ 191
SARĀ 235 total
includes taxes & fees
21 Nov - 22 Nov
OYO Hickory House Inn
A modern kitchen with a coffee machine, a sink, and a counter. There are four chairs and a table in the dining area.

10. Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very good, (1,001 reviews)
"Rooms were large and clean. Bathroom was large with a nice shower. Parking was convenient Would definitely stay again."
United States
Jim
The price is SARĀ 267
SARĀ 299 total
includes taxes & fees
22 Nov - 23 Nov
Motel 6 Poplar Bluff, MO
A hotel lobby with a reception desk, a blue sofa, a fireplace, and a television.

11. Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North
2.5 star property
Poplar Bluff
7.8 out of 10, Good, (444 reviews)
"Excellent every things"
United States
Muhammad
The price is SARĀ 269
SARĀ 304 total
includes taxes & fees
6 Dec - 7 Dec
Comfort Inn Poplar Bluff North
A hotel room with two beds, a desk with a computer, a TV, and a bathroom with a bathtub.

12. Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri
2.0 star property
Poplar Bluff
6.6 out of 10, (680 reviews)
"I stay here quite often when I come into town, most the time room is clean and fresh, this time the room had a urine smell, the bed needed repair or replaced, there was an issue with expedia and I got charged twice but expedia did refund the money. Overall disappointed with this stay and will start staying at the drury from now on."
United States
Michael
The price is SARĀ 239
SARĀ 270 total
includes taxes & fees
15 Nov - 16 Nov
Super 8 by Wyndham Poplar Bluff Missouri
A living room with a blue wall, a fireplace, a sofa, and a chair.

13. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.4 out of 10, Exceptional, (118 reviews)
"Awesome hotel and staff was first rate, everything was fantastic. If you are in the area, stay at this hotel and eat in!!"
United States
Jan
The price is SARĀ 395
SARĀ 430 total
includes taxes & fees
15 Nov - 16 Nov
EC Reed's Mercantile and Hotel
A rustic cabin with a metal roof, surrounded by a wooden deck and picnic tables, set in a forested area.

14. Lake Wappapello

Lake Wappapello
2.0 star property
Williamsville
8.4 out of 10, Very good, (7 reviews)
"Pet friendly. Family-friendly "
United States
Tonya
The price is SARĀ 338
SARĀ 356 total
includes taxes & fees
9 Nov - 10 Nov
Lake Wappapello
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Puxico

Check out the local area in Puxicoā€”home to attractions like Mark Twain National Forest and Mingo Wilderness.

See all hotels in Puxico
A night scene with a clear sky, a crescent moon, and two silhouetted trees against a twilight sky.
Photo by Mike McClain
Open Photo by Mike McClain

Top Puxico Hotel Reviews

A modern hotel lobby with a central dining area, a minibar, and a view of the outdoors.
Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
Dexter

10/10 Excellent

I loved this property! They had everything I look for. Indoor pool was spotless & stocked well with towels. We enjoyed the layout of the lobby, bar & eating area with multiple big screens & gift shop with frozen food & treats for those that get a little hungry. Our room & bathroom were spacious & well designed. We travel with our pup so we were very happy with the area on 2 sides with grassy areas & dog baggy collection to keep the yard clean for all dog walkers. It was the most area Iā€™ve seen...
United States
ANGELA
Reviewed October 24, 2026
Hampton Inn By Hilton Dexter

Frequently Asked Questions

What are some of the best vacation home rentals in Puxico?

Lake Wappapello 2 Bedroom Home 1/8 mile to beach and boat ramp: This vacation home rental near Puxico has air-conditioning and laundry facilities to help you feel perfectly comfortable in your new surroundings. See all vacation rentals in Puxico.

If I need to cancel my hotel reservation in Puxico, will I receive a refund?

Yes, you'll find most hotel bookings are refundable provided that you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Puxico.

Where can I learn more about changing or cancelling my trip to Puxico?

To find more details about picking new dates or cancelling your trip to Puxico, click here.