Find Resorts & Hotels with Spas in Pickens, SC

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Pickens Resorts & Hotels with Spas

Tonight
6 Dec - 7 Dec
Tomorrow
7 Dec - 8 Dec
Next weekend
12 Dec - 14 Dec
In two weeks
19 Dec - 21 Dec

Top Pickens Resorts & Hotels with Spas

Bar (on property)
Hotel Domestique

Hotel Domestique

4.0 star property
Travelers Rest
9.6 out of 10, Exceptional, (30)
"Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away."
United States
Chuck
The price is SAR 1,220
SAR 1,342 total
includes taxes & fees
1 Jan - 2 January 2026
Hotel Domestique
Couples treatment rooms, body treatments, aromatherapy
Greystone Inn

Greystone Inn

3.5 star property
Lake Toxaway
9.4 out of 10, Exceptional, (85)
"Most beautiful quiet and peaceful old guest home. "
Canada
Tanya
The price is SAR 935
SAR 1,170 total
includes taxes & fees
7 Dec - 8 Dec
Greystone Inn
Spa
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4.0 star property
Greenville Downtown
9.6 out of 10, Exceptional, (413)
"The staff were really sweet and responsive. The views from the rooms are breathtaking! "
United States
Krystal
The price is SAR 1,077
SAR 1,217 total
includes taxes & fees
4 Jan - 5 January 2026
Grand Bohemian Lodge Greenville, Autograph Collection
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Pickens Hotel Reviews

Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

10/10 Excellent
"Very nice staff. Martha was very nice and helpful. She deserves a raise. "
pedro 1-night trip
Posted 2 days ago
Embassy Suites Greenville Golf Resort & Conference Center

Explore a world of travel with Expedia

Frequently asked questions

Looking for a spa hotel in Pickens?
Soothe the senses with some time in one of our wonderful spa hotels. Check out the natural parks in Pickens - worth a picture or two! Hotels with spas are the perfect way to take a break from your daily routine and add a layer of luxury to your vacation.
What's there to see and do in Pickens?
Experience Pickens and visit Table Rock State Park, Table Rock, and Lake Keowee. If you have a little extra time during your trip, you might want to check out Irma Morris Museum of Fine Arts and Hagood Mill Historic Site.
What is a Pickens spa hotel?
Spa hotels in Pickens provide lodging and have an on-site spa offering services such as massages and body treatments. Some also offer in-room treatments. Spa hotels are ideal if you are looking for some R&R during your vacation.