Find Boutique Hotels in Over-the-Rhine, OH

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Check availability on Over-the-Rhine Boutique Hotels

Tonight
6 Dec - 7 Dec
Tomorrow
7 Dec - 8 Dec
Next weekend
12 Dec - 14 Dec
In two weeks
19 Dec - 21 Dec

Top Over-the-Rhine Boutique Hotels

Egyptian cotton sheets, premium bedding, in-room safe, laptop workspace
21c Museum Hotel Cincinnati

21c Museum Hotel Cincinnati

4.5 star property
Downtown Cincinnati
8.6 out of 10, Excellent, (1004)
"Very clean rooms, great bar, friendly staff."
United States
Theodore
The price is SAR 539
SAR 662 total
includes taxes & fees
2 Jan - 3 January 2026
21c Museum Hotel Cincinnati
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Over-the-Rhine Hotel Reviews

21c Museum Hotel Cincinnati

21c Museum Hotel Cincinnati

10/10 Excellent
"Beautiful stay in 21C. The only thing that was unusual was the amount of time it took to be served Brunch on Sunday. They were severely understaffed. "
Ellen 1-night trip
Posted 2 days ago
21c Museum Hotel Cincinnati

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Frequently asked questions

What's there to see and do in Over-the-Rhine?
The restaurants is one thing to enjoy while you're in the area. Cincinnati Music Hall, Findlay Market, and Hard Rock Casino Cincinnati are some of the local sights worth visiting. Some other things you might want to enjoy include Know Theatre of Cincinnati, Ensemble Theatre, and Elementz.
What's the best way to get to my boutique hotel in Over-the-Rhine?
You have a few options for traveling to and around Over-the-Rhine. The nearest major airport is Cincinnati, OH (LUK-Cincinnati Municipal - Lunken Field), which is located 4.6 mi (7.4 km) away, but Cincinnati-Northern Kentucky Int'l Airport (CVG) may also be an option. Walk to nearby metro stations like Liberty & Race Tram Stop, 12th & Vine Tram Stop, and Washington Park Tram Stop.