Find Resorts & Hotels with Spas in Mission District, CA

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Mission District Resorts & Hotels with Spas

Our top choices for Mission District hotels with a spa

Exterior
Kimpton Alton Fisherman's Wharf by IHG

Kimpton Alton Fisherman's Wharf by IHG

Kimpton Alton Fisherman's Wharf by IHG
4.5 star property
Fisherman's Wharf
9.2 out of 10, Wonderful, (1514)
"Great hotel with excellent service and a delicious restaurant. "
United States
Kerry
The price is SAR 428
SAR 658 total
includes taxes & fees
22 Dec - 23 Dec
Kimpton Alton Fisherman's Wharf by IHG
Terrace/patio
Fairmont San Francisco

Fairmont San Francisco

Fairmont San Francisco
5.0 star property
Downtown San Francisco
9.0 out of 10, Wonderful, (1429)
"Beautiful hotel "
United States
Xandy
The price is SAR 844
SAR 1,148 total
includes taxes & fees
14 Dec - 15 Dec
Fairmont San Francisco
Exterior
Argonaut Hotel

Argonaut Hotel

Argonaut Hotel
4.5 star property
Fisherman's Wharf
9.4 out of 10, Exceptional, (1198)
"Great location, excellent staff."
United States
Walter
The price is SAR 773
SAR 1,069 total
includes taxes & fees
4 Jan - 5 January 2026
Argonaut Hotel
Terrace/patio
Four Seasons Hotel San Francisco

Four Seasons Hotel San Francisco

Four Seasons Hotel San Francisco
5.0 star property
Downtown San Francisco
9.4 out of 10, Exceptional, (1002)
"great room and staff. "
United States
chunguang
The price is SAR 1,182
SAR 1,391 total
includes taxes & fees
8 Jan - 9 January 2026
Four Seasons Hotel San Francisco
Steam room, aromatherapy, hot stone massages, deep-tissue massages
Casa Madrona Hotel & Spa

Casa Madrona Hotel & Spa

Casa Madrona Hotel & Spa
4.0 star property
Downtown
9.0 out of 10, Wonderful, (1003)
"Nice rooms and friendly staff. The location was excellent!"
United States
Brian
Casa Madrona Hotel & Spa
Couples treatment rooms, deep-tissue massages, Swedish massages, facials
Claremont Resort & Club

Claremont Resort & Club

Claremont Resort & Club
5.0 star property
Claremont Hills
8.8 out of 10, Excellent, (1005)
"Everything about our stay with you was excellent !!!!"
United States
Gene
The price is SAR 1,272
SAR 1,692 total
includes taxes & fees
14 Dec - 15 Dec
Claremont Resort & Club
Gift shop
1 Hotel San Francisco

1 Hotel San Francisco

1 Hotel San Francisco
5.0 star property
Downtown San Francisco
9.2 out of 10, Wonderful, (483)
"The staff was incredible and we loved all of the design touches in the room. The attention to detail was impressive. "
United States
Eric
The price is SAR 1,347
SAR 1,798 total
includes taxes & fees
24 Dec - 25 Dec
1 Hotel San Francisco
Front of property
Oceano Hotel and Spa

Oceano Hotel and Spa

Oceano Hotel and Spa
4.0 star property
El Granada
9.4 out of 10, Exceptional, (1000)
"Great resort"
United States
David
The price is SAR 1,179
SAR 1,329 total
includes taxes & fees
5 Jan - 6 January 2026
Oceano Hotel and Spa
Penthouse Suite, 1 King Bed with Sofabed, Ocean View | Premium bedding, down comforters, in-room safe, desk
The Beach House Hotel Half Moon Bay

The Beach House Hotel Half Moon Bay

The Beach House Hotel Half Moon Bay
3.5 star property
El Granada
9.2 out of 10, Wonderful, (987)
"We booked only one night in the hotel but we had a nice time and enjoyed it so much. We liked the complimentary breakfast and our ocean views. "
United States
Tamara
The price is SAR 1,107
SAR 1,298 total
includes taxes & fees
11 Dec - 12 Dec
The Beach House Hotel Half Moon Bay
Hot tub, body treatments, aromatherapy, hot stone massages
Cavallo Point

Cavallo Point

Cavallo Point
4.5 star property
Sausalito
9.2 out of 10, Wonderful, (980)
"Great place to escape near the city. Sebastian at the front desk was great with his customer service. "
United States
Birgit
The price is SAR 2,049
SAR 2,577 total
includes taxes & fees
17 Dec - 18 Dec
Cavallo Point
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Mission District Hotel Reviews

The Marina Inn on San Francisco Bay

The Marina Inn on San Francisco Bay

10/10 Excellent
"Nice"
Felicia 1-night trip
Posted 8 hours ago
The Marina Inn on San Francisco Bay

Explore a world of travel with Expedia

Frequently asked questions

Looking to vacation at a spa hotel in Mission District?
Book one of our wonderful spa hotels and treat yourself from the moment you arrive. Check out the art galleries and bars in Mission District—your day trip starts here. Be sure to pay a visit to the museums during your stay. Spa hotels are the perfect way to break away from your routine and add a layer of luxury to your vacation.
What's there to see and do in Mission District?
Experience Mission District with a stop at San Francisco Public Library, SF Armory, and Mission San Francisco de Asís. If you have a little extra time during your trip, you might want to make a stop at SOMA Pilipinas and Paxton Gate.
What is a Mission District spa hotel?
Spa hotels in Mission District provide lodging and have an on-site spa which offers services such as massages as well as beauty treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on vacation.