Find Luxury Hotels in Mission District, CA

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Check availability on Mission District Luxury Hotels

Tonight
4 Dec - 5 Dec
Tomorrow
5 Dec - 6 Dec
This weekend
5 Dec - 7 Dec
Next weekend
12 Dec - 14 Dec

Top Mission District Luxury Hotels

Lobby sitting area
El Capitan Hotel

El Capitan Hotel

2.0 star property
Mission District
4.6 out of 10, (826)
"Mission district is amazing for food and nightlife. Stayed here because of that. Made a mistake roaches and bugs in the room. Crackheads in parking lot break on to your car (no security) "
United States
Doug
El Capitan Hotel
Outdoor spa tub
Inn San Francisco

Inn San Francisco

2.5 star property
Mission District
9.6 out of 10, Exceptional, (577)
"Amazing breakfast and staff is super helpful."
United States
Stephanie
The price is SAR 910
SAR 1,059 total
includes taxes & fees
4 Jan - 5 January 2026
Inn San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mission District Hotel Reviews

Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

10/10 Excellent
"Hands down the most friendly, helpful staff of any hotel we’ve ever stayed at. Every employee we spoke with was so incredibly kind and eager to help. Very clean rooms. Gorgeous views. We were able to walk to the warf and felt very safe having our car in the garage at the hotel. "
Kathleen 2-night trip
Posted 1 day ago
Hotel Riu Plaza Fisherman's Wharf

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Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Mission District?
Use Expedia to arrange your flight to San Francisco Intl. Airport (SFO) airport or Oakland Intl. Airport (OAK) airport, and then select from a variety of places to stay that will deliver the luxury you want. Amenities are an important consideration when you plan a vacation, so we make it easy to find what you need to make your stay relaxing and comfortable. If you want a posh hotel that has a spa, an indoor pool, or luxury bedding, Expedia can help you find the best luxury hotel experience that Mission District offers. During your visit, you might want to enjoy the bars which Mission District is known for.
What's there to see and do in Mission District?
Take in the sights and attractions that Mission District offers with a visit to San Francisco Public Library, SF Armory, and Mission San Francisco de Asís. If you have spare time during your trip, you might want to make a stop at SOMA Pilipinas and Paxton Gate.
How can I get around Mission District?
It's easier to get around town comfortably when you know your options. Nearby metro stations include 16th Street Mission Station, 24th Street Mission Station, and Right Of Way/20th St Stop.