The Best Hotels Closest to Fort Defiance State Park in Cairo for 2026

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Fort Defiance State Park hotels

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a painting on the wall.

1. La Center Motel

17.5 km from Fort Defiance State Park

Carrie

SAR 209 total

includes taxes & fees

6 Nov - 7 Nov

A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

2. Super 8 by Wyndham Charleston/Sikeston East MO

17.5 km from Fort Defiance State Park

zandra

SAR 247 total

includes taxes & fees

1 Dec - 2 Dec

A building with a fountain and flower beds in front.

3. The Riverstone Hotel Charleston-Sikeston

20.2 km from Fort Defiance State Park

Kathleen

SAR 279 total

includes taxes & fees

7 Nov - 8 Nov

A hotel lobby with a reception desk, seating area, and a large window.

4. Quality Inn Cairo I-57

7.8 km from Fort Defiance State Park

Santiago

SAR 287 total

includes taxes & fees

15 Nov - 16 Nov

A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

5. Eagle Inn Charleston

16.2 km from Fort Defiance State Park

Jackson

SAR 277 total

includes taxes & fees

6 Nov - 7 Nov

View all properties

Compare popular hotels close to Fort Defiance State Park

Property	Property class	Guest rating
La Center Motel	2.0 star property	7.8 Good 24 reviews	View
Super 8 by Wyndham Charleston/Sikeston East MO	2.0 star property	6.8 683 reviews	View
The Riverstone Hotel Charleston-Sikeston	2.5 star property	6.8 443 reviews	View
Quality Inn Cairo I-57	2.5 star property	6.4 296 reviews	View
Eagle Inn Charleston	2.0 star property	6.6 107 reviews	View

Other attractions near Fort Defiance State Park

Columbus-Belmont State Park

7.4/10 (23 reviews)

You can learn about the history of Columbus with a stop at Columbus-Belmont State Park.

See properties

Top Fort Defiance State Park Hotel Reviews

La Center Motel

La Center

10/10 Excellent

Jeffrey

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

Drury Inn & Suites Sikeston, MO

Sikeston

10/10 Excellent

Judy

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

Best Western Plus Sikeston I-55

Sikeston

10/10 Excellent

Anonymous traveler

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

10/10 Excellent

Anonymous traveler

A spacious indoor area with multiple seating arrangements, including benches and tables, and large windows offering views of the outdoors.

Drury Inn & Suites Paducah

Paducah

10/10 Excellent

We were so impressed with all the attention to the detail in everything by everyone, cleanliness of hotel, the kind and helpful staff...for instance, Hannah,we were somehow loss and called for some directions and Hannah's patient help over the phone brought us directly to the Hotels door on/near our arrival. Chase was remarkable from helping get food placed, serving drinks, answering questions behind the desk and those in need of help with the cart all with care and a smile. Because of the...

Diana, Ron, David

A Holiday Inn Express building with a stone facade, multiple windows, and a covered entrance.

Holiday Inn Express Hotel & Suites Paducah West by IHG

Paducah

10/10 Excellent

John

A hotel room with a bed, a desk with a TV, a chair, a bathroom with a bathtub, and a window with curtains.

Comfort Inn & Suites Sikeston I-55

Sikeston

10/10 Excellent

This is a fantastic hotel! The staff is very wonderful and helpful and thoughtful when my father passed away in November of 2017, part of my family stayed at this hotel. Now I am back here waiting for my mother to arrive for we are going to finally get to see my father who was a Vietnam veteran and was buried at the Bloomfield Cemetery has his headstone put up anyhow I have had some difficulties with a lot of the hotels around here in this one is by far the best I would recommend it to anyone.

Anonymous traveler

A conference room with a long table, multiple chairs, and a television screen on the wall.

Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

10/10 Excellent

Anonymous traveler

TownePlace Suites by Marriott Sikeston

Sikeston

10/10 Excellent

Mark

A hotel lobby with a reception desk, a television, and several seating areas with chairs and tables.

Hampton Inn & Suites Paducah

Paducah

10/10 Excellent

Brenda

A spacious lobby with a fireplace, comfortable seating, and a large rug.

Fairfield Inn & Suites by Marriott Paducah

Paducah

10/10 Excellent

Colleen

A modern hotel with a large entrance, multiple floors, and a well-lit facade.

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

Metropolis

10/10 Excellent

Jason

A swimming pool with multiple lanes, lounge chairs, and a view of the outdoors through large windows.

La Quinta Inn & Suites by Wyndham Paducah

Paducah

10/10 Excellent

Maria

Frequently Asked Questions

What's the area like around Fort Defiance State Park?

Fort Defiance State Park is located in Cairo. When you want to settle in and find a place to stay, check out some of the hotels and other accommodations that Expedia offers in the area.

What's the best place to stay close to Fort Defiance State Park?

Quality Inn Cairo I-57 is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and free parking. It's located 4.8 mi (7.8 km) from Fort Defiance State Park. Other good choices around the area include Super 8 by Wyndham Charleston/Sikeston East MO and The Riverstone Hotel Charleston-Sikeston.

If I need to cancel the hotel reservation for my stay near Fort Defiance State Park, will I receive a refund?

Yes! The majority of hotel reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of booking. Put your dates in and click on "Search", then filter by "fully refundable" to review the best options available near Fort Defiance State Park.

Where can I learn more about changing or cancelling my trip in the area near Fort Defiance State Park?

For more information about updating your stay near Fort Defiance State Park or cancelling it, head over to our customer service page.

Find hotels near Fort Defiance State Park, Cairo from SAR 176

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for Fort Defiance State Park hotels

1. La Center Motel

2. Super 8 by Wyndham Charleston/Sikeston East MO

3. The Riverstone Hotel Charleston-Sikeston

4. Quality Inn Cairo I-57

5. Eagle Inn Charleston

Compare popular hotels close to Fort Defiance State Park

Other attractions near Fort Defiance State Park

Columbus-Belmont State Park

Top Fort Defiance State Park Hotel Reviews

La Center Motel

10/10 Excellent

Frequently Asked Questions

What's the area like around Fort Defiance State Park?

What's the best place to stay close to Fort Defiance State Park?

If I need to cancel the hotel reservation for my stay near Fort Defiance State Park, will I receive a refund?

Where can I learn more about changing or cancelling my trip in the area near Fort Defiance State Park?