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12 Aug - 13 Aug
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13 Aug - 14 Aug
This weekend
14 Aug - 16 Aug
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21 Aug - 23 Aug

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Our top choices for Cairo hotels

1. Quality Inn Cairo I-57

Quality Inn Cairo I-57
Cairo
United States
Sharon
SAR 270
SAR 300 total
includes taxes & fees
25 Aug - 26 Aug
Quality Inn Cairo I-57

2. Eagle Inn Charleston

Eagle Inn Charleston
Charleston
United States
Jackson
SAR 260
SAR 289 total
includes taxes & fees
15 Aug - 16 Aug
Eagle Inn Charleston

3. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
Charleston
United States
France
SAR 223
SAR 248 total
includes taxes & fees
16 Aug - 17 Aug
Super 8 by Wyndham Charleston/Sikeston East MO

4. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
Charleston
United States
Bobby
SAR 250
SAR 277 total
includes taxes & fees
7 Sep - 8 Sep
The Riverstone Hotel Charleston-Sikeston

5. La Center Motel

La Center Motel
La Center
United States
Carrie
SAR 176
SAR 209 total
includes taxes & fees
17 Aug - 18 Aug
La Center Motel

6. Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
Cunningham
SAR 559
SAR 1,091 total
includes taxes & fees
22 Aug - 23 Aug
Quiet Country Stay: Modern Home Near Paducah
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Stay near popular Cairo attractions

Fort Defiance State Park

7.4/10 (15 reviews)
Where the mighty Mississippi and Ohio rivers converge, Fort Defiance Park offers a rare view of this natural phenomenon. Explore the historic grounds where Lewis and Clark once trained the Corps of Discovery in 1803.
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Learn more about Cairo

At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artifacts from this once-thriving river port town.

See all hotels in Cairo
A steel bridge with a sunset in the background.

Top Cairo Hotel Reviews

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

10/10 Excellent
"A very clean, quiet, charming house with a fully stocked kitchen. The fresh eggs were delicious and we really enjoyed the property. Jayna was a great host and we would definitely like to return in the future."
Dave R. 3-night trip
Posted 16 hours ago
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

8/10 Good
"The ad and picture for the hotel is a little deceiving. It shows a large fountain in front of the front lobby. There was none. This is the former Quality Inn Hotel was not good at all. The hotel has been cleaned up and rebranded. The room was nice. My only concern was all the bugs that were outside the room door and flew into the room when you opened your door at night. The other thing that I did not like was the surprise $100 fee that I had to pay up front for potential damage to the room. This fee was returned during check out."
James 2-night trip
Posted 2 days ago
The Riverstone Hotel Charleston-Sikeston
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

10/10 Excellent
"Nice staff. Very accommodating."
Domingo 1-night trip
Posted 3 days ago
Super 8 by Wyndham Charleston/Sikeston East MO
Beautiful newly renovated farm house overlooking 5 acre lake. ****New Rates ***

Beautiful newly renovated farm house overlooking 5 acre lake. ****New Rates ***

10/10 Excellent
"When I arrived the beauty of the house and property far exceeded my expectations. Walking into home you can feel 100 years of history, but you quickly realize that the Host has been so attentive to every detail imaginable to make your stay incredible. When you’re in the kitchen sitting around the island enjoying time with friends and family take a moment to look at a book that is there on the shelf telling the history of Union county Illinois. This wonderful home is located in Union County Illinois and to my pleasant surprise, I found a picture of my Great Great Grandfather in this book. He was born in 1876. This is 5 Star accommodations and I encourage you to treat yourself to such luxury."
Anonymous traveler 2-night trip
Posted 4 days ago
Beautiful newly renovated farm house overlooking 5 acre lake. ****New Rates ***
Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge

Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge

10/10 Excellent
"Great place to stay with our dogs while in town visiting family. We were kept busy by the activities available in the cabin and enjoyed the peace outside. We were tempted to ride the trails, which looked nice, but only didn’t because we opted for mud. High likelihood we will be back. Our dogs were happy and so were we."
Alexia G. 2-night trip
Posted 3 weeks ago
Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge
Peaceful secluded cabin located near Horseshoe Lake

Peaceful secluded cabin located near Horseshoe Lake

10/10 Excellent
"We had a great stay at this cabin. This was a dreamy cabin, cozy, and quiet within beautiful nature. The town was small and cute to enjoy local stuff. The hosts were very nice and friendly and give us really good suggestions to enjoy our stay. Very clean, nicely designed, and accessible. Staying in this cabin is a must if you are in the neighborhood."
Banafsheh B. 1-night trip
Posted 3 weeks ago
Peaceful secluded cabin located near Horseshoe Lake
Charming Home just minutes from Interstate and Mall

Charming Home just minutes from Interstate and Mall

10/10 Excellent
"This place is a cozy, charming, clean, close to everything we wanted to see in Paducah place to stay. The neighborhood is quiet and peaceful. The host is very responsive and helpful. I wish we could have stayed longer. We would stay here again."
Vinette M. 2-night trip
Posted 2 months ago
Charming Home just minutes from Interstate and Mall
Charming cottage overlooking Lake Acre

Charming cottage overlooking Lake Acre

10/10 Excellent
"This was our second time staying here and we stayed for a full week. Fully enjoyed the time away from home. I did a lot of fishing and my wife did some crafting. Enjoyed a fire down by the lake with roasted hotdogs and s'mores. Grilled for dinner a couple of times also. Other nights we brought pre-prepared meals. It's a great getaway out away from the cities. Be prepared to relaxed and enjoy!"
Paul B. 6-night trip
Posted 2 months ago
Charming cottage overlooking Lake Acre
Welcoming 4-bedroom house with AC in charming La Center

Welcoming 4-bedroom house with AC in charming La Center

10/10 Excellent
"We needed a 1 night stay, got in late. Great house and it was clean. The only comment I would say and they are very minor is, there was no light outside and it was very dark. Also, the rug at the front door both inside and out, had no grip so we slid around a bit."
vickie b. 1-night trip
Posted 3 months ago
Welcoming 4-bedroom house with AC in charming La Center

More cheap stays in Cairo

La Center Motel

La Center Motel

474 W Kentucky Dr La Center KY
SAR 176
SAR 209 total
17 Aug - 18 Aug
includes taxes & fees
7.6/10 Good! (22 reviews)
La Center Motel
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St Charleston MO
SAR 223
SAR 248 total
16 Aug - 17 Aug
includes taxes & fees
6.6/10 (657 reviews)
Super 8 by Wyndham Charleston/Sikeston East MO
The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

102 Drake St Charleston MO
SAR 250
SAR 277 total
7 Sep - 8 Sep
includes taxes & fees
6.8/10 (426 reviews)
The Riverstone Hotel Charleston-Sikeston
Eagle Inn Charleston

Eagle Inn Charleston

2811 East Marshall Street Charleston MO
SAR 260
SAR 289 total
15 Aug - 16 Aug
includes taxes & fees
6.6/10 (106 reviews)
Eagle Inn Charleston
Quality Inn Cairo I-57

Quality Inn Cairo I-57

13201 Kessler Road Cairo IL
SAR 270
SAR 300 total
25 Aug - 26 Aug
includes taxes & fees
6.4/10 (293 reviews)
Quality Inn Cairo I-57

Find out more about Cairo

Top reasons to visit Cairo

  • Outdoor Adventures: Enjoy golfing, riverboat tours, and scenic recreational areas perfect for nature lovers.
  • Rich History: Explore local attractions that showcase Cairo's unique historical charm and cultural insights.
  • Family-Friendly Atmosphere: Experience a welcoming environment suitable for visitors of all ages.
  • Beautiful Parks: Discover stunning parks that offer relaxing spaces and outdoor activities.
  • Diverse Accommodations: Choose from various lodging options, including agritourism properties and pet-friendly hotels.

Find great hotels in and around Cairo

Discover a variety of hotel accommodations in Cairo, Illinois, perfect for every type of traveler. Whether you're seeking a charming agritourism property, a convenient motel, or pet-friendly options, Cairo has something to offer. Enjoy family-friendly amenities, business travel conveniences, and a welcoming atmosphere for vacationers. Explore the best hotels in the area, read reviews, and find the ideal lodging to enhance your stay in this unique destination.

  • Super 8 by Wyndham Charleston/Sikeston East MO: Nestled 16.1km from Cairo, Super 8 by Wyndham Charleston/Sikeston East MO is an ideal choice for families and pet lovers seeking a comfortable stay. This motel is designed to accommodate families with children, featuring amenities such as complimentary cribs upon reservation. Additionally, the property welcomes pets, making it a convenient option for travelers with furry companions. With a focus on family-friendly services and a welcoming atmosphere, this motel ensures that both kids and pets feel at home during their stay.
  • Quality Inn Charleston - Sikeston: Located 19.3km from Cairo, Quality Inn Charleston - Sikeston caters to pet-friendly travelers and business professionals alike. This hotel provides a comfortable setting for those on the go, with amenities that include flexible pet policies allowing pets with some restrictions. The property is well-equipped for business travel, ensuring all guests have the tools they need for a productive stay. With its blend of convenience and comfort, this hotel offers a reliable option for both work and leisure travelers.
  • Quality Inn Cairo I-57: Situated right in Cairo, Quality Inn Cairo I-57 is perfect for families and pet owners seeking a homey atmosphere. The hotel features child-friendly amenities such as complimentary cribs and a First Aid Kit for peace of mind. Pets are also welcome, making this location ideal for those traveling with dogs. With an emphasis on family-friendly services and a convenient location, this hotel provides a warm and inviting environment for all guests.

Where to stay near Cairo

Cairo, Illinois offers a unique blend of outdoor adventures and historical charm. Visitors can explore beautiful parks, enjoy warm weather, and discover local shops filled with cultural insights. Nearby neighborhoods provide a family-friendly atmosphere perfect for all ages. Whether you're seeking scenic views or engaging in community activities, Cairo and its surroundings promise a memorable experience filled with rich history and vibrant local culture.

  • Mound City: Nestled just 9.7km from Cairo, Mound City offers a delightful mix of outdoor adventure and family-friendly experiences. With its peak visitor seasons in March, July, and October, the city is a popular spot for those looking to enjoy recreational activities. Golf enthusiasts will appreciate its well-kept courses, while nature lovers can explore the nearby national park, forest, and lake. Mound City is the perfect getaway for those wanting to immerse themselves in the great outdoors.
  • Charleston: Located 17.7km from Cairo, Charleston is a vibrant city renowned for its stunning scenery and adventurous spirit. With peak tourism in April and June through July, visitors flock here for outdoor activities and educational experiences. The city boasts a variety of recreational areas and an entertainment arena that hosts various events. Close to historic sites and the national state park, Charleston is a cultural gem waiting to be explored.
  • Villa Ridge: Also situated 17.7km from Cairo, Villa Ridge is an ideal destination for outdoor enthusiasts and sports lovers. The city sees its highest visitor numbers during the summer months of June to August. Guests can enjoy recreational areas and golf courses, all while taking in the picturesque scenery. Surrounded by a national park, lush forests, and serene lakes, Villa Ridge offers a perfect blend of relaxation and adventure.

Things to do near Cairo

Cairo, Illinois, offers a delightful escape for outdoor enthusiasts and adventure seekers. You can enjoy activities like golfing, exploring scenic recreational areas, and embarking on riverboat tours. Additionally, weekend getaways and camping sites provide great options for relaxation and adventure. Don’t miss the chance to explore local attractions and immerse yourself in the area's unique charm.

Shopping

Cairo offers unique shopping experiences at local spots like the Cairo Market for handmade goods and gifts. If you're up for a drive, check out the River Oaks Center in Calumet City, which features a variety of stores and dining options for a more extensive shopping experience.

Recreation

At eDen Spa & Salon, located 45.1km from Cairo, indulge in rejuvenating body treatments that promote relaxation and wellness. The serene atmosphere enhances your experience, allowing you to unwind and recharge in a tranquil setting designed for ultimate relaxation.

Adventure

At Cape Splash Family Aquatic Center, located 49.9km from Cairo, enjoy thrilling water slides and family-friendly pools for a fun-filled day. For outdoor enthusiasts, the Limekin Springs Trail Trailhead, 32.2km away, offers scenic hiking trails perfect for exploring nature and immersing yourself in adventure.

Nightlife

In Cairo, Illinois, the nightlife is laid-back yet inviting, featuring local bars like The Landing and Riverside Grill, where you can enjoy live music and friendly atmospheres. For a relaxed evening, head to the nearby riverfront, perfect for scenic strolls and casual gatherings with friends.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Cairo

To save money on your trip to Cairo, Illinois, consider visiting between November and January when prices are lower. Tuesday is the best day for budget stays, while Saturday tends to be more expensive. Use Expedia to refine your hotel search by budget and location, and look for Eco-certified hotels for sustainable options. For the best deals, arrange your search from lowest to highest price and consider booking a package that combines your hotel, flights, and activities. Enjoy free local attractions and use public transport to further cut costs.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Cairo are November to January, where the prices are slightly lower. This is in comparison to April to May and August, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Cairo is Tuesday. The most expensive day to stay in Cairo is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia's search tool to refine your preferences, such as your budget, desired location, and the type of hotel you’re looking for. For instance, selecting the Eco-certified option will showcase sustainable and environmentally-friendly hotels that are currently available. To find the best prices and deals, simply arrange the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your hotel stay in Cairo with your flights and activities by booking a package through Expedia.

Find the best attractions in and around Cairo

Cairo, Illinois, is perfect for outdoor enthusiasts and adventure seekers, offering a range of scenic experiences. The area features popular attractions such as national parks, nature preserves, and event venues, catering to those interested in culture and nature. Be sure to explore the local sights and immerse yourself in the beautiful surroundings during your visit to Cairo.

  • Fort Defiance State Park: Experience the rich history and culture at Fort Defiance State Park, located right in Cairo. This historic fort offers stunning views where the Mississippi and Ohio Rivers meet, providing a unique backdrop for exploration and relaxation.
  • Ballard Wildlife Management Area: Just 8.0km from Cairo, Ballard Wildlife Management Area is a serene preserve that offers historical insights and a budget-friendly escape. Enjoy birdwatching and wildlife photography amid its diverse habitats.
  • Columbus-Belmont State Park: Located 27.4km away, Columbus-Belmont State Park is a national treasure where outdoor enthusiasts can hike, picnic, and enjoy breathtaking scenery along the river. Adventure awaits with various recreational activities.

Best time to go to Cairo

The best time to visit Cairo is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are moderately low and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January35.2°F (1.8°C)Light RainMostly SunnyModerately LowSlightly Low
February38.5°F (3.6°C)Light RainMostly SunnyModerately LowAverage
March48.7°F (9.3°C)Light RainMostly SunnyModerately HighAverage
April57.7°F (14.3°C)Light RainMostly SunnyModerately HighSlightly High
May67.5°F (19.7°C)Light RainMostly SunnyAverageSlightly High
June76.5°F (24.7°C)Light RainMostly SunnyAverageAverage
July79.0°F (26.1°C)Light RainMostly SunnyAverageAverage
August77.2°F (25.1°C)Light RainMostly SunnyModerately HighSlightly High
September71.6°F (22.0°C)Light RainMostly SunnyAverageAverage
October60.1°F (15.6°C)Light RainMostly SunnyAverageAverage
November47.8°F (8.8°C)Light RainMostly SunnyModerately LowSlightly Low
December40.6°F (4.8°C)Light RainMostly SunnyAverageSlightly Low

The nearest major airports for your trip to Cairo

To visit Cairo, Illinois, you have several airport options. Paducah, KY (PAH-Barkley Regional) is 37.0km away, with nearby hotels like The Respite Bed and Breakfast, rated 4.5 stars, 14.5km from the airport. Marion, IL (MWA-Williamson County Regional) is located 83.7km from Cairo, offering hotels such as Drury Inn & Suites Marion, just 3.2km from the airport. Cape Girardeau, MO (CGI-Cape Girardeau Municipal) is 41.8km away, with Drury Plaza Hotel Cape Girardeau Conference Center, 9.7km from the airport. All these airports provide access to a variety of transportation services to make your stay convenient.

Frequently asked questions

Where is the best place for a stay in Cairo?
Based on our traveler data, Quality Inn Cairo I-57 is one of the top choices for your stay. This hotel offers free breakfast and free parking. Other good choices for your trip to the area are Super 8 by Wyndham Charleston/Sikeston East MO and The Riverstone Hotel Charleston-Sikeston. See all available top hotels, or vacation rentals in Cairo.
What are some of the best vacation rentals in Cairo?
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286: This vacation home rental near Cairo is located in a rural location and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a fridge, a stovetop, and a microwave, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. See all vacation rentals in Cairo.
If I need to cancel my hotel reservation in Cairo, will I receive a refund?
Yes! Most hotel room reservations are refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Cairo.
Where can I learn more about changing or cancelling my trip to Cairo?
For more information about updating your trip to Cairo or cancelling it, head over to our customer service page.
Where is the best hotel to stay close to Fort Defiance?
Quality Inn Cairo I-57 is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and free parking. It's located 4.9 mi (7.8 km) from Fort Defiance. Other good options around the area include Victorian Splendor in So. Illinois: wallmanor.com and Eagle Inn Charleston.
What's the best hotel for staying near Barkley Regional Airport (PAH)?
Drury Inn & Suites Paducah is one of the top choices for your stay and is a popular 3-star hotel featuring free breakfast and an indoor pool. It's located 4.7 mi (7.6 km) from Barkley Regional Airport. Other choices close to the airport include La Quinta Inn & Suites by Wyndham Paducah and Baymont by Wyndham Paducah.
What is staying in Cairo like?
Visitors can enjoy all that Cairo has to offer including the restaurants, entertainment choices, and riverfront. This city also attracts tourists with its small-town vibe. There are 28 hotels and other accommodations in the surrounding area. Find out more about Cairo.
What should I see while I'm in Cairo?
The picturesque setting of Mississippi River and Ohio River Valley exemplify the area's natural beauty. Additionally, you might want to add Fort Defiance State Park to your itinerary. Check out what more to see and do in Expedia's Cairo guide.
What's the seasonal weather like in Cairo?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Cairo is 61 inches.