Our top choices for Upstate South Carolina hotels

The Inn at Patrick Square

Clemson

Karyn

SAR 621 total

includes taxes & fees

14 Jul - 15 Jul

Hampton Inn & Suites Clinton - I-26

Clinton

Sarah

SAR 462 total

includes taxes & fees

26 Jul - 27 Jul

Clemson University's James F. Martin Inn

Clemson

Melissa

SAR 600 total

includes taxes & fees

16 Jul - 17 Jul

Hampton Inn Greer Greenville, SC

Greer

Trina

SAR 569 total

includes taxes & fees

19 Jul - 20 Jul

Holiday Inn Express Gaffney by IHG

Gaffney

melvin

SAR 393 total

includes taxes & fees

17 Jul - 18 Jul

Tru by Hilton Seneca Clemson

Seneca

Jason

SAR 427 total

includes taxes & fees

19 Jul - 20 Jul

Courtyard by Marriott Greenville Mauldin

Greenville

Jonathan

SAR 491 total

includes taxes & fees

12 Jul - 13 Jul

The Shepherd Hotel Downtown Clemson

Clemson

Amy

SAR 583 total

includes taxes & fees

13 Jul - 14 Jul

Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Janet

SAR 452 total

includes taxes & fees

2 Aug - 3 Aug

Four Points by Sheraton Spartanburg

Spartanburg

Susan

SAR 496 total

includes taxes & fees

19 Jul - 20 Jul

Hilton Garden Inn Anderson

Anderson

Maureen

SAR 414 total

includes taxes & fees

15 Jul - 16 Jul

Hampton Inn Gaffney

Gaffney

Cristen

SAR 357 total

includes taxes & fees

2 Aug - 3 Aug

3 restaurants; breakfast and dinner served

AC Hotel by Marriott Spartanburg

Spartanburg

Carla

SAR 663 total

includes taxes & fees

19 Jul - 20 Jul

Hampton Inn & Suites Greenville Airport, SC

Greenville

Thomas Christian

SAR 442 total

includes taxes & fees

24 Jul - 25 Jul

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Anderson

Gina

SAR 458 total

includes taxes & fees

2 Aug - 3 Aug

Tru by Hilton Spartanburg

Spartanburg

Hester L.

SAR 382 total

includes taxes & fees

23 Jul - 24 Jul

Spartanburg Marriott

Spartanburg

Katherine

SAR 492 total

includes taxes & fees

19 Jul - 20 Jul

Lakeside Lodge Clemson

Seneca

Kelly

SAR 508 total

includes taxes & fees

10 Jul - 11 Jul

Best Western Plus Clemson Hotel & Conference Center

Clemson

Nancy

SAR 397 total

includes taxes & fees

10 Jul - 11 Jul

Embassy Suites by Hilton Greenville Downtown Riverplace

Greenville Downtown

Robert

SAR 589 total

includes taxes & fees

2 Aug - 3 Aug

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Vacation Rentals in Upstate South Carolina

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Awesome place "

Apartment

Landing Apartments Greer - Sugar Creek

Greer

"The apartment was clean. Excellent value for stay. Amenities were great. Will book again!"

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Great deal for the location. Apartment needed a little bit of love/attention."

Aparthotel

Full-size fridge, microwave, oven, stovetop

stayAPT Suites Greenville-Haywood Mall

Greenville

"This is a great hotel for the price!!"

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

2 Mi to Downtown: Luxe Greenville Retreat!

Greenville

"Great house! Very clean and comfortable. Outstanding amenities. Conveniently located. "

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

Cottage

Greer Guest House < 1 Mi to Park & Downtown Area!

Greer

"Nice place en Greenville area "

Cottage

Waterfront Seneca Cabin ~ 4 Mi to Boat Launch!

Seneca

"Beautiful and quaint cabin! Highly recommend, great view of the lake."

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

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An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Top Upstate South Carolina Hotel Reviews

Hyatt Place Greenville Downtown

10/10 Excellent

"We like Hyatt Place wherever we go!"

Best Western Plus Greenville I-385 Inn & Suites

10/10 Excellent

"We were just passing through and stayed one night. We were very impressed. Staff was great, easy check-in, room was clean and spacious. We loved that it was a huge shower only. Dining places nearby. Not noisy despite being in a busy area on the interstate. The breakfast area was nice and clean and the breakfast was really good with a great variety of food options."

Hotel Hartness

10/10 Excellent

"Hotel Hartness delivered exactly the kind of refined, quietly confident hospitality my wife and I look for — especially on a birthday stay. We visited June 25–26, and the experience felt thoughtfully elevated without ever drifting into pretense. The property itself has that rare balance of architectural clarity and warmth: clean lines, beautiful natural light, and a sense of calm that feels intentional rather than manufactured. As someone who spent years at Michelin North America helping launch the Michelin Guide in the U.S., I’m attuned to the small signals of a well-run hotel — staff cadence, service pacing, environmental detail, and the ability to make a stay feel personal without being intrusive. Hartness hits those notes. Our room was immaculate, quiet, and genuinely comfortable, with the kind of finishing touches that show someone cared about the guest experience rather than just the design brief. My wife’s birthday was acknowledged with sincerity, not script — a detail that matters more than any amenity. Patterson Kitchen + Bar Dinner at Patterson Kitchen + Bar was the highlight. The kitchen cooks with confidence: balanced seasoning, clean execution, and a sense of place in the ingredients. Hotel Hartness is a property that understands modern Southern hospitality: understated luxury, genuine warmth, and a culinary program that stands on its own. For a birthday getaway, it was exactly right."