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Our top choices for Upstate South Carolina hotels

Spa

1. Best Western Plus Greenville I-385 Inn & Suites

Greenville

Robin

SAR 430 total

includes taxes & fees

2 Aug - 3 Aug

2. Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Angela

SAR 437 total

includes taxes & fees

13 Aug - 14 Aug

3. Drury Inn & Suites Greenville

Greenville

Mark

SAR 475 total

includes taxes & fees

13 Aug - 14 Aug

4. SpringHill Suites by Marriott Greenville Downtown

Greenville Downtown

Robert

SAR 511 total

includes taxes & fees

16 Aug - 17 Aug

5. Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Greenville

Jessica

SAR 376 total

includes taxes & fees

30 Aug - 31 Aug

6. Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG

Simpsonville

Alicia

SAR 450 total

includes taxes & fees

14 Aug - 15 Aug

7. Courtyard by Marriott Greenville Mauldin

Greenville

sarah

SAR 450 total

includes taxes & fees

9 Aug - 10 Aug

8. Homewood Suites by Hilton Greenville Downtown

Greenville Downtown

Christion

SAR 567 total

includes taxes & fees

13 Aug - 14 Aug

9. Comfort Suites Greenville Airport

Greenville

Chandler

SAR 418 total

includes taxes & fees

23 Aug - 24 Aug

10. DoubleTree by Hilton Greenville Woodruff Road

Greenville

Jennifer

SAR 471 total

includes taxes & fees

23 Aug - 24 Aug

11. Hampton Inn & Suites Greenville-Downtown-RiverPlace

Greenville Downtown

Danny

SAR 623 total

includes taxes & fees

16 Aug - 17 Aug

12. Greenville Marriott

Greenville

John

SAR 434 total

includes taxes & fees

14 Aug - 15 Aug

13. Hyatt Place Greenville Downtown

Greenville Downtown

Mark

SAR 575 total

includes taxes & fees

16 Aug - 17 Aug

14. Hilton Garden Inn Greenville

Greenville

Robert

SAR 415 total

includes taxes & fees

23 Aug - 24 Aug

15. Staybridge Suites Greenville I-85 Woodruff Road by IHG

Greenville

Dean B.

SAR 555 total

includes taxes & fees

28 Aug - 29 Aug

16. Embassy Suites by Hilton Greenville Downtown Riverplace

Greenville Downtown

Michael

SAR 606 total

includes taxes & fees

16 Aug - 17 Aug

17. Courtyard by Marriott Greenville Haywood Mall

Greenville

Sherise

SAR 415 total

includes taxes & fees

23 Aug - 24 Aug

18. Courtyard by Marriott Greenville Downtown

Greenville Downtown

rola

SAR 554 total

includes taxes & fees

16 Aug - 17 Aug

19. Hampton Inn Greer Greenville, SC

Greer

Teresa

SAR 569 total

includes taxes & fees

9 Aug - 10 Aug

20. Holiday Inn Greenville - Woodruff Road by IHG

Greenville

Jennifer

SAR 425 total

includes taxes & fees

30 Aug - 31 Aug

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Vacation Rentals in Upstate South Carolina

Aparthotel

Coffee/tea maker, full-size fridge, microwave, oven

stayAPT Suites Greenville-Haywood Mall

Greenville

"This is a great hotel for the price!!"

Apartment

Landing Apartments Greer - Sugar Creek

Greer

"Very good check in instructions. Very roomy and very quiet. Much more relaxing than a hotel room. Worth every penny."

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"We had a great time, very close to eating and shopping. The amenities were very helpful and we felt the area was very safe. We had an issue with getting a ticket even though we paid for parking but it was taken care of within an hour!"

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Cabin very cozy, pet friendly… great place to be disconnected for a couple days!! "

Aparthotel

The Station by Compo Hotels

Travelers Rest

"Lovely place to stay. Very clean and well appointed. The host was responsive and welcoming. Comfortable bed and quiet. Highly recommend."

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

Cozy Home in Historic Area ~ 2 Mi to Main St!

Greenville

"Absolutely adorable property. Little bit of an interesting part of town. We weren’t spending a bunch of time on property so it didn’t mater. Super close to down town and the house is well kept. "

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cottage

2 Mi to Downtown: Luxe Greenville Retreat!

Greenville

"Great house! Very clean and comfortable. Outstanding amenities. Conveniently located. "

Cottage

Cozy Greenville Bungalow ~ 2 Mi to Downtown!

Greenville

"Amazing place. Great host. "

Cottage

Stay at Jos Taylor Retreat: 9 Mi to Greenville!

Taylors

"This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer."

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina

An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Top Upstate South Carolina Hotel Reviews

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

10/10 Excellent

"The front desk lady was so sweet and helpful i think her name was rose"

Embassy Suites Greenville Golf Resort & Conference Center

10/10 Excellent

"I ended up staying for an extra night because my flight was delayed. Both staff that checked me in each time were top notch. Very professional and polite. Asked us about our trip and thanked us for staying there. Best service I could ever expect. Thank you."