Midtown, MO

St. Louis

Midtown
Photo by throwingsofas
Photo by Karissa Krull
Photo by Linda Garrison
Photo by Sophie R

Popular places to visit


Midtown Hotel Deals

Element St. Louis Midtown

Element St. Louis Midtown

3 out of 5
3763 Forest Park Avenue St. Louis MO
The price is SAR 506 per night from Jan 23 to Jan 24
SAR 506
SAR 592 total
23 Jan - 24 Jan
includes taxes & fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
9/10 Wonderful! (658 reviews)
Clean room, staff, location

Reviewed on 30 December 2025

Element St. Louis Midtown
Residence Inn by Marriott St Louis Downtown

Residence Inn by Marriott St Louis Downtown

3 out of 5
525 S Jefferson Ave St. Louis MO
The price is SAR 428 per night from Jan 25 to Jan 26
SAR 428
SAR 508 total
25 Jan - 26 Jan
includes taxes & fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, a 24-hour fitness center, and parking (surcharge). Our guests praise the breakfast ...
7.8/10 Good! (1,000 reviews)
Staff was courteous. Breakfast was great. Bedroom and bathroom were clean.

Reviewed on 1 January 2026

Residence Inn by Marriott St Louis Downtown
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
The price is SAR 469 per night from Jan 18 to Jan 19
SAR 469
SAR 553 total
18 Jan - 19 Jan
includes taxes & fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (4,043 reviews)
Room was clean, excellent view!

Reviewed on 13 January 2026

Hyatt Regency St. Louis at The Arch
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
The price is SAR 539 per night from Feb 8 to Feb 9
SAR 539
SAR 649 total
8 Feb - 9 Feb
includes taxes & fees
Book a stay at this luxury hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the restaurant in our ...
9/10 Wonderful! (1,543 reviews)
Quirky and boho chic accommodate

Reviewed on 12 January 2026

21C Museum Hotel St Louis
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4 out of 5
421 N 8th St St. Louis MO
The price is SAR 327 per night from Jan 25 to Jan 26
SAR 327
SAR 389 total
25 Jan - 26 Jan
includes taxes & fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
8.6/10 Excellent! (1,190 reviews)
Wonderful stay

Reviewed on 8 January 2026

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
The price is SAR 353 per night from Jan 24 to Jan 25
SAR 353
SAR 412 total
24 Jan - 25 Jan
includes taxes & fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.8/10 Excellent! (3,070 reviews)
Nice place — this hotel is a little older but clean, the rooms are spacious and nice— the showers are amazing and the breakfast buffet is great — could use better and stronger coffee.

Reviewed on 14 January 2026

Clayton Plaza Hotel & Extended Stay
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighborhoods around Midtown

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The Gate

While there might not be top attractions in The Gate, you can explore the larger area and discover places like St. Louis Union Station and Busch Stadium.

The Gate
St. Louis which includes interior views

Downtown West

If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.

Downtown West
Lafayette Square which includes a house and a garden

Lafayette Square

The restaurants and shopping are a few reasons travelers visit Lafayette Square. Though there aren't many top sights in the neighborhood, you can visit St. Louis Union Station and Busch Stadium, a few notable attractions nearby.

Lafayette Square
Not just bars but also loft apartments are lit in rainbow lights for Pride weekend in the Grove neighborhood in St. Louis! #LifeAtExpedia

The Grove

The Grove might not have many top sights, but St. Louis Science Center and Missouri Botanical Gardens and Arboretum are two attractions nearby that you can check out.

The Grove
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Shaw

4.5/5(3 area reviews)

While there might not be top attractions in Shaw, you can explore the larger area and discover places like Missouri Botanical Gardens and Arboretum and St. Louis Science Center.

Shaw
Central West End

Central West End

4.5/5(450 area reviews)

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

Central West End