Find all hotels by Motel 6 in Depew, NY from SAR 222
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Check prices for these dates
Our top choices for Depew Motel 6

6.6 out of 10, (1001)
The price is SAR 208
SAR 236 total
includes taxes & fees
16 Jan - 17 January 2026

6.2 out of 10, (1237)
The price is SAR 186
SAR 222 total
includes taxes & fees
31 Dec - 1 January 2026
The price is SAR 233
SAR 264 total
includes taxes & fees
24 Dec - 25 Dec
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Top Depew Hotel Reviews

La Quinta Inn & Suites by Wyndham Buffalo Amherst
10/10 Excellent
Explore a world of travel with Expedia
Depew Hotels by Brand
Hotels near popular Buffalo Attractions
- Hotels near Highmark Stadium
- Hotels near KeyBank Center
- Hotels near University At Buffalo - North Campus
- Hotels near Walden Galleria Mall
- Hotels near Six Flags Darien Lake
- Hotels near Fashion Outlets of Niagara Falls
- Hotels near Buffalo Niagara Convention Center
- Hotels near Shea's Performing Arts Center
- Hotels near University at Buffalo - South Campus
- Hotels near Buffalo Zoo
More Accommodation Types in Depew
Explore more hotels
- La Quinta Inn by Wyndham Buffalo Airport
- The Richardson Hotel
- Homewood Suites by Hilton Buffalo/Amherst
- Motel 6 Amherst, NY - Buffalo
- Hilton Garden Inn Buffalo Airport
- Comfort Inn & Suites Buffalo Airport
- Hilton Garden Inn Buffalo Downtown
- Fairfield Inn & Suites by Marriott Buffalo Amherst/University
- Tru by Hilton Williamsville Buffalo Airport
- Extended Stay America Suites - Buffalo - Airport
- Holiday Inn Express Cheektowaga North East by IHG
- Hyatt Place Buffalo/Amherst
- Hampton Inn & Suites Buffalo Downtown
- Wyndham Garden Buffalo Downtown
- Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG
- Staybridge Suites Buffalo-Amherst by IHG
- Econo Lodge At The Falls North
- La Quinta Inn & Suites by Wyndham Lackawanna
- Holiday Inn Express Hotel & Suites Buffalo-Airport by IHG
- Best Western Summit Inn


















