A bench, a bicycle, and a lake surrounded by trees.

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Go beyond your typical stay in Upstate South Carolina

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Our top choices for Upstate South Carolina hotels

Bed & breakfast

Best Western Plus Greenville I-385 Inn & Suites

Greenville

Terri

SAR 430 total

includes taxes & fees

2 Aug - 3 Aug

Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Bonita

SAR 437 total

includes taxes & fees

12 Aug - 13 Aug

Drury Inn & Suites Greenville

Greenville

Aaron

SAR 491 total

includes taxes & fees

21 Aug - 22 Aug

SpringHill Suites by Marriott Greenville Downtown

Greenville Downtown

Samir

SAR 511 total

includes taxes & fees

9 Aug - 10 Aug

Courtyard by Marriott Greenville Mauldin

Greenville

Jonathan

SAR 450 total

includes taxes & fees

14 Aug - 15 Aug

Hampton Inn & Suites Greenville Airport, SC

Greenville

Dianna

SAR 451 total

includes taxes & fees

21 Aug - 22 Aug

Hilton Greenville

Greenville

Thomas

SAR 484 total

includes taxes & fees

14 Aug - 15 Aug

Homewood Suites by Hilton Greenville Downtown

Greenville Downtown

Christion

SAR 563 total

includes taxes & fees

13 Aug - 14 Aug

Hilton Garden Inn Greenville

Greenville

Robert

SAR 415 total

includes taxes & fees

14 Aug - 15 Aug

Embassy Suites by Hilton Greenville Downtown Riverplace

Greenville Downtown

Sharon

SAR 572 total

includes taxes & fees

16 Aug - 17 Aug

DoubleTree by Hilton Greenville Woodruff Road

Greenville

Jennifer

SAR 471 total

includes taxes & fees

9 Aug - 10 Aug

Comfort Suites Greenville Airport

Greenville

Gary

SAR 418 total

includes taxes & fees

16 Aug - 17 Aug

Hyatt Place Greenville Downtown

Greenville Downtown

Mark

SAR 539 total

includes taxes & fees

26 Jul - 27 Jul

Holiday Inn Express & Suites Greenville S- Piedmont by IHG

Piedmont

Melissa

SAR 432 total

includes taxes & fees

26 Jul - 27 Jul

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Greenville

Ashli

SAR 351 total

includes taxes & fees

16 Aug - 17 Aug

Courtyard by Marriott Greenville Downtown

Greenville Downtown

rola

SAR 554 total

includes taxes & fees

9 Aug - 10 Aug

Holiday Inn Greenville - Woodruff Road by IHG

Greenville

Kimberley

SAR 409 total

includes taxes & fees

26 Jul - 27 Jul

Hampton Inn & Suites Greenville-Downtown-RiverPlace

Greenville Downtown

Cole

SAR 612 total

includes taxes & fees

16 Aug - 17 Aug

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

Greenville

Kelley

SAR 327 total

includes taxes & fees

5 Aug - 6 Aug

Hotel Hartness

Greenville

Lauren

SAR 843 total

includes taxes & fees

26 Jul - 27 Jul

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Vacation Rentals in Upstate South Carolina

Aparthotel

Coffee/tea maker, full-size fridge, microwave, oven

stayAPT Suites Greenville-Haywood Mall

Greenville

"This is a great hotel for the price!!"

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Love the location. Room was great."

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Cabin very cozy, pet friendly… great place to be disconnected for a couple days!! "

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

Cozy Home in Historic Area ~ 2 Mi to Main St!

Greenville

"Absolutely adorable property. Little bit of an interesting part of town. We weren’t spending a bunch of time on property so it didn’t mater. Super close to down town and the house is well kept. "

Cottage

2 Mi to Downtown: Luxe Greenville Retreat!

Greenville

"Great house! Very clean and comfortable. Outstanding amenities. Conveniently located. "

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cottage

Cozy Greenville Bungalow ~ 2 Mi to Downtown!

Greenville

"Amazing place. Great host. "

Cottage

Stay at Jos Taylor Retreat: 9 Mi to Greenville!

Taylors

"This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer."

Cottage

Families Welcome, Fenced Yard: Inviting Greer Home

Greer

"This property is such an amazing find. Three large bedrooms, very clean and well maintained. Close to town of Greer and all amenities. Very easy check-in. Beds very comfortable. Kitchen well equipped for the week we were there."

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina

An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Top Upstate South Carolina Hotel Reviews

Lakeside Lodge Clemson

10/10 Excellent

"The only place we will stay!"

The Shepherd Hotel Downtown Clemson

10/10 Excellent

"We have found an absolute treasure in downtown Clemson, S.C.! From the moment we arrived we were greeted with smiling faces that made us feel like we were honored guests. From the maintenance staff to the front desk, everyone was eager to help us relax and enjoy our stay. The bar service was excellent, and we really enjoyed our hand mixed signature cocktails on the terrace overlooking downtown and Death Valley. The hotel is just steps from the campus and about a 15-minute walk to the world's best ice cream at Clemson's famous '55 Exchange. The hotel itself is absolutely beautiful, the bathrooms are spotless, and the bedding in our room was perfectly comfortable. There are plenty of boutiques, restaurants, and bars in walking distance. There are also a number of state parks, Lake Hartwell, and the South Carolina Botanical Garden if you love to get outside. The Clemson University campus, though experiencing exponential growth and construction projects, is still full of natural beauty worth exploring. Being it was summer and most students had left campus for break; the area bars and restaurants were much less crowded and relaxed. We look forward to staying here again soon."

Best Western Plus Clemson Hotel & Conference Center

10/10 Excellent

"Location was great for our visit to Clemson University. Close to everything. Good breakfast included in our room, Spacious rooms and confortable beds. The only suggestion would be that the hotel in general needs to be refreshed. Although well maintained, you can tell that it needs some updating."