Top 10 Hotels in Upstate South Carolina, SC - Competitive Prices

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Upstate South Carolina hotels

Spa

1. Best Western Plus Greenville I-385 Inn & Suites

Greenville

Sidney

SAR 434 total

includes taxes & fees

9 Aug - 10 Aug

2. Drury Inn & Suites Greenville

Greenville

Aaron

SAR 475 total

includes taxes & fees

16 Aug - 17 Aug

3. SpringHill Suites by Marriott Greenville Downtown

Greenville Downtown

Don

SAR 526 total

includes taxes & fees

16 Aug - 17 Aug

4. DoubleTree by Hilton Greenville Woodruff Road

Greenville

Jennifer

SAR 485 total

includes taxes & fees

9 Aug - 10 Aug

5. Courtyard by Marriott Greenville Mauldin

Greenville

sarah

SAR 450 total

includes taxes & fees

9 Aug - 10 Aug

6. Comfort Suites Greenville Airport

Greenville

Chandler

SAR 419 total

includes taxes & fees

30 Aug - 31 Aug

7. Hampton Inn & Suites Greenville-Downtown-RiverPlace

Greenville Downtown

Danny

SAR 619 total

includes taxes & fees

16 Aug - 17 Aug

8. Embassy Suites by Hilton Greenville Downtown Riverplace

Greenville Downtown

cade

SAR 590 total

includes taxes & fees

9 Aug - 10 Aug

9. Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Greenville

Jessica

SAR 413 total

includes taxes & fees

16 Aug - 17 Aug

10. Courtyard by Marriott Greenville Downtown

Greenville Downtown

Cheryl

SAR 571 total

includes taxes & fees

9 Aug - 10 Aug

11. Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG

Simpsonville

Alicia

SAR 500 total

includes taxes & fees

13 Aug - 14 Aug

12. The Westin Poinsett Greenville

Greenville Downtown

Andre

SAR 773 total

includes taxes & fees

16 Aug - 17 Aug

13. Hyatt Place Greenville Downtown

Greenville Downtown

Jessica

SAR 575 total

includes taxes & fees

9 Aug - 10 Aug

14. Hilton Greenville

Greenville

Thomas

SAR 485 total

includes taxes & fees

10 Aug - 11 Aug

15. Fairfield Inn & Suites by Marriott Greenville Simpsonville

Simpsonville

Carole

SAR 330 total

includes taxes & fees

13 Aug - 14 Aug

16. La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

Greenville

Kelley

SAR 345 total

includes taxes & fees

1 Sep - 2 Sep

17. Hampton Inn Greenville I-385 - Woodruff Rd.

Greenville

Anne

SAR 433 total

includes taxes & fees

16 Aug - 17 Aug

18. Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

Greenville

Steven

SAR 316 total

includes taxes & fees

18 Aug - 19 Aug

19. Aloft by Marriott Greenville Downtown

Greenville Downtown

Frank S.

SAR 591 total

includes taxes & fees

16 Aug - 17 Aug

20. Hampton Inn & Suites Greenville Airport, SC

Greenville

Kristina

SAR 483 total

includes taxes & fees

14 Aug - 15 Aug

View all properties

Vacation Rentals in Upstate South Carolina

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"We had a great time, very close to eating and shopping. The amenities were very helpful and we felt the area was very safe. We had an issue with getting a ticket even though we paid for parking but it was taken care of within an hour!"

Aparthotel

Coffee/tea maker, full-size fridge, microwave, oven

stayAPT Suites Greenville-Haywood Mall

Greenville

"All the staff from front desk to housekeeping were excellent, friendly and helpful. If looking for rooms with a feel like home StayApt is what you are looking for. I recommend reserving here great place if you want to cook your own meals"

Apartment

Landing Apartments Greer - Sugar Creek

Greer

"The apartment was clean. Excellent value for stay. Amenities were great. Will book again!"

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Aparthotel

The Station by Compo Hotels

Travelers Rest

"Lovely place to stay. Very clean and well appointed. The host was responsive and welcoming. Comfortable bed and quiet. Highly recommend."

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Cabin very cozy, pet friendly… great place to be disconnected for a couple days!! "

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

Cozy Home in Historic Area ~ 2 Mi to Main St!

Greenville

"Absolutely adorable property. Little bit of an interesting part of town. We weren’t spending a bunch of time on property so it didn’t mater. Super close to down town and the house is well kept. "

Cottage

2 Mi to Downtown: Luxe Greenville Retreat!

Greenville

"Great house! Very clean and comfortable. Outstanding amenities. Conveniently located. "

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cottage

Cozy Greenville Bungalow ~ 2 Mi to Downtown!

Greenville

"Amazing place. Great host. "

Cottage

Stay at Jos Taylor Retreat: 9 Mi to Greenville!

Taylors

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

See all vacation rentals

Save an average of 15% on thousands of hotels when you're signed in

Sign in

Sign up, it's free

Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.

See properties

Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina

An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Top Upstate South Carolina Hotel Reviews

Hyatt Regency Greenville

8/10 Good

"This location was beautiful...we had the Friday on Main block party and Saturday Farmers market a drug store and a zillion restaurants and boutiques almost right outside the door. I am a walker and the walk to the museums, parks and river trails was very manageable. There are public restrooms and beautiful sights right in town. No need for a car rental. The restaurant in the hotel (The Roost) was excellent and very accommodating."

Embassy Suites by Hilton Greenville Downtown Riverplace

10/10 Excellent

"Location and set-up were just what we needed for our anniversary trip with family. From registration staff to house-keeping staff all employees we interacted with were friendly and proactive in caring for us. Will have to return to experience the rooftop. Made-to-order omelettes were really a nice touch. Happy hour a plus. Loved the size of our room. Nice view of downtown from the pool area."

Hilton Greenville

8/10 Good

"Check-in was a breeze and I can appreciate that after traveling. The fruit-infused water and complimentary water bottles were also appreciated. The lobby was clean and modern. Cons: The room was a bit dated as the top of the closet was peeling and the bench fabric as well. The beds were lackluster and I found hair under the sheets and a few stains on the comforter. We made it work, but for the costs, expectations were high. Would I Book Again: If the rooms are updated to match the lobby asthetic and the amenities are upgraded, I would book again."