A bench, a bicycle, and a lake surrounded by trees.

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Go beyond your typical stay in Upstate South Carolina

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Our top choices for Upstate South Carolina hotels

Bed & breakfast

Best Western Plus Greenville I-385 Inn & Suites

Greenville

Shabana

SAR 416 total

includes taxes & fees

22 Jul - 23 Jul

Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Bonita

SAR 415 total

includes taxes & fees

16 Aug - 17 Aug

Drury Inn & Suites Greenville

Greenville

Aaron

SAR 475 total

includes taxes & fees

12 Aug - 13 Aug

SpringHill Suites by Marriott Greenville Downtown

Greenville Downtown

Samir

SAR 511 total

includes taxes & fees

2 Aug - 3 Aug

Hyatt Place Greenville Downtown

Greenville Downtown

John

SAR 540 total

includes taxes & fees

16 Aug - 17 Aug

Hilton Garden Inn Greenville

Greenville

Marcus

SAR 415 total

includes taxes & fees

14 Aug - 15 Aug

DoubleTree by Hilton Greenville Woodruff Road

Greenville

Jennifer

SAR 485 total

includes taxes & fees

9 Aug - 10 Aug

Embassy Suites by Hilton Greenville Downtown Riverplace

Greenville Downtown

Sharon

SAR 590 total

includes taxes & fees

9 Aug - 10 Aug

Holiday Inn Express & Suites Greenville S- Piedmont by IHG

Piedmont

Melissa

SAR 432 total

includes taxes & fees

9 Aug - 10 Aug

Homewood Suites by Hilton Greenville Downtown

Greenville Downtown

Christion

SAR 557 total

includes taxes & fees

16 Aug - 17 Aug

Courtyard by Marriott Greenville Mauldin

Greenville

Jonathan

SAR 450 total

includes taxes & fees

3 Aug - 4 Aug

Hotel Hartness

Greenville

Vlatka

SAR 825 total

includes taxes & fees

19 Jul - 20 Jul

Holiday Inn Greenville - Woodruff Road by IHG

Greenville

Kimberley

SAR 409 total

includes taxes & fees

2 Aug - 3 Aug

Comfort Suites Greenville Airport

Greenville

Cecilia

SAR 418 total

includes taxes & fees

9 Aug - 10 Aug

Hampton Inn & Suites Greenville-Downtown-RiverPlace

Greenville Downtown

Jennifer

SAR 639 total

includes taxes & fees

19 Jul - 20 Jul

Hampton Inn & Suites Greenville Airport, SC

Greenville

Dianna

SAR 415 total

includes taxes & fees

14 Aug - 15 Aug

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

Greenville

Anthony

SAR 337 total

includes taxes & fees

10 Aug - 11 Aug

Aloft by Marriott Greenville Downtown

Greenville Downtown

Johari

SAR 503 total

includes taxes & fees

2 Aug - 3 Aug

Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

Greenville

Steven

SAR 316 total

includes taxes & fees

2 Aug - 3 Aug

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Greenville

Ashli

SAR 345 total

includes taxes & fees

9 Aug - 10 Aug

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Vacation Rentals in Upstate South Carolina

Aparthotel

Coffee/tea maker, full-size fridge, microwave, oven

stayAPT Suites Greenville-Haywood Mall

Greenville

"This is a great hotel for the price!!"

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Love the location. Room was great."

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Awesome place "

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

Cozy Home in Historic Area ~ 2 Mi to Main St!

Greenville

"Absolutely adorable property. Little bit of an interesting part of town. We weren’t spending a bunch of time on property so it didn’t mater. Super close to down town and the house is well kept. "

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cottage

2 Mi to Downtown: Luxe Greenville Retreat!

Greenville

"Great house! Very clean and comfortable. Outstanding amenities. Conveniently located. "

Cottage

Cozy Greenville Bungalow ~ 2 Mi to Downtown!

Greenville

"Amazing place. Great host. "

Cottage

Stay at Jos Taylor Retreat: 9 Mi to Greenville!

Taylors

"This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer."

Cottage

Families Welcome, Fenced Yard: Inviting Greer Home

Greer

"This property is such an amazing find. Three large bedrooms, very clean and well maintained. Close to town of Greer and all amenities. Very easy check-in. Beds very comfortable. Kitchen well equipped for the week we were there."

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina

An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Top Upstate South Carolina Hotel Reviews

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

10/10 Excellent

"Clean room, helpful staff, okay breakfast, and close to everything in town"

Days Inn by Wyndham Greenville

8/10 Good

"We were on the 2nd floor and had a brand new TV! However we only got about 20 stations as all the others had no signal. Our door did not have a bar to so it never closed by itself and when it did close the dead bolt wouldn't work because the door was not fully flush at the bottom. The ac did not work well and did this high pitch squeal all night so I turned it off only to hear traffic and ambulance and police sirens all night."

Courtyard by Marriott Greenville Haywood Mall

8/10 Good

"The hotel is nice, not the top notch Marriott. Since they don't offer breakfast, they should at least have free coffee in the lounge. It's crazy to pay $10 a night for self-parking in their lot. We didn't see any sign of security around. Room was comfortable."