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Our top choices for Upstate South Carolina hotels

Spa

1. Best Western Plus Greenville I-385 Inn & Suites

Greenville

Sidney

SAR 390 total

includes taxes & fees

9 Aug - 10 Aug

2. Drury Inn & Suites Greenville

Greenville

Aaron

SAR 475 total

includes taxes & fees

12 Aug - 13 Aug

3. SpringHill Suites by Marriott Greenville Downtown

Greenville Downtown

Robert

SAR 511 total

includes taxes & fees

16 Aug - 17 Aug

4. DoubleTree by Hilton Greenville Woodruff Road

Greenville

Jennifer

SAR 467 total

includes taxes & fees

30 Aug - 31 Aug

5. Courtyard by Marriott Greenville Mauldin

Greenville

sarah

SAR 450 total

includes taxes & fees

9 Aug - 10 Aug

6. Comfort Suites Greenville Airport

Greenville

Chandler

SAR 418 total

includes taxes & fees

23 Aug - 24 Aug

7. Hampton Inn & Suites Greenville-Downtown-RiverPlace

Greenville Downtown

Danny

SAR 623 total

includes taxes & fees

17 Aug - 18 Aug

8. Embassy Suites by Hilton Greenville Downtown Riverplace

Greenville Downtown

Michael

SAR 625 total

includes taxes & fees

16 Aug - 17 Aug

9. Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Greenville

Jessica

SAR 376 total

includes taxes & fees

30 Aug - 31 Aug

10. Courtyard by Marriott Greenville Downtown

Greenville Downtown

rola

SAR 571 total

includes taxes & fees

9 Aug - 10 Aug

11. Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG

Simpsonville

Alicia

SAR 450 total

includes taxes & fees

14 Aug - 15 Aug

12. The Westin Poinsett Greenville

Greenville Downtown

Andre

SAR 751 total

includes taxes & fees

16 Aug - 17 Aug

13. Hyatt Place Greenville Downtown

Greenville Downtown

Mark

SAR 574 total

includes taxes & fees

9 Aug - 10 Aug

14. Hilton Greenville

Greenville

Thomas

SAR 484 total

includes taxes & fees

30 Aug - 31 Aug

15. Fairfield Inn & Suites by Marriott Greenville Simpsonville

Simpsonville

Carole

SAR 348 total

includes taxes & fees

2 Aug - 3 Aug

16. La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

Greenville

Kelley

SAR 345 total

includes taxes & fees

5 Aug - 6 Aug

17. Hampton Inn Greenville I-385 - Woodruff Rd.

Greenville

Anne

SAR 502 total

includes taxes & fees

31 Aug - 1 Sep

18. Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

Greenville

Steven

SAR 316 total

includes taxes & fees

16 Aug - 17 Aug

19. Aloft by Marriott Greenville Downtown

Greenville Downtown

Johari

SAR 515 total

includes taxes & fees

9 Aug - 10 Aug

20. Hampton Inn & Suites Greenville Airport, SC

Greenville

Kristina

SAR 469 total

includes taxes & fees

23 Aug - 24 Aug

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Vacation Rentals in Upstate South Carolina

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"We had a great time, very close to eating and shopping. The amenities were very helpful and we felt the area was very safe. We had an issue with getting a ticket even though we paid for parking but it was taken care of within an hour!"

Aparthotel

Coffee/tea maker, full-size fridge, microwave, oven

stayAPT Suites Greenville-Haywood Mall

Greenville

"This is a great hotel for the price!!"

Apartment

Landing Apartments Greer - Sugar Creek

Greer

"Very good check in instructions. Very roomy and very quiet. Much more relaxing than a hotel room. Worth every penny."

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Cabin very cozy, pet friendly… great place to be disconnected for a couple days!! "

Aparthotel

The Station by Compo Hotels

Travelers Rest

"Lovely place to stay. Very clean and well appointed. The host was responsive and welcoming. Comfortable bed and quiet. Highly recommend."

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

Cozy Home in Historic Area ~ 2 Mi to Main St!

Greenville

"Absolutely adorable property. Little bit of an interesting part of town. We weren’t spending a bunch of time on property so it didn’t mater. Super close to down town and the house is well kept. "

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cottage

2 Mi to Downtown: Luxe Greenville Retreat!

Greenville

"Great house! Very clean and comfortable. Outstanding amenities. Conveniently located. "

Cottage

Cozy Greenville Bungalow ~ 2 Mi to Downtown!

Greenville

"Amazing place. Great host. "

Cottage

Stay at Jos Taylor Retreat: 9 Mi to Greenville!

Taylors

"This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer."

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina

An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Top Upstate South Carolina Hotel Reviews

Best Western Plus Greenville I-385 Inn & Suites

8/10 Good

"Came down for a two day trip. Location was cool to downtown. Everything was good(breakfast , staff, room) except the pool. The pool needs to be cleaned."

Embassy Suites Greenville Golf Resort & Conference Center

10/10 Excellent

"I ended up staying for an extra night because my flight was delayed. Both staff that checked me in each time were top notch. Very professional and polite. Asked us about our trip and thanked us for staying there. Best service I could ever expect. Thank you."