A bench, a bicycle, and a lake surrounded by trees.

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Go beyond your typical stay in Upstate South Carolina

Spa

Apart hotel

Our top choices for Upstate South Carolina hotels

Bed & breakfast

Hampton Inn Greer Greenville, SC

Greer

Trina

SAR 569 total

includes taxes & fees

12 Jul - 13 Jul

Hampton Inn & Suites Clinton - I-26

Clinton

Bobby

SAR 462 total

includes taxes & fees

9 Aug - 10 Aug

Holiday Inn Express Gaffney by IHG

Gaffney

melvin

SAR 374 total

includes taxes & fees

2 Aug - 3 Aug

The Inn at Patrick Square

Clemson

Karyn

SAR 621 total

includes taxes & fees

20 Jul - 21 Jul

Lakeside Lodge Clemson

Seneca

Kelly

SAR 508 total

includes taxes & fees

22 Jul - 23 Jul

Best Western Plus Greenville I-385 Inn & Suites

Greenville

Shabana

SAR 337 total

includes taxes & fees

12 Jul - 13 Jul

Tru by Hilton Seneca Clemson

Seneca

Jason

SAR 433 total

includes taxes & fees

19 Jul - 20 Jul

Clemson University's James F. Martin Inn

Clemson

Jesse

SAR 600 total

includes taxes & fees

19 Jul - 20 Jul

Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Janet

SAR 403 total

includes taxes & fees

2 Aug - 3 Aug

3 restaurants; breakfast and dinner served

AC Hotel by Marriott Spartanburg

Spartanburg

Carla

SAR 663 total

includes taxes & fees

12 Jul - 13 Jul

Hampton Inn & Suites Greenville Airport, SC

Greenville

Dianna

SAR 442 total

includes taxes & fees

24 Jul - 25 Jul

Hampton Inn Gaffney

Gaffney

Cindy

SAR 363 total

includes taxes & fees

2 Aug - 3 Aug

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Anderson

Edna

SAR 412 total

includes taxes & fees

26 Jul - 27 Jul

Fairfield Inn & Suites by Marriott Greenville Simpsonville

Simpsonville

Nayeli

SAR 348 total

includes taxes & fees

12 Jul - 13 Jul

Best Western Spartanburg I-26

Spartanburg

Daniel

SAR 363 total

includes taxes & fees

17 Jul - 18 Jul

Best Western Plus Clemson Hotel & Conference Center

Clemson

Tammy

SAR 397 total

includes taxes & fees

13 Jul - 14 Jul

Tru by Hilton Spartanburg

Spartanburg

Michael

SAR 383 total

includes taxes & fees

23 Jul - 24 Jul

SpringHill Suites by Marriott Greenville Downtown

Greenville Downtown

Samir

SAR 511 total

includes taxes & fees

19 Jul - 20 Jul

Spartanburg Marriott

Spartanburg

Katherine

SAR 492 total

includes taxes & fees

19 Jul - 20 Jul

Four Points by Sheraton Spartanburg

Spartanburg

Susan

SAR 496 total

includes taxes & fees

19 Jul - 20 Jul

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Vacation Rentals in Upstate South Carolina

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Awesome place "

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Great deal for the location. Apartment needed a little bit of love/attention."

Aparthotel

Full-size fridge, microwave, oven, stovetop

stayAPT Suites Greenville-Haywood Mall

Greenville

"This is a great hotel for the price!!"

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Apartment

Lake Keowee Resort Condo: Waterfront Balcony

Salem

"Very clean. Amazing amenities. Lake view that takes your breath away."

Cottage

2 Mi to Downtown: Luxe Greenville Retreat!

Greenville

"Great house! Very clean and comfortable. Outstanding amenities. Conveniently located. "

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cottage

Stay at Jos Taylor Retreat: 9 Mi to Greenville!

Taylors

"This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer."

Cottage

Families Welcome, Fenced Yard: Inviting Greer Home

Greer

"This property is such an amazing find. Three large bedrooms, very clean and well maintained. Close to town of Greer and all amenities. Very easy check-in. Beds very comfortable. Kitchen well equipped for the week we were there."

Cottage

Cozy Greenville Bungalow ~ 2 Mi to Downtown!

Greenville

"Amazing place. Great host. "

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina

An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Top Upstate South Carolina Hotel Reviews

Hotel Hartness

8/10 Good

"I have loved this hotel since it opened, and I have given it rave reviews in the past. I stay at least once a year, but this trip was definitely a surprise. If you are a repeat guest and you haven’t been around since December, then you’ll be sad to find as I was that the vibe has changed from what I think made it so special into much more of a Corporate hotel. There was always a breakfast that was free and everybody would gather around eat together, Chat, meet each other like a community. It truly represented the vibe and feel of this property. Sadly that is gone now to almost a Starbucks like counter with prices behind the board and a shopping area.. While I appreciate having an area where I can buy popcorn and drinks if I would like that, it completely changes what made this hotel so special. You can get past that with the amazing restaurant fantastic spa gorgeous ROOMS and refreshing Pool. Sadly, the pool service, which used to have amazing food, with a person there and a bar downstairs seems now at least during the week,, (also Friday) not available any longer. There was just a small little menu and everybody walking all the way up to the building to bring their own drinks down. Not the end of the world but definitely another change that isn’t the spirit of this hotel and both of these decisions made this particular trip, lacking. The property is beautiful, beds are comfortable. Restaurant is fantastic. The staff iA+ it was just better before. Solid B+ to A~"

Best Western Plus Clemson Hotel & Conference Center

8/10 Good

"Room was clean as taff was nice our bathroom pipes were making sounds in the room so they let us Change rooms with no issues. The new girl at the front desk was new and very kind but charged us after we had reservation with Expedia but that is being credited to us. Expedia helped in that situation. But all in all it was a nice comfortable hotel and I would stay again. It was a good location as well."