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Our top choices for Upstate South Carolina hotels

Best Western Plus Greenville I-385 Inn & Suites

Greenville

Terri

SAR 429 total

includes taxes & fees

2 Aug - 3 Aug

Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Angela

SAR 403 total

includes taxes & fees

16 Aug - 17 Aug

Drury Inn & Suites Greenville

Greenville

Mark

SAR 475 total

includes taxes & fees

16 Aug - 17 Aug

SpringHill Suites by Marriott Greenville Downtown

Greenville Downtown

Robert

SAR 511 total

includes taxes & fees

9 Aug - 10 Aug

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Greenville

SAR 351 total

includes taxes & fees

16 Aug - 17 Aug

Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG

Simpsonville

Alicia

SAR 512 total

includes taxes & fees

15 Aug - 16 Aug

Courtyard by Marriott Greenville Mauldin

Greenville

sarah

SAR 450 total

includes taxes & fees

9 Aug - 10 Aug

Homewood Suites by Hilton Greenville Downtown

Greenville Downtown

Christion

SAR 553 total

includes taxes & fees

13 Aug - 14 Aug

Comfort Suites Greenville Airport

Greenville

Chandler

SAR 437 total

includes taxes & fees

24 Aug - 25 Aug

DoubleTree by Hilton Greenville Woodruff Road

Greenville

Jennifer

SAR 471 total

includes taxes & fees

9 Aug - 10 Aug

Hampton Inn & Suites Greenville-Downtown-RiverPlace

Greenville Downtown

Lee

SAR 612 total

includes taxes & fees

16 Aug - 17 Aug

Greenville Marriott

Greenville

John

SAR 434 total

includes taxes & fees

14 Aug - 15 Aug

Hyatt Place Greenville Downtown

Greenville Downtown

Mark

SAR 575 total

includes taxes & fees

2 Aug - 3 Aug

Hilton Garden Inn Greenville

Greenville

SAR 415 total

includes taxes & fees

14 Aug - 15 Aug

Staybridge Suites Greenville I-85 Woodruff Road by IHG

Greenville

SAR 520 total

includes taxes & fees

2 Aug - 3 Aug

Embassy Suites by Hilton Greenville Downtown Riverplace

Greenville Downtown

Michael

SAR 572 total

includes taxes & fees

9 Aug - 10 Aug

Courtyard by Marriott Greenville Haywood Mall

Greenville

Sherise

SAR 414 total

includes taxes & fees

14 Aug - 15 Aug

Courtyard by Marriott Greenville Downtown

Greenville Downtown

rola

SAR 554 total

includes taxes & fees

9 Aug - 10 Aug

Hampton Inn Greer Greenville, SC

Greer

Teresa

SAR 569 total

includes taxes & fees

9 Aug - 10 Aug

Holiday Inn Greenville - Woodruff Road by IHG

Greenville

Jennifer

SAR 408 total

includes taxes & fees

23 Aug - 24 Aug

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Vacation Rentals in Upstate South Carolina

Aparthotel

Coffee/tea maker, full-size fridge, microwave, oven

stayAPT Suites Greenville-Haywood Mall

Greenville

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Love the location. Room was great."

Apartment

Landing Apartments Greer - Sugar Creek

Greer

"Very good check in instructions. Very roomy and very quiet. Much more relaxing than a hotel room. Worth every penny."

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Cabin very cozy, pet friendly… great place to be disconnected for a couple days!! "

Aparthotel

The Station by Compo Hotels

Travelers Rest

"Lovely place to stay. Very clean and well appointed. The host was responsive and welcoming. Comfortable bed and quiet. Highly recommend."

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

Cozy Home in Historic Area ~ 2 Mi to Main St!

Greenville

"Absolutely adorable property. Little bit of an interesting part of town. We weren’t spending a bunch of time on property so it didn’t mater. Super close to down town and the house is well kept. "

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cottage

2 Mi to Downtown: Luxe Greenville Retreat!

Greenville

"Great house! Very clean and comfortable. Outstanding amenities. Conveniently located. "

Cottage

Cozy Greenville Bungalow ~ 2 Mi to Downtown!

Greenville

"Amazing place. Great host. "

Cottage

Stay at Jos Taylor Retreat: 9 Mi to Greenville!

Taylors

"This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer."

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina

An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Top Upstate South Carolina Hotel Reviews

Lakeside Lodge Clemson

8/10 Good

"The first floor room was a little musty smelling but overall a great stay!"

Best Western Plus Clemson Hotel & Conference Center

8/10 Good

"The staff was helpful. Good breakfast. Comforter had a stain…which was not great. Found a towel hook in bathroom on the floor in the morning because it had been put in the wall so many times the wall was coming apart. The toilet seat was coming off. I let staff know about the problems when I checked out and they appreciated it. Seemed like the room/walls need a deep cleaning/updating. However, it was still fine, quiet, and comfortable."

Embassy Suites Greenville Golf Resort & Conference Center

10/10 Excellent

"I ended up staying for an extra night because my flight was delayed. Both staff that checked me in each time were top notch. Very professional and polite. Asked us about our trip and thanked us for staying there. Best service I could ever expect. Thank you."