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Go beyond your typical stay in Upstate South Carolina

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Apart hotel

Our top choices for Upstate South Carolina hotels

Hampton Inn Gaffney

Gaffney

Theresa

SAR 337 total

includes taxes & fees

31 May - 1 Jun

Fairfield Inn & Suites Seneca Clemson Univ Area

Seneca

Sarah

SAR 534 total

includes taxes & fees

25 May - 26 May

Carolina Inn Anderson Clemson Area

Anderson

Trevor

SAR 229 total

includes taxes & fees

24 May - 25 May

Quality Inn Seneca Clemson Area US-123

Downtown

Cheryl

SAR 392 total

includes taxes & fees

10 Jun - 11 Jun

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Anderson

Gina

SAR 442 total

includes taxes & fees

19 Jun - 20 Jun

Lakeside Lodge Clemson

Seneca

Valarie Tina

SAR 508 total

includes taxes & fees

25 May - 26 May

Embassy Suites Greenville Golf Resort & Conference Center

Greenville

James

SAR 453 total

includes taxes & fees

25 May - 26 May

Premium bedding, in-room safe, individually furnished, laptop workspace

Carolina Camp Cedar

Pickens

Katlynn

SAR 967 total

includes taxes & fees

21 May - 22 May

Clemson University's James F. Martin Inn

Clemson

Sara

SAR 621 total

includes taxes & fees

21 May - 22 May

Single Room, 1 King Bed, Non Smoking | Desk, laptop workspace, free WiFi

Deluxe Inn

Mauldin

SAR 260 total

includes taxes & fees

14 Jun - 15 Jun

Hampton Inn Easley

Easley

Jenine

SAR 509 total

includes taxes & fees

7 Jun - 8 Jun

Tru by Hilton Spartanburg

Spartanburg

Gerad

SAR 362 total

includes taxes & fees

14 Jun - 15 Jun

Hampton Inn Greer Greenville, SC

Greer

Alberto

SAR 569 total

includes taxes & fees

22 May - 23 May

The Abernathy of Clemson

Clemson

William

SAR 560 total

includes taxes & fees

24 May - 25 May

Holiday Inn Express Gaffney by IHG

Gaffney

melvin

SAR 348 total

includes taxes & fees

31 May - 1 Jun

Best Western Plus Clemson Hotel & Conference Center

Clemson

Janis

SAR 457 total

includes taxes & fees

31 May - 1 Jun

Comfort Inn & Suites Greer - Greenville

Greer

Paula

SAR 428 total

includes taxes & fees

24 May - 25 May

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

Greenville

Allison

SAR 352 total

includes taxes & fees

24 May - 25 May

Suite, 1 King Bed with Sofa bed, Non Smoking (Efficiency) | Premium bedding, individually decorated, desk, laptop workspace

Comfort Inn & Suites Clemson - University Area

Clemson

Lon

SAR 421 total

includes taxes & fees

14 Jun - 15 Jun

Hilton Garden Inn Anderson

Anderson

Maureen

SAR 414 total

includes taxes & fees

26 May - 27 May

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Vacation Rentals in Upstate South Carolina

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Awesome place "

Cottage

Deck, Grill & Dock Access: Lake Keowee Retreat!

Seneca

"The best, perfect "

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Arrived after office closing, getting pack with key was no problem. The gate code was not on packet, had to call emergency number to get it and got quite the attitude with whom answered."

Aparthotel

Full-size fridge, microwave, oven, stovetop

stayAPT Suites Greenville-Haywood Mall

Greenville

"Great place, clean and quiet."

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Great spot"

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cottage

8 Mi to Clemson: Peaceful Family Home w/ Yard

Seneca

"The place was all out perfect the owner was polite and perfect. It was a very peaceful place to stay thank you so much."

Cottage

Wooded Cottage - 3 Mi to Clemson University

Clemson

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

Cottage

Cozy Greenville Bungalow ~ 2 Mi to Downtown!

Greenville

"Amazing place. Great host. "

Cottage

9 Mi to Devils Fork State Park: Getaway w/ Porch!

Tamassee

"Fall weekend getaway and this was perfect location. Loved the back porch for coffee and views of the sun through all the colorful leaves. Felt like we were away from it all but just a short drive to restaurants, stores, lakes and parks!!!"

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Stay near popular Upstate South Carolina attractions

Clemson University

4.8/5 (1,439 reviews)

Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina

Top Upstate South Carolina Hotel Reviews

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

10/10 Excellent

"Very nice, modern room/bathroom...comfortable bed...black out drape. Staff was exceptional. Great location and beautiful area."

Woodspring Suites Greenville Airport

6/10 Okay

"Room was clean and spacious. All kitchen utensils must be supplied by customer. Laundry room was large with multiple washer and dryer’s. Staff were helpful and friendly. Now here are my complaints, fire alarm went off 3 times in the middle of the night. Other rooms were very loud during the middle of the night. I had multiple rooms playing loud music all through the night. Hotel is worth the price but some of the customers made it hard me to enjoy."

Drury Inn & Suites Greenville

10/10 Excellent

"The staff was very nice. Ty assisted with all my questions and more. Site was very clean and our room was comfortable. I would stay at this site again. Hot breakfast and the time was good for me. I hate getting up at 5:30 am for breakfast. Everything was great; however, I did not care for the grits at all. I like mine creamy. Great place to stay and a lot of places near walking distance as well."

Hotel Hartness

10/10 Excellent

"We loved the property! Lush, green hiking trails with ponds and a farm, right behind the hotel. The hotel staff were all very friendly and helpful. The hotel was meticulously maintained. One evening, I witnessed a hotel employee doing an inspection of the pool and even ran his hand over every Adirondack chair around the pool area. I quizzed him, of course. He was checking to make sure every screwhead was flush so as not to snag a guest's clothing. His name was Patrick and I saw him all over the property, working hard and ensuring all was well. Amazing place, the gardens were fabulous with fragrant gardenia bushes everywhere. Restaurant had delicious food. It was a wonderful experience!"

Mint House Greenville Downtown by Kasa

8/10 Good

"The ad for this property undersold what we got. This was a large apartment with a full kitchen, huge bathroom and separate laundry room. We were not expecting how nice it was. Great location, only a block of the river. Great food options. Downtown a very short walk. Riverwalk one block away. This was a great place to stay. We would stay again without hesitation. Note there was a separate damage deposit that was a little suspect because it wasn't mentioned in the Expedia reservation. I went through with it and received the deposit refund within a week of checking out. Turned out fine, even though it was a little odd. Last thing-pay for parking onsite. It is worth the convenience."