Photo by Ryan Coleman

Find Resorts & Hotels with Spas in Sikeston, MO

Start date: Check-in selected.
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Sikeston Resorts & Hotels with Spas

Top Sikeston Resorts & Hotels with Spas

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Exterior

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
9.4 out of 10, Exceptional, (1006)
"The hotel was very nice and the staff were super helpful. I would stay here again!"
The price is SAR 356
SAR 402 total
includes taxes & fees
5 Oct - 6 Oct
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Spa hotels with pools in Sikeston

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Exterior

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
9.4 out of 10, Exceptional, (1006)
The price is SAR 356
SAR 402 total
includes taxes & fees
5 Oct - 6 Oct
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
View all properties

Spa hotels with free breakfast in Sikeston

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Exterior

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
9.4 out of 10, Exceptional, (1006)
The price is SAR 356
SAR 402 total
includes taxes & fees
5 Oct - 6 Oct
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Sikeston Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Very busy from September 12 to September 14 with one working elevator. Great food. Comfortable room. The bathroom could have used an exhaust fan. Steam and heat from the shower didn't affect the room temperature very much. Sofa bed matress was thin. My son didn’t complain about it though. Shower got hot quick, but you cannot adjust the shower pressure."
Amanda 2-night trip
Posted 1 day ago
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

10/10 Excellent
"The service was top notch! There was several separate large groups staying at the hotel, and the staff went the extra mile and moved up breakfast since most people were leaving at 7am. Room and Beds were comfy and clean. Plenty of hot water. Kids enjoyed the amenities of dinner, breakfast (great), and pool. The Bavarian theme actually was super cute. A lot of hotels are going for modern and sleek ( which to me translates to sterile ( which I totally get translates to clean) but that motif comes off cold. It’s refreshing to see a good mix of the past and present. "
Erin 1-night trip
Posted 3 days ago
Drury Inn & Suites Jackson MO

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

Looking for a spa hotel in Sikeston?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Travelers like the gourmet restaurants and popular shops in Sikeston. Enjoy the museums and riverfront during your vacation. Hotels with spas are the perfect way to break out of your daily routine and add a layer of luxury to your holiday.
What's there to see and do in Sikeston?
Experience Sikeston and visit Sikeston Depot Museum, Central Park, and Front Street Studio & Art Gallery. If you have a little extra time during your trip, you might want to make a stop at Stoddard County Civil War Memorial Cemetery and Hunter-Dawson State Historic Site.
What is a Sikeston spa hotel?
Spa hotels in Sikeston provide lodging and have an on-site spa offering services including therapies and beauty treatments. Some also offer in-room treatments. Spa hotels are ideal if you are looking for some R&R during your vacation.