The Best Hotels Closest to Roswell Park Cancer Institute in Buffalo for 2026

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Our top choices for Roswell Park Cancer Institute hotels

A grand staircase with ornate woodwork and a chandelier, leading to a room with a large wooden door and a stained glass window.

A spacious room with a wooden floor, a fireplace, a dining area with a table and chairs, and a large rug.

A large, two-story building with a prominent entrance, multiple windows, and a well-maintained garden.

A grand room with a chandelier, a fireplace, and ornate furniture.

1. InnBuffalo off Elmwood

Elmwood Village, 2.5 km from Roswell Park Cancer Institute

Terese

SAR 574

SAR 659 total

includes taxes & fees

26 Oct - 27 Oct

A spacious room with a wooden floor, a fireplace, a dining table, and several chairs.

A historic building with a prominent tower and a traditional brick facade.

A grand hallway with a wooden staircase, a chandelier, and a patterned floor.

A room with a textured ceiling, a chandelier, and walls painted in a two-tone color scheme.

2. Buffalo Harmony House

Allentown, 1.2 km from Roswell Park Cancer Institute

John

SAR 1,223

SAR 1,422 total

includes taxes & fees

6 Oct - 7 Oct

A spacious dining area with a long table, multiple chairs, a chandelier, and a fireplace.

A spacious room with a large wooden table, several chairs, a sofa, and two chandeliers.

A bedroom with a four-poster bed, a yellow sofa, a white coffee table, and a desk with a chair.

A grand staircase with a wooden handrail and a leopard print carpet, leading to a room with a large window and a door with frosted glass panels.

3. The Edward Hotel

Elmwood Village, 2.3 km from Roswell Park Cancer Institute

Barbara

SAR 436

SAR 600 total

includes taxes & fees

11 Oct - 12 Oct

A grand entrance with a staircase leading to a door, surrounded by lush greenery and a well-maintained garden.

A living room with a red wall, white furniture, a fireplace, and a large abstract painting.

A bar area with wooden furniture, a large wooden cabinet, and a clock on the wall.

A pool table in a room with dark walls, large windows, and green upholstered chairs.

4. The Mansion On Delaware Ave

Allentown, 0.8 km from Roswell Park Cancer Institute

Marilyn

SAR 740

SAR 849 total

includes taxes & fees

18 Oct - 19 Oct

A two-story building with a white exterior, a red door, and large windows.

A living room with a fireplace, a chandelier, leather sofas, and a glass coffee table.

A living room with a fireplace, leather sofa, and a television mounted on the wall.

A spacious living area with a granite island, wooden chairs, a fireplace, and a television.

5. Buffalo Guesthouse

Allentown, 0.5 km from Roswell Park Cancer Institute

Jan

SAR 588

SAR 675 total

includes taxes & fees

12 Oct - 13 Oct

A breakfast buffet with various food items and beverages, a large window with a view of buildings, and a patterned floor.

A modern bar area with a curved counter, leather bar stools, and a large chandelier.

A heated outdoor swimming pool with lounge chairs and a bar area, surrounded by brick walls and a balcony with decorative lighting.

6. Curtiss Hotel, an Ascend Collection Hotel

Buffalo Theater District, 1.3 km from Roswell Park Cancer Institute

Janet

SAR 986

SAR 1,151 total

includes taxes & fees

3 Nov - 4 Nov

A modern hotel room with a large window, a sofa, a coffee table, and a TV.

A hotel lobby with a seating area, dining tables, and large windows offering views of the cityscape.

A spacious bedroom with a large bed, a comfortable armchair, and a view of a body of water through floor-to-ceiling windows.

A modern kitchen with a central island, bar stools, and built-in appliances.

7. Buffalo Marriott at LECOM HARBORCENTER

Downtown Buffalo, 2.6 km from Roswell Park Cancer Institute

Vincent

SAR 909

SAR 1,061 total

includes taxes & fees

18 Oct - 19 Oct

A spacious lobby with modern furniture, large windows, and a high ceiling with exposed beams.

An outdoor patio area with seating, a fire feature, and a glass-enclosed space with greenery.

A gym with treadmills and a rowing machine, large windows, and a city view.

The Westin hotel entrance with a glass facade and a sign indicating it's now open.

8. The Westin Buffalo

Buffalo Theater District, 1.2 km from Roswell Park Cancer Institute

Sarah

SAR 890

SAR 1,039 total

includes taxes & fees

18 Oct - 19 Oct

A modern hotel lobby with a bar area, seating, and a large TV screen.

A modern hotel lobby with seating areas, a flat-screen TV, and a bookshelf.

A modern building with a Starbucks on the ground floor, featuring large windows and a flat roof.

A modern restaurant with a long counter, bar stools, and a refrigerated display.

9. Residence Inn by Marriott Buffalo Downtown

Allentown, 0.7 km from Roswell Park Cancer Institute

Karen

SAR 890

SAR 1,040 total

includes taxes & fees

12 Oct - 13 Oct

A spacious lobby with a large sofa, a coffee table, and potted plants. There is a decorative wall with a painting and a large window providing natural light.

A multi-story hotel with a modern facade, large windows, and a covered entrance area.

A compact kitchen with wooden cabinets, a black refrigerator, a microwave, and a coffee maker.

A modern lobby with a sofa set, coffee table, potted plants, and a large window providing natural light.

10. Wyndham Garden Buffalo Downtown

Downtown Buffalo, 0.2 km from Roswell Park Cancer Institute

Julian

SAR 591

SAR 691 total

includes taxes & fees

11 Oct - 12 Oct

A modern outdoor patio with stone walls, a fire feature, and outdoor furniture.

A multi-story hotel with a modern design, featuring a prominent entrance with a covered walkway and a courtyard.

A modern lobby with a wooden reception desk, comfortable seating, and a decorative wall with shelves.

A modern indoor swimming pool with clear water, lounge chairs, and a large wall with a textured pattern.

11. Courtyard Buffalo Downtown / Canalside

Downtown Buffalo, 2.4 km from Roswell Park Cancer Institute

Diana

SAR 859

SAR 1,002 total

includes taxes & fees

18 Oct - 19 Oct

A hotel room with a bed, desk, chair, TV, and a bathroom with a sink and mirror.

A hotel lobby with a curved reception desk, a chandelier, a seating area with leather chairs, and a tiled floor.

A modern kitchen with a central island, bar stools, and various appliances.

A modern hotel lobby with a round coffee table, two grey armchairs, a TV, and a reception desk.

12. Best Western on the Avenue

Allentown, 0.7 km from Roswell Park Cancer Institute

John

SAR 571

SAR 667 total

includes taxes & fees

19 Oct - 20 Oct

A hotel with a prominent red sign, large windows, and a parking lot with multiple cars.

A hotel room with a sofa, a desk, a chair, a television, and a large mirror.

A breakfast buffet with various pastries, fruits, and bread.

An indoor swimming pool with clear blue water, a metal pool ladder, and a seating area with tables and chairs.

13. Hampton Inn & Suites Buffalo Downtown

Buffalo Theater District, 1.3 km from Roswell Park Cancer Institute

Frank

SAR 641

SAR 749 total

includes taxes & fees

25 Oct - 26 Oct

An indoor swimming pool with tiled walls, a lifeguard chair, and a pool ladder.

The exterior of the Hilton Garden Inn, featuring a prominent entrance with a large sign, a flag, and a well-maintained sidewalk.

A modern lobby with a leather sofa, a fireplace, and a television mounted on the wall.

A lobby area with a reception desk, seating arrangements, a coffee station with beverages and snacks, and a decorative wall with a fireplace.

14. Hilton Garden Inn Buffalo Downtown

Buffalo Theater District, 1.5 km from Roswell Park Cancer Institute

Mercedes

SAR 603

SAR 704 total

includes taxes & fees

11 Oct - 12 Oct

A dining area with a wooden table and chairs, a fireplace, and large windows with a view of greenery outside.

A traditional living room with a wooden floor, a sofa, a coffee table, and a fireplace.

A grand staircase with a decorative railing and a Christmas tree adorned with ornaments and ribbons.

A casino interior with slot machines, a large illuminated pillar, and comfortable seating areas.

15. Summer Street Guest House

Bryant, 1.3 km from Roswell Park Cancer Institute

Anthony

SAR 1,348

SAR 1,978 total

includes taxes & fees

6 Oct - 7 Oct

A long, ornate hallway with marble walls and a patterned floor, leading to a set of double doors.

A spacious lobby with a central seating area, large columns, and a chandelier.

A spacious indoor area with wooden flooring, multiple tables and chairs, a central bar area, and large windows allowing natural light.

A modern hotel room with a fireplace, a flat-screen TV, a sofa, and a bed.

16. Hotel at the Lafayette Trademark Collection by Wyndham

Buffalo Theater District, 1.6 km from Roswell Park Cancer Institute

Angela

SAR 581

SAR 678 total

includes taxes & fees

18 Oct - 19 Oct

A hotel room with a bed, a TV, a desk, a chair, and a sofa.

A modern hotel room with a wooden dresser, a flat-screen TV, a kitchenette, a blue sofa, and a small table.

A brick building with a storefront labeled 'FRIDAYS' and a green sign with a white 'H' indicating a Holiday Inn Express & Suites.

A coffee station with two coffee makers, a coffee dispenser, and various coffee cups and containers.

17. Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

Buffalo Theater District, 1.1 km from Roswell Park Cancer Institute

Michael

SAR 492

SAR 574 total

includes taxes & fees

15 Oct - 16 Oct

A modern hotel with a curved glass facade, a central staircase, and a well-lit interior.

A conference room with two chairs and a table, large windows with a city view, and a patterned carpet.

A hotel room with a large bed, a TV mounted on the wall, a city view through the window, and a wooden shelf.

A modern bar area with seating, a counter with bottles, and a large window.

18. Embassy Suites Buffalo

Buffalo Theater District, 1.3 km from Roswell Park Cancer Institute

Michelle

SAR 667

SAR 779 total

includes taxes & fees

18 Oct - 19 Oct

A lobby with a staircase, seating area, and a view of the outdoors.

A bathroom with a toilet, sink, and shower curtain.

A reception area with a marble wall, a reception desk with glass panels, a clock, and a television mounted on the wall.

A hotel with a classic brick facade, a glass entrance, and flags.

19. Lenox Hotel and Suites

Allentown, 0.8 km from Roswell Park Cancer Institute

Richarda

SAR 336

SAR 385 total

includes taxes & fees

27 Oct - 28 Oct

An indoor swimming pool with clear glass walls, a wooden wall, and a view of buildings outside.

A Hyatt Regency hotel with a large entrance, a statue of a bull, and a landscaped garden with various plants.

A hotel room with a sofa set, a small coffee table, a TV, and a lamp.

A restaurant with multiple tables and chairs, large windows with curtains, and a chandelier.

20. Hyatt Regency Buffalo / Hotel and Conference Center

Buffalo Theater District, 1.3 km from Roswell Park Cancer Institute

Joseph

SAR 571

SAR 667 total

includes taxes & fees

25 Oct - 26 Oct

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Compare popular hotels close to Roswell Park Cancer Institute

Property	Property class	Guest rating
InnBuffalo off Elmwood	10.0 Exceptional 224 reviews	View
Buffalo Harmony House	10.0 Exceptional 55 reviews	View
The Edward Hotel	9.6 Exceptional 266 reviews	View
The Mansion On Delaware Ave	9.4 Exceptional 1,001 reviews	View
Buffalo Guesthouse	9.4 Exceptional 216 reviews	View

Top Roswell Park Cancer Institute Hotel Reviews

Buffalo Guesthouse

10/10 Excellent

"Cleanliness was a ten- Staff was exceptional. Breakfast was home-cooked and plentiful. Very pleasant stay just minutes to town."

The Mansion On Delaware Ave

8/10 Good

"Nice hotel, shower needs an update"

Embassy Suites Buffalo

10/10 Excellent

"Very good experience, would highly recommend this property and great location. Rooms very nicely appointed, and they allowed early check-in without any grief. Nice bar and restaurant attached. with a small self-check store/coffee stand."

Lenox Hotel and Suites

10/10 Excellent

"We really enjoyed this property. Obviously it's an old building but very enjoyable experience."

Hilton Garden Inn Buffalo Downtown

10/10 Excellent

"Everything was great! Clean room, friendly staff."

Best Western on the Avenue

8/10 Good

"na"

Downtown King Bed Suite- Very Walkable- Flexible Cancellation

10/10 Excellent

"Location and apartment were perfect for a long weekend getaway. The place was clean and the hosts were communicative. There was a construction project next door which limited some of the parking options but there were plenty of additional spaces across the street."

Newly Renovated Downtown Gem!

10/10 Excellent

"We absolutely loved our stay here! The place was spotless, comfortable, and in the perfect location for everything we wanted to do. The bed deserves a special shoutout, it was hands down the most comfortable bed we’ve ever slept in while traveling! The hosts were incredibly helpful, responsive, and made everything so easy. We would definitely stay here again and highly recommend it!"

Cozy & Modern Victorian in Historic Allentown, Buffalo

10/10 Excellent

"This house was in a great location in a quiet tree lined residential street. We were able to walk to all of the bars and restaurants that were on our list. This house was very neat, orderly and meticulously furnished. We did not spend much time is the house other than to sleep however there were nice spaces to gather. The yard looks very nice as well and there was room for a car in the driveway. Overall, we had a great stay,"

Other attractions near Roswell Park Cancer Institute

Wilcox Mansion - Theodore Roosevelt Inaugural National Historic Site

8.2/10 (144 reviews)

You can browse the exhibits at Wilcox Mansion - Theodore Roosevelt Inaugural National Historic Site, a museum with a storied past, during your trip to Buffalo. Experience the area's entertainment choices and acclaimed theater scene.

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Studio Arena Theater

Enjoy a performance at Studio Arena Theater, a storied theater in Buffalo. Experience the area's great live music and entertainment choices.

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Shea's 710 Theatre

You can enjoy a show at Shea's 710 Theatre during your stay in Buffalo. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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Town Ballroom

You can make plans for a show at Town Ballroom during your trip to Buffalo. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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Trinity Episcopal Church

You can learn about the history of Buffalo with a stop at Trinity Episcopal Church. Experience the great live music or attend a sporting event in this family-friendly area.

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Alleyway Theatre

You can make plans for a show at Alleyway Theatre during your stay in Buffalo. Experience the acclaimed theater scene and great live music in this family-friendly area.

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The 9th Ward

You can make plans for a show at The 9th Ward during your trip to Buffalo. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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Asbury Hall at Babeville

You can make plans for a show at Asbury Hall at Babeville during your stay in Buffalo. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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Frequently asked questions

What's the area like around Roswell Park Cancer Institute?

Roswell Park Cancer Institute is located in a historic area of Buffalo known for its popular theater scene. If you're looking for a convenient place to stay, check out the 71 hotels and other accommodations you'll find within a mile.

What's the best hotel to stay close to Roswell Park Cancer Institute?

Adjacent to Roswell Park Cancer Institute, Wyndham Garden Buffalo Downtown is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and a 24-hour fitness center. Other good choices close by include Hyatt Regency Buffalo / Hotel and Conference Center and Buffalo Guesthouse.

How many hotels will I find near Roswell Park Cancer Institute?

Expedia has 71 hotels and other accommodations within a mile from Roswell Park Cancer Institute.

If I need to cancel the hotel reservation for my stay near Roswell Park Cancer Institute, will I receive a refund?

Yes! Most hotel reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If you have a reservation that's non-refundable, it may still be possible to cancel it and receive a refund within 24 hours of booking. Add dates, click "Search", then you can use the "fully refundable" filter to review the top deals on offer near Roswell Park Cancer Institute.

Where can I learn more about changing or cancelling my trip in the area near Roswell Park Cancer Institute?

For more details about changing or cancelling your stay near Roswell Park Cancer Institute, click here.

What can I see and do near Roswell Park Cancer Institute?

You might want to spend some time browsing the exhibits at Buffalo Museum of Science, Buffalo and Erie County Naval and Military Park, or Buffalo AKG Art Museum. Statler Tower, Buffalo Central Terminal, and Peace Bridge are monuments to see when you're exploring the area around Roswell Park Cancer Institute. You can catch a show at Kleinhans Music Hall, Town Ballroom, and Road Less Traveled Productions.

How can I get to Roswell Park Cancer Institute?

With so many transportation options, seeing all of the area near Roswell Park Cancer Institute is easy. Take advantage of metro transit at Fountain Plaza Station, Lafayette Square Station, and Church Station. If you're taking a train into town, Buffalo-Exchange Street Station is the closest stop to Downtown Buffalo.

Find hotels near Roswell Park Cancer Institute, Buffalo from SAR 385

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Treat yourself

Be picky

Check prices for these dates

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Star rating

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Our top choices for Roswell Park Cancer Institute hotels

1. InnBuffalo off Elmwood

2. Buffalo Harmony House

3. The Edward Hotel

4. The Mansion On Delaware Ave

5. Buffalo Guesthouse

6. Curtiss Hotel, an Ascend Collection Hotel

7. Buffalo Marriott at LECOM HARBORCENTER

8. The Westin Buffalo

9. Residence Inn by Marriott Buffalo Downtown

10. Wyndham Garden Buffalo Downtown

11. Courtyard Buffalo Downtown / Canalside

12. Best Western on the Avenue

13. Hampton Inn & Suites Buffalo Downtown

14. Hilton Garden Inn Buffalo Downtown

15. Summer Street Guest House

16. Hotel at the Lafayette Trademark Collection by Wyndham

17. Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

18. Embassy Suites Buffalo

19. Lenox Hotel and Suites

20. Hyatt Regency Buffalo / Hotel and Conference Center

Compare popular hotels close to Roswell Park Cancer Institute

Top Roswell Park Cancer Institute Hotel Reviews

Buffalo Guesthouse

The Mansion On Delaware Ave

Embassy Suites Buffalo

Lenox Hotel and Suites

Hilton Garden Inn Buffalo Downtown

Best Western on the Avenue

Downtown King Bed Suite- Very Walkable- Flexible Cancellation

Newly Renovated Downtown Gem!

Cozy & Modern Victorian in Historic Allentown, Buffalo

Other attractions near Roswell Park Cancer Institute

Wilcox Mansion - Theodore Roosevelt Inaugural National Historic Site

Studio Arena Theater

Shea's 710 Theatre

Town Ballroom

Trinity Episcopal Church

Alleyway Theatre

The 9th Ward

Asbury Hall at Babeville

Frequently asked questions