The Best Hotels Closest to Roswell Park Cancer Institute in Buffalo for 2026

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Roswell Park Cancer Institute hotels

A spacious room with a wooden floor, a fireplace, a dining table, and several chairs.

A traditional living room with a green sofa, a wooden coffee table with books, a blue armchair, and various potted plants.

A room with a textured ceiling, a chandelier, and walls painted in a two-tone color scheme.

A historic building with a prominent tower and a traditional brick facade.

1. Buffalo Harmony House

Allentown, 1.2 km from Roswell Park Cancer Institute

John

SAR 1,223

SAR 1,422 total

includes taxes & fees

30 Sep - 1 Oct

A grand staircase with ornate woodwork and a chandelier, leading to a room with a large wooden door and a stained glass window.

A grand room with a chandelier, a fireplace, and ornate furniture.

A large, two-story building with a prominent entrance, multiple windows, and a well-maintained garden.

A spacious room with a wooden floor, a fireplace, a dining area with a table and chairs, and a large rug.

2. InnBuffalo off Elmwood

Elmwood Village, 2.5 km from Roswell Park Cancer Institute

Terese

SAR 582

SAR 668 total

includes taxes & fees

5 Oct - 6 Oct

A spacious dining area with a long table, multiple chairs, a chandelier, and a fireplace.

A living room with a fireplace, two leather armchairs, a coffee table, and a chandelier.

A bedroom with a four-poster bed, a yellow sofa, a white coffee table, and a desk with a chair.

A spacious room with a large wooden table, several chairs, a sofa, and two chandeliers.

3. The Edward Hotel

Elmwood Village, 2.3 km from Roswell Park Cancer Institute

Barbara

SAR 436

SAR 600 total

includes taxes & fees

1 Oct - 2 Oct

A two-story building with a white exterior, a red door, and large windows.

A living room with a fireplace, leather sofa, and a television mounted on the wall.

A spacious living area with a granite island, wooden chairs, a fireplace, and a television.

A hot tub with a wooden fence and a brick building in the background.

4. Buffalo Guesthouse

Allentown, 0.5 km from Roswell Park Cancer Institute

Jan

SAR 588

SAR 675 total

includes taxes & fees

5 Oct - 6 Oct

A grand entrance with a staircase leading to a door, surrounded by lush greenery and a well-maintained garden.

A living room with a red wall, white furniture, a fireplace, and a large abstract painting.

A bar area with wooden furniture, a large wooden cabinet, and a clock on the wall.

A pool table in a room with patterned carpet, a dining table with chairs, and a red sofa.

5. The Mansion On Delaware Ave

Allentown, 0.8 km from Roswell Park Cancer Institute

Marilyn

SAR 740

SAR 849 total

includes taxes & fees

18 Oct - 19 Oct

A modern hotel room with a large window, a sofa, a coffee table, and a TV.

A modern kitchen with a central island, bar stools, and built-in appliances.

A modern hotel lobby with a reception desk, seating area, and a large window offering a view of the city.

A spacious bedroom with a large bed, a comfortable armchair, and a view of a body of water through floor-to-ceiling windows.

6. Buffalo Marriott at LECOM HARBORCENTER

Downtown Buffalo, 2.6 km from Roswell Park Cancer Institute

Vincent

SAR 909

SAR 1,061 total

includes taxes & fees

18 Oct - 19 Oct

A breakfast buffet with various food items and beverages, a large window with a view of buildings, and a patterned floor.

A modern bar area with a curved counter, leather bar stools, and a large chandelier.

A heated outdoor swimming pool with lounge chairs and a bar area, surrounded by brick walls and a balcony with decorative lighting.

A circular fire pit with a metal railing, surrounded by a stone base, set on a tiled patio with a city skyline in the background.

7. Curtiss Hotel, an Ascend Collection Hotel

Buffalo Theater District, 1.3 km from Roswell Park Cancer Institute

Janet

SAR 986

SAR 1,151 total

includes taxes & fees

28 Oct - 29 Oct

A spacious lobby with a large sofa, a coffee table, and potted plants. There is a decorative wall with a painting and a large window providing natural light.

A compact kitchen with wooden cabinets, a black refrigerator, a microwave, and a coffee maker.

A hotel dining area with multiple tables and chairs, a reception desk, and framed pictures on the walls.

A multi-story hotel with a modern facade, large windows, and a covered entrance area.

8. Wyndham Garden Buffalo Downtown

Downtown Buffalo, 0.2 km from Roswell Park Cancer Institute

Amir

SAR 591

SAR 690 total

includes taxes & fees

5 Oct - 6 Oct

A modern outdoor patio with stone walls, a fire feature, and outdoor furniture.

A modern indoor swimming pool with clear water, lounge chairs, and a large wall with a textured pattern.

A modern lobby with a wooden reception desk, comfortable seating, and a decorative wall with shelves.

A modern lobby with a seating area, a fireplace, and a large window offering a view of the city.

9. Courtyard Buffalo Downtown / Canalside

Downtown Buffalo, 2.4 km from Roswell Park Cancer Institute

Diana

SAR 843

SAR 984 total

includes taxes & fees

18 Oct - 19 Oct

A hotel room with a bed, desk, chair, TV, and a bathroom with a sink and mirror.

A modern kitchen with a central island, bar stools, and various appliances.

A hotel lobby with a curved reception desk, a chandelier, a seating area with leather chairs, and a tiled floor.

A modern hotel lobby with a round coffee table, two grey armchairs, a TV, and a reception desk.

10. Best Western on the Avenue

Allentown, 0.7 km from Roswell Park Cancer Institute

John

SAR 571

SAR 667 total

includes taxes & fees

19 Oct - 20 Oct

A hotel with a prominent red sign, large windows, and a parking lot with multiple cars.

An indoor swimming pool with clear blue water, a metal pool ladder, and a seating area with tables and chairs.

A modern living room with a fireplace, comfortable seating, and a herringbone-patterned wall.

A hotel room with a sofa, a desk, a chair, a television, and a large mirror.

11. Hampton Inn & Suites Buffalo Downtown

Buffalo Theater District, 1.3 km from Roswell Park Cancer Institute

Frank

SAR 613

SAR 715 total

includes taxes & fees

25 Oct - 26 Oct

An indoor swimming pool with tiled walls, a lifeguard chair, and a pool ladder.

A modern lobby with a leather sofa, a fireplace, and a television mounted on the wall.

A lobby area with a reception desk, seating arrangements, a coffee station with beverages and snacks, and a decorative wall with a fireplace.

The exterior of the Hilton Garden Inn, featuring a prominent entrance with a large sign, a flag, and a well-maintained sidewalk.

12. Hilton Garden Inn Buffalo Downtown

Buffalo Theater District, 1.5 km from Roswell Park Cancer Institute

Mercedes

SAR 582

SAR 679 total

includes taxes & fees

11 Oct - 12 Oct

A dining area with a wooden table and chairs, a fireplace, and large windows with a view of greenery outside.

A casino interior with slot machines, a large illuminated pillar, and comfortable seating areas.

A grand staircase with a decorative railing and a Christmas tree adorned with ornaments and ribbons.

A traditional living room with a wooden floor, a sofa, a coffee table, and a fireplace.

13. Summer Street Guest House

Bryant, 1.3 km from Roswell Park Cancer Institute

Anthony

SAR 1,348

SAR 1,978 total

includes taxes & fees

30 Sep - 1 Oct

A long, ornate hallway with marble walls and a patterned floor, leading to a set of double doors.

A modern hotel room with a fireplace, a flat-screen TV, a sofa, and a bed.

The facade of Hotel at the Lafayette with a classic architectural style, large windows, and a prominent entrance.

A spacious indoor area with wooden flooring, multiple tables and chairs, a central bar area, and large windows allowing natural light.

14. Hotel at the Lafayette Trademark Collection by Wyndham

Buffalo Theater District, 1.6 km from Roswell Park Cancer Institute

Angela

SAR 574

SAR 671 total

includes taxes & fees

18 Oct - 19 Oct

A hotel room with a bed, a TV, a desk, a chair, and a sofa.

A breakfast bar with a variety of food options including cereal, fruit, yogurt, eggs, and milk.

A gym with exercise equipment, a mirror, and a television.

A modern hotel room with a wooden dresser, a flat-screen TV, a kitchenette, a blue sofa, and a small table.

15. Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

Buffalo Theater District, 1.1 km from Roswell Park Cancer Institute

Robert

SAR 492

SAR 574 total

includes taxes & fees

15 Oct - 16 Oct

A lobby with a staircase, seating area, and a view of the outdoors.

A reception area with a marble wall, a reception desk with glass panels, a clock, and a television mounted on the wall.

A bathroom with a toilet, sink, and shower curtain.

A hotel with a classic brick facade, a glass entrance, and flags.

16. Lenox Hotel and Suites

Allentown, 0.8 km from Roswell Park Cancer Institute

Thomas

SAR 346

SAR 397 total

includes taxes & fees

18 Oct - 19 Oct

An indoor swimming pool with clear glass walls, a wooden wall, and a view of buildings outside.

A Hyatt Regency hotel with a large entrance, a statue of a bull, and a landscaped garden with various plants.

A Starbucks coffee shop with a modern design, featuring wooden furniture and a spacious layout.

A hotel room with a sofa set, a small coffee table, a TV, and a lamp.

17. Hyatt Regency Buffalo / Hotel and Conference Center

Buffalo Theater District, 1.3 km from Roswell Park Cancer Institute

Joseph

SAR 571

SAR 667 total

includes taxes & fees

25 Oct - 26 Oct

A dining area with a wooden table set for four, surrounded by chairs. There is a kitchen area with cabinets and appliances in the background.

A bedroom with a bed, bedside lamps, a nightstand, a window with curtains, and wall art.

A kitchen with wooden cabinets, a dishwasher, and a dining area with a table and chairs.

A kitchen with wooden cabinets, stainless steel appliances, and a red toaster.

18. 4 Mi to Dtwn: Family Home in Buffalo

Masten Park, 1.6 km from Roswell Park Cancer Institute

SAR 1,115

SAR 1,975 total

includes taxes & fees

30 Sep - 1 Oct

A buffet setup with various food items and utensils.

A hotel room with a large bed, a desk with a chair, a bathroom with a bathtub, and a mirror.

A hotel room with a sofa, a bed, a desk, and a chair. There are lamps on the desk and bedside tables.

A hotel reception desk with a large mirror, a chandelier, and a 'HOTEL' sign.

19. Salvatores Grand Hotel

15.2 km from Roswell Park Cancer Institute

Margaret

SAR 635

SAR 722 total

includes taxes & fees

30 Sep - 1 Oct

A hotel with a prominent entrance, a clock tower, and the name "REIKART HOUSE" displayed above the entrance.

An outdoor patio area with tables and chairs, string lights, and greenery.

A spacious living area with a fireplace, a large sofa, and a dining area with a table and chairs.

20. Reikart House, Buffalo, a Tribute Portfolio Hotel

10.4 km from Roswell Park Cancer Institute

Kenneth

SAR 1,010

SAR 1,149 total

includes taxes & fees

18 Oct - 19 Oct

View all properties

Compare popular hotels close to Roswell Park Cancer Institute

Property	Property class	Guest rating
Buffalo Harmony House	10.0 Exceptional 55 reviews	View
InnBuffalo off Elmwood	10.0 Exceptional 224 reviews	View
The Edward Hotel	9.6 Exceptional 264 reviews	View
Buffalo Guesthouse	9.4 Exceptional 213 reviews	View
The Mansion On Delaware Ave	9.4 Exceptional 1,009 reviews	View

Top Roswell Park Cancer Institute Hotel Reviews

Buffalo Guesthouse

8/10 Good

"The room was very clean and the staff was super helpful and accommodating. My biggest criticism here is that for the price I paid of almost $250 per night that it was definitely not worth it. The location was decent, but did not make up for the boarding room style rooms."

Best Western on the Avenue

8/10 Good

"Room was good , staff friendly Very helpful. Wood stay here again"

Lenox Hotel and Suites

8/10 Good

"the hotel was clean and staff were friendly"

Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

10/10 Excellent

"L'emplacement est pratique, le quartier le soir a beaucoup d'itinérants comme partout ailleurs à Buffalo. Les fenêtres extérieures sont sales."

Embassy Suites Buffalo

10/10 Excellent

"Wonderful experience"

Downtown King Bed Suite- Very Walkable- Flexible Cancellation

10/10 Excellent

"Location and apartment were perfect for a long weekend getaway. The place was clean and the hosts were communicative. There was a construction project next door which limited some of the parking options but there were plenty of additional spaces across the street."

Newly Renovated Downtown Gem!

10/10 Excellent

"We absolutely loved our stay here! The place was spotless, comfortable, and in the perfect location for everything we wanted to do. The bed deserves a special shoutout, it was hands down the most comfortable bed we’ve ever slept in while traveling! The hosts were incredibly helpful, responsive, and made everything so easy. We would definitely stay here again and highly recommend it!"

Cozy & Modern Victorian in Historic Allentown, Buffalo

10/10 Excellent

"This house was in a great location in a quiet tree lined residential street. We were able to walk to all of the bars and restaurants that were on our list. This house was very neat, orderly and meticulously furnished. We did not spend much time is the house other than to sleep however there were nice spaces to gather. The yard looks very nice as well and there was room for a car in the driveway. Overall, we had a great stay,"

Unique Castle in Buffalo NY

10/10 Excellent

"Great home. Awesome layout. Host communicated very well. Would recommend if you love history and old homes. Beautiful neighborhood too. Lots of history. "

Other attractions near Roswell Park Cancer Institute

Wilcox Mansion - Theodore Roosevelt Inaugural National Historic Site

8.2/10 (144 reviews)

You can browse the exhibits at Wilcox Mansion - Theodore Roosevelt Inaugural National Historic Site, a museum with a storied past, during your trip to Buffalo. Experience the area's entertainment choices and acclaimed theater scene.

See properties

Studio Arena Theater

Enjoy a performance at Studio Arena Theater, a storied theater in Buffalo. Experience the area's great live music and entertainment choices.

See properties

Shea's 710 Theatre

You can enjoy a show at Shea's 710 Theatre during your stay in Buffalo. Attend a sporting event or simply enjoy the lively bars while you're in the area.

See properties

Town Ballroom

You can make plans for a show at Town Ballroom during your trip to Buffalo. Attend a sporting event or simply enjoy the lively bars while you're in the area.

See properties

Trinity Episcopal Church

You can learn about the history of Buffalo with a stop at Trinity Episcopal Church. Experience the great live music or attend a sporting event in this family-friendly area.

See properties

Alleyway Theatre

You can make plans for a show at Alleyway Theatre during your stay in Buffalo. Experience the acclaimed theater scene and great live music in this family-friendly area.

See properties

The 9th Ward

You can make plans for a show at The 9th Ward during your trip to Buffalo. Attend a sporting event or simply enjoy the lively bars while you're in the area.

See properties

Asbury Hall at Babeville

You can make plans for a show at Asbury Hall at Babeville during your stay in Buffalo. Attend a sporting event or simply enjoy the lively bars while you're in the area.

See properties

Frequently asked questions

What's the area like around Roswell Park Cancer Institute?

Roswell Park Cancer Institute is located in a historic area of Buffalo known for its popular theater scene. If you're looking for a convenient place to stay, check out the 71 hotels and other accommodations you'll find within a mile.

What's the best hotel to stay close to Roswell Park Cancer Institute?

Adjacent to Roswell Park Cancer Institute, Wyndham Garden Buffalo Downtown is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and a 24-hour fitness center. Other good choices close by include Hyatt Regency Buffalo / Hotel and Conference Center and Buffalo Guesthouse.

How many hotels will I find near Roswell Park Cancer Institute?

Expedia has 71 hotels and other accommodations within a mile from Roswell Park Cancer Institute.

If I need to cancel the hotel reservation for my stay near Roswell Park Cancer Institute, will I receive a refund?

Yes! Most hotel reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If you have a reservation that's non-refundable, it may still be possible to cancel it and receive a refund within 24 hours of booking. Add dates, click "Search", then you can use the "fully refundable" filter to review the top deals on offer near Roswell Park Cancer Institute.

Where can I learn more about changing or cancelling my trip in the area near Roswell Park Cancer Institute?

For more details about changing or cancelling your stay near Roswell Park Cancer Institute, click here.

What can I see and do near Roswell Park Cancer Institute?

You might want to spend some time browsing the exhibits at Buffalo Museum of Science, Buffalo and Erie County Naval and Military Park, or Buffalo AKG Art Museum. Statler Tower, Buffalo Central Terminal, and Peace Bridge are monuments to see when you're exploring the area around Roswell Park Cancer Institute. You can catch a show at Kleinhans Music Hall, Town Ballroom, and Road Less Traveled Productions.

How can I get to Roswell Park Cancer Institute?

With so many transportation options, seeing all of the area near Roswell Park Cancer Institute is easy. Take advantage of metro transit at Fountain Plaza Station, Lafayette Square Station, and Church Station. If you're taking a train into town, Buffalo-Exchange Street Station is the closest stop to Downtown Buffalo.

Find hotels near Roswell Park Cancer Institute, Buffalo from SAR 397

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Roswell Park Cancer Institute hotels

1. Buffalo Harmony House

2. InnBuffalo off Elmwood

3. The Edward Hotel

4. Buffalo Guesthouse

5. The Mansion On Delaware Ave

6. Buffalo Marriott at LECOM HARBORCENTER

7. Curtiss Hotel, an Ascend Collection Hotel

8. Wyndham Garden Buffalo Downtown

9. Courtyard Buffalo Downtown / Canalside

10. Best Western on the Avenue

11. Hampton Inn & Suites Buffalo Downtown

12. Hilton Garden Inn Buffalo Downtown

13. Summer Street Guest House

14. Hotel at the Lafayette Trademark Collection by Wyndham

15. Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

16. Lenox Hotel and Suites

17. Hyatt Regency Buffalo / Hotel and Conference Center

18. 4 Mi to Dtwn: Family Home in Buffalo

19. Salvatores Grand Hotel

20. Reikart House, Buffalo, a Tribute Portfolio Hotel

Compare popular hotels close to Roswell Park Cancer Institute

Top Roswell Park Cancer Institute Hotel Reviews

Buffalo Guesthouse

Best Western on the Avenue

Lenox Hotel and Suites

Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

Embassy Suites Buffalo

Downtown King Bed Suite- Very Walkable- Flexible Cancellation

Newly Renovated Downtown Gem!

Cozy & Modern Victorian in Historic Allentown, Buffalo

Unique Castle in Buffalo NY

Other attractions near Roswell Park Cancer Institute

Wilcox Mansion - Theodore Roosevelt Inaugural National Historic Site

Studio Arena Theater

Shea's 710 Theatre

Town Ballroom

Trinity Episcopal Church

Alleyway Theatre

The 9th Ward

Asbury Hall at Babeville

Frequently asked questions