A calm river with clear water, surrounded by dense trees and rocky banks.

Find hotels in O Brien, FL from SAR 156

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
26 Jun - 28 Jun
Next weekend
3 Jul - 5 Jul

Filter by

Guest rating
Guest rating
Star rating

Our top choices for O Brien hotels

Breakfast area

Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75
2.5 star property
Alachua
9.4 out of 10, Exceptional, (526 reviews)
"Wonderful place to stay"
United States
Tamela
The price is SAR 397
SAR 447 total
includes taxes & fees
1 Jul - 2 Jul
Hampton Inn & Suites Alachua I-75
Desk, blackout drapes, iron/ironing board, rollaway beds

Americas Best Value Inn Alachua

Americas Best Value Inn Alachua
2.0 star property
Alachua
5.0 out of 10, (629 reviews)
"It was a place to stay"
United States
Jennifer
Americas Best Value Inn Alachua
Standard Room, 2 Double Beds | Blackout drapes, free WiFi, bed sheets

Royal Inn

Royal Inn
2.0 star property
Alachua
7.2 out of 10, Good, (202 reviews)
"For the price it's an okay stay. There's a bed and a tv if you need some entertainment. So, good deal if you need an affordable place to lay your head. Staff is very nice and friendly as well. However, the beds are a little hard, fridge took a while to cool down drinks, and I had to use the microwave twice on the same item before it got hot. So, it's really up to what you are looking for."
United States
Alec
The price is SAR 270
SAR 304 total
includes taxes & fees
28 Jun - 29 Jun
Royal Inn
Exterior

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
3.5 star property
Alachua
9.4 out of 10, Exceptional, (1,001 reviews)
"The staff were amazing, great location, big rooms, great breakfast"
United States
Brittani
The price is SAR 390
SAR 439 total
includes taxes & fees
12 Jul - 13 Jul
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Garden view

Vista Verde Farm Retreat

Vista Verde Farm Retreat
2.0 star property
Lake City
9.8 out of 10, Exceptional, (19 reviews)
"Calm peaceful stay, staff was very helpful and attentive. "
United States
Patrick
The price is SAR 433
SAR 749 total
includes taxes & fees
29 Jun - 30 Jun
Vista Verde Farm Retreat
Fountain

BlueGem Motel

BlueGem Motel
2.0 star property
High Springs
9.2 out of 10, Wonderful, (455 reviews)
"Renovated room- friendly staff - Great Location - Charming Quaint"
United States
ellie
The price is SAR 424
SAR 477 total
includes taxes & fees
30 Jun - 1 Jul
BlueGem Motel
Double Room, Non Smoking | Laptop workspace, free WiFi

High Springs Country Inn

High Springs Country Inn
2.0 star property
High Springs
8.4 out of 10, Very Good, (36 reviews)
"Nice parking space , great location , bed was confi "
United States
Susana
The price is SAR 221
SAR 249 total
includes taxes & fees
1 Jul - 2 Jul
High Springs Country Inn
Premium bedding, desk, blackout drapes, soundproofing

Palms Garden Inn

Palms Garden Inn
2.0 star property
Lake City
7.6 out of 10, Good, (626 reviews)
"REALLY NICE PLACE, VERY CLEAN, WONDERFUL STAFF"
United States
Caroline
The price is SAR 244
SAR 274 total
includes taxes & fees
2 Jul - 3 Jul
Palms Garden Inn
Reception

The Blanche

The Blanche
2.0 star property
Lake City
9.4 out of 10, Exceptional, (194 reviews)
"Great property! Beautiful renovated!"
United States
Brandi
The price is SAR 482
SAR 542 total
includes taxes & fees
6 Jul - 7 Jul
The Blanche
Individually decorated, desk, laptop workspace, iron/ironing board

Days Inn by Wyndham Lake City I-10

Days Inn by Wyndham Lake City I-10
2.0 star property
Lake City
7.0 out of 10, Good, (1,003 reviews)
"Nice and restful place to stay"
United States
Frederick
The price is SAR 222
SAR 250 total
includes taxes & fees
28 Jun - 29 Jun
Days Inn by Wyndham Lake City I-10
View from property

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
2.0 star property
High Springs
10.0 out of 10, Exceptional, (227 reviews)
"Amazing spot to be out of the world."
United States
Tati
The price is SAR 672
SAR 1,070 total
includes taxes & fees
29 Jun - 30 Jun
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
Down comforters, pillowtop beds, blackout drapes, free WiFi

Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
2.0 star property
Lake City
7.4 out of 10, Good, (730 reviews)
"The room was clean, staff were very nice and the breakfast was outstanding."
United States
Michelle
The price is SAR 246
SAR 276 total
includes taxes & fees
20 Jul - 21 Jul
Super 8 by Wyndham Lake City
Coffee service

Driftwood Inn

Driftwood Inn
2.0 star property
Lake City
7.8 out of 10, Good, (789 reviews)
"Very happy with my stay!"
United States
Dmitriy
The price is SAR 178
SAR 200 total
includes taxes & fees
6 Jul - 7 Jul
Driftwood Inn
Lobby

Regal Inn

Regal Inn
2.5 star property
Lake City
8.4 out of 10, Very Good, (605 reviews)
"Surprisingly well maintained and clean for the price. Lady at the front desk was kind and sweet."
United States
Johnny
The price is SAR 233
SAR 262 total
includes taxes & fees
9 Jul - 10 Jul
Regal Inn
Exterior

Courtyard By Marriott Lake City

Courtyard By Marriott Lake City
3.0 star property
Lake City
9.6 out of 10, Exceptional, (267 reviews)
"Had an amazing stay. The hotel was nice and clean and up to date."
United States
Mary Magdalene
The price is SAR 436
SAR 490 total
includes taxes & fees
12 Jul - 13 Jul
Courtyard By Marriott Lake City
Lobby

Knights Inn Lake City

Knights Inn Lake City
1.5 star property
Lake City
5.4 out of 10, (661 reviews)
"The staff was very nice and helpful and it was a whole lot nicer then the regal inn"
United States
Melissa
The price is SAR 206
SAR 232 total
includes taxes & fees
4 Jul - 5 Jul
Knights Inn Lake City
Exterior

Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG
3.0 star property
Lake City
8.8 out of 10, Excellent, (1,003 reviews)
"Staff friendly and helpful. Beds very comfortable."
United States
Candice
The price is SAR 409
SAR 460 total
includes taxes & fees
5 Jul - 6 Jul
Holiday Inn & Suites Lake City by IHG
Pillowtop beds, desk, iron/ironing board, free WiFi

Quality Inn Lake City

Quality Inn Lake City
2.5 star property
Lake City
8.0 out of 10, Very Good, (1,000 reviews)
"It was clean and comfortable bed !"
United States
Glenda
The price is SAR 272
SAR 305 total
includes taxes & fees
12 Jul - 13 Jul
Quality Inn Lake City
Exterior

La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
3.0 star property
Lake City
8.6 out of 10, Excellent, (1,127 reviews)
"Enjoyed our stay"
United States
Tammie
The price is SAR 355
SAR 399 total
includes taxes & fees
29 Jun - 30 Jun
La Quinta Inn & Suite by Wyndham Lake City
Pillowtop beds, in-room safe, desk, blackout drapes

Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
2.0 star property
Lake City
7.6 out of 10, Good, (1,001 reviews)
"Great for a short stay and clean"
United States
Brizheet
The price is SAR 237
SAR 267 total
includes taxes & fees
29 Jun - 30 Jun
Days Inn by Wyndham Lake City I-75
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida

Top O Brien Hotel Reviews

La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

8/10 Good
"Clean room."
Thomas 1-night trip
Posted 17 hours ago
La Quinta Inn & Suite by Wyndham Lake City

More cheap stays in O Brien

Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75

3598 W Us Highway 90 Lake City FL
The price is SAR 217 per night from Jun 29 to Jun 30
SAR 217
SAR 244 total
29 Jun - 30 Jun
includes taxes & fees
5/10 (1,001 reviews)

Frequently asked questions

Where is the best place to stay in O Brien?
La Quinta Inn & Suite by Wyndham Lake City, located 18.2 mi (29.3 km) from the heart of O Brien, is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy. See all available top hotels, or vacation rentals in O Brien.
What's the top vacation rental in O Brien?
Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!: Visitors give good reviews to this O Brien vacation home rental, which is located on the beach and has a balcony, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. Our travelers also rate MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY as a favorite home for rent in O Brien. See all vacation rentals in O Brien.
If I need to cancel my hotel reservation in O Brien, will I receive a refund?
Yes! You'll find that most hotel reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.
Where can I learn more about changing or cancelling my trip to O Brien?
To access more information about picking new dates or cancelling your trip to O Brien, click here.
Where is the best hotel to stay near Ichetucknee Springs State Park?
Escape to Nature - 2 miles from Ichetucknee park is one of the top choices for your stay based on our traveler data, and this property features in-room kitchens and fireplaces. It's located 2.3 mi (3.8 km) from Ichetucknee Springs State Park. Another good choice is A Riverview of a Magical Sunrise every morning, located 5.6 mi (9.1 km) away.
What are some accommodations with pools in O Brien?
La Quinta Inn & Suite by Wyndham Lake City: Features on-the-go, an indoor pool, and free self parking. Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! and Little River Spring Cave divers poolside Hideaway are two additional hotels that feature an onsite pool. View all hotels with pools in O Brien.
What's the best hotel for staying near Gainesville Regional Airport (GNV)?
Hampton Inn & Suites Gainesville Downtown is one of the top choices for your stay and is a popular hotel, featuring free breakfast and an outdoor pool. It's located 3.7 mi (6 km) from Gainesville Regional Airport. Other good choices close to the airport include Sweetwater Branch Inn and Travelers Inn.
How is it to stay in O Brien?
Visitors to O Brien are sure to find plenty to explore and enjoy. In O Brien, there are 10 hotels and other accommodations to choose from. Find out more about O Brien.
What should I see while I'm in O Brien?
Natural beauty is on display at Suwannee River, Ichetucknee River, and Ichetucknee Springs State Park. You'll also find Wes Skiles Peacock Springs State Park and First Federal Sportsplex in the area. Check out what more to see and do in Expedia's O Brien guide.
What's the seasonal weather like in O Brien?
The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 58°F. Average annual precipitation for O Brien is 50 inches.