Photo by Dr__Vlad
Find 2 Star Hotels in O Brien, FL from SAR 217
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Check availability on O Brien 2 Star Hotels
Compare O Brien 2 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Tru by Hilton Lake City
Tru by Hilton Lake City
9.0 out of 10, Wonderful, (1014)
The price is SAR 372
SAR 418 total
includes taxes & fees
14 Sep - 15 Sep

Holiday Inn Express & Suites Live Oak by IHG
Holiday Inn Express & Suites Live Oak by IHG
8.4 out of 10, Very Good, (736)
The price is SAR 428
SAR 471 total
includes taxes & fees
14 Sep - 15 Sep

Hampton Inn & Suites Lake City
Hampton Inn & Suites Lake City
9.4 out of 10, Exceptional, (1000)
The price is SAR 409
SAR 460 total
includes taxes & fees
7 Sep - 8 Sep

La Quinta Inn & Suite by Wyndham Lake City
La Quinta Inn & Suite by Wyndham Lake City
8.8 out of 10, Excellent, (1009)
The price is SAR 351
SAR 395 total
includes taxes & fees
10 Sep - 11 Sep

Comfort Suites Lake City
Comfort Suites Lake City
9.6 out of 10, Exceptional, (1006)
The price is SAR 393
SAR 443 total
includes taxes & fees
14 Sep - 15 Sep

Best Western Plus Lake City
Best Western Plus Lake City
9.2 out of 10, Wonderful, (1015)
The price is SAR 282
SAR 318 total
includes taxes & fees
10 Sep - 11 Sep

Baymont by Wyndham Lake City
Baymont by Wyndham Lake City
5.0 out of 10, (1001)
The price is SAR 217
SAR 244 total
includes taxes & fees
7 Sep - 8 Sep

Postcard Cabins Gilchrist Springs
Postcard Cabins Gilchrist Springs
10.0 out of 10, Exceptional, (94)
The price is SAR 372
SAR 553 total
includes taxes & fees
3 Sep - 4 Sep
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 3-star hotels
Many 3-star hotels have the same amenities as 2-star hotels. See all 3-star hotels in O Brien.

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
16367 NW 167TH BLVD, Alachua, FL
The price is SAR 458 per night from Sep 30 to Oct 1
SAR 458
SAR 515 total
30 Sep - 1 Oct
includes taxes & fees
Still don't see what you're looking for?
See all properties in O Brien.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Learn more about O Brien
Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

Photo by Dr__Vlad
Open Photo by Dr__Vlad
Top O Brien Hotel Reviews
Explore a world of travel with Expedia
Explore a world of travel with Expedia
O Brien Hotels by Star Rating
Stay near popular O Brien attractions
- Hotels near Ichetucknee Springs State Park
- Hotels near Ginnie Spring
- Hotels near Ruth B. Kirby Gilchrist Blue Springs State Park
- Hotels near Ichetucknee River
- Hotels near Suwannee River State Park
- Hotels near Santa Fe River
- Hotels near Poe Springs Park
- Hotels near Florida Department of Transportation
- Hotels near Southside Sports Complex
- Hotels near Lake City Mall
- Hotels near Lake City Veterans Affairs Medical Center
- Hotels near O'Leno State Park
- Hotels near North Florida Speedway
- Hotels near Big Shoals State Park
- Hotels near Columbia County Courthouse
- Hotels near Wes Skiles Peacock Springs State Park
- Hotels near Southside Recreation Complex
- Hotels near Troy Spring State Park
- Hotels near Lafayette Blue Springs State Park
- Hotels near Epiphany Catholic Church
More Accommodation Types in O Brien
Explore more hotels
- Courtyard By Marriott Lake City
- Americas Best Value Inn Alachua
- Baymont by Wyndham Lake City
- Holiday Inn Express & Suites Live Oak by IHG
- Home2 Suites by Hilton Lake City
- BlueGem Motel
- Fairfield Inn & Suites Lake City
- TownePlace Suites by Marriott Lake City
- Americas Best Value Inn Lake City
- Days Inn by Wyndham Lake City I-75
- Royal Inn
- Palms Garden Inn
- Quality Inn Lake City
- Super 8 by Wyndham Lake City
- Driftwood Inn
- Quality Inn White Springs Suwanee
- Days Inn by Wyndham Lake City I-10
- Suwannee River Rendezvous
- Gateway Inn
- Regal Inn