Mytilene Vacations

Book a Hotel + Flight together to unlock savings

Photo by Jadranka Džepina

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    Save up to SAR 390 when you book a flight and hotel together*
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Find the Best Mytilene Vacation Packages

Mytilene Hotel Deals

Heliotrope Hotels

Heliotrope Hotels

4 out of 5
Varia, Mytilene, Lesvos, Lesvos Island
Fully refundableReserve now, pay when you stay
The price is SAR 554 per night from Jul 31 to Aug 1
SAR 554
SAR 651 total
31 Jul - 1 Aug
includes taxes & fees
8.6/10 Excellent! (182 reviews)
"Great people. Beautiful island"

Reviewed on 21 July 2025

Heliotrope Hotels
Mythical Coast Wellness Retreat

Mythical Coast Wellness Retreat

5 out of 5
Agrilia, Lesvos
8.8/10 Excellent! (33 reviews)
"Great property with lovely views and friendly staff. Only issue is that the upper floors of some buildings are not handicapped accessible and you will have to carry luggage’s up the stairs. To avoid stay on one of the main buildings"

Reviewed on 2 August 2024

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Mythical Coast Wellness Retreat
Theofilos Paradise Boutique Hotel

Theofilos Paradise Boutique Hotel

4 out of 5
7, Skra str, Hatzidimitriou Park, Mytilene, Lesvos
9.6/10 Exceptional! (147 reviews)
"Hotel’s location is great. There are a lot of food/drinks options within minutes. It is located in a very lively part of the town, yet secluded for a quiet stay. The breakfast was also very good."

Reviewed on 13 July 2025

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Theofilos Paradise Boutique Hotel
See all 161 properties in Mytilene
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Mytilene

Port of Mytilene

Explore the waterfront in Mytilene with a trip to Port of Mytilene. While you're in the area, stroll along the seaside.

Port of Mytilene

Bus Station

After visiting Bus Station, make a plan to see the other sights and activities in Mytilene. While you're in the area, stroll along the seaside.

Bus Station

Mytilini Castle

Learn about the local history of Mytilene when you take a trip to Mytilini Castle. While you're in the area, stroll along the seaside.

Mytilini Castle

Frequently asked questions

How much does a Mytilene vacation package cost?
You can grab a vacation package to this top destination on Expedia. But how much your vacation to Mytilene costs will depend on the season, length of stay and hotel choice.
What are the cheapest months to go to Mytilene?
If you're hoping to score a cheap Mytilene vacation package, consider visiting in February, March and December. You're likely to find lower prices on flights and accommodations during these months — ideal for budget-conscious travelers.
How to find the best Mytilene package deals?
Use Expedia's handy filters to help you find some fabulous Mytilene package deals. When you start your search, just set your maximum budget and then order the results by "Price: low to high." If you want to save, plan your trip for midweek, or browse for Mytilene package deals in the off-season. Play around with your travel dates and you may score even better discounts. As a rule of thumb, it's usually best to book your vacation package well in advance.
Is it cheaper to book a Mytilene vacation as a package?
An Expedia vacation package could land you great savings when compared to booking stays and flights separately. Better still, you can personalize your Mytilene escape to match your exact needs. Pick your preferred flight time, select the hotel type and add a car rental. Check out our great deals to see how much you can save.
When to book a vacation package to Mytilene?
Land incredible discounts by reserving your flights ahead of time with Expedia. If being spontaneous is more your thing, snap up one of our last-minute deals for an impromptu Mytilene escape.
How to plan a trip to Mytilene?

  1. Pick your dates: The things you want to do in Mytilene and your preferred season can help you decide when to go.
  2. Set your budget: Factor in costs such as flights, food and transportation when calculating how much to save for your trip to Mytilene. Then, choose a hotel that suits your budget, whether that's a wallet-friendly stay or a high-end getaway.
  3. Decide your trip length: Think about how much time you'd like to spend discovering Mytilene. Plan your itinerary so you can get to all the experiences and attractions you're interested in at a leisurely pace.
  4. Bundle your bookings: With your travel dates in place, you can combine your flights, car rental, hotels and more into a customized Mytilene vacation package.