Find Luxury Hotels in Main Street Hyannis, MA

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Pick from 4 Main Street Hyannis Luxury Hotels and compare room rates, reviews, and availability. Most hotels are fully refundable.

Cape Cod Inn
Exterior
Cape Cod Inn
2.0 star property
8.8 out of 10, Excellent, (332)
"It's good, clean, convenient and well located."
The price is SAR 356
SAR 408 total
includes taxes & fees
3 Jum. II - 4 Jum. II
Cape Cod Inn
Comfort Inn Hyannis - Cape Cod
Exterior
Comfort Inn Hyannis - Cape Cod
2.5 star property
7.6 out of 10, Good, (1005)
"Very easy and quick access from Steamship Authority ferry service."
The price is SAR 424
SAR 485 total
includes taxes & fees
4 Jum. II - 5 Jum. II
Comfort Inn Hyannis - Cape Cod
Americas Best Value Inn & Suites Hyannis Cape Cod
Pool
Americas Best Value Inn & Suites Hyannis Cape Cod
2.0 star property
7.4 out of 10, Good, (1002)
"Good"
The price is SAR 356
SAR 408 total
includes taxes & fees
3 Jum. II - 4 Jum. II
Americas Best Value Inn & Suites Hyannis Cape Cod
Hyannis Plaza Hotel
Outdoor pool
Hyannis Plaza Hotel
2.5 star property
6.8 out of 10, (530)
"The shower wouldn’t work the second night we were there. "
The price is SAR 318
SAR 396 total
includes taxes & fees
3 Jum. II - 4 Jum. II
Hyannis Plaza Hotel
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See all available properties in Main Street Hyannis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

Are you looking for a luxury hotel for your stay in Main Street Hyannis?
During your visit, you might want to enjoy the beaches and shopping which Main Street Hyannis is known for.
How many luxury hotels can I expect to find in Main Street Hyannis?
Lie in the lap of luxury during your getaway to Main Street Hyannis in one of Expedia’s 6 luxury hotels.
What's the best time to vacation in Main Street Hyannis?
Planning for the weather is an important factor for making your trip to Main Street Hyannis a success, especially when you’re splurging. The hottest months are usually August and July with an average temp of 67°F, while the coldest months are February and January with an average of 37°F. Average annual precipitation for Main Street Hyannis is 52 inches.
What's there to see and do in Main Street Hyannis?
Experience Main Street Hyannis with a stop at John F. Kennedy Hyannis Museum, Cape Cod Baseball Hall of Fame, and Cape Cod Carousel. If you have extra time while you’re in the area, you might want to stop by Cape Cod Maritime Museum and Hyannis Harbor.

Recent reviews of Main Street Hyannis hotels
Expedia verified reviews

Hyannis Travel Inn

Hyannis Travel Inn

5/5 Excellent
"We stayed there for memorial weekend. The staff were very friendly and professional, I highly recommend this hotel. "
A verified traveler stayed at Hyannis Travel Inn
Posted 23 hours ago
Hyannis Travel Inn