South Central Houston, TX
Houston
Visit South Central Houston
Popular places to visit
MD Anderson Cancer Center
Though MD Anderson Cancer Center might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
Rice University
Enjoy the collegiate vibe when you visit Rice University, during your travels in Houston. Experience the area's acclaimed art scene and great live music.
Houston Zoo
Why not visit the native and exotic animals who call Houston Zoo home during your trip to Houston? Experience the area's fascinating museums and lively festivals.
University of Houston
Enjoy the collegiate vibe when you visit University of Houston, during your travels in Houston. Experience the acclaimed theater scene and lively festivals in this vibrant area.
Children's Museum of Houston
You can take time to visit Children's Museum of Houston during your travels to Houston. Experience the area's entertainment choices and acclaimed theater scene.
Houston Natural Science Museum
You can spend time studying the exhibits at Houston Natural Science Museum in Houston. Experience the area's acclaimed art scene and entertainment choices.
South Central Houston Hotel Deals
Hotel Zaza Houston Museum District
Great b
Reviewed on 4 April 2026
Hilton Houston Plaza/Medical Center
Was given the option to upgrade to a suite and breakfast voucher. Excellent service at the front desk. Good staff at breakfast. Food was exceptional. Loved the Self-park option with room key in and out access. Would HIGHLY recommend this location. Also, decor in the lobby is nice with a small but ...
Reviewed on 5 April 2026
InterContinental Houston by IHG
Everyone is always friendly as usual!
Reviewed on 27 March 2026
The Westin Houston Medical Center/Museum District
I did see a few service pets there.
Reviewed on 5 April 2026
DoubleTree by Hilton Houston Medical Center Hotel & Suites
Nice staff.
Reviewed on 6 April 2026
Americas Best Value Inn Medical Center Downtown
Positive experience across the board.
Reviewed on 5 April 2026
Check South Central Houston hotel availability
Other neighborhoods around South Central Houston
Greater Third Ward
While you're in Greater Third Ward, take in top sights like Barbara Jordan & Mickey Leland Archives or Fertitta Center, and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Midtown
Characterized by a vibrant nightlife and young residents, this central Houston neighborhood boasts Ensemble Theatre, the largest African-American theater company in the US, and various parks like Midtown Park and Elizabeth Baldwin Park. Easily accessible via METRORail Red Line.
East Downtown Houston
Get to know East Downtown Houston and its many features like its restaurants and live music. You might want to explore sights like Shell Energy Stadium and Giant Beatles Statues, and you can jump on the metro at Leeland/Third Ward Station or EaDo/Stadium Station to get around the city.
Museum District
Known for its ample dining options and fascinating museums, there's plenty to explore in Museum District. You can visit top attractions like Children's Museum of Houston and Houston Natural Science Museum, and jump on the metro at Museum District Station or Hermann Park/Rice U Station to see more of the city.
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.
Downtown Houston
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.
