A water feature with multiple tiers and a circular viewing platform at the top.

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13 Nov - 15 Nov
Next weekend
20 Nov - 22 Nov

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Our top choices for South Central Houston hotels

A rooftop pool area with lounge chairs and a view of a tall building at night.

1. The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1,286 reviews)
"Good hotel. Clean and nice staff."
United States
Ariane
The price is SAR 447
SAR 556 total
includes taxes & fees
15 Nov - 16 Nov
The Westin Houston Medical Center/Museum District
A modern hotel building with a prominent entrance, large windows, and a visible name sign.

2. InterContinental Houston by IHG

InterContinental Houston by IHG
4.0 star property
South Central Houston
9.4 out of 10, Exceptional, (1,011 reviews)
"Great stay!"
United States
Luke
The price is SAR 571
SAR 743 total
includes taxes & fees
22 Nov - 23 Nov
InterContinental Houston by IHG
A modern hotel room with a large bed, a black leather sofa, a wooden coffee table, and a desk with a mirror.

3. Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown
2.0 star property
South Central Houston
9.2 out of 10, Wonderful, (280 reviews)
"Great place and close to downtown."
United States
Israel
The price is SAR 346
SAR 405 total
includes taxes & fees
25 Nov - 26 Nov
Downtowner Inns - Houston Downtown
A modern restaurant with a bar area, featuring a patterned floor, multiple dining tables, and contemporary lighting fixtures.

4. Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District
4.0 star property
South Central Houston
9.0 out of 10, Wonderful, (1,000 reviews)
"Location was best"
United States
Nafisa
The price is SAR 571
SAR 788 total
includes taxes & fees
27 Nov - 28 Nov
Houston Marriott Medical Center/Museum District
A spacious living area with a dining table, chairs, and a chandelier.

5. Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.2 out of 10, Wonderful, (1,013 reviews)
"Courteous staff, conveniently located. Very good amenities."
United States
David
The price is SAR 724
SAR 1,025 total
includes taxes & fees
25 Nov - 26 Nov
Hotel Zaza Houston Museum District
A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.

6. Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
South Central Houston
8.6 out of 10, Excellent, (2,258 reviews)
"Very nice, would stay again!"
United States
Amanda
The price is SAR 313
SAR 370 total
includes taxes & fees
26 Nov - 27 Nov
Hilton Houston Plaza/Medical Center
A spacious dining area with multiple tables and chairs, large windows, and hanging pendant lights.

7. DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites
4.0 star property
South Central Houston
8.4 out of 10, Very good, (722 reviews)
"Nice and convenient to the medical center"
United States
CHRISTY
The price is SAR 428
SAR 501 total
includes taxes & fees
22 Nov - 23 Nov
DoubleTree by Hilton Houston Medical Center Hotel & Suites
A high-rise hotel with a rooftop pool, multiple floors, and a cityscape view.

8. Sentral Forme Houston

Sentral Forme Houston
4.5 star property
South Central Houston
9.2 out of 10, Wonderful, (102 reviews)
"Enjoyable stay with all the comforts of home."
United States
ebony noelle
The price is SAR 784
SAR 1,028 total
includes taxes & fees
10 Dec - 11 Dec
Sentral Forme Houston
A multi-story hotel with a brick facade, balconies, and a well-lit entrance.

9. La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B
3.5 star property
South Central Houston
9.8 out of 10, Exceptional, (609 reviews)
"The breakfast was fantastic. Property was clean. Staff is awesome"
United States
Justin
The price is SAR 605
SAR 708 total
includes taxes & fees
19 Nov - 20 Nov
La Maison in Midtown an urban B&B
A modern kitchen with dark wood cabinets, a granite countertop, and a built-in island with a glass enclosure.

10. Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown
2.0 star property
South Central Houston
8.0 out of 10, Very good, (1,001 reviews)
"Great Stay"
United States
Randy
The price is SAR 327
SAR 382 total
includes taxes & fees
12 Nov - 13 Nov
Americas Best Value Inn Medical Center Downtown
A large, multi-story house with a swimming pool, outdoor seating, and a red umbrella.

11. Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
South Central Houston
9.6 out of 10, Exceptional, (221 reviews)
"The room was very clean, the staff was just great and the breakfast was very good! The Parking was a little difficult, but it was very safe!"
United States
Walter
The price is SAR 544
SAR 693 total
includes taxes & fees
12 Nov - 13 Nov
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
A modern kitchen with a large island, bar stools, and a stainless steel refrigerator.

12. Wanderstay Boutique Hotel

Wanderstay Boutique Hotel
3.0 star property
South Central Houston
9.8 out of 10, Exceptional, (83 reviews)
"Everything about our stay here was wonderful."
United States
jennifer k
The price is SAR 492
SAR 576 total
includes taxes & fees
1 Dec - 2 Dec
Wanderstay Boutique Hotel
Private kitchen

13. 2824 Aeon Living

2824 Aeon Living
3.5 star property
South Central Houston
The price is SAR 443
SAR 518 total
includes taxes & fees
15 Nov - 16 Nov
2824 Aeon Living
A multi-level atrium with a glass ceiling, balconies, and indoor plants.

14. 2820 Blodgett St

2820 Blodgett St
South Central Houston
The price is SAR 766
SAR 896 total
includes taxes & fees
12 Nov - 13 Nov
2820 Blodgett St
A hotel room with a bed, a desk, a chair, a mirror, a television, and a heater.

15. Scott Inn Suites - Downtown Houston

Scott Inn Suites - Downtown Houston
2.0 star property
South Central Houston
8.4 out of 10, Very good, (49 reviews)
"great value for money"
United States
Abdulmuiz
The price is SAR 244
SAR 285 total
includes taxes & fees
22 Nov - 23 Nov
Scott Inn Suites - Downtown Houston
A spacious lobby with a large sectional sofa, a coffee table, and a reception desk.

16. Hilton University of Houston

Hilton University of Houston
3.5 star property
South Central Houston
9.0 out of 10, Wonderful, (999 reviews)
"Great stay!"
United States
Elizabeth
The price is SAR 551
SAR 645 total
includes taxes & fees
25 Nov - 26 Nov
Hilton University of Houston
A large outdoor swimming pool with a slide and multiple lanes, surrounded by a modern building with large windows.

17. Historic Loft - 1 Medcenter NRG DT Fifa

Historic Loft - 1 Medcenter NRG DT Fifa
2.0 star property
South Central Houston
The price is SAR 574
SAR 672 total
includes taxes & fees
12 Nov - 13 Nov
Historic Loft - 1 Medcenter NRG DT Fifa
A spacious lobby with a high ceiling, a central seating area with sofas and armchairs, a staircase leading to an upper level, and a flat-screen TV mounted on the wall.

18. Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl
2.5 star property
South Central Houston
6.2 out of 10, (1,006 reviews)
"The perfect place to stay!"
Mexico
Maria Fernanda
The price is SAR 290
SAR 341 total
includes taxes & fees
26 Nov - 27 Nov
Extended Stay America Suites Houston Med Ctr Braeswood Bl
A hotel room with a bed, bedside table, desk, and a mirror.

19. Southmore Boulevard Motel

Southmore Boulevard Motel
2.0 star property
South Central Houston
5.8 out of 10, (245 reviews)
"Very sweet lady I will be back"
United States
LaKeara
The price is SAR 220
SAR 257 total
includes taxes & fees
22 Nov - 23 Nov
Southmore Boulevard Motel
A modern kitchen with dark cabinets, a stainless steel refrigerator, and a microwave.

20. Houston Lux Townhome

Houston Lux Townhome
2.0 star property
South Central Houston
9.8 out of 10, Exceptional, (9 reviews)
"The proximity to places we wanted to go was very close."
United States
Bobbi
The price is SAR 799
SAR 935 total
includes taxes & fees
2 Dec - 3 Dec
Houston Lux Townhome
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare top hotels in South Central Houston

A rooftop pool area with lounge chairs and a view of a tall building at night.

The Westin Houston Medical Center/Museum District

4.0 star property
South Central Houston
View
A modern hotel building with a prominent entrance, large windows, and a visible name sign.

InterContinental Houston by IHG

4.0 star property
South Central Houston
View
A modern hotel room with a large bed, a black leather sofa, a wooden coffee table, and a desk with a mirror.

Downtowner Inns - Houston Downtown

2.0 star property
South Central Houston
View
A modern restaurant with a bar area, featuring a patterned floor, multiple dining tables, and contemporary lighting fixtures.

Houston Marriott Medical Center/Museum District

4.0 star property
South Central Houston
View
A spacious living area with a dining table, chairs, and a chandelier.

Hotel Zaza Houston Museum District

4.5 star property
South Central Houston
View
9.2
Wonderful
1,286 reviews
9.4
Exceptional
1,011 reviews
9.2
Wonderful
280 reviews
9.0
Wonderful
1,000 reviews
9.2
Wonderful
1,013 reviews
The price is SAR 447
SAR 556 total
includes taxes & fees
15 Nov - 16 Nov
The price is SAR 571
SAR 743 total
includes taxes & fees
22 Nov - 23 Nov
The price is SAR 346
SAR 405 total
includes taxes & fees
25 Nov - 26 Nov
The price is SAR 571
SAR 788 total
includes taxes & fees
27 Nov - 28 Nov
The price is SAR 724
SAR 1,025 total
includes taxes & fees
25 Nov - 26 Nov
  • No Breakfast included
  • Yes, Pool
  • No Spa
  • Yes, Pet friendly
  • No WiFi included
  • Yes, Parking
  • No Breakfast included
  • Yes, Pool
  • No Spa
  • Yes, Pet friendly
  • Yes, WiFi included
  • Yes, Parking
  • Yes, Breakfast included
  • No Pool
  • No Spa
  • No Pet friendly
  • Yes, WiFi included
  • Yes, Parking
  • No Breakfast included
  • No Pool
  • No Spa
  • Yes, Pet friendly
  • No WiFi included
  • Yes, Parking
  • No Breakfast included
  • Yes, Pool
  • Yes, Spa
  • Yes, Pet friendly
  • Yes, WiFi included
  • Yes, Parking

Where to stay in South Central Houston

Find the best South Central Houston areas and neighborhoods for the activities you enjoy most.
A bridge with the words "Welcome to Downtown Houston" and a star emblem.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

A tall, modern building with a unique, vertical design, surrounded by trees and a partly cloudy sky.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

A cityscape with dense high-rise buildings, a river, and surrounding greenery.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

A city skyline with modern skyscrapers and a river flowing through a park.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

A modern cityscape with a tram and tall buildings.
Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

Top South Central Houston Hotel Reviews

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

10/10 Excellent
"I enjoyed my stay at this Hilton. I love the brand for their comfortable beds and their cleanliness. The staff was friendly, the food was good and it is in a good location. HOWEVER, the hotel is very old and needs a face-lift. My tub was cracked and peeling in several places, my curtains were damaged and there were several items with permanent stains."
Bryan 3-night trip
Posted 7 hours ago
Hilton Houston Plaza/Medical Center

Frequently asked questions

What's it like in South Central Houston?
Travelers are sure to enjoy a stay in Houston's South Central Houston neighborhood. Be sure to check out TDECU Stadium and Children's Museum of Houston as part of your South Central Houston travel plans.
What's the best accommodation in South Central Houston?
Based on our traveler data, Hotel Zaza Houston Museum District is one of the top choices for your stay in South Central Houston. This hotel is a short 6-minute walk from Rice University, and it offers a full-service spa and a restaurant. Other good options for your stay in the area include Hilton Houston Plaza/Medical Center and The Westin Houston Medical Center/Museum District.
How many hotels can I expect to find in the South Central Houston area?
Expedia has 1272 hotels and other accommodations in South Central Houston to choose from, making this an ideal home base for exploring the greater Houston area.
If I need to cancel my hotel reservation in South Central Houston, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to review the best options available in South Central Houston.
Where can I learn more about changing or cancelling my trip to South Central Houston?
To access more information about changing or cancelling your trip to South Central Houston, go to https://www.expedia.com/service/.
What is there to do around this Houston neighborhood?
Spend some time exploring the great outdoors at Hermann Park, Cullen Sculpture Garden, and Twilight Epiphany Skyspace. TDECU Stadium and Children's Museum of Houston are some other stops to visit in the neighborhood. Daikin Park and Toyota Center are some favorite places to visit in the area around South Central Houston. Shape Community Center and Project Row Houses are also worth a visit when you're out sightseeing in Houston.
How can I get around South Central Houston and the greater Houston area?
For a quick way to explore the city, catch a ride on metro transit at Elgin/Third Ward Station, TSU/UH Athletics District Station, or Ensemble/HCC Station. If you want to venture out of town, M. D. Anderson Station is the closest train station. You can also catch a ride at Kinder Station.