Find hotels in East Main Street, Grand Junction from SAR 266
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Discover 565 East Main Street hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Camp Eddy
Camp Eddy
9.4 out of 10, Exceptional, (234)
The price is SAR 344
SAR 588 total
includes taxes & fees
20 Jul - 21 Jul

Best Western Grande River Inn & Suites
Best Western Grande River Inn & Suites
9.0 out of 10, Wonderful, (723)
The price is SAR 493
SAR 519 total
includes taxes & fees
7 Aug - 8 Aug

Super 8 by Wyndham Fruita
Super 8 by Wyndham Fruita
8.6 out of 10, Excellent, (1004)
The price is SAR 266
SAR 304 total
includes taxes & fees
3 Aug - 4 Aug

Ramada by Wyndham Grand Junction
Ramada by Wyndham Grand Junction
8.4 out of 10, Very Good, (1632)
The price is SAR 268
SAR 307 total
includes taxes & fees
20 Jul - 21 Jul

Econo Lodge
Econo Lodge
8.4 out of 10, Very Good, (1001)
The price is SAR 277
SAR 317 total
includes taxes & fees
3 Aug - 4 Aug

Quality Inn Grand Junction near University
Quality Inn Grand Junction near University
8.6 out of 10, Excellent, (1002)
The price is SAR 334
SAR 383 total
includes taxes & fees
20 Jul - 21 Jul
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in East Main Street
Find the best East Main Street areas and neighborhoods for the activities you enjoy most.
Redlands
1 out of top 10 points of interest in this area
You'll enjoy the mountain views and wineries in Redlands. You might want to make time for a stop at Colorado National Monument or Redlands Mesa Golf Club.
Downtown
1 out of top 10 points of interest in this area
While there might not be top attractions in Downtown, you can explore the larger area and discover places like Western Colorado Botanical Gardens and Bananas Fun Park.
Pear Park
If you're spending some time in Pear Park, Colorado River and James M. Robb – Colorado River State Park are top sights worth seeing.
Horizon Drive District
While there might not be top attractions in Horizon Drive District, you can explore the larger area and discover places like Canyon View Park and Bananas Fun Park.
Orchard Mesa
1 out of top 10 points of interest in this area
If you're spending some time in Orchard Mesa, Mesa County Fairgrounds and Gunnison River are top sights worth seeing.
Top East Main Street Hotel Reviews

Wine Country Inn Palisade
10/10 Excellent
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Hotels near popular Grand Junction Attractions
- Hotels near Colorado Mesa University
- Hotels near Colorado River
- Hotels near Colorado National Monument
- Hotels near Canyon View Park
- Hotels near Two Rivers Convention Center
- Hotels near Redlands Mesa Golf Club
- Hotels near Bananas Fun Park
- Hotels near Gunnison River
- Hotels near Mesa County Fairgrounds
- Hotels near Western Colorado Botanical Gardens
More Accommodation Types in East Main Street
Hotels Close to Nearby Airports
East Main Street Hotels by Star Rating
East Main Street Hotels by Brand
Explore more hotels
- Studio 6 Grand Junction, CO
- Doubletree Hotel Grand Junction
- Hotel Maverick
- Red Roof Inn Grand Junction
- Tru by Hilton Grand Junction Downtown
- La Quinta Inn & Suites by Wyndham Fruita
- Quality Inn Grand Junction near University
- Courtyard by Marriott Grand Junction
- Motel 6 Grand Junction, CO
- Holiday Inn and Suites Grand Junction by IHG
- Holiday Inn Express & Suites Grand Junction by IHG
- Candlewood Suites Grand Junction by IHG