Find hotels in East Main Street, Grand Junction from SAR 238
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Discover 565 East Main Street hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Wine Country Inn Palisade
Wine Country Inn Palisade
9.6 out of 10, Exceptional, (1023)

Best Western Grande River Inn & Suites
Best Western Grande River Inn & Suites
9.0 out of 10, Wonderful, (740)
The price is SAR 475
SAR 500 total
includes taxes & fees
29 Sep - 30 Sep

La Quinta Inn & Suites by Wyndham Grand Junction
La Quinta Inn & Suites by Wyndham Grand Junction
8.8 out of 10, Excellent, (2563)
The price is SAR 447
SAR 512 total
includes taxes & fees
3 Sep - 4 Sep

Tru by Hilton Grand Junction Downtown
Tru by Hilton Grand Junction Downtown
9.2 out of 10, Wonderful, (870)
The price is SAR 596
SAR 684 total
includes taxes & fees
7 Sep - 8 Sep

Spoke and Vine Motel
Spoke and Vine Motel
9.8 out of 10, Exceptional, (151)
The price is SAR 757
SAR 834 total
includes taxes & fees
3 Sep - 4 Sep

Clarion Inn Grand Junction
Clarion Inn Grand Junction
8.6 out of 10, Excellent, (1652)
The price is SAR 358
SAR 410 total
includes taxes & fees
28 Sep - 29 Sep
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in East Main Street
Find the best East Main Street areas and neighborhoods for the activities you enjoy most.
Downtown
1 out of top 10 points of interest in this area
While there might not be top attractions in Downtown, you can explore the larger area and discover places like Western Colorado Botanical Gardens and Bananas Fun Park.
Redlands
1 out of top 10 points of interest in this area
You'll enjoy the mountain views and wineries in Redlands. You might want to make time for a stop at Colorado National Monument or Redlands Mesa Golf Club.
Pear Park
If you're spending some time in Pear Park, Colorado River and James M. Robb – Colorado River State Park are top sights worth seeing.
Horizon Drive District
While there might not be top attractions in Horizon Drive District, you can explore the larger area and discover places like Canyon View Park and Bananas Fun Park.
Orchard Mesa
1 out of top 10 points of interest in this area
If you're spending some time in Orchard Mesa, Mesa County Fairgrounds and Gunnison River are top sights worth seeing.
Top East Main Street Hotel Reviews

Hotel Maverick
10/10 Excellent

Super 8 by Wyndham Grand Junction Colorado
10/10 Excellent
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Hotels near popular Grand Junction Attractions
- Hotels near Colorado Mesa University
- Hotels near Colorado River
- Hotels near Colorado National Monument
- Hotels near Canyon View Park
- Hotels near Two Rivers Convention Center
- Hotels near Redlands Mesa Golf Club
- Hotels near Bananas Fun Park
- Hotels near Mesa County Fairgrounds
- Hotels near Gunnison River
- Hotels near Western Colorado Botanical Gardens
More Accommodation Types in East Main Street
Hotels Close to Nearby Airports
East Main Street Hotels by Star Rating
East Main Street Hotels by Brand
Explore more hotels
- Hotel Maverick
- Wine Country Inn Palisade
- La Quinta Inn & Suites by Wyndham Fruita
- Tru by Hilton Grand Junction Downtown
- Red Roof Inn Grand Junction
- Quality Inn Grand Junction near University
- Doubletree Hotel Grand Junction
- Days Inn by Wyndham Grand Junction
- Comfort Inn Grand Junction I-70
- Best Western Grande River Inn & Suites
- Motel 6 Grand Junction, CO
- Courtyard by Marriott Grand Junction