Find hotels in East Main Street, Grand Junction from SAR 281
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Discover 567 East Main Street hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Wine Country Inn Palisade
Wine Country Inn Palisade
9.6 out of 10, Exceptional, (1014)

La Quinta Inn & Suites by Wyndham Grand Junction
La Quinta Inn & Suites by Wyndham Grand Junction
8.8 out of 10, Excellent, (2478)
The price is SAR 409
SAR 469 total
includes taxes & fees
6 Jul - 7 Jul

Super 8 by Wyndham Fruita
Super 8 by Wyndham Fruita
8.6 out of 10, Excellent, (1009)
The price is SAR 281
SAR 322 total
includes taxes & fees
24 Jun - 25 Jun

Tru by Hilton Grand Junction Downtown
Tru by Hilton Grand Junction Downtown
9.2 out of 10, Wonderful, (841)
The price is SAR 545
SAR 625 total
includes taxes & fees
13 Jul - 14 Jul

Quality Inn Grand Junction near University
Quality Inn Grand Junction near University
8.6 out of 10, Excellent, (1004)
The price is SAR 353
SAR 404 total
includes taxes & fees
29 Jun - 30 Jun

Hotel Maverick
Hotel Maverick
9.6 out of 10, Exceptional, (1004)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in East Main Street
Find the best East Main Street areas and neighborhoods for the activities you enjoy most.
Redlands
1 out of top 10 points of interest in this area
You'll enjoy the mountain views and wineries in Redlands. You might want to make time for a stop at Colorado National Monument or Redlands Mesa Golf Club.
Downtown
1 out of top 10 points of interest in this area
While there might not be top attractions in Downtown, you can explore the larger area and discover places like Western Colorado Botanical Gardens and Bananas Fun Park.
Pear Park
If you're spending some time in Pear Park, Colorado River and James M. Robb – Colorado River State Park are top sights worth seeing.
Horizon Drive District
While there might not be top attractions in Horizon Drive District, you can explore the larger area and discover places like Canyon View Park and Bananas Fun Park.
Orchard Mesa
1 out of top 10 points of interest in this area
If you're spending some time in Orchard Mesa, Mesa County Fairgrounds and Gunnison River are top sights worth seeing.
Recent reviews of East Main Street hotels
Recent reviews of East Main Street hotels

La Quinta Inn & Suites by Wyndham Grand Junction
5/5 Excellent
"Interactions with staff were pleasant. "
A verified traveler stayed at La Quinta Inn & Suites by Wyndham Grand Junction
Posted 21 hours ago
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Hotels near popular Grand Junction Attractions
- Hotels near Colorado Mesa University
- Hotels near Colorado River
- Hotels near Colorado National Monument
- Hotels near Canyon View Park
- Hotels near Two Rivers Convention Center
- Hotels near Redlands Mesa Golf Club
- Hotels near Bananas Fun Park
- Hotels near Mesa County Fairgrounds
- Hotels near Western Colorado Botanical Gardens
- Hotels near Gunnison River
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Hotels Close to Nearby Airports
East Main Street Hotels by Star Rating
East Main Street Hotels by Brand
Explore more hotels
- Red Roof Inn Grand Junction
- Wine Country Inn Palisade
- Super 8 by Wyndham Fruita
- Hotel Maverick
- Courtyard by Marriott Grand Junction
- La Quinta Inn & Suites by Wyndham Fruita
- Quality Inn Grand Junction near University
- Motel 6 Grand Junction, CO
- Holiday Inn and Suites Grand Junction by IHG
- Holiday Inn Express & Suites Grand Junction by IHG
- Best Western Grande River Inn & Suites
- Comfort Inn Grand Junction I-70